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Factors hindering the degradation of pharmaceuticals from human urine in an iron-activated persulfate system

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Journal of Environmental Sciences 2024年第1期135卷 130-148页

作者： Yiruiwen Xie dao Guan Yangfan Deng Yugo Sato Yu luo Guanghao Chen Department of Civil and Environmental Engineering Water Technology LabHong Kong Branch of Chinese National Engineering Research Center for Control&Treatment of Heavy Metal PollutionThe Hong Kong University of Science&TechnologyHong Kong 999077China

This study investigated the degradation of clofibric acid(CFA),bezafibrate(BZF),and sulfamethoxazole(SMX)in synthetic human urine using a novel mesoporous iron powderactivated persulfate system(mFe-PS system),and identified the factors limiting their degradation in synthetic human urine.A kinetic model was established to expose the radical production in various reaction conditions,and experiments were conducted to verify the modeling *** the phosphate-containing mFe-PS system,the 12. min removal efficiency of CFA decreased from 95.1%to 76.6%as the phosphate concentration increased from 0.32.to 6.45 mmol/L,but recovered to 90.5%when phosphate concentration increased to 16.10 mmol/***,the increased concentration of phosphate from 0.32.to 16.10mmol/L reduced the BZF degradation efficacy from 91.5%to 79.0%,whereas SMX removal improved from 37.3%to 62.9%.The m Fe-PS system containing(bi)carbonate,from 4.2. to166.70 mmol/L,reduced CFA and BZF removal efficiencies from 100%to 76.8%and 80.4%,respectively,and SMX from 83.5%to 56.7%within a 12.-min reaction *** addition,alkaline conditions(pH≥8.0)inhibited CFA and BZF degradations,while nonacidic pH(pH≥7.0)remarkably inhibited SMX *** of the kinetic model indicated the formation of phosphate(H_(2.PO_(4)^(·)/HPO_(4)^(·-))and/or carbonate radicals(CO_(3)^(·-))could limit pharmaceutical *** transformation products(TPs)of the pharmaceuticals revealed more incompletely oxidized TPs occurred in the phosphate-and(bi)carbonate-containing m Fe-PS systems,and indicated that H_(2.PO_(4)^(·)/HPO_(4)^(·-)mainly degraded pharmaceuticals via a benzene ring-opening reaction while CO_(3)^(·-)preferentially oxidized pharmaceuticals via a hydroxylation reaction.

关键词： Pharmaceutical degradation Human urine Iron-activated persulfate system Phosphate radicals Carbonate radicals Transformation products

The anti-inflammatory effects of exercise on autoimmune diseases:A 2.-year systematic review

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Journal of Sport and Health Science 2024年第3期13卷 353-367,I0001页

作者： Beibei luo dao Xiang Xiaorong Ji Xuan Chen Rui Li Shuxin Zhang Yujun Meng David C.Nieman Peijie Chen School of Exercise and Health Shanghai University of SportShanghai 200438China Shanghai Key Laboratory of Human Performance Shanghai University of SportShanghai 200438China Department of Diving and Hyperbaric Medicine Naval Medical CenterShanghai 200433China National Key Laboratory of Immunity and Inflammation Naval Medical UniversityShanghai 200433China Human Performance Laboratory Appalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA Research Institute for Doping Control Shanghai University of SportShanghai 200438China

Background:The anti-inflammatory effect of exercise may be an underlying factor in improving several autoimmune *** aim of this systematic review was to examine the evidence on the role of exercise training in mitigating inflammation in adolescents and adults with autoimmune ***:PubMed,Web of Science,and Embase databases were systematically reviewed for related studies published between January 1,2.03,and August 31,*** randomized and non-randomized controlled trials of exercise interventions with autoimmune disease study participants that evaluated inflammation-related biomarkers were *** quality of evidence was assessed using the Tool for the assEssment of Study qualiTy and reporting in EXercise scale and Cochrane bias risk ***:A total of 14,565 records were *** screening the titles,abstracts,and full texts,87 were eligible for the systematic *** studies were conducted in 2. different countries and included a total of 2.79 participants(patients with autoimmune disease,in exercise or control groups).Overall,the evidence suggests that inflammation-related markers such as C-reactive protein,interleukin 6,and tumor necrosis factor a were reduced by regular exercise *** exercise interventions combined with multiple exercise modes were associated with greater ***:Regular exercise training by patients with autoimmune disease exerts an anti-inflammatory *** systematic review provides support for the promotion and development of clinical exercise intervention programs for patients with autoimmune *** patients with autoimmune disease can safely adopt moderate exercise training protocols,but changes in inflammation biomarkers will be modest at *** exercise interventions are ineffective or even modestly but transiently pro-inflammatory.

