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Recent progress in understanding mitokines as diagnostic and therapeutic targets in hepatocellular carcinoma

World Journal of Clinical Cases 2023年第23期11卷 5416-5429页

作者： Jiang Wang Lan-Zhu Luo dao-Miao Liang Chao guo Zhi-Hong Huang Xiao-Hong Jian Jie Wen Children Medical Center Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina Department of Hepatobiliary Surgery Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina Department of Anatomy Hunan Normal University School of MedicineChangsha 410013Hunan ProvinceChina Department of Pediatric Orthopedics Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina

Hepatocellular carcinoma(HCC)is one of the most prevalent tumors worldwide and the leading contributor to cancer-related *** progression and metastasis of HCC are closely associated with altered mitochondrial metabolism,including mitochondrial stress ***,soluble proteins produced and secreted in response to mitochondrial stress,play an essential immunomodulatory *** has emerged as a crucial treatment option for ***,a positive response to therapy is typically dependent on the interaction of tumor cells with immune regulation within the tumor ***,exploring the specific immunomodulatory mechanisms of mitokines in HCC is essential for improving the efficacy of *** study provides a comprehensive overview of the association between HCC and the immune microenvironment and highlights recent progress in understanding the involvement of mitochondrial function in preserving liver *** addition,a systematic review of mitokines-mediated immunomodulation in HCC is ***,the potential diagnostic and therapeutic roles of mitokines in HCC are prospected and *** progress in mitokine research represents a new prospect for mitochondrial *** the potential of mitokines to regulate immune function,investigating them as a relevant mole cular target holds great promise for the diagnosis and treatment of HCC.

关键词： Hepatocellular carcinoma Mitochondria Mitokine Immune escape Autophagy

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Insulin promotes sinusoidal endothelial cell proliferation mediated by upregulation of vascular endothelial growth factor in regenerating rat liver after partial hepatectomy

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World Journal of Gastroenterology 2005年第38期11卷 5978-5983页

作者： Jian-guo Qiao Long Wu dao-Xiong Lei Lu Wang Department of General Surgery Zhongnan Hospital Affiliated to Wuhan University Wuhan 430071 Hubei Province China

AIM： To determine whether insulin could promote sinusoidal endothelial cell （SEC） proliferation mediated by upregulation of vascular endothelial growth factor （VEGF） in regenerating rat liver after partial hepatectomy （PHx）. METHODS： Adult male Sprague-Dawley rats undergoing 70% PHx were injected with insulin （300 MU/kg） or saline via the tail veins every 8 h after surgery for 7 d and killed at 0, 24, 48, 72, 96, 120, 144, and 168 h after surgery. Proliferation of both hepatocytes and SECs was monitored by evaluating the proliferating cell nuclear antigen （PCNA） labeling index （LI）. The expression of VEGF protein was evaluated by immunohistochemistJv. The mRNA expressions of VEGF and its receptors FIt-1 and FIk-1 were evaluated by semi-quantitative reverse transcription-PCR. RESULTS： Insulin markedly increased the expression of VEGF mRNA between 24 and 120 h after hepatectomy compared to controls. Similarly, insulin significantly increased the expression of Fit-1 between 24 and 96 h. However, insulin had no significant effect on FIk-1. Furthermore, the immunohistochemical staining revealed that expression of VEGF protein increased in the insulin groups. Insulin significantly increased the PCNA LI of hepatocytes and SECs compared to controls. CONCLUSION： Exogenous insulin may promote SEC proliferation with an enhanced expression of VEGF and its receptor Fit-1 in regenerating rat liver after PHx.

