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Dynamic evolution of Co species and morphological reconstruction on Co-N-C during the nitrate reduction reaction in neutral solution

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Nano Research 2025年第1期18卷 164-172页

作者： yuanlin Fu Xiaoting Yang Ya yu Kang Zhou Xiaoyang Ye Aoxiang Zhang Xiaojiao Hou Bingbing Chen Fuqiang Fan yuhang Li yu Fu Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China Department of Physical Education Shen Yang Institute of Science and TechnologyShenyang 110167China Sungrow Power Supply Co. Ltd.Hefei 230088China

The electrochemical nitrate reduction reaction(eNO_(3)^(-)RR)is considered an effective approach for converting nitrate-containing wastewater to *** adsorption and activation of NO_(3)^(-)is the critical step for many materials and the high energy barrier inhibits the continuation of the reduction *** Co nanoparticles encapsulated in the carbon layer we prepared spontaneously react with NO_(3)^(-)and the resulting Co^(2+)is then reduced by electroreduction to Co^(0),which circulates *** resulted in overcoming the energy input required for NO_(3)^(-)adsorption and conversion,thereby increasing the catalytic *** the same time,the morphology of the catalyst reconstructed from a dodecahedron to an interwoven nanosheet structure and the increased surface area also gives it better *** obtained Co(OH)_(2)@Co-N-C has an excellent eNO_(3)^(-)RR of 2774.7μg·h^(-1)·cm^(-2)with a Faraday efficiency of 81.4%in neutral *** the same time,the material-modified electrode can run stably for more than 100 *** work provides a new idea for the design of Co-based catalysts for eNO_(3)^(-)RR.

关键词： electrochemical nitrate reduction reaction Co-based catalyst dynamic evolution of Co species morphological reconstruction

Piperine treating sciatica through regulating inflammation and MiR-520a/P65 pathway

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Chinese Journal of Natural Medicines 2021年第6期19卷 412-421页

作者： yu Jiu-Wang LI Sha BAO Li-dao WANG Lu Department of Pharmacy Affiliated Hospital of Inner Mongolia Medical UniversityHohhot 010059China Mongolia Medical School Inner Mongolia Medical UniversityHohhot 010110China

Although the etiology of sciatica remains uncertain,there is increasing evidence that the disease process of sciatica is associated with the levels of inflammatory ***,an alkaloid isolated from Piper nigrum,has previously been demonstrated to inhibit inflammation and analgesic *** purpose of this study is to verify the regulatory relationship between miR-520a and p65 and to explore how miR-520a/P65 affects the level of cytokines under the action of piperine,so as to play a therapeutic role in *** ELISA experiment,we confirmed that four inflammatory factors(IL-1β,TNF-α,IL-10,TGF-β1)can be used as evaluation indexes of *** differentially expressed miRNA was screened as miR-520a,by microarray technology,and the downstream target of miR-520a was P65 by ***-time fluorescence quantitative PCR confirmed that the expression of miR-520a was negatively correlated with pro-inflammatory cytokines,positively correlated with anti-inflammatory cytokines and negatively correlated with p65 expression at mRNA *** expression of p65 was positively correlated with pro-inflammatory cytokines and negatively correlated with anti-inflammatory cytokines at the protein level verified by ELISA and Western *** staining analysis showed that the nerve fibers were repaired by piprine,the vacuoles were significantly reduced,and the degree of nerve fiber damage was also *** analysis showed that the expression of p65 decreased after administration of ***-luciferase reporter gene assay confirmed that the luciferase signal decreased significantly after cotransfection of miR-520a mimics and p653'UTR recombinant *** sum up,in the rat model of non-compressed lumbar disc herniation,piperine plays a significant role in ***-520a can specifically and directly target P65,and piperine can promote the expression of miR-520a,then inhibit the expression of p65,down-regulate the pro-inflammatory

关键词： Piperine Sciatica miR-520a P65 Inflammatory factor

The F-box protein SHORT PRIMARY ROOT modulates primary root meristem activity by targeting SEUSS-LIKE protein for degradation in rice

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Journal of Integrative Plant Biology 2023年第8期65卷 1937-1949页

作者： Nini Ma Nian Li Zhongmao yu Chunli Chen dao-Xiu Zhou yu Zhao National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China Institute of Plant Science Paris-Saclay(IPS2) CNRSINRAEUniversity Paris-SaclayOrsay 91405France