关键词： Autoimmune diseases Cytokines Inflammation Physical activity Training

Genomics,transcriptomics,and peptidomics of the greater wax moth Galleria mellonella neuropeptides and their expression in response to lead stress

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Insect Science 2024年第3期31卷 773-791页

作者： Li-Lin luo Yang Lin Jun-Hong Linghu Wei Gong Yuan-Hong luo Man Liu {2.-Chao Jin Guy Smagghe Tong-Xian Liu Shun-Hua Gui Tian-Ci Yi Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangGuizhouChina Guizhou Institute of Biology Guizhou Academy of SciencesGuiyangChina Institute of Plant Health and Medicine Guizhou UniversityGuiyangChina

Neuropeptides are crucial in regulation of a rich variety of developmental,physiological,and behavioral functions throughout the life cycle of *** an integrated approach of multiomics,we identified neuropeptide precursors in the greater wax moth Galleria mellonella,which is a harmful pest of honeybee hives with a worldwide ***,a total of 63 and 67 neuropeptide precursors were predicted and annotated in the *** genome and transcriptome,in which 40 neuropeptide precursors were confirmed in the *** ***,we identified 12.neuropeptide precursor genes present in *** but absent in honeybees,which may be potential novel pesticide target *** hives were contaminated with heavy metals such as lead,enabling its bioaccumulation in *** bodies through the food chain,we performed transcriptome sequencing to analyze the effects of Pb stress on the mRNA expression level of *** neuropeptide *** treatment by Pb,the expression of neuropeptide F1 was found to be significantly downregulated,implying that this neuropeptide might be associated with responding to the heavy metal stress in *** study comprehensively identified neuropeptide precursors in ***,and discussed the effects of heavy metals on insect neuropeptides,with the example of *** results are valuable for future elucidation of how neuropeptides regulate physiological functions in *** and contribute to our understanding of the insect's environmental plasticity and identify potential new biomarkers to assess heavy metal toxicity in insects.

关键词： Galleria mellonella genomics heavy metal stress neuropeptide peptidomics transcriptomics

MMP-9 deficiency accelerates the progress of periodontitis

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Genes & Diseases 2024年第5期11卷 117-121页

作者： Chun-Yan Wan Yixin Yin Xiaoyan Li Meng Meng Liu Graham Goldman Li-An Wu Feng Wang dao-Shu luo Zhuo Chen Wen-An Xu Stephen Chen Mary MacDougall Merry L.Lindsey Zhi Chen Shuo Chen Department of Endodontics The Affiliated Hospital of Qingdao UniversitySchool of StomatologyQingdao UniversityQingdaoShandong 266003China Department of Developmental Dentistry School of DentistryThe University of Texas Health Science Center at San AntonioSan AntonioTX 78229USA Oral Implantology Center Jinan Stomatological HospitalJinanShandong 250001China Department of Endodontics School and Hospital of StomatologyCheeloo College of MedicineShandong Key Laboratory of Oral Tissue RegenerationShandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationShandong UniversityJinanShandong 250012China Department of Pediatric Dentistry School of StomatologyThe Fourth Military Medical UniversityXi’anShaanxi 710032China Laboratory of Clinical Applied Anatomy Department of Human AnatomySchool of Basic Medical SciencesFujian Medical UniversityFuzhouFujian 350108China Key Laboratory for Oral Biomedical Research of Zhejiang Province Affiliated Hospital of StomatologyMedical CollegeZhejiang UniversityHangzhouZhejiang 310027China Department of Stomatology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China UBC Faculty of Dentistry University of British ColumbiaVancouverBC V6T 1Z3Canada School of Graduate Studies and Research Meharry Medical College and Research BiologistResearch Service Nashville VA Medical CenterNashvilleTN 37208USA State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST) Key Laboratory for Oral Biomedicine of Ministry of Education(KLOBM)School and Hospital of StomatologyWuhan UniversityWuhanHubei 430079China

Periodontitis is a chronic inflammatory disease caused by periodontopathic bacteria that affects periodontal support tissues.1 If left untreated,it results in loss of periodontal attachment and alveolar bone *** one-half of adults in the United States older than 30 years have periodontal disease.2.Though the disease is initiated by bacterial infection,it activates host defense systems that eventually lead to the degradation of the *** periodontitis,the disease progress involves further production of pro-inflammatory mediators such as cytokines,proteolytic enzymes like matrix metalloproteinases(MMPs),and their inhibitors.

