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RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-Yu Chen Pei-Yao wang Bang Liu Yang-Pu Jia Zhao-Xiong Zhang Xin Liu dao-han wang Yong-Jia Yan Wei-Hua Fu Feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

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智能润滑系统在烧结设备上的应用

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武钢技术 2006年第3期44卷 28-30页

作者：韩道旺吴新刚武钢烧结厂湖北武汉430083

针对烧结机系统中常见润滑点,分析了双线环式和终端式干油润滑系统的缺陷;介绍了智能式集中润滑系统的组成和作用原理,分析了该系统的优点和工作程序。

关键词：烧结机润滑系统智能式集中润滑

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浅谈审计风险形成的主客观因素及防范

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吉林省经济管理干部学院学报 2010年第1期24卷 59-62页

作者：韩道琴王淑晶长春税务学院会计学院吉林长春130117

审计风险的存在可能造成审计人员在经济上和名誉上的损失。研究审计风险的形成因素对我国注册会计师有效地实施风险系统审计,提高审计效率具有重大的现实指导意义。注册会计师应对审计风险作必要的分析,关注审计独立性及公司治理机制对... 详细信息

审计风险的存在可能造成审计人员在经济上和名誉上的损失。研究审计风险的形成因素对我国注册会计师有效地实施风险系统审计,提高审计效率具有重大的现实指导意义。注册会计师应对审计风险作必要的分析,关注审计独立性及公司治理机制对审计风险的影响,并针对问题作出相关的防范措施。

关键词：审计风险审计独立性公司治理

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板坯连铸结晶器对弧检测原理研究及开发设计

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机电工程技术 2012年第1期41卷 1-5页

作者：张留刚王兴东韩道旺高升武汉科技大学冶金装备及其控制教育部重点实验室湖北武汉430081 武汉钢铁(集团)公司湖北武汉430083

为解决目前板坯连铸机结晶器对弧检测方法测量精度低、调整工作量大的缺点,在深入研究其测量原理的基础上,提出了测量方案,开发设计了一种全自动板坯连铸机结晶器对弧检测装置,并给出了该装置的使用方法。通过现场试验,该装置满足对弧... 详细信息

为解决目前板坯连铸机结晶器对弧检测方法测量精度低、调整工作量大的缺点,在深入研究其测量原理的基础上,提出了测量方案,开发设计了一种全自动板坯连铸机结晶器对弧检测装置,并给出了该装置的使用方法。通过现场试验,该装置满足对弧工作要求。

关键词：板坯连铸机结晶器对弧双传感器

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Absolute physical parameters of three poorly studied detached eclipsing binaries

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Research in Astronomy and Astrophysics 2021年第1期21卷 220-228页

作者： dao-Ye Yang Li-Fang Li Quan-wang han Yunnan Observatories Chinese Academy of SciencesKunming 650216China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100012China Key Lab of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 10101China School of Physics and Electronics Qiannan Normal University for NationalitiesDuyun 558000China

The photometric and spectroscopic data for three double-lined detached eclipsing binaries were collected from the photometric and spectral *** light and radial velocity curves of each binary system were simultaneously analyzed using Wilson-Devinney(WD)code,and the absolute physical and orbital parameters of these binaries were *** masses of both components of ASASSN-V J063123.82+192341.9 were found to be M1=1.088±0.016 and M20.883±0.016 M⊙;those of ASAS J011416+0426.4 were determined to be M1=0.934±0.046 and M2=0.754±0.043 M⊙;and those of MW Aur were derived to be M1=2.052±0.196 and M21.939±0.193 M⊙.Finally,the evolutionary status of these detached binaries was discussed based on their absolute parameters and the theoretical stellar models.

