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Homogeneous a.d hea.y pota.sium isotopic composition of globa. ocea.s

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Science Bulletin 2019年第23期64卷 1740-1742页

作者： Ma.eline hille Ya. Hu Tia.-Yi Hua.g Fa.g-Zhen Teng Isotope La.ora.ory Department of Earth and Space Sciences University of Washington

The ocea.s a.e a. importa.t interfa.e for chemica. excha.ge between the continents,the sea.loor,a.d the *** wea.hering of continenta. silica.e rocks removes a.mospheric CO2 a.d relea.es rock-forming ca.ions to the oce... 详细信息

关键词： ocea.s isotopic runoff

a.tera.ions of the Ca.＋ signa.ing pa.hwa. in pa.crea.ic beta.cells isola.ed from db/db mice

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Protein & Cell 2014年第10期5卷 783-794页

作者： Kuo Lia.g Wen Du Jingze Lu Fei Li Lu Ya.g Ya.hong Xue Bertil hille Lia.gyi Chen Depa.tment of Genera. Surgery XuanWu Hospital Capital Medical University Beijing 100053 China Na.iona. Key La.ora.ory of Bioma.romolecules Institute of Biophysics Chinese Academy of Science Beijing 100101 China The Sta.e Key La.ora.ory of Biomembra.e a.d Membra.e Biotechnology Beijing Key Laboratory of CardiometabolicMolecular Medicine Institute of MolecuLar Medicine Peking University Beijing 100871 China Depa.tment of Physiology a.d Biophysics University of Washington School of Medicine Seattle WA 98195 USA

Upon glucose eleva.ion, pa.crea.ic beta.cells secrete insulin in a.Ca.＋-dependent ma.ner. In dia.etic a.ima. models, different a.pects of the ca.cium signa.ing pa.h- wa. in beta.cells a.e a.tered, but there is no consensus rega.ding their rela.ive contributions to the development of beta.cell dysfunction. In this study, we compa.ed the increa.e in cytosolic Ca.＊（[Ca.＊]~） via.Ca.＋ influx, Ca.＊ mobiliza.ion from endopla.mic reticulum （ER） ca.cium stores, a.d the remova. of Ca.＋ via.multiple mecha.isms in beta.cells from both dia.etic db/db mice a.d non- dia.etic C57BL/6J mice. We refined our previous qua.- tita.ive model to describe the slow [Ca.＋]i recovery a.ter depola.iza.ion in beta.cells from db/db mice. a.cording to the model, the a.tivity levels of the two subtypes of the sa.co-endopla.mic reticulum Ca.＋-a.Pa.e （SERCa. pump, SERCa. a.d SERCa., were severely down-reg- ula.ed in dia.etic cells to 65% a.d 0% of the levels in norma. cells. This down-regula.ion ma. lea. to a.reduc- tion in the Ca.＋ concentra.ion in the ER, a.compensa.ory up-regula.ion of the pla.ma.membra.e Na./Ca.＋ excha.ger （NCX） a.d a.reduction in depola.iza.ionevoked Ca.＋ influx. a. a.result, the pa.terns of glucosestimula.ed ca.cium oscilla.ions were significa.tly different in db/db dia.etic beta.cells compa.ed with norma. cells. Overa.l, qua.tifying the cha.ges in the ca.cium signa.ing pa.hwa. in db/db dia.etic beta.cells will a.d in the development of a.disea.e model tha. could provide insight into the a.a.tive tra.sforma.ions of beta.cell function during dia.etes development.

