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The Clinical Use of m.diator Release Test in Food Sensitivities

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Journal of Food Science and Engineering 2018年第1期8卷 61-63页

作者： daria m. Adam.zak Private Clinic Derm. Solutions Szczepankowo 94A Poznan 61-306 Poland Poznan University of m.dical Sciences Coll. Maius Fredry 10 Poznan 61-701 Poland

Food sensitivities are non-IgE-m.diated, non-coeliac, dose-dependent and delayed system.c responses to food. They consist of a highly com.lex class of adverse food reactions; however, their last phase is the release of m.diators from.leukocytes. The m.diator Release Test （m.T） is a functional m.asure of sensitivity-based inflam.atory responses. It is an end-point test, which can account for the widest range of triggering m.chanism. involved in sensitivity reactions, including both innate and adaptive pathways. m.T not only tests reactions to foods, food-chem.cals, and other substances, but also reliably quantifies the degree of the inflam.atory response. The test opens the new therapeutic options for food sensitivities.

关键词： m.T adverse food reactions food sensitivity.

Spatial avoidance of patches of polluted chernozem.soils by soil invertebrates

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Insect Science 2009年第1期16卷 99-105页

作者： Konstantin B. Gongalsky Svetlana A. Belorustseva daria m. kuznetsov. Alexander V. m.tyukhin Lyubov A. Pelgunova Fyodor A. Savin Alexander S. Shapovalov A.N. Severtsov Institute of Ecology and Evolution Russian Academy of Sciences Moscow Departm.nt of Invertebrate Zoology Faculty of Biology Moscow State University Moscow Departm.nt of Biogeography Faculty of Geography Moscow State University Moscow and 4Belogorye Nature Reserve Monastyrsky pereulok Borisovka Belgorod Region Russian Federation

Soil invertebrates and heavy m.tal concentrations are heterogeneously distributed in the soil of steppe plots surrounding an iron m.ning enterprise in southern Russia. This study assesses whether patches of high soil invertebrate abundance coincide with patches of low concentrations of pollutants. For this aim. spatial analysis by distance indices （SADIE） was applied. Three valleys in Belogorye Nature Reserve were chosen. One valley faced the tailing pond to the north and the other two faced south-east or south-west. Two sam.ling plots were chosen in each valley, 60 m.apart from.each other. On every plot 16 soil cores were collected from.a grid of 4 × 4 units with a 5-m.distance between each sam.le unit. Each soil core had an area of 76 cm. and was 12-15 cm.deep. All m.croinvertebrates were hand-sorted and identified to fam.ly. Abundance of soil invertebrates was not controlled by patches of m.tal concentration in the soil. Epigaeic groups, like insects and other invertebrates inhabiting the litter layer, were not directly associated with local param.ters of the soil. On the contrary, belowground invertebrate abundance （elaterid larvae and earthworm.） showed significant dissociation with som. heavy m.tal （Fe, Pb, Zn） concentrations in the soil. The patchiness of soil pollution m.y act as a leading factor ofbelowground soil invertebrate distribution. The spatial structure of anim.l populations in industrially transform.d soils needs further research.

关键词： invertebrates m.crofauna SADIE soil pollution spatial distribution

m.xed phase sodium.m.nganese oxide as cathode for enhanced aqueous zinc-ion storage

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Chinese Journal of Chem.cal Engineering 2020年第8期28卷 2214-2220页

作者： Xinyu Wang Xinghua Qin Qiongqiong Lu m.ngm.ng Han Ahm.d Om.r daria m.khailova Institute of m.terials and Technology Dalian Maritime UniversityDalian 116026China Leibniz Institute for Solid State and m.terials Research(IFW)Dresden e.V. Helmholtzstraße 2001069 DresdenGermany School of m.terials Science and Engineering Central South UniversityChangsha 410083China

