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中国实用内科杂志 2018年第9期38卷 788-791页

作者：袁思依李景南中国医学科学院北京协和医学院北京协和医院消化内科北京100730

结直肠癌在我国的发病率呈逐渐升高趋势,结直肠癌筛查是降低发病率的有效手段。分子标志物检测由于其无创性和较高的特异性,在结直肠癌筛查中发挥着越来越重要的作用。文章总结了近年来分子标志物在结直肠癌筛查中的应用情况。

关键词：结直肠癌筛查分子标志物粪便基因检测外周血基因检测

EGFR Gene Mutation and Methodological Evaluation in 399 Patients with Non-small Cell Lung Cancer

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Current Medical Science 2020年第1期40卷 78-84页

作者： Hong-yun ZHENG Hai-bo WANG Fu-jin SHEN Yong-qing TONG Qian YAO Bin QIAO si SUN Yan LI Department of Clinical Laboratory Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Gynecology Renmin Hospital of Wuhan UniversityWuhan 430060China

The purpose of the present study was to study the characteristics of epidemic growth factor receptor(EGFR)gene distribution in patients with non-small cell lung cancer(NSCLC),and to detect the mutation rate of EGFR gene by Sanger sequencing and amplification refractory mutation system(ARMS)-***-embedded sections of NSCLC tissues from 399 NSCLC patients diagnosed in Renmin Hospital of Wuhan University were collected,103 of them were detected for exons 18-21 mutation of EGFR by Sanger sequencing method,296 cases were detected for exons 18-21 mutation by ARMS-PCR *** extraction of both groups was performed with Qiagen QLAamp DNA FFPE Tissue *** of detection rates between the two methods were conducted by row X list chi-square *** total mutation rate of EGFR gene detected by Sanger sequencing was 21.4%,exons 18-21 and combined mutation rates were 1.0%,9.7%,1.0%,7.8%and 2.0%,*** the proportions were 4.7%,45.2%,4.7%,36.3%and 9.4%*** total mutation rate detected by ARMS-PCR was 51.4%,exons 18-21 and combined mutation rates were 2.7%,27%,1.7%,18.2%and 1.7%,*** proportions were 5.3%,52.6%,3.3%,35.5%and 3.3%*** analysis of mutation rate showed that there was significant difference between the two methods in detecting total mutation of EGFR gene(Psignificant differences in mutation detection rates of exons 19 and 21(Psignificant differences in other *** there was no significant difference in mutation detection rates between the two *** mutation rate of EGFR gene in NSCLC patients was 50%.And exon 19 deletion was the most common mutation type,followed by exon 21 *** with Sanger sequencing method,ARMS method is more sensitive with significant advantages in detecting exon 19 deletions and exon 21 mutations,which can be widely used in clinical detection of EGFR gene *** results of this study will further

关键词： epidemic growth factor receptor targeted therapy amplification refratory mutation systePCR Sanger sequencing

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粤澳初中学生身体自我满意度的比较研究

心理发展与教育 2006年第2期22卷 100-103页

作者：许思安聂衍刚苏斌原华南师范大学心理学系广州510631 广州大学教育学院心理学系广州510405

对1179名粤澳两地初中生进行身体自我测试结果表明:粤澳两地学生对自己身体的满意程度存在显著差异;广州生对自己身体的满意度要普遍高于澳门生;男生对身体的满意程度明显高于女生;随着年级的升高,初中生对自己身体的满意度呈现下降趋势。

关键词：身体自我满意度初中生广州澳门

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再论梯形明渠临界水深计算法

水利学报 1999年第4期30卷 14-17页

作者：王正中袁驷武成烈西北农业大学水利与建筑工程学院清华大学土木系陕西省水利厅

梯形明渠临界水深计算方法已有近３０种，本文在分析总结前人研究的基础上，提出两套实用简捷计算法，以满足生产实践之需要．

关键词：梯形明渠临界水深计算公式明渠

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基于GPS及气压传感器定位仪的设计

西北大学学报（自然科学版） 2012年第4期42卷 577-580,584页

作者：吴思远马建仓西北工业大学电子信息学院陕西西安710129

目的在以气压测量集成传感器研制高度计的基础上,设计一款高度与GPS相结合的便携式定位仪,以满足实际应用需求。方法利用气压传感器来解算相应的高度信息,配合上GPS模块传输的经纬度信息实现完整的三维定位。结果该定位仪由GPS模块、气... 详细信息

目的在以气压测量集成传感器研制高度计的基础上,设计一款高度与GPS相结合的便携式定位仪,以满足实际应用需求。方法利用气压传感器来解算相应的高度信息,配合上GPS模块传输的经纬度信息实现完整的三维定位。结果该定位仪由GPS模块、气压计模块、单片机模块、电源管理模块、LCD显示模块、矩阵键盘六大部分构成。单片机为主控芯片,GPS接收经纬度信息;气压计通过温度补偿获得高精度的气压信息进而可解算为高度信息;最终通过LCD实时显示;按键实现数据的输入以及显示界面之间的功能跳转;整个系统通过电源管理模块供电,并具有充电功能。结论具有高精度、稳定性、低功耗和便携式特点,可应用于地质勘探、汽车导航或高空作业上。在海拔高度方面,测量范围还有待进一步扩展。

