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Long-term follow-up of distal intestinal obstruction syndrome in cystic fibrosis

World Journal of Gastroenterology 2015年第1期21卷 318-325页

作者： Moran Lavie Tzipora Manovitz daphna vilozni Sarina Levy-Mendelovich Ifat Sarouk Ilana Weintraubv David Shoseyov Malena Cohen-Cymberknoh Joseph Rivlin Ori Efrati Pediatric Pulmonary Unit and the National Center for Cystic Fibrosis Edmond and Lily Safra Children’s HospitalSheba Medical CenterTel Hashomer 52621Israel Cystic Fibrosis Center and Pediatric Pulmonary Unit Hadassah Hebrew University Medical CenterJerusalem 91120Israel Cystic Fibrosis Center Carmel Medical CenterHaifa 34362Israel

AIM: To investigate the long-term follow-up of distal intestinal obstruction syndrome(DIOS) in Israeli cystic fibrosis(CF) ***: This is a multi-center,comparative,retrospective study in which we reviewed the medical records of all CF patients from three major CF centers in Israel who were treated in the period from 1980 to *** diagnosed with DIOS were defined as the study *** patients were diagnosed with DIOS based on their clinical presentation and typical findings on either abdominal X-ray or computerized tomography *** the control group,CF patients with no DIOS were matched to the patients in the study group for age,sex,and cystic fibrosis transmembrane conductance regulator(CFTR) *** both groups,the collected data included age,sex,CFTR genotype,weight,height,and body mass *** data included respiratory function tests in the last five years prior to the study,respiratory function test immediately before and after the DIOS event,number of hospitalizations,sputum culture results,and CFrelated conditions diagnosed according to the CF clinical practice *** the study group,data on the DIOS treatment and tendency for DIOS recurrence were also ***: The medical charts for a total of 350 CF patients were *** the 350 CF patients,26(7.4%) were diagnosed with *** control group included 31 CF patients with no DIOS *** mean follow-up period was 21.6 ± 8.2 *** total of DIOS episodes in the follow-up period was *** distribution of DIOS episodes was as follows: 6/26(23.1%) study patients had one episode of DIOS intheir lifetime,7/26(26.9%) had two episodes,7/26(26.9%) had three episodes,and 6/26(23.1%) had four or more *** to the control group,DIOS patients had a significantly higher incidence of meconium ileus in the past(65.4% vs 0%,respectively,P < 0.02),more Aspergillus ***(34.6% vs 3.2%,respectively,P < 0.02),and a higher number of hospitali

关键词： Distal intestinal obstruction syndrome Cystic fibr

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