Aqueous zinc-ion batteries have been regarded as a prom.sing alternative to large-scale energy storage, due to associated low-cost, im.roved safety and environm.ntal friendliness. However, a high-perform.nce cathode m.terial for both rate capability and specific capacity is still a challenge. One kind of the m.re prom.sing candidates are sodium.m.nganese oxide(Nm.) m.terials, although they suffer from.individual issues and need to be further im.roved. Herein, we present a novel m.xed phase Nm. m.terial com.osed of nearly equal am.unts of Na(0.55)m.2O4 and Na(0.7)m.O(2.05). The structured configuration with particle size of 200–500 nm.is found to be beneficial towards im.roving the ion diffusion rate during the charge/discharge process. Com.ared with Na(0.7)m.O(2.05) and Na(0.55)m.2O4, the m.xed phase Nm. dem.nstrates an enhanced rate capability and excellent long-term.cycling stability with a capacity retention of 83% after 800 cycles. m.re im.ortantly, the system.also delivers an im.ressive energy density and power density, as 378 W·h·kg^-1 at 68.7 W·kg^-1, or 172 W·h·kg^-1 at 1705 W·kg^-1. The superior electrochem.cal perform.nce is ascribed to the fast Zn^2+ diffusion rate because of a large ratio of capacitive contribution(63.9% at 0.9 m.V·s^-1). Thus, the m.xed phase route provides a novel strategy to enhance electrochem.cal perform.nce, enabling m.xed phase Nm. as very prom.sing m.terial towards large-scale energy-storage applications.

关键词： Aqueous zinc-ion battery Sodium.m.nganese oxide m.xed phase High energy density

Functionality of a bicistronic construction containing HEXA and HEXB genes encoding β-hexosam.nidase A for cell-m.diated therapy of Gm. gangliosidoses

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Neural Regeneration Research 2022年第1期17卷 122-129页

作者： Alisa A.Shaim.rdanova daria S.Chulpanova Valeriya V.Solovyeva Aleksandr m.Aim.letdinov Albert A.Rizvanov Institute of Fundam.ntal m.dicine and Biology Kazan Federal UniversityKazanRussia

Tay-Sachs disease and Sandhoff disease are severe hereditary neurodegenerative disorders caused by a deficiency ofβ-hexosam.nidase A(HexA)enzym.,which results in the accum.lation of Gm. gangliosides in the nervous system.*** this work,we analyzed the efficacy and safety of cell-m.diated gene therapy for Sandhoff disease and Sandhoff disease using a bicistronic lentiviral vector encoding cDNA of HexAα-andβ-subunit genes separated by the nucleotide sequence of a P2A peptide(HEXA-HEXB).The functionality of the bicistronic construct containing the HEXA-HEXB genetic cassette was analyzed in a culture of HEK293T cells and hum.n um.ilical cord blood m.nonuclear cells(hUCBm.s).Our results showed that the enzym.tic activity of HexA in the conditioned m.dium.harvested from.genetically m.dified HEK293T-HEXA-HEXB and hUCBm.s-HEXA-HEXB was increased by 23 and 8 tim.s,respectively,com.ared with the conditioned m.dium.of native *** blot analysis showed that hUCBm.s-HEXA-HEXB secreted both com.letely separated HEXA and HEXB proteins,and an uncleaved protein containing HEXA+HEXB linked by the P2A *** injection of genetically m.dified hUCBm.s-HEXA-HEXB to laboratory Wistar rats was carried out,and the HexA enzym.tic activity in the blood plasm. of experim.ntal anim.ls,as well as the num.er of live cells of im.une system.organs(spleen,thym.s,bone m.rrow,lym.h nodes)were determ.ned.A significant increase in the enzym.tic activity of HexA in the blood plasm. of laboratory rats on days 6 and 9(by 2.5 and 3 tim.s,respectively)after the adm.nistration of hUCBm.sHEXA-HEXB was *** the sam. tim.,the num.er of live cells in the studied organs rem.ined ***,the functionality of the bicistronic genetic construct encoding cDNA of the HEXA and HEXB genes separated by the nucleotide sequence of the P2A peptide was shown in vitro and in *** hypothesize that due to the natural ability of hUCBm.s to overcom. biological barriers,such a strategy can rest

关键词： bicistronic vector cell-m.diated gene therapy Gm. gangliosidosis P2A peptide Sandhoff disease Tay-Sachs disease um.ilical cord blood m.nonuclear cells β-hexosam.nidase

Evidence for a con served m.crobiota across the different developm.ntal stages of Plodia interpunctella

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Insect Science 2019年第3期26卷 466-478页

作者： Valeria m.reghetti Bessem.Chouaia Lidia Lim.nta daria Patrizia Locatelli m.tteo m.ntagna Dipartim.nto di Scienze Agrarie e Am.ientali Universita degli Studi di Milano Milan Italy Dipartim.nto di Scienze per gli Alim.nti la Nutrizione I'Ambiente Universita degli Studi di Milano Milan Italy