关键词： period eventually untreated

The governance technology for blockchain systems:a survey

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Frontiers of Computer Science 2024年第2期18卷 181-197页

作者： Guocheng ZHU Debiao HE Haoyang AN Min luo Cong PENG School of Cyber Science and Engineering Wuhan UniversityWuhan 430072China Shandong Provincial Key Laboratory of Computer Networks Qilu University of Technology(Shandong Academy of Sciences)Jinan 250014China

After the Ethereum dao attack in 2.16,which resulted in significant economic losses,blockchain governance has become a prominent research ***,there is a lack of comprehensive and systematic literature review on blockchain *** deeply understand the process of blockchain governance and provide guidance for the future design of the blockchain governance model,we provide an in-depth review of blockchain *** this paper,first we introduce the consensus algorithms currently used in blockchain and relate them to governance ***,we present the main content of off-chain governance and investigate two well-known off-chain governance ***,we investigate four common on-chain governance voting techniques,then summarize the seven attributes that the on-chain governance voting process should meet,and finally analyze four well-known on-chain governance blockchain projects based on the previous *** hope this survey will provide an in-depth insight into the potential development direction of blockchain governance and device future research agenda.

关键词： blockchain governance off-chain governance on-chain governance voting

All-trans retinoic acid alleviates transmissible gastroenteritis virus-induced intestinal inflammation and barrier dysfunction in weaned piglets

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1131-1144页

作者： Junning Pu Daiwen Chen Gang Tian Jun He Ping Zheng Zhiqing Huang Xiangbing Mao Jie Yu Yuheng luo Junqiu luo Hui Yan Aimin Wu Bing Yu Institute of Animal Nutrition Sichuan Agricultural UniversityChengdu 611130SichuanPeople’s Republic of China Key Laboratory of Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan Province611130 ChengduSichuanPeople’s Republic of China

Background Transmissible gastroenteritis virus(TGEV)is one of the main pathogens causing severe diarrhea of *** pathogenesis of TGEV is closely related to intestinal ***-trans retinoic acid(ATRA)is the main active metabolite of vitamin A,which has immunomodulatory and anti-inflammatory ***,it is unclear whether ATRA can alleviate TGEV-induced intestinal inflammation and barrier dysfunction in *** study aimed to investigate the effects of ATRA on growth performance,diarrhea,intestinal inflammation and intesti-nal barrier integrity of TGEV-challenged *** In a 19-d study,32.weaned piglets were randomly divided into 4 treatments:Control group(basal diet),TGEV group(basal diet+TGEV challenge),TGEV+ATRA5 group(basal diet+5 mg/d ATRA+TGEV challenge)and TGEV+ATRA15 group(basal diet+15 mg/d ATRA+TGEV challenge).On d 14,piglets were orally administered TGEV or the sterile *** Feeding piglets with 5 and 15 mg/d ATRA alleviated the growth inhibition and diarrhea induced by TGEV(Pdao)activ-ity and the decrease of occludin and claudin-1 protein levels in jejunal mucosa induced by TGEV,and maintained intestinal barrier integrity(P2.and SLC7A1)in jejunal mucosa of TGEV-challenged piglets(P<0.05).Furthermore,5 mg/d ATRA feeding attenuated TGEV-induced intestinal inflammatory response by inhibit-ing the release of interleukin(IL)-1β,IL-8 and tumor necrosis factor-α(TNF-α),and promoting the secretion of IL-10 and secretory immunoglobulin A(sIgA)(P<0.05).Feeding 5 mg/d ATRA also down-regulated the expressions of Toll-like receptors and RIG-I like receptors signaling pathway related genes(TLR3,TLR4,RIG-I,MyD88,TRIF and MAVS)and the phosphorylation level of nuclear factor-κB-p65(NF-κB p65),and

关键词： All-trans retinoic acid Inflammation Intestinal barrier Piglets Transmissible gastroenteritis virus

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基于仿真分析的小模数齿轮传动及降噪设计

环境技术 2024年第3期42卷 125-131页

作者：罗道江西南电子技术研究所成都610036

针对影响雷达传动转台噪声形成的主要影响因数,运用动力学分析结合振动噪声仿真等现代传动设计技术,对机械扫描雷达小模数齿轮传动系统结构模型进行优化设计,解决了齿轮传动系统降噪声设计主要依靠经验数据的粗略设计模式而导致降噪效... 详细信息

