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Tissue-specific melt electrowritten polymeric scaffolds for coordinated regeneration of soft and hard periodontal tissues

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Bioactive Materials 2023年第1期19卷 268-281页

作者： Arwa Daghrery Jessica A.Ferreira Jinping Xu Nasim Golafshan darnell Kaigler Sarit B.Bhaduri Jos Malda Miguel Castilho Marco C.Bottino Department of Cariology Restorative Sciencesand EndodonticsSchool of DentistryUniversity of MichiganAnn ArborMIUnited States Department of Restorative Dental Sciences School of DentistryJazan UniversityJazanKingdom of Saudi Arabia Department of Orthopedics University Medical Center UtrechtUtrechtthe Netherlands Regenerative Medicine Center Utrechtthe Netherlands Department of Periodontics and Oral Medicine School of DentistryUniversity of MichiganAnn ArborMIUnited States Department of Mechanical Industrial and Manufacturing EngineeringUniversity of ToledoToledoOHUnited States eeC Division Directorate of EngineeringThe National Science FoundationAlexandriaVAUnited States Department of Clinical Sciences Faculty of Veterinary MedicineUtrecht UniversityUtrechtthe Netherlands Department of Biomedical engineering Eindhoven University of TechnologyEindhoventhe Netherlands Institute for Complex Molecular Systems Eindhoven University of TechnologyP.O.Box 5135600 MB Eindhoventhe Netherlands Department of Biomedical engineering College of EngineeringUniversity of MichiganAnn ArborMIUnited States

Periodontitis is a chronic inflammatory condition that often causes serious damage to tooth-supporting *** limited successful outcomes of clinically available approaches underscore the need for therapeutics that cannot only provide structural guidance to cells but can also modulate the local immune ***,three-dimensional melt electrowritten(i.e.,poly(ε-caprolactone))scaffolds with tissue-specific attributes were engineered to guide differentiation of human-derived periodontal ligament stem cells(hPDLSCs)and mediate macrophage *** investigated tissue-specific scaffold attributes comprised fiber morphology(aligned ***)and highly-ordered architectures with distinct strand spacings(small 250μm and large 500μm).Macrophages exhibited an elongated morphology in aligned and highly-ordered scaffolds,while maintaining their round-shape on randomly-oriented fibrous *** of periostin and IL-10 were more pronounced on the aligned and highly-ordered *** hPDLSCs on the scaffolds with 500μm strand spacing show higher expression of osteogenic marker(Runx2)over 21 days,cells on randomly-oriented fibrous scaffolds showed upregulation of M1 *** an orthotopic mandibular fenestration defect model,findings revealed that the tissue-specific scaffolds(i.e.,aligned fibers for periodontal ligament and highly-ordered 500μm strand spacing fluorinated calcium phosphate[F/CaP]-coated fibers for bone)could enhance the mimicking of regeneration of natural periodontal tissues.

关键词： Periodontitis Melt electrowriting 3D printing Inflammation Periodontal regeneration Scaffold

Molecular cell bioloby 3rd ed. 3rd ed.

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Life Stage, Gender and Movement of Blue Crabs (Callinectes sapidus) in Lake Mattamuskeet and Connecting Canals

1995年

作者： James darnell ... [et al.]

来源：畅想之星图书光盘版（南... 评论

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Journal of Fisheries Science 2019年第2期1卷 7-19页

作者： Julia Chen Rinaldi James Hench M.Zachary darnell Matthew Kukurugya Daniel Rittschof Stantec 265 Clinton StBrooklynNY11201202-494-4462United States 135 Duke Marine Lab Road MSC Nicholas SchoolDuke University BeaufortNC 2851650-759-6639United States Gulf Coast Research Lab 703 E.Beach Dr.Ocean SpringsMS 39564Division of Coastal SciencesSchool of Ocean Science and EngineeringThe University of Southern Mississippi228-872-4298United States Molecular and Cell Biology UC Berkley 635 Tennessee St.San FranciscoCA 94107219-793-4375United States MSC Nicholas SchoolDuke University135 Duke Marine Lab RoadBeaufortNC 28516252-504-7634United States

In their ranges on east and south coasts of the Americas as well as their established invasions in the Adriatic and Baltic,blue crabs,Callinectes sapidus,inhabit estuaries,sounds and coastal oceans and are commercially and ecologically *** crabs move in response to physical variables is important to *** monitored life stages at canal control structures,assessed gender ratios with recreational crabbing,learned from crabbers,and studied movements of tagged crabs in a canal connecting Lake Mattamuskeet to the Pamlico *** enter the lake through two of 4 canals connecting to the *** migrate out through one *** lake standing population is about 70% *** of 240 crabs in August 2012 and 102 crabs in October 2014 were quantified using RFID tags with co-located meteorological and oceanographic ***-spawning females and males are *** released in the canal move in response to changes in water depth and go with the flow,toward the Pamlico Sound(summer 76% and fall 78%).What crabbers describe as a fall migration appears to be concentration of crabs in warmer deeper canals and then southern movement with flow generated by strong north *** be effective,management strategies like migratory corridors require understanding of crab movements.