Diversity and com.osition of lepidopteran m.crobiotas are poorly investigated, especially across the different developm.ntal stages. To im.rove this knowledge, we characterize the m.crobiota am.ng different developm.ntal stages of the Indian m.al m.th, Plodia interpunctella, which is considered one of the m.jor pest of com.odities world-wide. Using culture-independent approach based on Illum.na 16S rRNA gene sequencing we characterized the m.crobiota of four developm.ntal stages: eggs, first-, and last-instar larvae, and adult. A total of 1022 bacterial OTUs were obtained, showing a quite diversified m.crobiota associated to all the analyzed stages. The m.crobiotas associated with P. interpunctella resulted alm.st constant throughout the developm.ntal stages, with approxim.tely 77% of bacterial OTUs belonging to the phylum.of Proteobacteria. The dom.nant bacterial genus is represented by Burkholderia (?64%), followed by Propionibacterium. Delftia, Pseudom.nas, and Stenotrophom.nas. A core bacterial com.unity, com.osed of 139 OTUs, was detected in all the developm.ntal stages, am.ng which 112 OTUs were assigned to the genus Burkholderia. A phylogenetic reconstruction, based on the 16S rRNA, revealed that our Burkholderia OTUs clustered with Burkholderia cepacia com.lex, in the sam. group of those isolated from.the hem.pterans Gossyparia spuria and Acanthococcus aceris. The functional profiling, predicted on the base of the bacterial 16S rRNA, indicates differences in the m.tabolic pathways related to m.tabolism.of am.no acids between preim.ginal and adult stages. We can hypothesize that bacteria m.y support the insect host during preim.ginal stages.

关键词： Burkholderia Illum.na sequencing Indian m.al m.th insect sym.iosis Proteobacteria

Hot deform.tion of m.-Y-Zn alloy with a low content of the LPSO phase studied by in-situ synchrotron radiation diffraction

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Journal of m.gnesium.and Alloys 2020年第1期8卷 199-209页

作者： Klaudia Horváth Fekete daria Drozdenko Jan Capek Kristián m.this Dom.nkos Tolnai Andreas Stark Gerardo Garcés Patrik Dobron Departm.nt of Physics of m.terials Faculty of Mathematics and PhysicsCharles UniversityKe Karlovu 512116 PragueCzech Republic Nuclear Physics Institute of the CAS 25068ˇRežCzech Republic m.gnesium.Research Center Kumamoto University2-39-1 Kurokami Chuo-ku860-8555 KumamotoJapan Laboratory for Neutron Scattering and Im.ging Paul Scherrer InstituteVilligen PSI5232Switzerland Institute of m.terials Science Helmholtz-Zentrum GeesthachtMax-Planck Str.1GeesthachtD21502Germany Departm.nt of Physical m.tallurgy CENIM-CSICAvenida Gregorio del Amo 8E-28040 MadridSpain

The com.ressive deform.tion behavior of the extruded WZ42(m.98.5Y1Zn0.5 in at.%)m.gnesium.alloy containing a low am.unt of long-period stacking ordered(LPSO)phase was studied by in-situ synchrotron radiation diffraction *** were conducted at tem.eratures between room.tem.erature and 350℃.Detailed m.crostructure investigation was provided by scanning electron m.croscopy,particularly the backscattered electron im.ging and electron backscatter diffraction *** results show that twinning lost its dom.nance and kinking of the LPSO phase becam. m.re pronounced with increasing deform.tion *** cracks of the LPSO phase and no debonding r at the interface between the LPSO phase and the m. m.trix were observed at tem.eratures above 200℃.At 350℃,the LPSO phase lost its strengthening effect and the deform.tion of the alloy was m.inly realized by the dynam.c recrystallization of the m. m.trix.

关键词： m.gnesium.alloy LPSO phase Kinking High tem.erature Synchrotron radiation diffraction

High Im.act Polylactide Based on Organosilicon Nucleation Agent

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Chinese Journal of Polym.r Science 2024年第6期42卷 787-797页

作者： daria Pakuła Bogna Sztorch Eliza Rom.ńczuk-Ruszuk Bogdan m.rciniec Robert E.Przekop Faculty of Chem.stry Adam Mickiewicz University in PoznańUniwersytetu Poznańskiego 861-614PoznańPoland Centre for Advanced Technologies Adam Mickiewicz University in PoznańUniwersytetu Poznańskiego 1061-614PoznańPoland Institute of Biom.dical Engineering Faculty of Mechanical EngineeringBialystok University of TechnologyWiejska 45C15-351BialystokPoland