关键词：定位仪经纬度海拔高度低功耗便携式

Importance of conformance control in reinforcing synergy of CO_(2) EOR and sequestration

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Petroleum Science 2022年第6期19卷 3088-3106页

作者： Yang Zhao Zhen-Hua Rui Zheng Zhang si-Wei Chen Ren-Feng Yang Kai Du Birol Dindoruk Tao Yang Erling H.Stenby Malcolm A.Wilson State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing 102249China College of Petroleum Engineering China University of Petroleum(Beijing)Beijing 102249China College of Carbon Neutrality Future Technology China University of Petroleum(Beijing)Beijing 102249China College of Petroleum China University of Petroleum(Beijing)at KaramayKaramayXinjiang 83400China CNOOC Research Institute Co. Ltd.Beijing 100029China University of Houston USA Equinor Ovre StokkaveiStavangerNorway Technical University of Denmark Denmark University of Regina Canada

Injecting CO2into hydrocarbon reservoirs can enhance the recovery of hydrocarbon resources,and simultaneously,CO2can be stored in the rese rvoirs,reducing considerable amount of carbon emissions in the ***,injected CO_(2)tends to go through fractures,high-permeability channels and streaks present in reservoirs,resulting in inefficient hydrocarbon recovery coupled with low CO_(2)storage *** treatments with CO_(2)-resistant crosslinked polymer gels were performed in this study to mitigate the CO_(2)channeling issue and promote the synergy between enhanced oil recovery(EOR) and subsurface sequestration of CO_(2).Based on a typical low-permeability CO_(2)-flooding reservoir in China,studies were performed to investigate the EOR and CO_(2)storage performance with and without conformance *** effect of permeability contrast between the channels and rese rvoir matrices,treatment size,and plugging strength on the efficiency of oil recovery and CO_(2)storage was systematically *** results indicated that after conformance treatments,the CO_(2)channeling problem was mitigated during CO_(2)flooding and *** injected CO_(2)was more effectively utilized to recover the hydrocarbons,and entered wider spectrum of pore ***,more CO_(2)was trapped *** factors on the synergy of EOR and CO_(2)storage were figured *** with the treatment size,the CO_(2)storage efficiency was more sensitive to the plugging strength of the conformance treatment *** observation was important for conformance treatment design in CCUS-EOR *** to this study,the materials should reduce the channel permeability to make the channel/matrix permeability ratio below *** results demonstrate the importance of conformance treatment in maximizing the performance of CCUS-EOR process to achieve both oil recovery improvement and efficient carbon *** study provides guidelines for suc

关键词： Enhanced oil recovery(EOR) CO_(2)geological sequestration Conformance control Gel treatment CCUS Low-permeability reservoir

Skin tissue engineering advances in severe burns:review and therapeutic applications

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Burns & Trauma 2016年第1期4卷 13-26页

作者： Alvin Wen Choong Chua Yik Cheong Khoo Bien Keem Tan Kok Chai Tan Chee Liam Foo si Jack Chong singapore General Hospital Department of PlasticReconstructive andAesthetic Surgery20 College RoadAcademia Level 4Singapore 169845Singapore. singapore General Hospital Skin Bank UnitBlock 4 Level 3Room 15Outram RoadSingapore 169608Singapore. Transplant TissueCentre c/o Skin Bank UnitSingapore General HospitalBlock 4 Level 3 RoomA7Outram RoadSingapore 169608Singapore. singapore General Hospital Skin Bank UnitBlock 4 Level 3Room 15Outram RoadSingapore 169608Singapore. Transplant TissueCentre c/o Skin Bank UnitSingapore General HospitalBlock 4 Level 3 RoomA7Outram RoadSingapore 169608Singapore. singapore General Hospital Department of PlasticReconstructive andAesthetic Surgery20 College RoadAcademia Level 4Singapore 169845Singapore. singapore General Hospital Skin Bank UnitBlock 4 Level 3Room 15Outram RoadSingapore 169608Singapore.

Current advances in basic stem cell research and tissue engineering augur well for the development of improved cultured skin tissue substitutes:a class of products that is still fraught with limitations for clinical *** the ability to grow autologous keratinocytes in-vitro from a small skin biopsy into sheets of stratified epithelium(within 3 to 4 weeks)helped alleviate the problem of insufficient donor site for extensive burn,many burn units still have to grapple with insufficient skin allografts which are used as intermediate wound coverage after burn *** offered by tissue-engineered skin dermal replacements to meet emergency demand have been used fairly *** the availability of these commercial products,they all suffer from the same problems of extremely high cost,sub-normal skin microstructure and inconsistent engraftment,especially in full thickness *** practice for severe burn treatment has since evolved to incorporate these tissue-engineered skin substitutes,usually as an adjunct to speed up epithelization for wound closure and/or to improve quality of life by improving the functional and cosmetic results *** review seeks to bring the reader through the beginnings of skin tissue engineering,the utilization of some of the key products developed for the treatment of severe burns and the hope of harnessing stem cells to improve on current practice.

