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Rapid progression of heart failure secondary to radioactive iodine treatment of hyperthyroidism:A case report

World Journal of Clinical Cases 2023年第22期11卷 5316-5321页

作者： Zi-Han Li Lu-Jia Ni yuan-Qiao Liu dao-yuan si Department of Cardiology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Jilin Provincial Engineering Laboratory for Endothelial Function China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Ultrasound China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

BACKGROUND The deterioration of thyroid health is involved in the progression of heart failure(HF).This is usually a lengthy process,so there are almost no reports on its rapid *** we report a case of a young male who rapidly developed hypothyroid cardiomyopathy secondary to radioactive iodine treatment,suggesting that severe HF might occur even after a short period of *** SUMMARY A 26-year-old man was referred to our hospital for HF presenting with dyspnea on exertion and chest discomfort lasting for 1 *** received radioactive iodine treatment for hyperthyroidism 1 year ago and had an almost normal echocardiogram 6 mo *** echocardiogram and cardiac magnetic resonance(CMR)revealed left ventricle(LV)global hypokinesia and severely depressed systolic *** addition,late gadolinium enhancement indicated no obvious changes in the *** function tests showed decreased serum levels of thyroid hormone(TH)and elevated thyroid-stimulating *** on an exclusionary examination,the patient was diagnosed with hypothyroid cardiomyopathy and was started on replacement *** HF symptoms were completely relieved during the six-month follow-up,and echocardiogram and CMR revealed recovered LV size and ejection *** This report demonstrates that severe fluctuations in TH levels may lead to acute HF,which can completely recover with timely thyroid hormone *** addition,our findings highlight the importance of routinely detecting cardiac function in patients treated with radioactive iodine.

关键词： Heart failure Hypothyroid cardiomyopathy Hormone replacement therapy Radioactive iodine therapy Case report

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Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu si Wang Weiqi Zhang Jing Qu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

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Condensed Galerkin element of degree m for first-order initial-value problem with O(h^(2m+2))super-convergent nodal solutions

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Applied Mathematics and Mechanics(English Edition) 2022年第4期43卷 603-614页

作者： si yuan Quan yuan Department of Civil Engineering Key Laboratory of Civil Engineering Safety and Durability of China Education MinistryTsinghua UniversityBeijing 100084China

A new type of Galerkin finite element for first-order initial-value problems(IVPs)is *** the trial and test functions employ the same m-degreed *** adjoint equation is used to eliminate one degree of freedom(DOF)from the test function,and then the so-called condensed test function and its consequent condensed Galerkin element are *** is mathematically proved and numerically verified that the condensed element produces the super-convergent nodal solutions of O(h^(2m+2)),which is equivalent to the order of accuracy by the conventional element of degree m+*** related properties are addressed,and typical numerical examples of both linear and nonlinear IVPs of both a single equation and a system of equations are presented to show the validity and effectiveness of the proposed element.

关键词： Galerkin method finite element method(FEM) condensed element superconvergence adjoint operator initial-value problem(IVP)

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A review of nuclear magnetic resonance(NMR) technology applied in the characterization of polymer gels for petroleum reservoir conformance control

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Petroleum Science 2021年第6期18卷 1760-1775页

作者： dao-Yi Zhu Zhi-Hua Deng si-Wei Chen State Key Laboratory of Petroleum Resources and Prospecting and Petroleum School China University of Petroleum-Beijing at KaramayKaramay834000XinjiangChina

Polymer gel systems have been widely applied to control excessive water and improve oil recovery(IOR)in petroleum *** are usually divided into two main types,in-situ cross-linked polymer gels,and pre-formed polymer *** recent years,nuclear magnetic resonance(NMR) technology has been gradually applied to the research of polymer gel systems due to its unique analysis *** paper is intent to review these works *** in-situ cross-linked polymer gel systems,NMR can be used to characterize the chemical structure changes of the polymer,the cross-linker,and the auxiliary agent in the formulation of the polymer gel ***,the gelation time and the gel strength of the in-situ cross-linked polymer gel systems can also be measured by *** pre-formed polymer gels,NMR can be employed to detect the chemical structure of the designed ***,the NMR method can evaluate the plugging,water control,and oil improvement performance of the polymer gels in porous media without using *** review can help readers build a more systematic understanding of the application of NMR technology in polymer gel systems for IOR and help re searchers to more deeply study the performance of polymer gel systems.

关键词： Nuclear magnetic resonance Polymer gels Gelation time Gel strength Conformance control

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Influence of Ce and Mn addition on α-Fe morphology in recycled Al-si alloy ingots

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International Journal of Minerals,Metallurgy and Materials 2013年第9期20卷 890-895页

作者： Chao Fan si-yuan Long Huai-de Yang Xiang-jie Wang Jun-cheng Zhang College of Materials Science and Engineering Chongqing University Engineering Training Center Guangxi University of Science and Technology

The influence of Ce or Ce and Mn combined additions on the morphology of a-Fe phases in recycled Alosi alloys was experimentally investigated by microstructure observation and room temperature tensile testing. It is found that Ce modifies the morphology of a-Fe phase from the large Chinese script-like into the individual and fine nodular shape. A combined addition of Ce and Mn results in the promotion of primary a-Fe formation, and their size increases considerably with the increase in Ce content. The mechanism of the above morphological changes was discussed in accordance with the nucleation and growth of a-Fe phase during solidification.

