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Major complications following exenteration in cases of pelvic malignancy:A 10-year experience

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World Journal of Gastroenterology 2006年第7期12卷 1115-1119页

作者： dariusz Wydra Janusz Emerich Sambor Sawicki Katarzyna Ciach Andrzej Marciniak Department of Gynecology of Medical University of Gdansk Poland Department of Anesthesiology of Medical University of Gdansk Poland

AIM： To analyze the major complications after exenteration of gynecological and rectal malignancies.METHODS： Twenty-two patients with gynecological malignancy and 6 with rectal malignancy underwent pelvic exenteration （PE） between 1996 and 2005. PE was performed for primary malignancy in 71.4% of cases （vulvar cancer in 13, cancer rectal in 5, cervical cancer in 1 and Bartholin＇s gland cancer in 1 cases respectively and recurrent malignancy in 28.6% of cases （cervical cancer in 5, ovarian cancer in 1, uterine sarcoma in 1 and rectal cancer in 1 cases respectively）. Posterior PE, total PE and anterior PE were most often performed.RESULTS： Major complications in the operative field involving the urinary tract infection or the wound dehiscence occurred in 12 patients （42.9%）. Early complications included massive bleeding from the sacral plexus, adult respiratory distress syndrome （ARDS）, thrombophlebitis, acute renal failure, urinary bladder dysfunction, ureter damage, re-operation and pulmonary embolus. Urinary incontinence was observed in 2 women as a late complication. In 1 patient a nephrostomy was performed in 1 patient due to extensive hydronephrosis and 1 patient had complications connected with the gastrointestinal tract. The mortality rate was 7%, of which inter-operative mortality accounted for 3.5%. Major complications often occurred in advanced primary vulvar cancer affecting those with recurrent malignancies.CONCLUSION： PE is more beneficial to patients with primary vulvar and rectal cancer than to those with recurrent cancer. Knowledge of the inherent complications and morbidity of PE is essential.

关键词： Complications Pelvic exenteration Gynacological cancer Rectal cancer Vulvar cancer

Effect of interferon alpha and ribavirin treatment on serum levels of transforming growth factor-β1,vascular endothelial growth factor,and basic fibroblast growth factor in patients with chronic hepatitis C

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World Journal of Gastroenterology 2006年第6期12卷 961-965页

作者： Ewa Janczewska-Kazek Bogdan Marek dariusz Kajdaniuk Halina BorgieI-Marek Department of Infectious Diseases Medical University of Silesia Chorzow Poland Department of Pathophysiology Medical University of Silesia Zabrze Poland Medical University of Silesia KatowicePoland

AIM： To assess the role of transforming growth factor-β1 （TGF-β1）, vascular endothelial growth factor （VEGF） and basic fibroblast growth factor （bFGF） in the pathogenesis of fibrosis associated with chronic hepatitis C （CHC） and to evaluate the influence of the antiviral therapy on above parameter levels depending on the treatment results （complete response or no response）. METHODS： Study group included 100 patients with CHC, in whom fibrosis in liver specimens was assessed （Scheuer fibrosis score： 1-4 points）. Control group included 30 subjects with antibodies anti-HCV present and persistently normal ALT level, without fibrosis （Scheuer fibrosis score： 0 points）. Concentration of studied parameters was assayed in the serum by immunoenzymatic method before and after the therapy with interferon alpha-2b and ribavirin. RESULTS： TGF-β1 levels were significantly higher in the study group compared to the control group （35.89 vs 32.37 ng/mL; P= 0.023）. Such differences were not found in VEGF and bFGF levels. In patients showing complete response （negative HCV RNA and normal ALT level）, significant increase in VEGF （112.8 vs 315.03 pg/mL; P〈 0.05） and bFGF （2.51 vs 15.79 pg/mL; P=0.04） levels were found. Significant decrease in TGF-β1 level was observed both in responders （37.44 vs 30.02 ng/mL; P=0.05）, and in non-responders （38.22 vs 30.43 ng/mL; P=0.043）. bFGF levels before the treatment were significantly lower （2.51 vs 5.94 pg/mL; P=0.04）, and after the treatment significantly higher （15.79 vs 4.35 pg/mL; P=0.01） in patients with complete response response. CONCLUSION： Among the analyzed parameters TGF-β1 seems to play the most important role in the pathogenesis of fibrosis in CHC. Levels of this factor are significantly lower in subjects who do not have fibrosis developed in them. Good therapeutic effect in CHC patients is associated with significant changes in TGF-β1, VEGF, and bFGF levels, bFGF seems to have the highest usefulness in the prognosis of treatment

