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Chinese Journal of Structural Chemistry 2015年第5期34卷 741-748页

作者： GAO Rui zHAO Yong JIang dao-Yong DING Guo-hua College of Chemical and Bioengineering Guilin University of Technology

The ligand ethylenediamine-3,5-dichloro salicylaldehyde（HS） and its crystal Co（Ⅱ） complex（MS） were *** compounds have been characterized on the basis of elemental analysis,IR and 1H NMR spectral studies.X-ray single-crystal diffraction of crystal MS1 showed a classical Salen-N2O2 tetrahedral coordination model,space group P1 with a = 25.73（2）,b = 9.899（9）,c = 6.753（6） A,β = 103.467（10）o,V = 1673（3） A^3,z = 4,C16H10Cl4 Co N2O2,Mr = 462.99,Dc = 1.838 g/cm^3,F（000） = 924,μ（Mo Kα） = 1.678 mm^-1（λ = 0.71073 A）,R = 0.0275 and w R = 0.0567 for 1247 observed reflections with I 〉 2σ（I）.Furthermore,luminescent properties were evaluated by UV-Visible absorption and FL ***,the thermal stability of compound HS was ***-DTG showed that the decomposition temperature（Td） of the molecules is up to 256 ℃ and the compound has fine performance in thermal *** results also indicated that the target compound HS exhibited certain chemiluminescence properties under the conditions of different time of 365 nm UV light and different *** general,this kind of multi-functional compounds has potential applications in the fields of information storage and nonlinear optical materials.

关键词： photochromic thermochromic crystal structure

Plasmonic semiconductor nanogroove array enhanced broad spectral band millimetre and terahertz wave detection

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Light(Science & Applications) 2021年第4期10卷 600-609页

作者： Jinchao Tong Fei Suo Tianning z.ang zhiming huang Junhao Chu dao hua z.ang School of Electrical and Electronic Engineering Nanyang Technological UniversityNanyang Avenue639798 SingaporeSingapore State Key Laboratory of Infrared Physics Shanghai Institute of Technical

High-performance uncooled millimnetre and terahertz wave detectors are required as a building block for a wide range of *** state-of-the art technologies,however,are plagued by low sensitivity,narrow spectral bandwidth,and complicated ***,we report semiconductor surface plasmon enhanced high-performance broadband millimetre and terahertz wave detectors which are based on nanogroove InSb array epitaxially grown on GaAs substrate for room temperature *** making a nanogroove array in the grown InSb layer,strong millimetre and terahertz wave surface plasmon polaritons can be generated at the InSb-air interfaces,which results in significant improvement in detecting performance.A noise equivalent power(NEP)of 2.2× 10^(-14)WHz^(-1/2) or a detectivity(D)of 2.7× 10^(12)cmHz^(1/2) W^(-1) at 1.75 mm(0.171 THz)is achieved at room *** lowering the temperature to the thermoelectric cooling available 200 K,the corresponding NEP and D'of the nanogroove device can be improved to 3.8× 10^(-15)WHz^(-1/2) and 1.6× 10^(13) cm Hz^(-1/2) w^(-1),*** addition,such a single device can perform broad spectral band detection from 0.9 mm(0.330 THz)to 9.4 mm(0.032 THz).Fast responses of 3.5μs and 780 ns are achieved at room temperature and 200 K,*** high-performance millimnetre and terahertz wave photodetectors are useful for wide applications such as high capacity communications,walk-through security,biological diagnosis,spectroscopy,and remote *** addition,the integration of plasmonic semiconductor nanostructures paves a way for realizing high performance and multifunctional long-wavelength optoelectrical devices.