Root meristem activity is essential for root morphogenesis and adaptation,but the molecular mechanism regulating root meristem activity is not fully ***,we identify an F-box family E3 ubiquitin ligase named SHORT PRIMARY ROOT(SHPR) that regulates primary root(PR)meristem activity and cell proliferation in *** loss-of-function mutations impair PR elongation in *** is involved in the formation of an SCF complex with the Oryza sativa SKP1-like protein OSK1/*** show that SHPR interacts with Oryza sativa SEUSS-LIKE(OsSLK) in the nucleus and is required for OsSLK polyubiquitination and degradation by the ubiquitin 26S-proteasome system(UPS).Transgenic plants overexpressing OsSLK display a shorter PR phenotype,which is similar to the SHPR loss-of-function *** analysis suggests that SHPR promotes PR elongation in an OsSLK-dependent ***,our study establishes SHPR as an E3 ubiquitin ligase that targets OsSLK for degradation,and uncovers a protein ubiquitination pathway as a mechanism for modulating root meristem activity in rice.

关键词： F-box protein primary root development rice SLK(SEUSS-LIKE) ubiquitination

3-D distribution of tensile stress in rock specimens for the Brazilian test

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Journal of University of Science and Technology Beijing 2005年第6期12卷 495-499页

作者： yong yu Chunyan Meng Department of Applied Mechanics and Engineering Southwest Jiaotong University Chengdu 610031 China Department of Computing Science University of Alberta Edmonton T6G 2C5 Canada

It is claimed that the formula used for calculating the tensile strength of a disk-shaped rock specimen in the Brazilian test is not accurate, because the formula is based on the 2-dimensional elastic theory and only suitable for very long or very short cylinders. The Matlab software was used to obtain the 2-dimensional distribution of stress in the rock specimen for Brazilian test. Then the 2-dimensional stress distribution in Brazilian disk was analyzed by the Marc FEM software. It can be found that the results obtained by the two software packages can verify each other. Finally, the 3-dimensional elastic stress in the specimen was calculated. The results demonstrate that the distribution of stress on the cross section of the specimen is similar to that in 2-dimension. However, the value of the stress on the cross section varies along the thickness of the specimen and the stress is bigger when getting closer to the end of the specimen. For the specimen with a height-to-diameter ratio of 1 and a Poisson＇s ratio of 0.25, the tensile strength calculated with the classical 2-D formula is 23.3% smaller than the real strength. Therefore, the classical 2-D formula is too conservative.

关键词： Brazilian test tensile strength FEM rock Marc Matlab

A stable biocompatible porous coordination cage promotes in vivo liver tumor inhibition

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Nano Research 2021年第10期14卷 3407-3415页

作者： yu Liang yu Fang yong Cui Hongcai Zhou State Key Laboratory for Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China Department of Chemistry Texas A&M UniversityCollege StationTX 77843USA

Many emerging strategies in chemo-,gene-,and immunotherapy require the accumulation of reagents in the cell ***,their delivery into the nucleus is often *** delivery could be enhanced with a rationally designed cargo-delivery scaffold,but this approach has rarely been successfully ***,a stable,biocompatible molecular capsule that encapsulates and delivers camptothecin,a DNA topoisomerase I inhibitor,into the nucleus of living cells was *** delivery is facilitated by the ultra-small diameter,zero net charge,and hydrophobicity of the *** encapsulated drug complex displays superior toxicity towards multiple cancer cells over the free drug,the Food and Drug Administration(FDA)approved drugs,as well as conventionally reported drug ***,it inhibits liver cancer tumor growth in a xenograft mouse *** of the properties of such molecular capsules may make it possible to design therapeutic strategies that target specific cell organelles.

关键词： metal-organic polyhedron biocompatible cage compound cavity drug delivery

PDA MEASUREMENTS OF TWO-PHASE FLOW STRUCTURE AND PARTICLE DISPERSION FOR A PARTICLE-LADEN JET IN CROSSFLOW

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Journal of Hydrodynamics 2010年第1期22卷 9-18页

作者： FAN Jing-yu XU Song-li WANG dao-zeng Shanghai Institute of Applied Mathematics and Mechanics Shanghai University Shanghai 200072 China

