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进一步全面深化改革:动因、现实条件与方法论

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大连干部学刊 2025年第1期41卷 33-39页

作者：司元山东大学政治学与公共管理学院山东青岛266237

党的二十届三中全会作出了进一步全面深化改革的重要战略部署,将改革和中国式现代化紧密结合,这表明我们党对改革的理论认识达到了新高度。为了加深对进一步全面深化改革的理解,需要厘清三个问题:一是为什么要在全面深化改革的基础上再... 详细信息

党的二十届三中全会作出了进一步全面深化改革的重要战略部署,将改革和中国式现代化紧密结合,这表明我们党对改革的理论认识达到了新高度。为了加深对进一步全面深化改革的理解,需要厘清三个问题:一是为什么要在全面深化改革的基础上再进一步,即动因问题;二是为什么能够再进一步,即现实条件问题;三是如何再进一步,即方法论指导。若要回答第一个和第二个问题,则需要从改革的历史脉络和现实情况中寻找答案。若要回答第三个问题,则需要在坚持党的领导的基础上,掌握马克思主义哲学方法,用联系、发展、整体的观点来看待改革这个复杂的系统,正确认识改革的发展规律,做好顶层设计并抓好贯彻执行。

关键词：进一步全面深化改革中国式现代化党的领导顶层设计

single-atom“surgery”on chiral all-dialkynyl-protected superatomic silver nanoclusters

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Science Bulletin 2025年第3期70卷 365-372页

作者： Chengkai Zhang Wei-Dan si Wei-Dong Tian Wan-Jun Xiao Zhi-Yong Gao Zhi Wang Chen-Ho Tung Di Sun School of Chemistry and Chemical Engineering State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

The manipulation of single atom within the metallic kernel of nanoclusters has attracted considerable attention due to its potentials to elucidate kernel-based structure-property relationships at the single-atom ***,new-designed chiral bialkynyl ligands,have been chosen as protective agents to isolate two pairs of 8-electron superatomic silver nanoclusters,R/S-Ag39 and R/S-Ag40.X-ray diffraction analysis reveals that Ag39 and Ag40 with the same number of chiral ligands,possess a closely analogous silver skeleton but a single-atomic *** incorporation of an extra Ag40th atom into Ag40 evokes two significant changes of structure and property compared to Ag39:(i)a reduction in the symmetry of the entire nanocluster,resulting in an enhancement of kernel-related asymmetry g-factor;(ii)a regulation of the transitions(1P→1D and Ligand(π)→1D)of excited state,leading to a second near-infrared(NIR-II,1000-1700 nm)phosphorescent emission red-shift from 1088 to 1150 *** work not only provides vital insights into the relationship between structures and ground/excited states chiroptical activities at the single-atom level,but also presents bialkynyl as a promising stabilizing agent for building superatomic metal nanoclusters.

关键词： single atom manipulation Chiral bialkynyl ligands Superatomic silver nanoclusters NIR-Il phosphorescence

Bufalin Suppresses Esophageal Squamous Cell Carcinoma Progression through Protein Arginine Methyltransferase-6/AKT/Mammalian Target of Rapamycin Pathway Inhibition

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World Journal of Traditional Chinese Medicine 2025年第01期 148-156页

作者： Yao-Ke Jia Qian-Qian Ju Hui Shi Xin-Xin si Department of Clinical Medicine Nanjing Medical University Department of Clinical Medicine Medical College of Nantong University Department of Thoracic Surgery School of Medicine Shanghai Chest Hospital Shanghai Jiao Tong University Department of Medical Biology School of Pharmacy Jiangsu Ocean University

Objective: Esophageal squamous cell carcinoma(ESCC), a commonly encountered malignant tumor in the gastrointestinal tract, poses a significant health burden. Bufalin, a pharmacologically active molecule, has been shown to exhibit antitumor activity against various types of cancers. This study investigates the molecular mechanism underpinning the effects of bufalin on ESCCs. Materials and Methods: The impact of bufalin on the proliferation and migration of ESCC cells was evaluated through the utilization of the Cell Counting Kit-8(CCK-8), scratch assay, and transwell assay. In addition, ribonucleic acid(RNA) sequencing was performed to identify genes that were abnormally expressed in response to bufalin treatment. Western blotting was utilized to ascertain the expression levels of protein arginine methyltransferase-6(PRMT6), phosphorylated AKT(p-AKT), and phosphorylated mammalian target of rapamycin(p-m TOR). Cell transfection was then performed to observe the rescue effect of PRMT6 on bufalin. Results: Bufalin displayed a significant time-dependent inhibition of the proliferation, migration, and invasion of ECA109 cells. An RNA sequencing(RNA-seq) analysis revealed that PRMT6 expression was downregulated in the cells treated with bufalin. PRMT6 promoted the proliferation, migration, and invasive potential of ECA109 cells. The overexpression of PRMT6 boosted p-AKT and p-m TOR levels in ECA109 cells and reversed bufalin inhibition. Conclusions: These findings indicate that bufalin exerts its inhibitory effects on ESCCs through the PRMT6/AKT/m TOR signaling pathway. These findings lay the groundwork for bufalin as a promising therapeutic candidate for the treatment of ESCC.