关键词： Crabs Meteorology Oceanography Movement Foraging Migration RFID Tagging Life History

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真核细胞中基因控制水平的变化

中国生物工程杂志 1984年第3期 72-82页

作者： James e ,darnell Jr ,杨志兴 ,杨学成

真核细胞中基因控制的研究在过去五年中已经成熟,进而成为一个实验生物学中最活跃而丰产的领域。早期关于真核基因控制的结论之所以推迟得出是,因为真核细胞中mRNA的产生并非是一种转录RNA的简单形式。特别是在脊椎动物细胞中,mRNA的转... 详细信息

真核细胞中基因控制的研究在过去五年中已经成熟,进而成为一个实验生物学中最活跃而丰产的领域。早期关于真核基因控制的结论之所以推迟得出是,因为真核细胞中mRNA的产生并非是一种转录RNA的简单形式。特别是在脊椎动物细胞中,mRNA的转录单位较之最终的mRNA产物更长些。mRNA在细胞质中出现并被翻译之前,在细胞核中对最初的RNA转录子进行几个步骤的“加工”,其中包括:在最初转录子的5’端加

关键词： mRNA 半衰期序列细胞核核(细胞学) 转录单位位点基因控制腺病毒感染 DNA 转录控制免疫球蛋白重链卵黄蛋白原转录子 Poly

动脉期短暂呼吸运动伪影是否影响诊断效能？一项同一病人采用细胞外钆剂和钆塞酸的对比研究

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国际医学放射学杂志 2021年第1期44卷 122-122页

作者： J.Rimola A.darnell e.Belmonte V.Sapena C.Caparroz N.Llarch 赵玉娇

摘要目的比较细胞外钆剂和钆塞酸注射后肝脏MRI中动脉期出现短暂呼吸-运动相关伪影的频率,并确定这些伪影对动脉期强化病灶检测的影响。方法前瞻性收集1个

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控制饮食在多囊卵巢综合征治疗中的作用

世界核心医学期刊文摘（妇产科学分册） 2006年第6期2卷 34-34页

作者： Douglas C.C. Gower B.A. darnell B.e. 朱磊 409 Webb Building 1675 University Boulevard Birmingham AL 35294- 3360 United StatesDr.

Objective: To determine whether eucaloric diets either enriched with monounsaturated fatty acids (MUFA; 17% energy) or low in carbohydrates (Low CHO; 43% energy) would increase insulin sensitivity (Si) and decrease circulating insulin concentrations, relative to a standard diet (STD; 56% CHO, 31% fat, 16% protein), among women with polycystic ovary syndrome (PCOS). Design: Crossover. Setting: Academic research environment. Patient(s): Healthy women with PCOS not on hormonal or insulin- sensitizing therapy. Intervention(s): Subjects consumed three, 16- day, eucaloric diets, each separated by a 3- week washout period. A frequently sampled, intravenous, glucose tolerance test was administered at baseline and following each diet. Main Outcome Measure(s): Fasting glucose, insulin, the acute insulin response to glucose (AIRg), Si, sex hormone- binding globulin (SHBG), dehydroepiandrosterone sulfate (DHeAS), total testosterone (T), free T, A4, total cholesterol, high- density lipoprotein cholesterol (HDL- C), tryglycerides (TG), and free fatty acids (FFA). Result( s): Fasting insulin was lower following the Low CHO diet relative to the STD diet; AIRg was lower following the Low CHO diet relative to the MUFA diet. Fasting glucose, Si, and the circulating concentrations of reproductive hormones were not significantly affected by the intervention. Conclusion(s): A moderate reduction in dietary carbohydrate reduced the fasting and postchallenge insulin concentrations among women with PCOS, which, over time, may improve reproductive/endocrine outcomes.

关键词：多囊卵巢综合征控制饮食富含单不饱和脂肪酸治疗静脉葡萄糖耐量试验胰岛素浓度低碳水化合物胰岛素敏感性饮食控制研究机构

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