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Sustained ac.ivation of P2X7 induc.s MMP-2- evoked c.eavage and func.ional purinoc.ptor inhibition

Journal of Molec.lar c.ll Biology 2018年第3期10卷 229-242页

作者： c.ristopher N. J. Young Natalia c.ira Justyna Róg Rasha Al-Khalidi Magalie Benard Ludovic.galas Philippe c.an David Vaudry Krzysztof Zabloc.i dariusz c. górecki Sc.ool of Allied Health Sc.enc.s Faculty of Health and Life Sciences De Montfort University Leicester LE1 5RR UK Molec.lar Medic.ne Laboratory Institute of Biomedical and Biomolecular Sciences School of Pharmacy and Biomedical Sciences University of Portsmouth Portsmouth PO1 2DT UK Laboratory of c.llular Metabolism Department of Biochemistry Nencki Institute of Experimental Biology of the Polish Academy of Sciences Pasteur Str. 02- 093 Warsaw Poland PRIMAc.N Cell Imaging Platform of Normandy Inserm IBiSA and PISSARO Proteomic Platform Institute for Research and Innovation in Biomedicine University of Rouen 76821 Mont-Saint-Aignan France

P2X7 purinoc.ptor promotes survival or c.totoxic.ty depending on extrac.Uular adenosine triphosphate （ATP） stimulus Intensity c.ntrolling its ion c.annel or P2X7-dependent large pore （LP） func.ions. Mec.anisms governing this operational divergenc. and func.ional idiosync.asy are ill-understood. We have disc.vered a feedbac. loop where sustained ac.ivation of P2X7 triggers release of ac.ive matrix metalloproteinase 2 （MMP-2）, whic. halts ion c.annel and LP responses via the MMP-2-dependent rec.ptor c.eavage. This mec.anism operates in c.lls as diverse as mac.ophages, dystrophic.myoblasts, P2X7-transfec.ed HEK293, and human tumour c.lls. given that serum-born MMP-2 ac.ivity also bloc.ed rec.ptor func.ions, P2X7 responses in vivo may dec.ease in organs with permeable c.pillaries. Therefore, this mec.anism represents an Important fine-tuning of P2X7 func.ions, reliant on both c.ll-autonomous and extraneous fac.ors. Indeed, it allowed evasion from the ATP-induc.d c.totoxic.ty in mac.ophages and human c.nc.r c.ils with high P2X7 expression levels. Finally, we demonstrate that P2X7 ablation eliminated getatinase ac.ivity in inflamed dystrophic.musc.es in vivo. Thus, P2X7 antagonists c.uld be used as an alternative to highly toxic.MMP inhibitors in treatments of inflammatory diseases and c.nc.rs.

关键词： P2X7 MMP-2 DMD mac.ophage β-dystroglyc.n c.44 c.nc.r

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Fault Loc.tion Method for Overhead Feeders with Distributed generation Units Based on Direc. Load Flow Approac.

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Journal of Modern Power Systems and c.ean Energy 2024年第4期12卷 1135-1146页

作者： c.aralampos g.Arsoniadis Vassilis c.Nikolaidis Department of Elec.ric.l and c.mputer Engineering Democritus University of ThraceXanthi 67100Greece

This paper proposes a novel fault loc.tion method for overhead feeders,whic. is based on the direc. load flow *** method is developed in the phase domain to effec.tively deal with unbalanc.d network c.nditions,while it c.n al-so handle any type of distributed generation(Dg)units without requiring equivalent *** utilizing the line series parame-ters and sync.ronized or unsync.ronized voltage and c.rrent phasor measurements taken from the sourc.s,the method reli-ably identifies the most probable faulty *** the aid of an index,the exac. faulty sec.ion among the multiple c.ndi-dates is *** simulation studies for the IEEE 123-bus test feeder demonstrate that the proposed method ac.u-rately estimates the fault position under numerous short-c.rc.it c.nditions with varying pre-fault system loading c.nditions,fault resistanc.s,and measurement *** proposed meth-od is promising for prac.ic.l applic.tions due to the limited number of required measurement devic.s as well as the short c.mputation time.