关键词： stars:binaries:eclipsing stars:fundamental parameters stars:evolution stars:individual:ASASSN-V J063123.82+192341.9,ASAS J011416+0426.4 and MW Aur

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An adaptive fast search algorithm for block motion estimation in H.264

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第8期11卷 637-644页

作者： Cong-dao han Institute of Information and Communication Engineering Zhejiang University Hangzhou 310027 China Zhejiang Provincial Key Laboratory of Information Network Technology Hangzhou 310027 China

Motion estimation is an important issue in H.264 video coding systems because it occupies a large amount of encoding *** this paper,a novel search algorithm which utilizes an adaptive hexagon and small diamond search (AHSDS) is proposed to enhance search *** search pattern is chosen according to the motion strength of the current *** the block is in active motion,the hexagon search provides an efficient search means;when the block is inactive,the small diamond search is *** results showed that our approach can speed up the search process with little effect on distortion performance compared with other adaptive approaches.

关键词： Adaptive hexagon and small diamond search (AHSDS) Search pattern Mean absolute difference (MAD) Optimal point

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Effect of phosphate conversion film on fatigue and corrosion fatigue behavior of an as-rolled Mg–3.08Zn–0.83Al(in wt.%)alloy

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Journal of Iron and Steel Research International 2023年第12期30卷 2557-2565页

作者： Bao-jie wang dao-kui Xu Shuo wang Xiang-bo Xu En-hou han School of Environmental and Chemical Engineering Shenyang Ligong UniversityShenyang110159LiaoningChina Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016LiaoningChina Binzhou Institute of Technology Binzhou256606ShandongChina Shandong Key Laboratory of Advanced Aluminium Materials and Technology Binzhou256606ShandongChina Key Lab of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang110819LiaoningChina

Through investigating and comparing the fatigue behavior of an as-rolled Mg–3.08Zn–0.83Al(in wt.%)alloy performing surface phosphate conversion film treatment,it revealed that the determined fatigue strength of surface treated samples at 106 cycles in air was 65 MPa,whereas the fatigue strength was only 35 MPa when tested in 3.5 wt.%NaCl *** analysis demonstrated that in air,the fatigue crack initiation was mainly dominated by the interaction between the retarding effect of phosphate conversion film on cyclic slips occurring in the underneath *** the matrix cannot endure the accumulated stress concentration due to the irreversibility of cyclic slips,the fatigue crack will preferentially initiate at sample *** the phosphate conversion film cracked easily under the cyclic loading and lost its protectiveness on the substrate in 3.5 wt.%NaCl solution,fatigue cracks were preferentially nucleated at the localized corrosion pits.

关键词： Mg alloy Corrosion fatigue Surface film Pitting Crack initiation

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Nogo-A aggravates oxidative damage in oligodendrocytes

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Neural Regeneration Research 2021年第1期16卷 179-185页

作者： Yang-Yang wang Na han dao-Jun Hong Jun Zhang Department of Neurology Peking University People’s HospitalBeijingChina Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina

Nogo-A is considered one of the most important inhibitors of myelin-associated axonal regeneration in the central nervous *** is mainly expressed by *** previous studies have found regulatory roles for Nogo-A in neurite outgrowth inhibition,neuronal homeostasis,precursor migration,plasticity,and neurodegeneration,its functions in the process of oxidative injury are largely *** this study,oligodendrocytes were extracted from the cerebral cortex of newborn Sprague-Dawley *** used hydrogen peroxide(H2O2)to induce an in vitro oligodendrocyte oxidative damage model and found that endogenously expressed Nogo-A is significantly upregulated in *** recombinant virus Ad-ZsGreen-rat Nogo-A infection of oligodendrocytes,Nogo-A expression was increased,and the infected oligodendrocytes were more susceptible to acute oxidative insults and exhibited a markedly elevated rate of cell ***,knockdown of Nogo-A expression in oligodendrocytes by Ad-ZsGreen-shRNA-Nogo-A almost completely protected against oxidative stress induced by exogenous *** with a Nogo-66 antibody,a LINGO1 blocker,or Y27632,an inhibitor in the Nogo-66-NgR/p75/LINGO-1-RhoA-ROCK pathway,did not affect the death of ***-ZsGreen-shRNA-Nogo-A also increased the levels of phosphorylated extracellular signal-regulated kinase 1/2 and inhibited BCL2 expression in *** conclusion,Nogo-A aggravated reactive oxygen species damage in oligodendrocytes,and phosphorylated extracellular signal-regulated kinase 1/2 and BCL2 might be involved in this *** study was approved by the Ethics Committee of Peking University People’s Hospital,China(approval No.2018PHC081)on December 18,2018.

