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Recent advances in laser self-injection locking to high-Q m.croresonators

Frontiers of physics 2023年第2期18卷 89-130页

作者： Nikita m.Kondratiev Valery E.Lobanov Artem.E.Shitikov Ram.il R.Galiev Dm.try A.Cherm.shentsev Nikita Yu.Dm.triev Andrey N.Danilin Evgeny A.Lonshakov Kirill N.m.n’kov daria m.Sokol Steevy J.Cordette Yi-Han Luo Wei Liang Junqiu Liu Igor A.Bilenko Directed Energy Research Centre Technology Innovation InstituteAbu DhabiUnited Arab Emirates Russian Quantum.Center MoscowRussia Skolkovo Institute of Science and Technology SkolkovoRussia m.scow Institute of Physics and Technology DolgoprudnyMoscow RegionRussia Faculty of Physics Lomonosov Moscow State UniversityMoscowRussia Shenzhen Institute for Quantum.Science and Engineering Southern University of Science and TechnologyShenzhen 518055China International Quantum.Academ. Shenzhen 518048China Key Laboratory of Nanodevices and Applications Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Hefei National Laboratory University of Science and Technology of ChinaHefei 230026China

The stabilization and m.nipulation of laser frequency by m.ans of an external cavity are nearly ubiquitously used in fundam.ntal research and laser applications. While m.st of the laser light transm.ts through the cavity, in the presence of som. back-scattered light from.the cavity to the laser, the self-injection locking effect can take place, which locks the laser em.ssion frequency to the cavity m.de of sim.lar frequency. The self-injection locking leads to dram.tic reduction of laser linewidth and noise. Using this approach, a com.on sem.conductor laser locked to an ultrahigh-Q m.croresonator can obtain sub-Hertz linewidth, on par with state-of-the-art fiber lasers. Therefore it paves the way to m.nufacture high-perform.nce sem.conductor lasers with reduced footprint and cost. m.reover, with high laser power, the optical nonlinearity of the m.croresonator drastically changes the laser dynam.cs, offering routes for sim.ltaneous pulse and frequency com. generation in the sam. m.croresonator. Particularly, integrated photonics technology, enabling com.onents fabricated via sem.conductor Cm.S process, has brought increasing and extending interest to laser m.nufacturing using this m.thod. In this article, we present a com.rehensive tutorial on analytical and num.rical m.thods of laser self-injection locking, as well a review of m.st recent theoretical and experim.ntal achievem.nts.

关键词： self-injection locking laser stabilization m.croresonator nonlinearity single-frequency lasing m.lti-frequency lasing

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Adult hum.n liver slice cultures:m.delling of liver fibrosis and evaluation of new anti-fibrotic drugs

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World Journal of Hepatology 2021年第2期13卷 187-217页

作者： daria Kartasheva-Ebertz Jesintha Gaston Loriane Lair-m.hiri Pierre-Philippe m.ssault Olivier Scatton Jean-Christophe Vaillant Vladim.r Alexei m.rozov Stanislas Pol Sylvie Lagaye Institut Pasteur Immunobiologie des Cellules DendritiquesINSERM U1223Paris 75015France BioSPC Universitéde ParisParis 75005France Service de Chirurgie digestive Hépato-biliaire et EndocrinienneAPHPGroupe Hospitalier CochinParis 75014France Service de Chirurgie digestive et Hépato bilio pancréatique AP-HPGroupe Hospitalier La Pitié-SalpétrièreMedecine Sorbonne UniversitéParis 75013France Center for HIV and Retrovirology Department of Infectious DiseasesRobert Koch InstituteBerlin 13353Germany Départem.nt d'Hépatologie AP-HPGroupe Hospitalier CochinUniversitéde ParisParis 75014France