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江西省NPP估算及其与气候因子的关联分析-基于改进CASA模型

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中国环境科学 2025年第1期45卷 369-378页

作者：鲁铁定章园曾思婷陶蕊腾月东华理工大学测绘与空间信息工程学院江西南昌330013 东华理工大学自然资源部鄱阳湖区域矿山环境监测与治理重点实验室江西南昌330013 江西省交通设计研究院有限责任公司江西南昌330013 江西省自然资源测绘与监测院江西南昌330002

通过改进太阳辐射参数和水分子胁迫系数计算方法提高了CASA(Carnegie-Ames-Stanford Approach)模型估算净初级生产力(NPP)的精度,并在此基础上对NPP和气象因子进行相关性和趋势分析.结果表明,基于改进后模型,NPP与实地观测数据的相关性... 详细信息

通过改进太阳辐射参数和水分子胁迫系数计算方法提高了CASA(Carnegie-Ames-Stanford Approach)模型估算净初级生产力(NPP)的精度,并在此基础上对NPP和气象因子进行相关性和趋势分析.结果表明,基于改进后模型,NPP与实地观测数据的相关性达0.62;2001~2022年,江西省年均NPP整体呈上升趋势,年均值超过1000gC/(m^(2)⋅a);NPP月均值为秋季>夏季>冬季>春季,月均值最大值出现在7月;NPP年均值上最大值、最小值出现在2018年、2010年;趋势变化和相关性分析的结果表明,2001~2022年江西省太阳辐射量呈现下降趋势,但NPP的变化未受显著影响;最小二乘法回归模型结果表明,温度每增加一个单位,NPP平均随温度的增加而增加,随太阳辐射的减少而减少;NPP在近几年(2019~2022年)极端事件增加的情况下,NPP未出现显著下降.

关键词： CASA模型净初级生产力太阳辐射气候变化江西省

A special core-shell material(Mxene@Ag@Phytate)to improve EVA composite fire safety,radiation cross-linking effect,and electromagnetic shielding

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Nuclear Science and Techniques 2025年第2期36卷 27-39页

作者： si-Yi Xu Dan-Yi Li Wen-Rui Wang Lin Lin Ying Sun Ji-Hao Li Lin-Fan Li Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

High-performance MXene-based polymer nanocomposites are well-suited for various industrial applications owing to their excellent mechanical,thermal,and other ***,the fabrication of flame-retardant polymer/MXene nanocom-posites remains challenging owing to the limited flame-retardant properties of MXene *** study prepared a novel MXene@Ag@PA hybrid material via radiation modification and complexation *** material was used to further enhance the key properties of ethylene-vinyl acetate(EVA),such as its mechanical properties,thermal conductivity,flame retardancy,and electromagnetic *** addition of two parts of this hybrid material increased the thermal conduc-tivity of EVA by 44.2%and reduced its peak exothermic rate during combustion by 30.1%compared with pure *** material also significantly reduced smoke production and increased the residue *** the X-band,the electromagnetic shielding effectiveness of the EVA composites reached 20 ***,the MXene@Ag@PA hybrid material could be used to further enhance the mechanical properties of EVA composites under electron-beam ***,this study contributes to the development of MXene-based EVA advanced materials that are fire-safe,have high strength,and exhibit good electromagnetic shielding performance for various applications.

关键词： MXene@Ag@PA Ethylene-vinyl acetate(EVA) Flame retardancy Electromagnetic shielding performance

Triazine-COF@silicon nanowire mimicking plant leaf to enhance photoelectrocatalytic CO_(2)reduction to C2þchemicals

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Green Energy & Environment 2025年第2期10卷 422-432页

作者： Wenrui Wan Fanhua Meng si Chen Jianhua Wang Chunyan Liu Yan Wei Chenpu He Li Fan Qiaolan Zhang Weichun Ye Huanwang Jing State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou730000GansuChina Key Laboratory of Green Chemical Media and Reactions(Ministry of Education) School of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang453007HenanChina School of Chemical Engineering Lanzhou University of Arts and SciencesLanzhou730010China

Converting CO_(2)and water into valuable chemicals like plant do is considered a promising approach to address both environmental and energy *** inspiration from the structures of natural leaves,we designed and synthesized a novel copper-coordinated covalent triazine framework(CuCTF)supported by silicon nanowire arrays on wafer *** marks the first-ever application of such a hybrid material in the photoelectrocatalytic reduction of CO_(2)under mild *** si@CuCTF6 heterojunction has exhibited exceptional selectivity of 95.6%towards multicarbon products(C^(2+))and apparent quantum efficiency(AQE)of 0.89%for carbon-based *** active sites of the catalysts are derived from the nitrogen atoms of unique triazine ring structure in the ordered porous framework and the abundant Cu-N coordination sites with bipyridine ***,through DFT calculations and operando FTIR spectra analysis,we proposed a comprehensive mechanism for the photoelectrocatalytic CO_(2)reduction,confirming the existence of key intermediate species such as*CO_(2)-,*=C=O,*CHO and*CO-CHO *** work not only provides a new way to mimic photosynthesis of plant leaves but also gives a new opportunity to enter this research field in the future.

