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World Journal of Gastroenterology 2011年第5期17卷 677-680页

作者： Giovanni D De Palma Stefania Staibano Saverio Siciliano Francesco Maione Maria Siano dario esposito Giovanni Persico Department of Surgery and Advanced Technologies Center of Excellence for Technical Innovation in SurgerySection of Diagnostic and Therapeutic EndoscopyUniversity of Naples Federico IISchool of Medicine80131NaplesItaly Department of Biomorphological and Functional Sciences Section of PathologyUniversity of Naples Federico IISchool of Medicine80131NaplesItaly

Recently,the use of confocal laser endomicroscopy(CLE) in the diagnosis of chronic ulcerative colitis(CUC) was *** this brief report we aimed to assess the application of probe-based CLE to characterize colonic mucosa and dysplasia in *** study involved a patient presenting long-standing *** imaging of both the inflamed mucosa,a circumscribed lesion(dysplasiaassociated lesional mass),and adjacent colonic mucosa are demonstrated and the correlation between the CLE and histological *** mucosa and dysplasia showed specific alteration of crypt architecture,cellular infiltration,and vessel architecture with an excellent correlation between CLE and standard histological examination.

关键词：溃疡性结肠炎共聚焦高清晰度激光探头表征体内结构改变

Lower gastrointestinal bleeding secondary to a rectal leiomyoma

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World Journal of Gastroenterology 2009年第14期15卷 1769-1770页

作者： Giovanni D De Palma Maria Rega Stefania Masone Saverio Siciliano Marcello Persico Francesca Salvatori Francesco Maione dario esposito Antonio Bellino Giovanni Persico Department of Surgery and Advanced Technologies Center for Technical Innovation in Surgery University of Naples Federico II School of Medicine Via Pansini 5 Naples 80131 Italy

The occurrence of leiomyoma of the rectum is uncommon. Most of these lesions are clinically silent and are found incidentally during laparotomy or endoscopic procedures for unrelated conditions. Symptomatic leiomyomas of the rectum are encountered less frequently, with only sporadic reports in the literature. We describe a case of a leiomyoma of the rectum presenting as recurrent lower gastrointestinal hemorrhage and secondary anemia.

关键词：症状性子宫肌瘤下消化道出血继发性贫血直肠

Endoscopic treatment of esophageal achalasia

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World Journal of Gastrointestinal Endoscopy 2016年第2期8卷 30-39页

作者： dario esposito Francesco Maione Alessandra D’Alessandro Giovanni Sarnelli Giovanni D De Palma Department of Clinical Medicine and Surgery University of Naples FedericoⅡSchool of Medicine80131 NaplesItaly Center of Excellence for Technical Innovation in Surgery University of Naples FedericoⅡSchool of Medicine80131 NaplesItaly

Achalasia is a motility disorder of the esophagus characterized by dysphagia, regurgitation of undigested food, chest pain, weight loss and respiratory symptoms. The most common form of achalasia is the idiopathic one. Diagnosis largely relies upon endoscopy, barium swallow study, and high resolution esophageal manometry(HRM). Barium swallow and manometry after treatment are also good predictors of success of treatment as it is the residue symptomatology. Short term improvement in the symptomatology of achalasia can be achieved with medical therapy with calcium channel blockers or endoscopic botulin toxin injection. Even though few patients can be cured with only one treatment and repeat procedure might be needed, long term relief from dysphagia can be obtained in about 90% of cases with either surgical interventions such as laparoscopic Heller myotomy or with endoscopic techniques such pneumatic dilatation or, more recently, with per-oral endoscopic myotomy. Age, sex, and manometric type by HRM are also predictors of responsiveness to treatment. Older patients, females and type Ⅱ achalasia are better after treatment compared to younger patients, males and type Ⅲ achalasia. Self-expandable metallic stents are an alternative in patients non responding to conventional therapies.