关键词： wave spectral terahertz

STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He z.B.He z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.hua G.S.huang J.S.huang M.huang Q.Y.huang W.Q.huang X.T.huang X.J.huang Y.B.huang Y.S.huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia z.K.Jia H.B.Jiang J.Jiang S.z.Jiang J.B.Jiao z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li z.J.Li H.Liang J.H.Liang Y.T.Liang G.R.Liao L.z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu z.Q.Liu z.Y.Liu z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

Self-powered solar-blind photodiodes based on EFG-grown(100)-dominant β-Ga_(2)O_(3) substrate

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Chinese Physics B 2021年第1期30卷 483-486页

作者： Xu-Long Chu zeng Liu Yu-Song zhi Yuan-Yuan Liu Shao-Hui z.ang Chao Wu ang Gao Pei-Gang Li dao-You Guo zhen-Ping Wu Wei-hua Tang Laboratory of Information Functional Materials and Devices School of Science&State Key Laboratory of Information Photonics and Optical CommunicationsBeijing University of Posts and TelecommunicationsBeijing 100876China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China The Engineering Research Center for Semiconductor Integrated Technology Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China China Aerospace System Simulation Technology Co. Ltd.(Beijing)Beijing 100195China Division of Interdisciplinary and Comprehensive Research&Platform for Characterization and Test Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Center for Optoelectronics Materials and Devices&Key Laboratory of Optical Field Manipulation of zhejiang Province Department of PhysicsZhejiang Sci-Tech UniversityHangzhou 310018China School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026China College of Electronic and Optical Engineering&College of Microelectronics Nanjing University of Posts and TelecommunicationsNanjing 210046China National and Local Joint Engineering Laboratory for RF Integration and Micro-Packing Technologies Nanjing University of Posts and TelecommunicationsNanjing 210046China

We report the edge-defined-film-fed(EFG)-grown β-Ga_(2)O_(3)-based Schottky *** device has a reverse leakage current of ~nA and a rectified ratio of ~10^(4) at ±5 *** addition,the photodiode detector shows a dark current of 0.3 pA,a photo-responsivity(R) of 2.875 mA/W,a special detectivity(D*) of 10^(10) Jones,and an external quantum efficiency(EQE) of 1.4% at zero bias,illustrating a self-powered *** work may advance the development of the Ga_(2)O_(3)-based Schottky diode solar-blind photodetectors.

关键词： β-Ga_(2)O_(3)substrate Schottky photodiode solar-blind detection

Storm of soluble immune checkpoints associated with disease severity of COVID-19

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Signal Transduction and Targeted Therapy 2020年第1期5卷 881-883页

作者： Yaxian Kong Yu Wang Xueying Wu Junyan Han Guoli Li Mingxi hua Kai Han Henghui z.ang ang Li Hui zeng Institute of Infectious Diseases Beijing Key Laboratory of Emerging Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Respiratory Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Immupeutics Medicine Institute Beijing 100191China Department of Intensive Care Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Dear Editor,As the outbreak of coronavirus disease 2019(COVID-19)turns into a pandemic,it has literally caused a worldwide public health *** lymphopenia,especially in T cells,was a prominent clinical feature of severe COVID-19 in addition to dyspnea,hypoxemia,acute respiratory distress,and cytokine release syndrome.1 Recently,several studies revealed a correlation between T cell depletion and increased expression levels of several inhibitory checkpoint molecules on T cells in severe COVID-19 cases.2 Classically,inhibitory checkpoint molecules have been documented as key factors for regulating T cell exhaustion in a variety of chronic viral infections and *** studies further implied a pivotal role of inhibitory checkpoint molecules in the pathophysiology of acute viral infections,such as Ebola virus or hantavirus *** note,soluble isoforms of checkpoints can be produced by cleavage of membrane-bound proteins or by alternative splicing of mRNA and competitively regulate the functions of their membrane-bound counterparts.3 Thus it is of great interest to determine whether soluble checkpoint molecules are involved in immune regulation and severity of COVID-19.

关键词： severity acute distress

药用植物生物信息数据库及生产布局可视化分析平台(以川产道地药材为例)

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中国中药杂志 2024年第8期49卷 1989-1995页

作者：华桦田韦韦马炅妤王云峰王亚强严志祥赵军宁四川省中医药转化医学中心四川省中医药科学院国家中医药管理局中药质量生物学评价重点研究室中医药转化医学四川省重点实验室四川省道地药材系统开发工程技术研究中心四川省道地药材形成原理与品质评价工程研究中心四川成都610041 自然资源部第三地理信息制图院数字城市工程中心四川成都610100 中国科学院微电子研究所数字健康芯片与系统实验室北京100029 成都信息工程大学软件工程学院四川成都610225 国家药品监督管理局药品监管科学全国重点实验室北京100037