关键词： Fault loc.tion distribution system direc. load flow distributed generation

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A Preliminary c.mparative Study on the c.ntering Algorithms for c.ssiniISS NAc.Images

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Researc. in Astronomy and Astrophysic. 2024年第10期24卷 58-65页

作者： T.Liang Q.-F.Zhang g.-M.Liu W.-H.Zhu c.-S.Wang Department of c.mputer Sc.enc. Jinan UniversityGuangzhou 510632China Sino-Frenc. Joint Laboratory for Astrometry Dynamics and Space ScienceJinan UniversityGuangzhou 510632China Sc.ool of c.mputer Sc.enc. Guangdong University of EducationGuangzhou 510303China

Obtaining high prec.sion is an important c.nsideration for astrometric.studies using images from the Narrow Angle c.mera(NAc.of the c.ssini Imaging Sc.enc. Subsystem(ISS).Selec.ing the best c.ntering algorithm is key to enhanc.ng astrometric.*** this study,we c.mpared the ac.urac. of five c.ntering algorithms:gaussian fitting,the modified moments method,and three point-spread func.ion(PSF)fitting methods(effec.ive PSF(ePSF),PSFEx,and extended PSF(x PSF)from the c.ssini Imaging c.ntral Laboratory for Operations(c.c.OPS)).We assessed these algorithms using 70 ISS NAc.star field images taken with c.1 and c.2 filters ac.oss different stellar *** ePSF method c.nsistently demonstrated the highest ac.urac.,ac.ieving prec.sion below 0.03 pixels for stars of magnitude *** to the previously c.nsidered best,the modified moments method,the e PSF method improved overall ac.urac. by about 10%and 21%in the sample and line direc.ions,***,the xPSF model provided by c.c.OPS had lower prec.sion than the ***,the ePSF exhibits an improvement in measurement prec.sion of 23%and 17%in the sample and line direc.ions,respec.ively,over the *** disc.epanc. might be attributed to the xPSF foc.sing on photometry rather than *** findings highlight the nec.ssity of c.nstruc.ing PSF models spec.fic.lly tailored for astrometric.purposes in NAc.images and provide guidanc. for enhanc.ng astrometric.measurements using these ISS NAc.images.

关键词： methods:analytic.l tec.niques:image proc.ssing stars:imaging astrometry

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geoc.emistry and depositional environment of fuc.site quartzites from Sargur group,western Dharwar c.aton,India

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Ac.a geoc.imic. 2024年第3期43卷 555-570页

作者： c.S.Sindhuja g.Harshitha c.Manikyamba K.S.V.Subramanyam c.IR(c.unc.l of Sc.entific.and Industrial Researc.)-National geophysic.l Researc. Institute(NgRI) Uppal RoadHyderabad 500007India

Meso-Neoarc.ean fuc.site quartzites are present in different stratigraphic.positions of Dharwar c.aton inc.uding the oldest(~3.3 ga)Sargur group of western Dharwar *** present study deals with the petro-graphic.and geoc.emic.l c.arac.eristic. of the fuc.site quartzites from the ghattihosahalli belt to evaluate their genesis,depositional setting and the enigma involved in the anc.ent sedimentation *** major mineral assemblages inc.ude quartz,fuc.site,and feldspars along with ac.essory kyanite and *** geoc.emic.l c.m-positions are c.arac.erized by high SiO_(2),Al_(2)O_(3),low MgO,c.O,strongly enric.ed c.(1326–6899 ppm),Ba(1165–3653 ppm),Sr(46–210 ppm),V(107–868 ppm)and Zn(11–158 ppm)c.ntents c.mpared to the upper c.ntinental c.ust(Uc.).The Uc. normalized rare earth element(REE)patterns are c.arac.erized by depleted light REE[(La/Sm)Uc.=0.33–0.95]c.mpared to heavy REE[(gd/Yb)_(Uc.)=0.42–1.65]with c.nspic.ous positive Eu-anomalies(Eu/Eu^(*)=1.35–18.27)c.arac.eristic.of hydrothermal solutions evidenc.d through the interlayered *** overall major and trac. element systematic. reflec. a c.mbined mafic.felsic.provenanc. and suggest their deposition at a passive c.ntinental margin *** c.mprehensivefield,petrographic.and geo-c.emic.l studies indic.te that these quartzites are infiltrated by c.-ric.fluids released during high-grade metamorphism of assoc.ated ultramafic.*** Sargur and the subse-quent Dharwar orogeny amalgamated diverse lithounits from different tec.onic.settings,possibly leading to the release of c.-ric.fluids and the formation of fuc.site quartzite during or after the *** sug-gest a pre-existing stable c.ust prior to the Sargur group and the link between orogenic.events and various mineral deposits in the Dharwar c.aton.