关键词： Burns Skin tissue engineering Stem cells Cultured epithelial autografts Dermal substitutes Microskin grafting

Malignant peritoneal mesothelioma with massive ascites as the first symptom:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10317-10325页

作者： Xi Huang Yu Hong si-Ya Xie Hui-Li Liao Hao-Ming Huang Jian-Hong Liu Wen-Jie Long Department of Geriatrics The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Department of Chinese Internal Medicine The First Clinical Medical CollegeGuangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Department of Geriatrics The First Clinical Medical CollegeGuangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Department of Emergency The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina

BACKGROUND Malignant peritoneal mesothelioma(MPM) is an extremely rare tumor with nonspecific clinical manifestations,which is extremely difficult to ***,we reported a case of MPM in the abdominal cavity with massive shortterm ascites as the first *** SUMMARY A 65-year-old woman presented to the hospital with abdominal pain,distention,and shortness of breath that persisted for 15 *** serum CA-125 level was 1075 U/m *** abdominal computed tomography showed massive ascites and no obvious tumor *** pathological examination of the ascitic fluid showed numerous heterotypic cells with some papillary *** immunohistochemistry and fluorescence in situ hybridization showed the deletion of CDX2(-),WT-1(-),Ki-67(about 10% +),CEA(-),Glut-1(+++),desmin(-),PD-L1(-),and CDKN2A(P16).The final diagnosis was *** patient refused tumor cytoreductive surgery and received two cycles of cisplatin plus pemetrexed bidirectional *** the second cycle,she received an additional cycle of hyperthermic intraperitoneal chemotherapy and immune checkpoint inhibitor therapy due to massive recalcitrant *** died of disease progression 2 mo after *** In case of massive unexplained ascites,the possibility of MPM should not be excluded to avoid misdiagnosis and delay in treatment.

关键词： Malignant peritoneal mesothelioma Ascites Immunohistochemistry Chemotherapy Immunotherapy Case report

Accommodation-Free Head Mounted Display with Comfortable 3D Perception and an Enlarged Eye-box

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Research 2019年第1期2019卷 603-611页

作者： Pawan K.Shrestha Matt J.Pryn Jia Jia Jhen-si Chen Hector Navarro Fructuoso Atanas Boev Qing Zhang Daping Chu Centre for Photonic Devices and Sensors University of Cambridge9 JJ Tomson AvenueCambridge CB30FAUK Huawei Technologies Duesseldorf GmbH European Research CentreRiesstrasse 25Munchen 80992Germany

An accommodation-free displays,also known as Maxwellian displays,keep the displayed image sharp regardless of the viewer’s focal ***,they typically sufer from a small eye-box and limited efective feld of view(FOV)which requires careful alignment before a viewer can see the *** paper presents a high-quality accommodation-free head mounted display(aHMD)based on pixel beam scanning for direct image forming on *** has an enlarged eye-box and FOV for easy viewing by replicating the viewing points with an array of beam splitters.A prototype aHMD is built using this concept,which shows high defnition,low colour aberration 3D augmented reality(AR)images with an FOV of 36∘.Te advantage of the proposed design over other head mounted display(HMD)architectures is that,due to the narrow,collimated pixel beams,the high image quality is unafected by changes in eye accommodation,and the approach to enlarge the eye-box is *** importantly,such an aHMD can deliver realistic three-dimensional(3D)viewing perception with no vergence-accommodation confict(VAC).It is found that viewing the accommodation-free 3D images with the aHMD presented in this work is comfortable for viewers and does not cause the nausea or eyestrain side efects commonly associated with conventional stereoscopic 3D or HMD displays,even for all day use.

关键词： Comfort mounted Mount

simulation of stray grain formation at the platform during Ni-base single crystal superalloy DD403 casting

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China Foundry 2015年第2期12卷 118-122页

作者： si-feng Gao Lin Liu Jun Zhang Jun-feng Xiao Wen-shu Tang Yong-jun Li Qing Nan Xi’an Thermal Power Research Institute Co. Ltd. State Key Laboratory of Solidifi cation Processing Northwestern Polytechnical University

The mechanism of stray grain formation at the platform of turbine blade simulator and the effect of withdrawal rate （V） on the stray grain phenomenon have been investigated using a macro-scale ProCAST coupled with a 3D Cel ular Automaton Finite Element （CAFE） model. The results indicate that the stray grains nucleate at the edges of platform at V=150μm·s-1 and 200μm·s-1. Using ProCAST computer simulation software, it was proven that the stray grain formation is signiifcantly dependent on the undercooling and the temperature ifeld distribution in the platform. The macroscopic curvature of the liquidus isotherm becomes markedly concave with an increase in the withdrawal rate. The probability of stray grain formation at the edges of platform can be increased by increasing the withdrawal rate in the range of 70μm·s-1 to 200μm·s-1.

关键词： nickel-based single crystal superalloy directional solidification stray grains undercooling