关键词： Achalasia High resolution manometrysubtypes Eckardt score Per-oral endoscopic myotomy Pneumatic dilatation Botulin toxin Myotomy

Eosinophilic esophagitis: From pathophysiology to treatment

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World Journal of Gastrointestinal Pathophysiology 2015年第4期6卷 150-158页

作者： Alessandra D’Alessandro dario esposito Marcella Pesce Rosario Cuomo Giovanni Domenico De Palma Giovanni Sarnelli Department of Clinical Medicine and Surgery Gastroenterology Unit Federico II University Department of Clinical Medicine and Surgery Endoscopy Unit Federico II University

Eosinophilic esophagitis(Eo E) is a chronic immune disease, characterized by a dense eosinophilic infiltrate in the esophagus, leading to bolus impaction and refluxlike symptoms. Traditionally considered a pediatric disease, the number of adult patients with Eo E is continuously increasing, with a relatively higher incidence in western countries. Dysphagia and food impaction represent the main symptoms complained by patients, but gastroesophageal reflux-like symptoms may also be present. Esophageal biopsies are mandatory for the diagnosis of Eo E, though clinical manifestations and proton pump inhibitors responsiveness must be taken into consideration. The higher prevalence of Eo E in patients suffering from atopic diseases suggests a common background with allergy, however both the etiology and pathophysiology are not completely understood. Elimination diets are considered the firstline therapy in children, but this approach appears less effective in adults patients, who often require steroids; despite medical treatments, Eo E is complicated in some cases by esophageal stricture and stenosis, that require additional endoscopic treatments. This review summarizes the evidence on Eo E pathophysiology and illustrates the safety and efficacy of the most recent medical and endoscopic treatments.

关键词： Eosinophilic esophagitis Eotaxin Immune system Pro

在在病人诊断发育异常的共焦的激光 endomicroscopy 的诊断精确性由长期的 ulcerative 大肠炎影响了

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World Journal of Gastrointestinal Endoscopy 2012年第9期4卷 414-420页

作者： Antonio Rispo Fabiana Castiglione Stefania Staibano dario esposito Maria Siano Francesco Maione Francesca Salvatori Stefania Masone Marcello Persico Giovanni Domenico De Palma Gastroenterology University 'Federico Ⅱ'of Naples80131 NaplesItaly Gastroenterology University 'Federico Ⅱ' of Naples80131 NaplesItaly Department of Biomorphological and Functional Sciences Section of PathologyUniversity 'Federico Ⅱ' of Naples80131 NaplesItaly Surgery and Advanced Technologies-University 'Federico Ⅱ' of Naples 80131 NaplesItaly Department of Biomorphological and Functional Sciences Section of PathologyUniversity'Federico Ⅱ'of Naples80131 NaplesItaly Surgery and Advanced Technologies-University 'Federico Ⅱ'of Naples 80131 NaplesItaly

AIM:To evaluate the diagnostic accuracy of confocal laser endomicroscopy(CLE) for the detection of dysplasia in long-standing ulcerative colitis(UC).METHODS:We prospectively performed a surveillance colonoscopy in 51 patients affected by long-standing ***,in the presence of macroscopic areas with suspected dysplasia,both targeted contrasted indigo carmine endoscopic assessment and probe-based CLE were *** mucosal biopsies and histology,utilised as the gold standard,were assessed randomly and on visible lesions,in accordance with current ***:Fourteen of the 51 patients(27%) showed macroscopic mucosal alterations with the suspected presence of dysplasia,needing chromoendoscopic and CLE *** 5 macroscopically suspected cases,the presence of dysplasia was confirmed by histology(3 flat dysplasia;2 DALMs).No dysplasia/cancer was found on any of the outstanding random *** diagnostic accuracy of CLE for the detection of dysplasia compared to standard histology was sensitivity 100%,specificity 90%,positive predictive value 83% and negative predictive value 100%.CONCLUSION:CLE is an accurate tool for the detection of dysplasia in long-standing UC and shows optimal values of sensitivity and negative *** scheduled combined application of chromoendoscopy and CLE could maximize the endoscopic diagnostic accuracy for diagnosis of dysplasia in UC patients,thus limiting the need for biopsies.

关键词： Ulcerative colitis Cancer Confocal Surveillance

Sennoside A,from the Traditional Chinese Medicine plant Rheum L.,is a New Reverse Transcriptase Inhibitor Effective Against HIV-1 Replication

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Sennoside A,from the Traditional Chinese Medicine plant Rheu...