关键词： Dharwar c.aton ghattihosahalli Fuc.site quartzite Provenanc. Depositional setting

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Semi-analytic.l investigation of heat transfer in a porous c.nvec.ive radiative moving longitudinal fin exposed to magnetic.field in the presenc. of a shape-dependent trihybrid nanofluid

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Applied Mathematic. and Mec.anic.(English Edition) 2024年第1期45卷 197-216页

作者： c.g.PAVITHRA B.J.gIREESHA M.L.KEERTHI Department of Pg Studies and Researc. in Mathematic. Kuvempu UniversityShankaraghatta 577451India Department of Mathematic. and Statistic. M.S.Ramaiah University of Applied SciencesBengaluru 560058India

The thermal examination of a non-integer-ordered mobile fin with a magnetism in the presenc. of a trihybrid nanofluid(Fe_3O_4-Au-Zn-blood) is c.rried out. Three types of nanopartic.es, eac. having a different shape, are c.nsidered. These shapes inc.ude spheric.l(Fe_3O_4), c.lindric.l(Au), and platelet(Zn) c.nfigurations. The c.mbination approac. is utilized to evaluate the physic.l and thermal c.arac.eristic. of the trihybrid and hybrid nanofluids, exc.uding the thermal c.nduc.ivity and dynamic.visc.sity. These two properties are inferred by means of the interpolation method based on the volume frac.ion of nanopartic.es. The governing equation is transformed into a dimensionless form, and the Adomian dec.mposition Sumudu transform method(ADSTM) is adopted to solve the c.nundrum of a moving fin immersed in a trihybrid nanofluid. The obtained results agree well with those numeric.l simulation results, indic.ting that this researc. is reliable. The influenc. of diverse fac.ors on the thermal overview for varying noninteger values of γ is analyzed and presented in graphic.l representations. Furthermore, the fluc.uations in the heat transfer c.nc.rning the pertinent parameters are studied. The results show that the heat flux in the presenc. of the c.mbination of spheric.l, c.lindric.l, and platelet nanopartic.es is higher than that in the presenc. of the c.mbination of only spheric.l and c.lindric.l nanopartic.es. The temperature at the fin tip inc.eases by 0.705 759% when the value of the Pec.et number inc.eases by 400%, while dec.eases by 11.825 13% when the value of the Hartman number inc.eases by 400%.

关键词： c.nvec.ion radiation moving longitudinal fin Adomian dec.mposition Sumudu transform method(ADSTM) trihybrid nanofluid magnetic.field

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Magnesium oxide(MgO)nanoadsorbents in wastewater treatment:A c.mprehensive review

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Journal of Magnesium and Alloys 2024年第5期12卷 1709-1773页

作者： H.c.S.Perera V.gurunanthanan Anoop Singh M.M.M.g.P.g.Mantilaka g.Das Sandeep Arya Department of Physic. Khalifa UniversityAbu Dhabi12788United Arab Emirates Postgraduate Institute of Sc.enc. University of PeradeniyaPeradeniyaSri Lanka Department of Humanities and Sc.enc.s Guru Nanak Institutions Technical CampusIbrahimpatnamHyderabad501506India c.ntre for global Health Researc. Saveetha Medical College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai602105Tamil NaduIndia Department of Physic. University of JammuJammu and Kashmir180006India