关键词： Liver fibrosis HCV Interferon Ribavirin Growth factor

The effect of the dietary inclusion of pea seeds of colored-flowered and white-flowered varieties on gastrointestinal function in turkeys

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Animal Nutrition 2022年第3期10卷 167-177页

作者： Zenon Zdunczyk dariusz Mikulski Jan Jankowski Bogdan A.Slominski Jerzy Juskiewicz Institute of Animal Reproduction and Food Research Polish Academy of SciencesOlsztyn 10-748Poland Department of Poultry Science and Apiculture University of Warmia and MazuryOlsztyn 10-718Poland Department of Animal Science University of ManitobaWinnipeg R3T 2N2Canada

This study investigated the effects of dietary replacement of soybean meal(SBM)with graded levels of pea seeds(PS)on the gastrointestinal function of *** of 2 pea varieties,a colored-flowered variety and a white-flowered variety(CFP and WFP,respectively)were fed to 56-d-old birds for 8 wk.A total of 539 female Hybrid turkeys were allocated to 7 groups,each group consisted of 7 pens with 11 birds per *** experiment had a 2-factorial design,with 3 dietary inclusion levels of PS(100,200 and 300 g/kg)and 2 pea varieties(CFP and WFP).The control group(diets without PS)was compared with CFP and WFP treatments by simple contrast *** comparison with CFP seeds,WFP seeds contained 7-fold less tannins(0.67 vs.4.66 g/kg)and less non-starch polysaccharides(NSP,117.8 vs.132.7 g/kg),but more trypsin inhibitors(1.34 vs.0.98 g/kg)and starch(489 vs.455 g/kg).A rise in the PS content of diets from 100 to 200 and 300 g/kg increased the weight of the small intestine(P=0.031)and the dry matter(DM)content of intestinal digesta(P=0.001),but it had no effect on the pH of *** the highest PS content differentiated the concentrations of short-chain fatty acids(SCFAs)in the small intestinal digesta(WFP>CFP,P=0.008),whereas PS did not cause any changes in the morphological parameters of the small intestinal *** dietary inclusion of PS had no influence on the levels of acetate,butyrate,putrefactive SCFAs or total SCFAs in the cecal *** from increasing the activities of b-glucosidase(P=0.017)and b-galactosidase(P=0.025),pea varieties did not affect the activities of the analyzed cecal microbial ***,CFP seeds decreased the DM content(P=0.041)and increased the pH of cecal digesta,compared with WFP seeds(P=0.013).The results of this study,pointing to a few differences in the functional parameters of the small intestine and cecum,indicate that tannins are not a factor differentiating the suitability of CFP and WFP seeds in the nutrition of f

关键词： Pea Tannin Growth performance Gastrointestinal tract Turkey

The 3,4-dimethoxybenzyl group as solubilizing protective group for the in situ deprotection/deposition of extended aromatic thiolate monolayers

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Nano Research 2023年第1期16卷 1695-1702页

作者： Adrian Wiesner Sonja Katzbach dariusz Bebej Martina Dettenhöfer Michael Zharnikov Andreas Terfort Institut für Anorganische und Analytische Chemie Johann Wolfgang Goethe Universität FrankfurtMax-von-Laue-Straße 7Frankfurt am Main D-60438Germany Angewandte Physikalische Chemie Universität HeidelbergIm Neuenheimer Feld 253Heidelberg D-69120Germany

While self-assembled monolayers(SAMs)of aromatic thiolates are frequently used in a wide range of applications,their formation is often hampered by the low solubilities of their *** we introduce the 3,4-dimethoxybenzyl group as a protective group for the thiol moiety,which increases the solubility and stability of the precursor,but becomes cleaved off during monolayer formation,especially at elevated temperature(60°C)and in presence of protons(trifluoroacetic acid).For a series of substituted terphenylthiols as model systems,it could be demonstrated by using ellipsometry,infrared-reflection absorption spectroscopy,and scanning-tunneling microscopy that the resulting SAMs have the same structure and quality as the ones obtained from the respective unprotected *** protective group has the additional advantage to be stable under Pdcatalyzed C–C bond formation reaction conditions,facilitating the syntheses of the respective precursors.