关键词： Insulin Sinusoidal endothelial cell VEGF

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Casticin Attenuates Stemness in Cervical Cancer Stem-Like Cells by Regulating Activity and Expression of DNMT1

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Chinese Journal of Integrative Medicine 2023年第3期29卷 224-232页

作者： WANG Xue-li CAO Xiao-zheng WANG dao-yuan QIU Ye-bei DENG Kai-yu CAO Jian-guo LIN Shao-qiang XU Yong REN Kai-qun Medical College Hunan University of MedicineHuaihuaHunan Province(418000)China Clinical Department of Guangdong Metabolic Disease Research Centre of Integrated Chinese and Western Medicine the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou(510062)China Institute of Chemical Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou(510530)China The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province Medical CollegeHunan Normal UniversityChangsha(410013)China The Key Laboratory of Study and Discover of Small Targeted Molecules of Hunan Province Medical CollegeHunan Normal UniversityChangsha(410013)China

Objective:To explore whether casticin(CAS)suppresses stemness in cancer stem-like cells(CSLCs)obtained from human cervical cancer(CCSLCs)and the underlying ***:Spheres from He La and Ca Ski cells were used as *** methyltransferase 1(DNMT1)activity and m RNA levels,self-renewal capability(Nanog and Sox2),and cancer stem cell markers(CD133 and CD44)were detected by a colorimetric DNMT activity/inhibition assay kit,quantitative real-time reverse transcription-polymerase chain reaction,sphere and colony formation assays,and immunoblot,*** and overexpression of DNMT1 by transfection with sh RNA and c DNA,respectively,were performed to explore the mechanism for action of CAS(0,10,30,and 100 nmol/L).Results:DNMT1 activity was increased in CCSLCs compared with He La and Ca Ski cells(P<0.05).In addition,He La-derived CCSLCs transfected with DNMT1 sh RNA showed reduced sphere and colony formation abilities,and lower CD133,CD44,Nanog and Sox2 protein expressions(P<0.05).Conversely,overexpression of DNMT1 in He La cells exhibited the oppositive ***,CAS significantly reduced DNMT1 activity and transcription levels as well as stemness in He La-derived CCSLCs(P<0.05).Interestingly,DNMT1 knockdown enhanced the inhibitory effect of CAS on *** expected,DNMT1 overexpression reversed the inhibitory effect of CAS on stemness in He La ***:CAS effectively inhibits stemness in CCSLCs through suppression of DNMT1 activation,suggesting that CAS acts as a promising preventive and therapeutic candidate in cervical cancer.

关键词： cervical cancer cancer stem cell casticin DNA methyltransferase 1 therapeutic action

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Synthesis of the D-Galactopyranoside Derivative of C_(60)

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Chinese Chemical Letters 1998年第2期9卷 113-115页

作者： guo Dong SUI Han Chun HU dao dao ZHANG Hou Ming WU Xia Fei LAO Jing Fei XU(Department of Chemistry, Fudan University, Shanghai 200433Stat. Key Laboratory of Bioorganic Chemistry and Natural Products Chemistry, Shanghai Instituteof Organic Chemistry, S Department of Chemistry Fudan University Shanghai 200433 China State Key Lab. Bioorg. Chem./N.P.C. Shanghai Inst. of Organic Chemistry Shanghai 200032 China

A D-Galactopyranoside of C60 has been synthesized and its structure has been identified by the NMR, FD-MS, FT-IR spectra, etc.

关键词： C_(60) D-Galactose azide

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Nonlinear Flux Diffusion and ac Susceptibility in High-T_(c) Superconductors

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Chinese Physics Letters 1998年第9期15卷 668-670页

作者： BAI Wei-ping CHEN Han-dong YIN dao-le LI Gang LI Chuan-yi CHEN Kai-xuan LU guo Department of Physics Peking UniversityBeijing 100871

It is shown that the flux motion in high-T_(c) superconductors can be well consistently analysed by a unified materials *** different models of U(J)so far suggested can be shown as specific forms or limits of this unified materials *** scaling law of flux pinning derived from this equation agrees with recent experimental observations on high-Jc NdBa2Gu3O7-δsingle *** amplitude dependence of ac susceptibility derived from this equation is compared with several experimental results of high-T_(c) superconductors and a general power law is found.