关键词： aluminum-silicon alloys cerium manganese modification morphology

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High Fe‑Loading single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： si Chen Fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin Yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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Estimating the maximum impact force of dry granular flow based on pileup characteristics

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Journal of Mountain Science 2019年第10期16卷 2435-2452页

作者： XIAO si-you SU Li-jun JIANG yuan-jun MEHTAB Alam LI Cheng LIU dao-chuan Key Laboratory of Mountain Hazards and Earth Surface Processes and Institute of Mountain Hazards andEnvironmentChinese Academy of SciencesChengdu610041China University of Chinese Academy of Sciences Beijing100049China CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing100101China sichuan Highway Planning DesignResearch Institute LtdChengdu610041China

The maximum normal impact resultant force(NIRF)is usually regarded as the sum of the static earth pressure of the dead zone and the dynamic impact pressure of the flowing *** influence of the interaction between the flowing layer and dead zone on the impact force is *** this study,we classified two impact models with respect to the pileup characteristics of the dead ***,we employed the discrete element method to investigate the influences of the pileup characteristics on the impact force of dry granular flow on a tilted rigid *** the final pileup height is equal to the critical value,the maximum NIRF can be estimated using a hydrostatic model,because the main contribution to the maximum NIRF is the static earth pressure of the dead *** the final pileup height is less than the critical value,however,the particles in the dead zone are squeezed along the slope surface by the impact ofthe flowing layer on the dead zone,and because of shear effects,the flowing layer causes an entrainment in the dead *** results in a decrease in the volume of the dead zone at the moment of maximum NIRF with increases in the slope *** such,the maximum NIRF mainly comprises the instant impact force of the flowing layer,so hydro-dynamic models are effective for estimating the maximum *** models will benefit from further study of the components and distribution of the impact force of dry granular flow.

关键词： Dry granular flow Tilted retaining wall Impact force Discrete element method Pileup height

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Influences of Charcoal Amendment on Adsorption-Desorption of Isoproturon in Soils

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Agricultural Sciences in China 2010年第2期9卷 257-265页

作者： TIAN Chao WANG Mi-dao si You-bin School of Sciences Anhui Agricultural University Hefei 230036 P.R.China School of Resources and Environment Anhui Agricultural University Hefei 230036 P.R.China

In order to prevent pesticide leaching from soil, the effects of charcoal amendment on adsorption-desorption of isoproturon in soils were studied and the mechanisms in reducing the loss of isoproturon from soils were suggested. Adsorption-desorption of isoproturon in five different particle sizes of charcoals and three different soils were studied using batch equilibration technique. The results showed that the experimental data were well fitted by the Freundlich empirical equation. Charcoal had a great adsorption capacity for isoproturon, and the smaller the particle size of charcoal, the more the adsorption of isoproturon. The amendment with charcoal could greatly improve the adsorption of isoproturon in soils. The adsorption of isoproturon in soils increased with the rate of charcoal amended （r= 0.9568＊＊, P 〈 0.01）. Desorption of isoproturon from charcoals and soils showed significant hystersis which was shown by the higher adsorption slope （1/nsds） compared to the desorption slope （1/ndes. The hysteresis effects of charcoal on desorption of isoproturon were closely correlated with the content of charcoal in the soils, and the hysteresis index （H） increased with the rate of charcoal amended. Observation of environmental scanning electron microscopy （ESEM） exhibitted the fine pore structure and special surface characteristics of the tested charcoal. Analysis of Fourier transform infrared spectra （FTIR） of isoproturon adsorbed on charcoal suggested probable bonding interactions between isoproturon and charcoal. This research suggests that charcoal amendment may be an effective management practice for controlling pesticide desorption and leaching in soils.

关键词： charcoal amendment isoproturon adsorption desorption soil

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P-FEMOL ANALYsiS OF PLATE BENDING PROBLEMS

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Acta Mechanica Solida sinica 1994年第1期7卷 39-45页

作者： si, yuan Tsinghua Univ Beijing China

In this paper, the p- version of the finite element method of lines (FEMOL) for the analysis of the Mindlin-Reissner plate bending problems is presented and a class of p-FEMOL elements with polynomial degrees as high as nine is developed. Numerical examples given in this paper show tremendous performance of the present method: namely, rapid convergence rate, high accuracy for both displacements and stress resultants, removal of shear-locking trouble, capability of dealing with difficult problems such as the boundary layer behavior near a free edge and stress concentration around a hole.

关键词： Bending (deformation) Boundary layers Convergence of numerical methods Differential equations Finite element method Geometry Mathematical models Performance Plates (structural components) Polynomials Stresses

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NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli si Naijia Xue Yi Liu Ran Zheng Ying Chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

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