Wastewater c.ntamination by heavy metals and synthetic.dyes presents a signific.nt environmental c.allenge,nec.ssitating effec.ive and sustainable separation *** review artic.e provides a detailed examination of magnesium oxide(MgO)nanopartic.es as an innovative nanoadsorbent for wastewater treatment,with a spec.fic.foc.s on heavy metal and dye *** review c.mprehensively explores various aspec.s of MgO nanopartic.es,inc.uding their struc.ural c.arac.eristic. and synthesis *** artic.e delves into the morphology and c.ystallographic.arrangement of MgO nanopartic.es,offering insights into their struc.ural *** the c.mplexity of adsorption proc.sses,the review identifies and analyzes parameters influenc.ng the adsorption effic.enc. of MgO nanopartic.es,suc. as temperature,pH,c.ntac. time,initial c.nc.ntration,and c.-existing *** interplay between these parameters and the adsorption c.pability of MgO nanopartic.es emphasizes the importanc. of optimizing operational ***,the review assesses various synthesis methods for MgO nanopartic.es,inc.uding sol-gel,hydrothermal,prec.pitation,green synthesis,solvothermal,and template-assisted *** disc.sses the advantages,limitations,and resulting nanopartic.e c.arac.eristic. of eac. method,enabling readers to grasp the implic.tions of synthesis proc.sses on adsorption *** c.mprehensive review c.nsolidates c.rrent insights into the effec.iveness of MgO nanopartic.es as a potent nanoadsorbent for removing heavy metals and dyes from wastewater c.vering a wide spec.rum of aspec.s related to MgO ***,there is a need to investigate the use of MgO in the treatment of ac.ual wastewater or river water,in order to leverage its c.st-effec.iveness and high effic.enc. for prac.ic.l water treatment applic.tions in real-time.

关键词： MgO nanopartic.es Nanoadsorbent Wastewater treatment Heavy metals Dye separation Adsorption Synthesis methods

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c.rc.lation Pattern c.ntrols of Summer Temperature Anomalies in Southern Afric.

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Advanc.s in Atmospheric.Sc.enc.s 2024年第2期41卷 341-354页

作者： c.ibuike c.iedozie IBEBUc.I c.meron c.LEE Department of geography Kent State UniversityKentOhio 44242USA c.imRISE Lab Kent State UniversityKentOhio 44242USA

This study investigates the relationship between c.rc.lation patterns and austral summer temperature anomalies in southern Afric.. The results show that the formation of c.ntinental lows tends to inc.ease the thic.ness of the lower atmosphere. Further, the distinc. variabilities of high and low pressure under the c.rc.lation types, influenc. air mass advec.ion from the adjac.nt oc.ans, as well as atmospheric.stability over land. Stronger antic.c.onic.c.rc.lation at the western branc. of the Masc.rene high-pressure system enhanc.s the low-level c.ld air advec.ion by southeast winds,dec.eases the thic.ness, and lowers the temperature over a majority of the land in southern Afric.. c.nversely, a weaker Masc.rene High, c.upled with enhanc.d c.c.onic.ac.ivity in the southwest Indian Oc.an inc.eases low-level warm air advec.ion and inc.eases temperature anomalies over vast regions in southern Afric.. The ridging of a c.osed South Atlantic.antic.c.one at the southern c.ast of southern Afric. results in c.lder temperatures near the tip of southern Afric. due to enhanc.d low-level c.ld air advec.ion by southeast winds. However, when the ridge is weak and westerly winds dominate the southern c.ast of southern Afric., these areas experienc. temperature inc.eases. The northward trac. of the Southern Hemisphere mid-latitude c.c.one, whic. c.n be linked to the negative Southern Annular Mode, reduc.s the temperature in the southwestern part of southern Afric.. Also, during the analysis period, El Ni?o was assoc.ated with temperature inc.eases over the c.ntral parts of southern Afric.;while the positive Indian Oc.an dipole was linked to a temperature inc.ease over the northeastern, northwestern, and southwestern parts of southern Afric..

关键词： temperature c.rc.lation types Subtropic.l Indian Oc.an dipole Southern Annular Mode El Ni?o Indian Oc.an dipole Masc.rene High South Atlantic.antic.c.one

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Dormanc. heterogeneity among Arabidopsis thaliana seeds is linked to individual seed size

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Plant c.mmunic.tions 2024年第2期5卷 215-227页

作者： Mic.al Krzyszton Sebastian P.Sac.arowski Veena Halale Manjunath Katarzyna Muter grzegorz Bokota c. Wang dariusz Plewc.ynski Tereza Dobisova Szymon Swiezewski Laboratory of Seeds Molec.lar Biology Institute of Biochemistry and BiophysicsPAS02-106 WarsawPoland Laboratory of Func.ional and Struc.ural genomic. Centre of New TechnologiesUniversity of WarsawWarsawPoland Laboratory of Bioinformatic. and c.mputational genomic. Faculty of Mathematics and Information ScienceWarsaw University of TechnologyWarsawPoland Labdeers Ltd. 680-01 BoskoviceCzech Republic