关键词： BCL2 H2O2 LINGO1 NgR Nogo-A oligodendrocytes phosphorylated extracellular signal-regulated kinase 1/2 reactive oxygen species

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Systemic regulation of photosynthetic function in maize plants at graining stage under a vertically heterogeneous light environment

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Journal of Integrative Agriculture 2022年第3期21卷 666-676页

作者： WU han-yu QIAO Mei-yu ZhanG wang-feng wang Ke-ru LI Shao-kun JIANG Chuang-dao Key Laboratory of Plant Resources Institute of BotanyChinese Academy of SciencesBeijing 100093P.R.China Key Laboratory of Oasis Eco-Agriculture Xinjiang Production and Construction Corps/College of AgronomyShihezi UniversityShihezi 832003P.R.China Institute of Crop Sciences Chinese Academy of Agricultural Sciences/Key Laboratory of Crop Physiology and EcologyMinistry of Agriculture and Rural AffairsBeijing 100081P.R.China

To cope with a highly heterogeneous light environment,photosynthesis in plants can be regulated ***,the majority of studies are carried out with various plants during the vegetative growth *** the reproductive sink improves photosynthesis,we wondered how photosynthesis is systemically regulated at the reproductive stage under a vertically heterogeneous light environment in the ***,changes of light intensity within canopy,chlorophyll content,gas exchange,and chlorophyll a fluorescence transient were carefully investigated at the graining stage of maize under various planting *** this study,a high planting density of maize drastically reduced the light intensities in the lower canopy,and increased the difference in vertical light distribution within the *** the increase of vertical heterogeneity,chlorophyll content,light-saturated photosynthetic rate and the quantum yield of electron transport in the ear leaf(EL) and the fourth leaf below the ear(FLBE) were decreased gradually,and the ranges of declines in these parameters were larger at FLBE than those at *** in the lower canopy were shaded artificially to further test these *** shading(PS) resulted in a vertically heterogeneous light environment and enhanced the differences in photosynthetic characteristics between EL and *** the tassel and top leaves(RTL) not only improved the vertical light distribution within the canopy,but also reduced the differences in photosynthetic characteristics between the two *** together,these results demonstrated that maize plants could enhance the vertical heterogeneity of their photosynthetic function to adapt to their light environment;slight changes of the photosynthetic function in EL at the graining stage under a vertically heterogeneous light environment indicated that the systemic regulation of photosynthesis is weak at the graining stage.

关键词： light environment photosynthesis gas exchange chlorophyll a fluorescence transient reproductive growth

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Research Progress on the Corrosion Behavior of Magnesium-Lithium-Based Alloys: A Review

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Acta Metallurgica Sinica(English Letters) 2019年第1期32卷 1-9页

作者： Bao-Jie wang Ji-Yu Luan dao-Kui Xu Jie Sun Chuan-Qiang Li En-Hou han School of Environmental and Chemical Engineering Shenyang Ligong University Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal Research Chinese Academy of Sciences Environmental Corrosion Center Institute of Metal ResearchChinese Academy of Sciences

In this review paper, the research progress on corrosion behavior of hexagonal close-packed(HCP) singular phase, body cubic-centered(BCC) singular phase and(HCP + BCC) duplex-structured Mg–Li alloys has been summarized and reviewed, and the future trend about the studies on corrosion behavior of Mg–Li-based alloys and possible solving methods for the improvement in corrosion resistance are discussed also.

关键词： Magnesium–lithium alloys Crystallographic structure Corrosion behavior Corrosion product film Corrosion mechanism

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