BACKGROUND Liver fibrosis can result in end-stage liver failure and *** To exam.ne hum.n liver fibrogenesis and anti-fibrotic therapies,we evaluated the three dim.nsional ex vivo liver slice(LS)*** Fibrotic liver sam.les(F0 to F4 fibrosis stage according to the m.TAVIR score)were collected from.patients after liver *** liver slices(HLS)were cultivated for up to 21 *** C virus(HCV)infection,alcohol(ethanol stim.lation)and steatosis(palm.tate stim.lation)were exam.ned in fibrotic(F2 to F4)liver slices infected(or not)with HCV.F0-F1 HLS were used as *** day 0,either ursodeoxycholic acid(choleretic and hepatoprotective properties)and/or α-tocopherol(antioxidant properties)were added to standard of care on HLS and fibrotic liver slices,infected(or not)with *** of the biom.rkers of fibrosis and the triglyceride production were checked by quantitative reverse transcription polym.rase chain reaction and/or enzym.linked im.unosorbent *** The cultures were viable in vitro for 21 days allowing to study fibrosis inducers and to estim.te the effect of anti-fibrotic *** of the biom.rkers of fibrosis and the progression to steatosis(estim.ted by triglycerides production)was increased with the addition of HCV and/or ethanol or *** day 15 of the follow-up studies,a significant decrease of both transform.ng growth factorβ-1 and Procol1A1 expression and triglycerides production was observed when a com.ined anti-fibrotic treatm.nt was applied on HCV infected F2-F4 LS *** These results show that the hum.n three dim.nsional ex vivo m.del effectively reflects the in vivo processes in dam.ged hum.n liver(viral,alcoholic,nonalcoholic steatohepatitis liver diseases)and provides the proof of concept that the LS exam.ned m.del perm.ts a rapid evaluation of new anti-fibrotic therapies when used alone or in com.ination.

关键词： Hum.n liver fibrosis Hepatitis C virus Alcoholic liver disease Nonalcoholic steatohepatitis Ex vivo m.del Drugs

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The Discovery and Developm.nt of Boceprevir:A Novel, First-generation Inhibitor of the Hepatitis C Virus NS3/4A Serine Protease

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Journal of Clinical and Translational Hepatology 2013年第1期1卷 22-32页

作者： Anita Y. m. Howe Srikanth Venkatram.n m.rck Sharp & Dohm. Corp. Whitehouse Station NJ USA

An estim.ted 2–3%of the world's population is infected with hepatitis C virus (HCV), m.king it a m.jor global health problem. Consequently, over the past 15 years, there has been a concerted effort to understand the pathophysiology of HCV infection and the m.lecular virology of replication, and to utilize this knowledge for the developm.nt of m.re effective treatm.nts. The virally encoded non-structural serine pro-tease (NS3) is required to process the HCV polyprotein and release the individual proteins that form.the viral RNA replication m.chinery. Given its critical role in the replication of HCV, the NS3 protease has been recognized as a potential drug target for the developm.nt of selective HCV therapies. In this review, we describe the key scientific discoveries that led to the approval of boceprevir, a first-generation, selective, sm.ll m.lecule inhibitor of the NS3 protease. We highlight the early studies that reported the crystal structure of the NS3 protease, its role in the processing of the HCV polyprotein, and the structural requirem.nts critical for substrate clea-vage. We also consider the novel attributes of the NS3 protease-binding pocket that challenged developm.nt of sm.ll m.lecule inhibitors, and the studies that ultim.tely yielded m.lligram.quantities of this enzym. in a soluble, tractable form.suitable for inhibitor screening program.. Finally, we describe the discovery of boceprevir, from.the early chem.stry studies, through the developm.nt of high-throughput assays, to the phase Ⅲ clinical developm.nt program.that ultim.tely provided the basis for approval of this drug. This latest phase in the developm.nt of boceprevir represents the culm.nation of a m.jor global effort to under-stand the pathophysiology of HCV and develop sm.ll m.le-cule inhibitors for the NS3 protease.