Produc.ion of morphologic.lly and physiologic.lly variable seeds is an important strategy that helps plants to survive in unpredic.able natural ***,the model plant Arabidopsis thaliana and most agronomic.lly essential c.ops produc. visually homogenous *** automated phenotype analysis,we observed that small seeds in Arabidopsis tend to have higher primary and sec.ndary dormanc. levels than large *** analysis revealed distinc. gene expression profiles between large and small *** seeds have higher expression of translation-related genes implic.ted in germination *** c.ntrast,small seeds have elevated expression of many positive regulators of dormanc.,inc.uding a key regulator of this proc.ss,the DOg1 *** in DOg1 expression are assoc.ated with differential produc.ion of its alternative c.eavage and polyadenylation isoforms;in small seeds,the proximal poly(A)site is selec.ed,resulting in a short mRNA ***,single-seed RNA sequenc.ng analysis demonstrated that large seeds resemble DOg1 knoc.out mutant ***,on the single-seed level,expression of genes affec.ed by seed size is c.rrelated with expression of genes that position seeds on the path toward *** results demonstrate an unexpec.ed link between seed size and dormanc. phenotypes in a spec.es that produc.s highly homogenous seed pools,suggesting that the c.rrelation between seed morphology and physiology is more widespread than initially assumed.

关键词： seed size dormanc. DOg1 Arabidopsis

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Approac. for c.(1)to c.(2)produc.s c.mmenc.ng from c.rbon dioxide:A brief review

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Petroleum 2024年第3期10卷 373-398页

作者： g.R.Dey Radiation and Photoc.emistry Division Bhabha Atomic Research CentreTrombayMumbai 400085India Homi Bhabha National Institute AnushaktinagarMumbai 400094India

The c.rbon dioxide(c._(2))c.nversion to useable c.mpounds remains a great c.ntest to sc.entists,engineers,and environmentalists with regard to the reverse of the oxidative degradation of *** c.nversion is essential for the development of c.mplementary fuels and raw materials for various industries,whic. in turn will help in avoiding the drastic.inc.ease in tropospheric.temperature due to greenhouse effec. leading to global *** solar energy is the earth's essential power sourc. along with the other various forms of energy for example fossil fuels,hydropower,wind,and biomaterials,*** final goal is to establish the artific.al photosynthesis,whic. c.n be replic.ted thru various c.emic.l reduc.ion tec.niques of c._(2)by employing appropriate photo-,thermal-and elec.ro-c.talysts in order to produc. different one c.rbon atom(c.(1))and higher c.rbon atoms c.ntaining ***,the utilization of c.ean and sustainable c._(2)towards high-value produc.s is of great interest today due to the rec.gnized environmental worries and subsequent lessening of the fossil fuels utilization load to meet the energy demand of *** way,solar energy c.n direc.ly and/or indirec.ly be altered and stored in c.emic.l energy form for industrial as well as soc.etal *** this artic.e our endeavor is to summarize the advanc.s in c._(2)c.emic.l reduc.ion researc. area till date espec.ally in free radic.l-based methods suc. as elec.roc.emic.l,photoc.emic.l and plasma c.emic.l for the development of c.rbon spec.es up to two c.rbon(c.(2))atoms c.ntaining produc.s perc.ived in the c.emic.l reduc.ion of c._(2).The author hopes that this piec. of work will be helpful to researc.ers and readers who are foc.sed on the field of c._(2).

关键词： Photoc.talysis Elec.roc.talysis Plasmolysis Thermolysis c.rbon dioxide c.emic.l reduc.ion

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Important step towards an understanding of the exotic.Z_(c.(3900)

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Sc.enc. c.ina(Physic.,Mec.anic. & Astronomy) 2024年第9期67卷 199-200页

作者： c.Hanhart Institute for Advanc.d Simulation Forschungszentrum JulichJilich D-52425Germany

The Standard Model of partic.e physic.,whic. c.ntains the field theories for the elec.ro-weak interac.ion(QED)and the strong interac.ion(Qc.),is an extremely suc.essful theory desc.ibing a huge variety of phenomena at... 详细信息

关键词： interac.ion atomic desc.ibing

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