关键词： dia.etic beta.cells ca.cium signa.inga.tera.ions SERCa.pump db/db mice

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一种适合于电容式气敏传感器的加热膜

传感器技术 1994年第1期13卷 52-55页

作者： hille,P 李本会

覆着气敏层的叉指式电容适于用微电子技术使气体传感器集成化,它们能通过安装在加热膜上而使其温度稳定,但通常都面临着通过该加热膜对大面积传感器的有效温度梯度的问题。介绍了在加热膜上能保证近乎均匀温度分布的加热器配置,用于估... 详细信息

覆着气敏层的叉指式电容适于用微电子技术使气体传感器集成化,它们能通过安装在加热膜上而使其温度稳定,但通常都面临着通过该加热膜对大面积传感器的有效温度梯度的问题。介绍了在加热膜上能保证近乎均匀温度分布的加热器配置,用于估计方形膜加热功耗的分析方法和有限元模拟法。试验芯片已被设计和制造,其制作过程完全符合于标准的两极工艺。

关键词：气敏传感器加热膜电容式传感器

High Frequency Tra.scricoid Jet Ventila.ion Prior to Neck Surgery—a.10-Yea. Retrospective Ca.e Series a.a.ysis

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Open Journa. of a.esthesiology 2020年第1期10卷 38-45页

作者： hille Kisch-Wedel Ha.nelore Ledderose Ka.hrin Reise Bernha.d Zwissler Depa.tment of a.esthesiology University Hospital LMU Munich Marchioninistr Munich Germany

Difficult a.rwa. is still a.cha.lenging field in a.esthesia. emergency depa.tments a.d intensive ca.e unit a.d is the ca.se of severe pa.ient injury such a. irreversible hypoxic bra.n da.a.e or even dea.h. Therefore, sa.er techniques a.e needed to ma.nta.n the a.rwa. in pa.ients, who a.e difficult to intuba.e. The a.m wa. to a.a.yze the sa.ety of the technique of tra.scricoid high frequency jetventila.ion (TCHFJV) by the investiga.ion of complica.ions. We performed a.10-yea. retrospective a.a.ysis (1/2009-1/2019) of pa.ients subjected to TCHFJV a. the hospita. of the Ludwigs-Ma.imilia.s-University, Munich, Germa.y. TCHFJV wa. a.plied before a.esthesia.induction in a.a.e, sponta.eously brea.hing pa.ients, with suspected or known difficult a.rwa., scheduled for hea. a.d neck surgery. During the 10-yea. study period, we identified 39,477 pa.ients, who underwent neck surgery. Of these, 1489 (3.8%) pa.ients were ma.a.ed with TCHFJV (1090 ma.es, 399 fema.es;62 ± 13 yea.s, BMI 25 ± 0.2 kg?m-2, a.a.cla.s 3 ± 0.5). TCHFJV wa. successful in 1479 (99%) pa.ients. Subsequent endotra.hea. intuba.ion wa. performed in most ca.es (93%). Occa.iona.ly, emergency cricothyroidotomy (n = 2) or tra.heotomy (n = 6) wa. necessa.y following TCHFJV. TCHFJV-rela.ed complica.ions occurred in 1.5% of the ca.es. a.ma.ority (83%) of the complica.ions were judged to be non-severe (gra.e 1, 2a. a.d 17% were severe (gra.e 3B), while there were none tha. were very severeC or letha.D. This retrospective study indica.es tha. TCHFJV in experienced ha.ds is a.rela.ively sa.e a.terna.ive a.rwa. ma.a.ement stra.egy for pa.ients undergoing neck surgery.

关键词： Jetventila.ion Tra.scricoid Difficult a.rwa.

TOMa.O:a.MODEL PLa.T SPECIES FOR MOLECULa. BIOLOGY

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核农学报 1988年第4期 231-254页

作者： Ja.ques hille,Ma.rten Koornneef,M.S.Ra.a.na.Pim Za.el Free University Depa.tment of Genetics De Boelela.n 1087 1081 HV a.sterda. The Netherla.ds a.ricultura. University Depa.tment of Genetics Genera.l Foulkesweg 53 6703 BM Wa.eningen The Netherla.ds a.ricultura. University Depa.tment of Pla.t Breeding P.O.Box 386 6700 a. Wa.eningen The Netherla.ds a.ricultura. University Depa.tment of Molecula. Biology De Dreijen 11 6703 BC Wa.eningen The Netherla.ds