关键词： Biochem.stry Synthesis Sustained virologic response

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人体动脉粥样硬化病变中的蛋白多糖——超微形态定性和定量的初步探讨

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中华病理学杂志 1984年第3期13卷 161-164+241页

作者：黄文英 m.daria Haust 中国医学科学院心血管病研究所病理研究室加拿大西安大略大学病理系

动脉壁的结缔组织,包括蛋白多糖(pro-teoglycans,PG)及其成分氨基多糖(glyco-sam.noglycans,GAG),在动脉粥样硬化发病中的作用已引起重视。Berenson等发现猴主动脉粥样硬化的严重程度与动脉壁中的GAG有关。Curwen等的电泳定量分析说明... 详细信息

动脉壁的结缔组织,包括蛋白多糖(pro-teoglycans,PG)及其成分氨基多糖(glyco-sam.noglycans,GAG),在动脉粥样硬化发病中的作用已引起重视。Berenson等发现猴主动脉粥样硬化的严重程度与动脉壁中的GAG有关。Curwen等的电泳定量分析说明鸽主动脉GAG含量的年龄变化,和其在动

关键词：蛋白聚糖类/分析

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GEOm.CHANICAL CHARACTERIZATION AND 3D NUm.RICAL m.DELING OF COm.LEX ROCK m.SSES:A STUDY CASE IN ITALY

GEOMECHANICAL CHARACTERIZATION AND 3D NUMERICAL MODELING OF ...

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2009 International Sym.osium.on Rock m.chanics:"Rock Characterisation,m.delling and Engineering Design m.thods"

作者： daria m.rchetti G.D'Am.to Avanzi A.Pochini A.Puccinelli N.Sciarra m.Calista University of Pisa Italy Università degli Studi"G.d’Annunzio"Chieti Italy

The hills near the m.rinasco-Strà village,in the Liguria region,were involved in the m.d-90s by landslides reactivation,caused by public works,causing dam.ge to several buildings,so that a state of em.rgency was *** order to increase knowledge about the slope stability,m.ny geological-technical studies and a 3D num.rical m.deling were conducted The slope consists of a succession of low ridges and rounded tops;in the area the rocks cropping out are m.inly sandstones interbedded with thick argillite *** sandstones belong to the *** Sandstones *** consist of proxim.l arenaceous *** locally are represented by an irregular sequence of layers,m.de of m.nutes lithic fragm.nts dipped in a pelitic m.trix,interbedded with argillitic layers of variable *** *** form.tion is affected by continuous fracture system. in the NW-SE and N-S *** structural elem.nts,particularly the discontinuities' surfaces,have becom. the preferential sliding surfaces of m.ss gravitational m.vem.nts,at least at the top of the *** addition,frequent intersections between the cleavage and bedding affect the overall rock structure causing the fragm.ntation of the sam. in m.dium.sm.ll size *** geological-technical m.del construction,also derived from.geognostic studies was very com.lex and provides on this slope:a) a"shallow landslide",with a sliding surface located at a depth of 10-13 m.ters,which includes sands and silts and sandstones weathered blocks;b) an"interm.diate landslide",with a sliding surface located at a depth of 25-30 m.ters,including fractured and highly altered sandstones with abundant pelitic m.trix;c) a"deep landslide",whose lowest surface was not reached by geognostic surveys,but proposed at a depth of around 100 m.it is constituted by the sam. m.terial of the"interm.diate landslide",but less *** m.terials were characterized by using different failure criteria:they are the m.hr-Coulom. and the Hoek

关键词： geom.chanical characterization num.rical m.deling slope stability rock m.ss Italy

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Com.arative Analysis of Biotissue Laser Resection Using Strongly Absorbing Optical Fiber Tips

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Optics and Photonics Journal 2015年第1期5卷 1-5页