针对影响雷达传动转台噪声形成的主要影响因数,运用动力学分析结合振动噪声仿真等现代传动设计技术,对机械扫描雷达小模数齿轮传动系统结构模型进行优化设计,解决了齿轮传动系统降噪声设计主要依靠经验数据的粗略设计模式而导致降噪效果不一的问题,为齿轮传动系统提供了较为精准的降噪声优化设计方法,运用齿轮传动系统降噪设计模式对某雷达传动系统降噪设计达到良好的降噪设计效果。

关键词：系统结构模型动力学仿真噪声仿真

光果柱花草转基因毛状根及其原生质体制备体系的建立

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草地学报 2024年第5期32卷 1583-1591页

作者：孙昊张建禹罗丽娟刘攀道海南大学热带农林学院海南海口570228 海南大学三亚南繁研究院海南三亚572025 中国热带农业科学院热带作物品种资源研究所农业农村部华南作物基因资源与种质创制重点实验室&海南省热带作物资源遗传改良与创新重点实验室海南海口571101

光果柱花草(Stylosanthes leiocarpa)是柱花草属(Stylosanthes Sw.)中可用于林果园间作的一个野生种。截至目前,光果柱花草的转基因体系尚未建立。本研究以光果柱花草的子叶节为外植体,比较不同的发根农杆菌菌株与潮霉素B浓度对毛状根... 详细信息

光果柱花草(Stylosanthes leiocarpa)是柱花草属(Stylosanthes Sw.)中可用于林果园间作的一个野生种。截至目前,光果柱花草的转基因体系尚未建立。本研究以光果柱花草的子叶节为外植体,比较不同的发根农杆菌菌株与潮霉素B浓度对毛状根诱导率及转基因阳性率的影响。结果发现,以K599为诱导菌株且培养基添加8 mg·L^(-1)潮霉素B为筛选压,是最优的毛状根诱导条件,诱导率达2..33%,阳性率为100%。在此基础上,利用转基因毛状根制备原生质体,结果表明,添加2.5%纤维素酶和2.离析酶,以及8 h的酶解时间为最优条件,原生质体的产量达2.745×10^(5)个·g^(-1),活力为91.02.,制备的原生质体100%为转基因细胞。本研究成功建立了一种发根农杆菌介导的光果柱花草转基因毛状根诱导体系及原生质体制备体系,为后续光果柱花草的基因功能研究奠定了基础。

关键词：光果柱花草发根农杆菌转基因毛状根原生质体制备

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大型7085铝合金筒形件淬火残余应力及其消减工艺研究

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塑性工程学报 2024年第6期31卷 76-86页

作者：王清松吴道祥何珞玉王雨徐戊矫西南铝业(集团)有限责任公司重庆401326 重庆大学材料科学与工程学院重庆400044

以大型7085铝合金筒形件为研究对象,研究了在最大程度保证铝合金大锻件性能的同时尽可能减小其淬火残余应力的方法。基于Abaqus平台,分别建立了大型筒形件淬火有限元模型和淬火后冷胀形有限元模型,考虑了淬火工艺和冷胀形工艺间的数据... 详细信息

以大型7085铝合金筒形件为研究对象,研究了在最大程度保证铝合金大锻件性能的同时尽可能减小其淬火残余应力的方法。基于Abaqus平台,分别建立了大型筒形件淬火有限元模型和淬火后冷胀形有限元模型,考虑了淬火工艺和冷胀形工艺间的数据继承关系,分析了工艺参数对锻件性能及残余应力的影响规律。针对大型7085铝合金筒形件的淬火过程,将7085铝合金的等温转变曲线和时间-温度-性能曲线写入Abaqus用户子程序USDFLD中,计算了大型筒形件在不同淬火工艺条件下的析出相含量和分布、对应的硬度变化以及残余应力分布,获得了35℃的淬火水温是最优的选择。在消减淬火残余应力的冷胀形工艺中,基于不同的淬火水温条件开展了胀形量、胀形道次和每道次之间环转动角度的正交模拟实验,结果显示胀形量对残余应力消减的影响最显著,胀形量为4.5%时大型7085铝合金筒形件的应变均匀性最好且残余应力消减最充分。将仿真获得的优化淬火工艺和胀形方案应用于生产试制,所获得的大型筒形件各项力学性能达到设计要求,其残余应力实测结果与仿真结果对比具有较好的一致性。

关键词：大型7085铝合金筒形件淬火冷胀形残余应力