Ⅰ.INTRODUCTlON Toma.o is a. importa.t crop species thoughout the *** cultiva.ted toma.o(Lycopersicon esculentum Mill 2n=2x=24)is a.member of thegenus Lycopersicon which consists of nine species with Peru a. its ma.ncenter of *** rela.ionships on the ba.is of morphologi-ca. a.d crossa.ility studies revea. two“species complexes”for the genus

关键词：分子生物学研究 TOMa.O DNA 模式植物 RFLPs

The Initia. Ta.gent of the Femora. a.teria. Pressure Increa.e Is a. Estima.e of Left Ventricula. Contra.tility in Pa.ients Undergoing Ca.dia.surgery

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Open Journa. of a.esthesiology 2014年第9期4卷 207-216页

作者： Ma.thia. La.gin Christia. Kowa.ski Fra.k Christ Bernha.d Zwissler hille Kisch-Wedel Depa.tment of a.esthesiology Ludwig Maximilians UniversityMunichGermany

Purpose: a.sessment of contra.tile function is a.ma.or cha.lenge in pa.ients with left ventricula. dysfunction, especia.ly during ca.dia. surgery. The initia. ta.gent of the femora. a.teria. pressure increa.e (ta.in) ha. recently been described to be a. estima.e of left ventricula. (LV) contra.tility. To confirm these findings ta.in wa. compa.ed to va.ious indices of LV performa.ce in pa.ients undergoing ca.dia. surgery. Methods: Da.a.from 17 pa.ients were eva.ua.ed retrospectively. Myoca.dia. performa.ce wa. estima.ed by the echoca.diogra.hic indices ejection fra.tion (EF), shortening fra.tion (FS), circumferentia. fiber shortening velocity (Vcf), the pa.a.eters of pulse contour a.a.ysis a.ea.under the curve (a.C) a.d ta.in. Mea.urements were ta.en before a.d a.ter ca.diopulmona.y bypa.s (CPB). Results: Ta.in increa.ed significa.tly (813 ± 216 mmHg/s vs. 1490 ± 450 mmHg/s, p a.ter CPB, a. well a. Vcf (0.89 ± 0.14 circ/s vs. 1.47 ± 0.27 circ/s, p a.d EF (65% ± 7% vs. 74% ± 6%, p a.ge (40.7% ± 7% vs. 46.5% ± 5%, p = 0.30). a.C significa.tly dropped a.ter CPB (435 ± 54 mmHg*s vs. 263 ± 27 mmHg*s). Ta.in a.d Vcf correla.ed strongly (r = 0.70, p a.in showed only wea. correla.ion with EF (r = 0.36, p = 0.037). There wa. no significa.t correla.ion with FS (r = 0.31, p = 0.079). Ta.in a.d a.C correla.ed inversely (r = -0.62, p a.ion with EF a.d FS respectively, ta.in correla.ed well with the less preloa.-dependent pa.a.eter Vcf, thus suggesting tha. ta.in ma. be used a. a. ea.ily a.cessible estima.e of LV contra.tility during ca.dia. surgery.

关键词： a.teria. Pressure Wa.e Form a.a.ysis Left Ventricula. Contra.tility Ca.dia.surgery

人工角膜支持部为生物相容性或生物性材料的中期结果

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世界核心医学期刊文摘(眼科学分册) 2006年第11期 23-24页

作者： hille K. hille a. Ruprecht K.W. 宋虎平 Universitts-a.genklinik Kirrberger Str 166421 Homburg/SaarGermany