关键词： self-assembled monolayers protective group solubility scanning-tunneling microscopy infrared-reflection absorption spectroscopy

Vibrational spectroscopy-are we close to finding a solution for early pancreatic cancer diagnosis?

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World Journal of Gastroenterology 2023年第1期29卷 96-109页

作者： Krzysztof Szymoński Łukasz Chmura Ewelina Lipiec dariusz Adamek Department of Pathomorphology Jagiellonian University Medical CollegeCracow 33-332Poland Department of Pathomorphology University Hospital in CracowCracow 31-501Poland M.Smoluchowski Institute of Physics Jagiellonian UniversityCracow 30-348Poland Department of Neuropathology Jagiellonian University Medical CollegeCracow 33-332Poland

Pancreatic cancer(PC)is an aggressive and lethal neoplasm,ranking seventh in the world for cancer deaths,with an overall 5-year survival rate of below 10%.The knowledge about PC pathogenesis is rapidly *** aspects of tumor biology,including its molecular and morphological heterogeneity,have been reported to explain the complicated“cross-talk”that occurs between the cancer cells and the tumor stroma or the nature of pancreatic ductal adenocarcinoma-associated neural ***,currently,there are no specific and sensitive diagnosis options for *** spectroscopy(VS)shows a promising role in the development of early diagnosis *** this review,we summarize recent reports about improvements in spectroscopic methodologies,briefly explain and highlight the drawbacks of each of them,and discuss available *** important aspects of spectroscopic data evaluation with multivariate analysis and a convolutional neural network methodology are *** conclude by presenting a study design for systemic verification of the VS-based methods in the diagnosis of PC.

关键词： Spectroscopic cancer diagnosis Raman spectroscopy Pancreatic cancer diagnosis DNA methylation Liquid biopsy biomarkers Convolutional neural networks

Ultrastructure of oval cells in children with chronic hepatitis B,with special emphasis on the stage of liver fibrosis:The first pediatric study

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World Journal of Gastroenterology 2007年第21期13卷 2918-2922页

作者： Maria Elzbieta Sobaniec-Lotowska Joanna Maria Lotowska dariusz Marek Lebensztejn Department of Clinical Pathomorphology Medical University of BialystokPoland IIIrd Department of Pediatrics Medical University of BialystokPoland

AIM:To investigate the ultrastructure of oval cells in children with chronic hepatitis B,with special emphasis on their location in areas of collagen fibroplasia. METHODS:Morphological investigations were conducted on biopsy material obtained from 40 children,aged 3-16 years with chronic hepatitis B. The stage of fibrosis was assessed histologically using the arbitrary semiquantitative numerical scoring system proposed by Ishak et al. The material for ultrastructural investigation was fixed in glutaraldehyde and paraformaldehyde and processed for transmission-electron microscopic analysis. RESULTS:Ultrastructural examination of biopsy specimens obtained from children with chronic hepatitis B showed the presence of two types of oval cells,the hepatic progenitor cells and intermediate hepatic-like cells. These cells were present in the parenchyma and were seen most commonly in areas of intense periportal fibrosis (at least stage 2 according to Ishak et al) and in the vicinity of the limiting plate of the lobule. The activated nonparenchymal hepatic cells,i.e. transformed hepatic stellate cells and Kupffer cells were seen in close proximity to the intermediate hepatic-like cells. CONCLUSION:We found a distinct relationship between the prevalence of oval cells (hepatic progenitor cells and intermediate hepatocyte-like cells) and fibrosis stage in pediatric patients with chronic hepatitis B.

关键词： Pediatric patients, Oval cells Ultrastructural study Chronic hepatitis B Liver biopsy Fibrosis

Path analysis and estimation of additive and epistatic gene effects of barley SSD lines

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Journal of Integrative Agriculture 2016年第9期15卷 1983-1990页

作者： Jan Bocianowski Katarzyna Górczak Kamila Nowosad Wojciech Rybiński dariusz Piesik Department of Mathematical and Statistical Methods Poznań University of Life Sciences Department of Genetics Plant Breeding and Seed Production Wroc?aw University of Environmental and Life Sciences Institute of Plant Genetics Polish Academy of Sciences Department of Entomology and Molecular Phytopathology UTP University of Science and Technology

In the paper presented, 99 single seed descent barley lines as well as their parental forms Roland and Apex were studied. The grain weight components and their interrelations were analyzed using simple coefficients of correlation. The direct and indirect effects of such components on grain weight per plant and 1 000-grain weight were estimated using path analysis. In the 2006 and 2007, the spike length and number of spikelets per spike were the determinants of grain weight. Genetic parameters as additive and epistasis effects were estimated for all studied traits. The results indicate the importance of both additive and epistasis gene effects of number of spikes per plant, grain weight per spike, grain number per plant and grain weight per plant in this study.