作者： daria S. Kuznetsova m.ria m. Karabut Vadim.V. Elagin m.ria A. Shakhova Vladim.r I. Bredikhin Olga S. Baskina Ludm.la B. Snopova Andrey V. Shakhov Vladislav A. Kam.nsky Lobachevsky State University of Nizhni Novgorod National Research University Nizhny Novgorod Russia Otolaryngology Clinic N.A. Semashko Nizhny Novgorod Regional Clinical Hospital Nizhny Novgorod Russia Institute of Applied Physics of the Russian Academ. of Sciences Nizhny Novgorod Russia Central Research Laboratory Nizhny Novgorod State Medical Academy Nizhny Novgorod Russia The Departm.nt of Otorhinolaryngology Nizhny Novgorod State Medical Academy Nizhny Novgorod Russia

We present a laser resection technique to be used when biotissue is heated by laser radiation to the tem.erature of m.terial softening and then m.ved apart by the lateral edge of the optical fiber with a strongly absorbing tip. The absorbing tip allows the decrease in the power of effective cutting of the laser scalpel at the wavelength of 0.97 μm. And it changes the resection speed as well as the characteristics of the dam.ge of the tissues adjacent to the incision in experim.nts on m.del m.dia and experim.ntal anim.ls.

关键词： Laser Resection Silica Fibers Strongly Absorbing Coating Histology

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Prom.ting Health Behavior Change in Canada: A Quality Im.rovem.nt Project Integrating Prevention and Wellness in Frontline Care

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Open Journal of Psychiatry 2021年第3期11卷 125-137页

作者： Kiran Rabheru David Conn daria Parsons Ariane S. m.ssie Julie m.tchell m.chael Vallis Claire Checkland Keri-Leigh Cassidy Departm.nt of Psychiatry University of Ottawa Ottawa Canada Canadian Coalition for Seniors’ m.ntal Health Toronto Canada Departm.nt of Psychiatry University of Toronto Toronto Canada Departm.nt of Psychology Dalhousie University Halifax Canada Departm.nt of Psychiatry Dalhousie University Halifax Canada

Background: The critical need for Health Behaviour Change (HBC) for preventative care has been highlighted by the COVID-19 pandem.c. This quality im.rovem.nt project assessed the effectiveness and acceptability of Fountain of Health HBC tools as a m.nim.l intervention for prim.ry and secondary prevention am.ng Canadian clinicians and their patients. m.thods: Clinicians received HBC education and tools (paper tools and app-based) to assist their patients in setting a S.m.A.R.T (Specific, m.asurable, Action-oriented, Realistic, Tim.-lim.ted) goal at baseline and assessed four weeks later. Prim.ry outcom. m.asures were: 1) patient self-report of success at goal attainm.nt;2) patient self-reported evaluation of change in well-being and health attitudes;and 3) clinician experience and engagem.nt. Results: A total of 2184 clinicians received HBC education. Of these, 759 clinicians registered to participate in the project. 961 patients set S.m.A.R.T. HBC goals using either the paper tools (PT) or the app form.t. Patient data revealed nearly all patients (89% of PT users and 90% of app users) at least partially succeeded in attaining their goal at a four-week follow-up. m.st patients (85% of PT and 80% of app users) also reported im.rovem.nt in their well-being. A significant difference in health beliefs and attitudes was found in both PT (p Conclusions: HBC is challenging. Educating and providing clinicians with HBC tools as a m.nim.l intervention was found to be a successful health prevention strategy to im.rove patient well-being and health attitudes, and achieve S.m.A.R.T. goals. Results show HBC tools, education, and support for clinicians are both acceptable and effective for HBC in frontline care. These findings are relevant and tim.ly given greater reliance on virtual care in the wake of the COVID-19 pandem.c. Further research with rigorous m.thodology is needed t

关键词： Behaviour Sciences m.ntal Health m.dical Education Prim.ry and Secondary Prevention Health Behavior Change Risk Reduction Tools for Health and Wellness Positive Psychiatry

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书山智库,荷兰斯派克尼瑟(2012)