关键词： equation. unified superconductors

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Electroless Nickel Plating and Electroplating on FBG Temperature Sensor

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Chemical Research in Chinese Universities 2008年第5期24卷 635-639页

作者： SHEN Ren-sheng TENG Rui LI Xiang-ping ZHANG Jin XIA dao-cheng FAN Zhao-qi YU Yong-sen ZHANG Yu-shu DU guo-tong State Key Laboratory of Materials Modification by Laser Ion and Electron Beams School of Physics and Optoeleetronic Technology Dalian University of Technology DaIian 116024 P. R. China State Key Laboratory on Integrated Optoelectronies College of Electronic Science and Engineering Jilin University Changchun 130012 P R. China

Metal-coated fiber Bragg grating（FBG）temperature sensors were prepared via electroless nickel（EN）plating and tin electroplating methods on the surface of normal bare *** surface morphologies of the metal-coated layers were observed under a metallographic *** effects of pretreatment sequence,pH value of EN plating solution and current density of electroplating on the performance of the metal-coated layers were ***, the Bragg wavelength shift induced by temperature was monitored by an optical spectrum *** of the metal-coated FBG（MFBG）sensor was almost two times that of normal bare FBG *** measuring temperature of the MFBG sensor could be up to 280℃,which was much better than that of conventional FBG sensor.

关键词： FBG Metal-coated layer Electroless nickel plating Electroplating Temperature sensor

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Experimental study of reservoir damage of water-based fracturing fluids prepared by different polymers

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Petroleum Science 2024年第5期21卷 3298-3306页

作者： guo-Dong Wu Li-Kun Wang Chun-Yan Zhao Ze-Jun Zhang Jian-Yu Yin Maryamgul Anwaier Hong-Da Ren Dan Yang Shu-Li Yin Zhuo-Lin Cai dao-Yi Zhu Engineering Technology Research Institute Xinjiang Oilfield CompanyKaramay834000XinjiangChina Luliang Oilfield Operation Area Xinjiang Oilfield CompanyKaramay834000XinjiangChina China University of Petroleum-Beijing at Karamay Karamay834000XinjiangChina

Fracturing operations can effectively improve the production of low-permeable reservoirs. The performance of fracturing fluids directly affects the fracturing efficiency and back flow capacity. As polymerbased fracturing fluids(such as guar gum(GG), polyacrylamide(HPAM), etc.) are high-viscosity fluids formed by viscosifiers and crosslinking agents, the degree of gel breakage after the fracturing operation directly influences the damage degree to the reservoir matrix and the mobility of oil angd gas produced from the reservoir into the wellbore. This study compared the viscosity, molecular weight, and particle size of the fracturing fluid after gel breakage prepared by GG and HPAM as viscosifiers, as well as evaluate their damage to the core. Results show that the viscosities of the gel-breaking fluid increased with the concentration of the viscosifier for both the HPAM-based and GG-based fracturing fluids. For the breaking fluid with the same viscosity, the molecular weight in the HPAM-based gel-breaking fluid was much larger than that in the GG-based system. Moreover, for the gel-breaking fluid with the same viscosity, the molecular particle size of the residual polymers in the HPAM-based system was smaller than that in the GG-based system. The damage to the core with the permeability of 1 × 10^(-3)μm^(2) caused by both the HPAM-based and GG-based gel-breaking fluids decreased with the increase in the solution viscosity. For the gel-breaking fluid systems with the same viscosity(i.e., 2-4 mPa s), the damage of HPAM-based fracturing fluid to low-permeability cores was greater than the GG-based fracturing fluid(45.6%-80.2%) since it had a smaller molecular particle size, ranging from 66.2% to 77.0%. This paper proposed that the damage caused by hydraulic fracturing in rock cores was related to the partilce size of residual polymers in gel-breaking solution, rather than its molecular weight. It was helpful for screening and optimizing viscosifiers used in hydraulic f