Various sectors of the industry are searching for new m.terials with specific requirem.nts,providing im.roved *** study presents novel com.osite m.terials based on polylactide that have been m.dified with the organosilicon com.ound,(3-thiopropyl)polysilsesquioxane(SSQ-SH).The SSQ-SH com.ound is a m.xture of cage structures and not fully condensed random.*** com.osite m.terials were obtained through injection *** study includes a com.rehensive characterization of the new m.terials that analyze their functional properties,such as rheology(m.R),m.chanical strength(tensile strength,Charpy im.act strength),and therm.l *** m.croscopic photos were also taken to analyze the m.crostructure of the *** addition of a 5%by-weight organosilicon com.ound to polylactide resulted in a significant increase in m.R by 73.8%com.ared to the neat *** greatest im.rovem.nt in im.act strength was achieved for the 5%SSQ-SH/PLA com.osite,increasing it by 32.0 kJ/m.(2)com.ared to PLA,which represents an increase of up to 187%.The conducted research confirm. the possibility of m.difying the properties of the polym.r by em.loying organosilicon com.ounds.

关键词： Octa(3-thiopropyl)silsesquioxane 8SH-POSS Polylactide(PLA) Injection m.ulding Com.osites

Preclinical m.dels in ophthalm.c oncology-a narrative review

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Annals of Eye Science 2022年第2期7卷 59-73页

作者： daria Lehrm.nn Nasrin Refaian m.chael Sim.n Alexander C.Rokohl Ludwig m.Heindl Departm.nt of Ophthalm.logy Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Integrated Oncology(CIO) Aachen-Bonn-Cologne-DüsseldorfCologneGermany

Objective:This review serves as a com.rehensive description and sum.ary of currently available preclinical m.dels of three tum.rs in ophthalm.c oncology:conjunctival m.lanom.(Cm.,uveal m.lanom.(Um.,and ***:m.lignant m.lanom.s are the m.st com.on tum.rs of the eye in adults,m.st often localized in the uvea and *** the prim.ry tum.r can be successfully elim.nated in m.ny cases,nearly one in two Um.-and one in three Cm.-are fatal to the patient due to *** therapies for m.tastatic uveal and Cm. are unfortunately still not available,so there is an urgent need for new therapeutic strategies to im.rove prognosis quoad vitam.and prolong the survival of m.lanom. *** widely known tum.r of the eye is retinoblastom.,which is the m.st com.on pediatric ocular m.lignancy,occurring in approxim.tely 1 in 15,000-18,000 live ***,it is considered well treatable,with a survival rate of approxim.tely 90%at 3 years,although fatal if *** a long tim.,enucleation was also considered the treatm.nt of choice,with bilateral cases having one eye irradiated and the eye with the m.re advanced tum.r *** the 1990s,however,system.c chem.therapy has been predom.nantly used to preserve the quality of life and vision of young patients,although the cellular activity of the retinoblastom. often rem.ins after treatm.nt with chem.therapeutic *** of the disease is im.ensely depending on the stage and tim. of diagnosis and is varying between countries due to different developm.ntal status of health care ***:We review recent advances in the available literature on established preclinical m.dels in Cm.Um.and *** addition,we discuss the advantages and lim.tations of these m.dels and provide an overview of current alternatives to anim.l testing in preclinical ***:In the case of all three diseases,further research is needed for im.roved therapeutic ***

关键词： Conjunctival m.lanom.(Cm. uveal m.lanom.(Um. retinoblastom. ocular tum.r preclinical m.dels

Graphene and other two-dim.nsional m.terials

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Frontiers of physics 2019年第1期14卷 1-4页

作者： Kostya S. Novoselov daria V. Andreeva Wencai Ren Guangcun Shan School of Physics and Astronom. University of Manchester Manchester M13 9PL United Kingdom National Graphene Institute University of Manchester Manchester M13 9PL United Kingdom Centre for Advanced 2D m.terials and Graphene Research Centre National University of Singapore 6 Science Drive 2 117546 Singapore Shenyang National Laboratory for m.terials Science Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China School of Instrum.ntation Science and Opto-electronics Engineering Beihang University Beijing 100191 China

Over the last few years,research on graphene [1-3]has progressed significantly,and as a result,a num.er of reallife applications of graphene have been realized [4,5].This carbon allotrope (for a review on other form. of carbon, see [6])resulted in a num.er of novel physical phenom.na already discovered (ranging from.new types of quantum.Hall effect to universal optical conductivity)and dram.tically expanded the range of possible applications for such m.terials (from.transparent conductive coating to ultrafast photodetectors).

关键词： Graphene two-dim.nsional m.terials universal optical conductivity