关键词： path analysis additive effect epistasis single seed descent(SSD) barley

Non-invasive EEG-based brain-computer interfaces in patients with disorders of consciousness

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Journal of Medical Colleges of PLA(China) 2014年第2期29卷 109-114页

作者： Emilia Mikoajewska dariusz Mikoajewski Rehabilitation Department Military Clinical Hospital No. 10 and Polyclinic Powstańców Warszawy 5 Bydgoszcz 85-681 Poland Disorders of Consciousness Research and Neurorehabilitation Unit Neurocognitive LaboratoryCentre for Modern Interdisciplinary Technologies Nicolaus Copernicus University Toruń Poland Disorders of Consciousness Research and Neurorehabilitation Unit Neurocognitive Laboratory Centre for Modern Interdisciplinary Technologies Nicolaus Copernicus University Toruń Poland Institute of Mechanics and Applied Computer Science Kazimierz Wielki University Bydgoszcz Poland Department of Applied Informatics Department of Physics Astronomy and Applied Informatics Nicolaus Copernicus University

Disorders of consciousness(DoCs) are chronic conditions resulting usually from severe neurological deficits. The limitations of the existing diagnosis systems and methodologies cause a need for additional tools for relevant patients with DoCs assessment, including brain-computer interfaces(BCIs). Recent progress in BCIs' clinical applications may offer important breakthroughs in the diagnosis and therapy of patients with DoCs. Thus the clinical significance of BCI applications in the diagnosis of patients with DoCs is hard to overestimate. One of them may be brain-computer interfaces. The aim of this study is to evaluate possibility of non-invasive EEG-based brain-computer interfaces in diagnosis of patients with DOCs in post-acute and long-term care institutions.

关键词： neurological disorders disorders of consciousness brain-computer interfaces EEG-based BCIs

Matrix-derived serum markers in monitoring liver fibrosis in children with chronic hepatitis B treated with interferon alpha

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World Journal of Gastroenterology 2006年第21期12卷 3338-3343页

作者： dariusz Marek Lebensztejn Maria Elzbieta Sobaniec-Lotowska Maciej Kaczmarski Michael Voelker Detlef Schuppan Ⅲrd Department of Pediatrics Medical University of Bialystok Poland Department of Clinical Pathomorphology Medical University of Bialystok Poland Bayer Research Krefeld Germany Department of Medicine Ⅰ University of Erlangen-Nuemberg Germanyand Division of Gastroenterology and HepatologyBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonUnited States

To evaluate prospectively 4 selected serum fibrosis markers （tenascin, hyaluronan, collagen Ⅵ, TIMP-1） before, during and 12 mo after IFN treatment of children with chronic hepatitis B. METHODS： Forty-seven consecutive patients with chronic hepatitis B （range 4-16 years, mean 8 years） underwent IFN treatment （3 MU tiw for 20 wk）. Fibrosis stage and inflammation grade were assessed in a blinded fashion before and 12 mo after end of treatment. Serum fibrosis markers were determined using automated ***： IFN treatment improved histological inflammation but did not change fibrosis in the whole group or in subgroups. Only hyaluronan correlated significantly with histological fibrosis（r = 0.3383, P = 0.022）. Basal fibrosis markers did not differ between responders （42.5%） and nonresponders（57.5%）. During IFN treatment only serum tenascin decreased significantly in the whole group and in nonresponders. When pretreatment values were compared to values 12 mo after therapy, TIMP-1 increased in all patients and in nonresponders, and hyaluronan decreased in all patients and in ***： Tenascin reflects hepatic fibrogenesis and inflammation which decreases during IFN treatment of children with chronic hepatitis B. TIMP-1 correlates with nonresponse and hyaluronan with histological fibrosis.

关键词： Biopsy Collagen Ⅵ Fibrogenesis Fibrosis Hepatitis B virus Hyaluronan Serum marker Tenascin TIMP-1