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Treatment repurposing for inflammatory bowel disease using literature-related discovery and innovation

World Journal of Gastroenterology 2020年第33期26卷 4889-4899页

作者： Ronald Neil Kostoff Michael Brandon Briggs darla roye shores School of Public Policy Georgia Institute of TechnologyGainesvilleVA 20155United States Independent Consultant RoscommonMI 48653United States The Hopkins Resource for Intestinal Vitality and Enhancement the Johns Hopkins University School of MedicineBaltimoreMD 21287United States

Inflammatory bowel disease(IBD)incidence has been increasing steadily,most dramatically in the Western developed *** often includes lifelong immunosuppressive therapy and *** is a critical need to reduce the burden of IBD and to discover medical therapies with better efficacy and fewer potential *** of treatments originally studied in other diseases with similar pathogenesis is less costly and time intensive than de novo drug *** study used a treatment repurposing methodology,the literature-related discovery and innovation(LRDI)text mining system,to identify potential treatments(developed for non-IBD diseases)with sufficient promise for extrapolation to treatment of *** searching for desirable patterns of twenty key biomarkers relevant to IBD(e.g.,inflammation,reactive oxygen species,autophagy,barrier function),the LRDI-based query retrieved approximately 9500 records from *** most recent 350 records were further analyzed for *** 18%(64/350)met the criteria for discovery(not previously studied in IBD human or animal models)and relevance for application to IBD *** of the treatments were compounds derived from herbal remedies,and the majority of treatments were being studied in cancer,diabetes,and central nervous system disease,such as depression and *** further validation of the search strategy,the query identified ten treatments that have just recently begun testing in IBD models in the last three ***-related discovery and innovation text mining contains a unique search strategy with tremendous potential to identify treatments for repurposing.A more comprehensive query with additional key biomarkers would have retrieved many thousands more records,further increasing the yield of IBD treatment repurposing discovery.

关键词： Treatment repurposing Treatment repositioning Inflammatory bowel disease Literature-based discovery Text mining Crohn’s disease Ulcerative colitis Novel treatments

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