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Validation of the chronic liver disease questionnaire in Serbian patients

World Journal of Gastroenterology 2013年第30期19卷 4950-4957页

作者： Dusan Dj Popovic Nada V Kovacevic darija b kisic tepavcevic Goran Z Trajkovic Tamara M Alempijevic Milan M Spuran Miodrag N Krstic Rada S Jesic Zobair M Younossi Tatjana D Pekmezovic Clinic for Gastroenterology Clinical Centre of Serbia Faculty of Medicine University of Belgrade Institute of Epidemiology Faculty of MedicineUniversity of Belgrade Institute of Statistics and Informatics Faculty of MedicineUniversity of Belgrade Center for Liver Diseases Department of MedicineInova Fairfax HospitalFalls ChurchAnnandale

AIM:To translate into Serbian and to investigate the validity of the cross-culturally adapted the chronic liver disease questionnaire(CLDQ).METHODS:The questionnaire was validated in 103 consecutive CLD patients treated between October 2009 and October 2010 at the Clinic for Gastroenterology,Clinical Centre of Serbia,belgrade(Serbia).Exclusion criteria were:age bleeding,and spontaneous bacterial peritonitis),hepatic encephalopathy(grade > 2)and liver *** of the CLDQ was done based on the following parameters:(1)acceptance is shown by the proportion of missing items;(2)internal reliabilities were assessed for multiple item scales by using Cronbach alpha coefficient;and(3)in order to assess whether the allocation of items in the domain corresponds to their distribution in the original questionnaire(construction validity),an exploratory factor analysis was *** validity was determined by comparing the corresponding CLDQ score/sub-score in patients with different severity of the ***:The Serbian version of CLDQ questionnaire completed 98% *** of missing items was 0.06%.The total time needed to fill the questionnaire was ranged from 8 to 15 *** in completing the questionnaire required 4.8% patients,while 2.9% needed help in reading,and 1.9% involved writing *** mean age of the selected patients was 53.8 ± 12.9 years and 54.4% were *** CLDQ score was 4.62 ± ***'s alpha for the whole scale was *** for all domains was above 0.70,except for the domain "Activity"(0.49).The exploratory factor analysis model revealed 6 factors with eigenvalue of greater than 1,explaining 69.7% of cumulative *** majority of the items(66%)in the Serbian version of the CLDQ presented the highest loading weight in the domain assigned by the CLDQ developers:"Fatigue"(5/5),"Emotiona

关键词： Chronic liver disease Quality of life Questionnaire Validation Factor analysis

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Arteriovenous fistulas and digital hypoperfusion ischemic syndrome in patients on hemodialysis

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World Journal of Nephrology 2013年第2期2卷 26-30页

作者： Radojica V Stolic Goran Z Trajkovic Dijana J Miric bojana kisic Zorana Djordje Goran Lj Azanjac Marijana S Stanojevic Dragica Z Stolic Medical Faculty University of Pristina Clinical Center Kragujevac Faculty of Medicine University of Kragujevac Health Center Pristina

AIM： To determine survival parameters as well as char-acteristics of patients with this syndrome. METHODS： The investigation was conducted over a period of eight years, as a prospective, non-random-ized, clinical study which included 204 patients, treated by chronic hemodialysis. Most patients received hemo-dialysis 12 h per week. As vascular access for hemodi-alysis all subjects had an arteriovenous fstulae. based on surveys the respondents were divided into groups of patients with and without digital hypoperfusion isch-emic syndrome. Gender, demographic and anthropo-metric characteristics, together with comorbidity and certain habits, were recorded. During this period 34.8% patients ***： Patients with digital hypoperfusion ischemic syndrome were older than those without ischemia （P = 0.01）. Hemodialysis treatment lasted signifcantly lon-ger in the patients with digital hypoperfusion ischemic syndrome （P = 0.02）. The incidence of cardiovascular disease （P 〈 0.001） and diabetes mellitus （P = 0.01）, as well as blood fow through the arteriovenous fstula （ P = 0.036）, were higher in patients with digital hypoper-fusion ischemic syndrome. Statistically significant dif-ferences also existed in relation to oxygen saturation （P = 0.04）. Predictive parameters of survival for patients with digital hypoperfusion ischemic syndrome were： adequacy of hemodialysis （b = -3.604, P 〈 0.001）, hypertension （b = -0.920, P = 0.018）, smoking （b = -0.901, P = 0.049）, diabetes mellitus （b = 1.227, P = 0.005）, erythropoietin therapy （b = 1.274, P = 0.002） and hemodiafltration （b = -1.242, P = 0.033）. Kaplan-Meier survival analysis indicated that subjects with and without digital hypoperfusion ischemic syndrome dif-fered regarding the length of survival （P 〈 0.001）, i.e. , patients with confrmed digital hypoperfusion ischemic syndrome died ***： Survival was signifcantly longer in the patients without digital hypoperfusion ischemic syn-drome.

关键词： Digital hypoperfusion ischemic syndrome Predictive parameters Survival Arteriovenous fistula Hemodialysis

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