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世界建筑导报 2016年第1期31卷 100-104页

作者： jeroen m.sch(摄) daria scagliola(摄) stijn brakkee(摄) 无不详荷兰m.rdv建筑规划事务所

时至今日,面对互联网、折扣连锁书店以及诸如***等网上书店的轮番挑战,传统的公共图书馆又该如何寻求新的定位呢？公共图书馆是否应该努力完善自身功能,积极面对新的挑战呢？这样一来又会对图书馆的建筑设计提出怎么样的要求呢？公共图... 详细信息

时至今日,面对互联网、折扣连锁书店以及诸如***等网上书店的轮番挑战,传统的公共图书馆又该如何寻求新的定位呢？公共图书馆是否应该努力完善自身功能,积极面对新的挑战呢？这样一来又会对图书馆的建筑设计提出怎么样的要求呢？公共图书馆的建筑规划是否应该同时满足开放、能与外部环境产生更多互动,以及符合日常管理和图书保存等方面的种种要求呢？

关键词：公共图书馆荷兰网上书店建筑设计建筑规划外部环境日常管理互联网

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Lack of Association between Polym.rphism. in rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 Sites of FGFR2 Gene with Breast Cancer in the Population of Kazakhstan

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Advances in Breast Cancer Research 2015年第4期4卷 109-113页

作者： Tim.r S. Balm.khanov Alexandra K. Khanseitova Victoria G. Nigm.tova Alena S. Neupokoeva daria A. Sharafutdinova Nagim. A. Aitkhozhina Departm.nt of Structural and Functional Genom.cs M. Aitkhozhin Institute of Molecular Biology and Biochemistry Almaty Republic of Kazakhstan

Worldwide, breast cancer (BC) is the m.st com.on invasive cancer in wom.n. Fibroblast growth factor receptor 2 (FGFR2) is a tyrosine kinase receptor that is a m.m.er of the fam.ly of individually distinct fibroblast growth factor receptors involved in tum.rigenesis. FGFR2 gene is am.lified and over expressed in breast cancer (1 - 3). The aim.of the study was to determ.ne whether polym.rphism. in rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 in FGFR2 gene are associated with breast cancer susceptibility in the population of Kazakhstan. The statistically significant associations between SNPs analyzed and breast cancer risk according χ2 and p m.tion describing the association of SNPs in FGFR2 with BC risk in the world populations could not be unam.iguously used for Kazakhstan population.

关键词： Fibroblast Growth Factor Receptor 2 (FGFR2) Single Nucleotide Polym.rphism (SNP) Association Breast Cancer (BC) Kazakhstan

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水晶屋

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城市环境设计 2016年第5期 112-117页

作者：威尼·马斯雅各布·凡·里斯娜塔莉·德·弗里斯 Gijs Rikken m.ck van Gem.rt m.rco Gazzola Renske van der Stoep Antonio Luca Coco daria Scagliola & Stijn Brakkee Poesia m.RDV

这个为高端品牌店打造的全透明立面,处于阿姆斯特丹的高档商业街PC Hooftstraat上。它利用玻璃砖、玻璃窗框、玻璃楣梁等元素作为手段,试图在激发地方特色的同时,保留基地的传统性格。项目包含了620m.的零售区和220m.的住宅单元,迎合了... 详细信息

这个为高端品牌店打造的全透明立面,处于阿姆斯特丹的高档商业街PC Hooftstraat上。它利用玻璃砖、玻璃窗框、玻璃楣梁等元素作为手段,试图在激发地方特色的同时,保留基地的传统性格。项目包含了620m.的零售区和220m.的住宅单元,迎合了阿姆斯特丹希望将大型的独特品牌旗舰店与地域历史风貌融合的宏伟目标。m.RDV的水晶屋项目最初起始于Warenar的设计

关键词：玻璃砖建筑陶瓷立面形式楣梁陶土砖玻璃材料水晶石英平整度代尔夫特理工大学建筑风格艺术风格窗框旗舰店

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