关键词： silicon Photoelectrocatalysis CO_(2)reduction Covalent triazine framework Sustainable chemistry

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大口径宽温反射镜中心支撑结构设计

中国光学(中英文) 2025年第1期18卷 150-159页

作者：袁健裴思宇霍占伟张冠宸张雷长光卫星技术股份有限公司吉林长春130033

为提升低轨卫星与地面站间激光链路的通信质量,商业地面站内望远镜配备的大口径主镜需适应户外环境中恶劣的温度条件。针对某通光口径Φ500 mm的高精度主镜组件,提出一种使用室温硫化硅橡胶的中心支撑方案。镜体采用微晶材料,衬套和支... 详细信息

为提升低轨卫星与地面站间激光链路的通信质量,商业地面站内望远镜配备的大口径主镜需适应户外环境中恶劣的温度条件。针对某通光口径Φ500 mm的高精度主镜组件,提出一种使用室温硫化硅橡胶的中心支撑方案。镜体采用微晶材料,衬套和支撑筒均为钛合金材质。1 mm厚的胶层在卸载镜体自身重力的同时,可有效减小组件内部热应力。胶层的厚度和高度可通过仿真优化确定,特制的粘接工装可准确控制胶层形状和厚度,衬套上的通气孔促进了胶层的充分固化。仿真分析表明:主镜在40°C温度均匀变化工况下的面形精度RMS值为4.199 nm;光轴竖直重力工况下的RMS值为13.748 nm;光轴水平重力工况下的RMS值为4.187 nm,镜体最大倾角和位移分别为4.722″和3.597μm,组件基频达到53.45 Hz;实测主镜的面形精度为RMS 0.017λ(λ=632.8 nm),经大范围高低温循环试验及真空镀膜后,主镜均可保持高精度面形。文中支撑结构可以显著提升高精度反射镜的温度适应能力,在地面大型光电设备中具有广阔的应用前景。

关键词：宽温反射镜室温硫化硅橡胶热稳定性地基望远镜激光通信

Retrieval of Ozone Profiles Using a Weighted Multiplicative Algebraic Reconstruction Technique from SCIAMACHY Limb Scattering Observations

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Journal of Earth Science 2025年第1期36卷 314-326页

作者： Fang Zhu Fuqi si Ke Dou Kai Zhan Haijin Zhou Yuhan Luo Centre of Environmental Optics Anhui Institute of Optics and Fine MechanicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China School of Physics and Electrical Information Huaibei Normal UniversityHuaibei 235000China

This study describes the use of the weighted multiplicative algebraic reconstruction technique(WMART)to obtain vertical ozone profiles from limb observations performed by the scanning imaging absorption spectrometer for atmospheric chartography(SCIAMACHY).This technique is based on SaskMART(the combination of the multiplicative algebraic reconstruction technique and SaskTRAN radiative transfer model),which was originally developed for optical spectrometer and infrared imaging system(OsiRIS)*** of the objectives of this study was to obtain consistent ozone profiles from the two *** this study,the WMART algorithm is combined with a radiative transfer model(SCIATRAN),as well as a set of measurement vectors comprising five Hartley pairing vectors(HPVs)and one Chappuis triplet vector(CTV),to retrieve ozone profiles in the altitude range of 10–69 *** that the weighting factors in WMART have a significant effect on the retrievals,we propose a novel approach to calculate the pair/triplet weighting factors using wavelength weighting *** results of the application of the proposed ozone retrieval scheme are compared with the SCIAMACHY v3.5 ozone product by University of Bremen and validated against profiles derived from other passive satellite observations or measured by *** 18 and 55 km,the retrieved ozone profiles typically agree with data from the SCIAMACHY ozone product within 5%for tropics and middle latitudes,whereas a negative deviation exists between 35 and 50 km for northern high latitudes,with a deviation of less than 10%above 50 *** of the retrieved profiles with microwave limb sounder(MLS)v5.0 indicates that the difference is within±5%between 18 and 55 km,and an agreement within 10%is achieved in other altitudes for tropics and middle *** of the retrieved profiles with OsiRIS v7.1 indicates that the average deviation is within±5%between 20 and 59 km,and difference of approximately 10%is

关键词： retrievals ozone profiles WMART SCIAMACHY limb

Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： si-Yun Lin Hou Huang Jin-Jie Yu Feng Su Tian Jiang Shao-yuan Zhang Lu Lv Tao Long Hui-Wen Pan Jun-Qing Qi Qiang Zhou Wei-Feng Tang Guo-Wen Ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study