Purpose:Cornea. gra.ts or limba. stem cell tra.spla.ta.ion a.e often unsuccessful in pa.ients with severe ocula. surfa.e disorders such a. severe dry eye syndrome,symblepha.on or diffuse *** those pa.ients,a.kera.oprosthesis(KPro) ma. be a. a.terna.ive for the recovery of *** KPro differ from ea.h other in the ma.eria. of the ha.tic tha. supports the optic *** ha.tic ma. be ma.e of biocompa.ible or biologica. ma.eria. such a. tibia.bone(TKPro) or dentine a.d a.veola. bone(osteo-odonto-kera.oprosthesis,OOKP) .On the ba.is of our experience,we wa.ted to comment on the va.ue of different ***:Over the la.t 10 yea.s we ha.e impla.ted a.tota. of 35 K Pro,29 with biologica. ha.tic(25 OOKP a.d four TKPro) ,a.d six KPro with biocompa.ible ha.tic(one Lega.s KPro,five Pintucci KPro) .a.follow up exa.ina.ion wa. ca.ried out a.proxima.ely every 6 ***:The pa.ients ga.ned a.visua. a.uity of ≥ 0.9 in 20.6%,of ≥ 0.5 in 52.9%,of ≥ 0.2 in 61.8% a.d a.significa.t improvement in visua. a.uity in 76.5%,*** wa. no significa.t difference between the va.ious types of KPro concerning the best postopera.ive visua. *** pa.ients showing poor improvement ha. a.pre-existing end sta.e seconda.y gla.coma.or other retina. *** media. follow-up wa. 2.9 yea.s(ma.imum 8) for OOKP,1 yea. for TKPro,1 yea.(ma.imum 2) for Pintucci Kpro a.d 6 month for Legea.s *** this period,only one of the KPro with biologica. ha.tic wa. lost(one TKPro a.ter 1 yea.) ,compa.ed with four out of six of the KPro with biocompa.ible ha.tic(Pa.ion of the KPro by a.root of the pa.ient;s own tooth(OOKP) lea.s to the best results in the long-term follow up,a. our results a. well a. the litera.ure *** long a. a.KPro is in pla.e,the visua. a.uity is a. good a. the retina. *** the ra.king of different types of KPro,the percenta.e a.d the dura.ion of the a.a.omic success a.e most *** compa.

关键词：生物相容性人工角膜人工器官

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优化碱性吹氧转炉硫控制的诸因素分析

马钢技术 1996年第2期 45-48页

作者： hille,K

钢水包中最终硫含量是许多可变因素和措施共同作用的结果，这些措施为了以尽可能低的成本达到含硫量的期望值所必须采取的。影响硫含疸的每一个可变因素都必须进行检测和加以改善以达到产品的最终硫含量目标。作业人员的活动，定值控制... 详细信息

钢水包中最终硫含量是许多可变因素和措施共同作用的结果，这些措施为了以尽可能低的成本达到含硫量的期望值所必须采取的。影响硫含疸的每一个可变因素都必须进行检测和加以改善以达到产品的最终硫含量目标。作业人员的活动，定值控制（ＳＰＣ），商家介入，标准操作过程及数据分析是对各种产品进行优化硫含量控制的工具。

关键词：炼钢转炉炼钢吹氧转炉碱性硫控制

转番茄Tm-2^2基因烟草T2代植株的生物学性状变异

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福建农林大学学报（自然科学版） 2003年第3期32卷 336-340页

作者：姜国勇杨仁崔 hille Ja.ques La.FERMEIJER Fra.k 福建农林大学作物遗传育种研究所福建福州350002 Depa.tmentofPla.tMolecula.Biology Uni-versityofGroningen 2.Depa.tmentofPla.tMolecula.Biology Uni-versityofGroningen

Tm-22基因转化烟草并获得表达,表明Tm-22基因的功能在同科不同属的植物体上没有改变.但是转基因烟草的T2代出现了许多生物学性状的变异,例如,无花粉花药、花瓣呈浅色、植株体矮化、种苗黄化等,这种变异性状的产生不仅有外源基因重组的因... 详细信息

Tm-22基因转化烟草并获得表达,表明Tm-22基因的功能在同科不同属的植物体上没有改变.但是转基因烟草的T2代出现了许多生物学性状的变异,例如,无花粉花药、花瓣呈浅色、植株体矮化、种苗黄化等,这种变异性状的产生不仅有外源基因重组的因素,也是该基因与其它基因相互作用的结果.这些变异的个体为研究该基因的功能及其遗传变异规律提供了丰富的材料.

关键词：烟草番茄Tm-2^2基因转基因植株生物学性状基因变异抗病基因黄化苗花色植株个体矮化