The two-phase flow structure and particle dispersion for a dilute particle-laden jet in crossflow （JICF） were experimentally investigated by means of Phase Doppler Anemometry （PDA） measurement. The two-phase flow experiments were conducted for different flow conditions and solid particle parameters, including the ratio of the jet velocity to crossflow velocity, the particle size and mass loading. The experimental results indicate that the fine particles with the size of 70 micron and the mass loading of 0.05% have a minor influence on the mean and fluctuation velocity fields of the two-phase JICF. However, the fine particle transport by the two-phase JICF is dominantly and preferentially affected by the shear layer vortices and exhibits a somewhat enhanced dispersion as compared to the fluid. For the coarse particles with the particle size ranging from 300 micron to 700 micron and the mass loading less than 0.16%, the effect of the particle parameters on the fluid phase is associated with both the anisotropic properties of the flow field and the trajectory deviation of the settling particles from the fluid. Compared to the single-phase JICF, the two-phase JICF laden with the coarse particles is recognized to possess more pronounced mean velocity alteration and turbulence modulation of the fluid phase in the presence of the particles with the larger particle size and higher mass loading.

关键词： jet crossflow two-phase flow structure particle dispersion Phase Doppler Anemometry (PDA) measurement

Effects ofmodulenumberand firing conditiononchargethermal safetyingunchamber

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Defence Technology（防务技术） 2022年第1期18卷 27-37页

作者： Huan-yu Qian yong-gang yu Jing Liu School of Energy and Power Engineering Nanjing University of Science and Technology Narjing 21094 China Acudemny of Opto-Electroric China Electronis Technology Group Corporation(AOE CETC)Tianjin300308China

Thermal safety of modular charge which is fed into and retained in the chamber after gun fires consecutively is first investigated with cook-off method,A two-dimensional cook-off model of modular charge in gun chamber is established and the cook-off process of modular charge in gun chamber is numerically *** the effects of module number and firing condition on charge thermal safety are evaluated by researching the cook-off response characteristics of *** results show that under conditions of different module numbers the cook-off responses all occur on the module closest to the boundary of missile,and the single-base propellants located at the inner surface of cartridge ignite *** the number of loaded module changes from 1 to 6,the cook-off response temperatures vary little,only in a small range of 478.1 K-482.4 *** cook-off response times decrease logarithmically in the range of 211.25-166.7 s with the increasing length of residual air gap in gun *** simulation results are well matched with the experimental ***,different firing conditions have greatinfluence on the cook-off response time,minor influence on the initial response position and little in-fluence on the response *** the three conditions of consecutive 32 launches with 5 rounds/min,43 launches with 1 round/min,and 41 launches with different firing frequencies,the cook off response temperatures are 479.2 K,481.1 K and 479.9 K respectively and the response times are 709.25,211.2 s and 214.4 s *** response position is near the middle area of the inner cartridge surface in the former condition and near the right area in the latter two conditions.

关键词： Thermal safety Modular charge Cook-off Firing condition

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu yu Leng Lei Ma yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

A two-step energy injection explanation for the rebrightenings of the multi-band afterglow of GRB 081029

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Research in Astronomy and Astrophysics 2013年第6期13卷 662-670页

作者： yong-Bo yu yong-Feng Huang Department of Astronomy Nanjing University Key Laboratory of Modern Astronomy and Astrophysics (Nanjing University) Ministry of Education

The afterglow of GRB 081029 showed unusual behavior, with a signifi- cant rebrightening being observed at the optical wavelength at about 3000 s after the burst. One possible explanation is that the rebrightening resulted from an energy in- jection. Here we present a detailed numerical study of the energy injection process and interpret the X-ray and optical afterglow light curves of GRB 081029. In our model, we have assumed two periods of energy injection, each with a constant injec- tion power. One injection starts at 2.8 × 10^3 s and lasts for about 2500 s, with a power of 7.0 × 10^47 erg s-1. This energy injection mainly accounts for the rapid rebrighten- ing at about 3000 s. The other injection starts at 8.0 × 10^3 s and lasts for about 5000 s. The injection power is 3.5 × 10^47 erg s-1. This energy injection can help to explain the slight rebrightening at about 10 000 s. It is shown that the observed optical after- glow, especially the marked rebrightening at about 3000 s, can be reproduced well. In the X-ray band, the predicted amplitude of the rebrightening is much shallower, which is also consistent with the observed X-ray afterglow light curve. It is argued that the two periods of energy injection can be produced by clumpy materials falling onto the central compact object of the burster, which leads to an enhancement of accretion and gives rise to a strong temporary outflow.

关键词： gamma-rays: bursts -- ISM: jets and outflows -- individual:GRB 081029