关键词： Fracturing fluid Guar gum HPAM Gel-breaking fluid Formation damage

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对构建政治民主化和谐社会的法理思考

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河北学刊 2007年第1期27卷 196-201页

作者：郭道晖中国法学会北京100034

“和谐社会”这一现代政治学、社会学概念,不能简单地套用于法学范畴。与“和谐”相对应的法学范畴是“平衡”,它主要体现为公民的个人自由与社会秩序的平衡,国家权力与公民权利的平衡,社会主体之间的权利平衡,以及国家与社会的二元格... 详细信息

“和谐社会”这一现代政治学、社会学概念,不能简单地套用于法学范畴。与“和谐”相对应的法学范畴是“平衡”,它主要体现为公民的个人自由与社会秩序的平衡,国家权力与公民权利的平衡,社会主体之间的权利平衡,以及国家与社会的二元格局的相互谐调,互补互动。建构和谐社会是社会矛盾运动的过程。当前的首要任务是化解因社会分配不公而产生的诸多社会矛盾和冲突。这一冲突的阶级性实质是权贵资产者阶层与工农弱势群体的矛盾与对立,而建构公民社会则是解决这些社会矛盾、构建和谐社会的基石和动力。

关键词：和谐社会社会矛盾公民社会政治民主化

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1921年前后的中国政治学科建设——以高一涵译《十九世纪政治思想史》为线索

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华南师范大学学报（社会科学版） 2018年第5期 142-155,192页

作者：郭道平中国社会科学院文学研究所

高一涵译于1921年前后的《十九世纪政治思想史》一书,原本系英国赫克特·麦克弗森(Hector Macpherson)所著A Century of Political Development,实则根据日本文明协会1914年出版的日译本转译而来。高一涵在译者弁言中提出"比较的"和"历... 详细信息

高一涵译于1921年前后的《十九世纪政治思想史》一书,原本系英国赫克特·麦克弗森(Hector Macpherson)所著A Century of Political Development,实则根据日本文明协会1914年出版的日译本转译而来。高一涵在译者弁言中提出"比较的"和"历史的"政治学研究方法,受到其时以胡适为代表的新式学者的启发,也在此书的翻译中得到印证。1920年代前期,高一涵编著了系列政治思想史教材,并在北京大学率先讲授政治思想史课程;而"政治思想史"这一名目的最初来源,很可能与此书的翻译相关。该书中对于埃德蒙·伯克(Edmund Burke)以及欧洲社会主义运动等的议论,对高一涵亦有较深影响。

关键词：高一涵《十九世纪政治思想史》赫克特·麦克弗森北京大学政治学系

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dao媒介:驱动未来社会算法化与自组织的元媒介

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新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 132-141页

作者：喻国明苏健威北京师范大学新闻传播学院北京师范大学传播创新与未来媒体实验平台北京100875

dao媒介是以区块链算法等技术为基础,支持数字社群协同自治的媒介,具有区块链、智能合约与投票等功能特性和要素确权、技术信任、规则构架以及场景聚合等价值禀赋。对于数字生态显露的各种问题,“算法化”是重构数字生态、降解社会系统... 详细信息

dao媒介是以区块链算法等技术为基础,支持数字社群协同自治的媒介,具有区块链、智能合约与投票等功能特性和要素确权、技术信任、规则构架以及场景聚合等价值禀赋。对于数字生态显露的各种问题,“算法化”是重构数字生态、降解社会系统复杂性的关键机制,dao媒介是支撑“自组织式”算法化的元媒介。dao媒介与数字文明时代喷发的微粒个体、微资源、微价值、微需求、微场景等相匹配,能够深度匹配人的个性与自我,形成有效的趣缘连接,进而极大地释放数字文明的生产力。dao媒介将深刻影响社会系统的构造,将微粒个体与相关社会要素“包裹”为闭环子系统,支持其准开放的系统边界、有效的异质性整合、可持续的规则重构、子系统与父级系统的持续分化和快速进化,等等。在数字文明时代,dao媒介将使“重新部落化”的“地球村”变为现实,其驱动构筑的dao社会将更加多元、更加富有创造力,不断拓展人类群体实践的自由度,使人类在高度异质性聚合基础上更加和谐有序地整合协同。

关键词： dao 数字媒介算法自组织社会系统

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