目前对药用植物的研究和认识已进入到跨组学、跨学科智能新阶段,迫切需要将这些大数据进行整合并交互应用,形成统一、多层次的研究体系和大数据平台。道地药材作为一类重要的药用植物来源,是中医药特有的品质优劣概念和综合判别标准。... 详细信息

目前对药用植物的研究和认识已进入到跨组学、跨学科智能新阶段,迫切需要将这些大数据进行整合并交互应用,形成统一、多层次的研究体系和大数据平台。道地药材作为一类重要的药用植物来源,是中医药特有的品质优劣概念和综合判别标准。国内外已建立中医药百科全书数据库(ETCM)、全球药典基因组数据库(GPGD)等为代表的数据库平台,但未能及时反映新近的大量地理资源、表型、化学成分和遗传信息等多维度数据。四川省是著名的“中医之乡,中药之库”,据四川省第四次全国中药资源普最新统计中药品种数超过8000种,川产道地药材品种86种,是我国药用植物多样性最具代表性的地区。该文基于四川省第四次全国中药资源普查最新数据及相关成果,以川产道地药材为例构建药用植物生物信息数据库及生产布局可视化分析平台,涵盖了地理资源数据、表型数据、化学成分数据和遗传资源数据等,有效地将川产道地药材多维度数据统一整合,并提供不同层面的数据交互应用。该平台不仅是首个针对川产道地药材的大型多维数据库和可视化平台,可为川产道地药材种质资源鉴定、药效成分生物合成途径解析、优良品种分子育种等奠定基础。该平台提供的以川产道地药材为代表的药用植物资源基础信息和数据支撑,对我国及全球药用植物开发利用也不无裨益。

关键词：药用植物川产道地药材生产布局生物信息数据化可视化

Haploidentical hematopoietic stem cell transplantation for pediatric patients with chronic active Epstein-Barr virus infection:a retrospective analysis of a single center

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World Journal of Pediatrics 2021年第6期17卷 626-636页

作者： Yan-Hui Luo Jun Yang ang Wei© Guang-hua zhu Bin Wang Rui z.ang Chen-Guang Jia Yan Yan Kai Wang Sidan Li Xuan zhou Mao-Quan Qin Tian-You Wang Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics(Capital Medical University)Key Laboratory of Major Diseases in ChildrenMinistry of EducationHematology Oncology CenterDepartment of Hematology and OncologyBeijing Children's HospitalCapital Medical UniversityNational Center for Children’s HealthNanlishi Road No.56Beijing 100045China

Background This study aimed to evaluate the feasibility and clinical effect of haploidentical hematopoietic stem cell transplantation(haplo-HSCT)for the treatment of pediatric patients with chronic active Epstein-Barr virus infection(CAEBV).Methods Children with CAEBV who did not have matched donors and underwent haplo-HSCT in Beijing Children's Hospital,Capital Medical University,from October 2016 to June 2020 were analyzed *** relating to the clinical manifestations,engraftment,and prognosis of the children were extracted from medical *** Twenty-five patients,including 16 males and 9 females,with an onset age of 5.0±2.6 years and a transplantation age of 6.9±2.9 years,were enrolled irnhis *** mean time from diagnosis to transplantation was 3.8(2.0-40.2)*** mean observation time was 19.0±12.0 *** patients received the reduced intensity conditioning regimen,and the remaining patients all received the modified myeloablative conditioning *** the end of the follow-up,23 patients were characterized by disease-free survival(DFS),22 were characterized by event-free survival(EFS).and two *** of the patients died of thrombotic microangiopathy(TMA),and another died of graft versus host disease(GVHD);this patient discontinued the treatment for economic *** 3-year overall survival(OS)rate was estimated to be 92.0%±5.4%,and the 3-year EFS rate was estimated to be 87.4%±6.8%.All active patients survived after HSCT *** GVHD degrees 1-3 were observed in ten patients(40.0%),and degree IV was observed in six(24.0%),who were all cured except for one *** GVHD was observed in nine(36.0%),and most of these cases were *** incidence of TMA and veno-occlusive disease(VOD)was 28.0%and 4.0%.Conclusions Haploidentical hematopoietic stem cell transplantation is safe and effective in the treatment of pediatric CAEBV and can be used as an alternative therapy without matched donors or emergency tr

关键词： Chronic active Epstein-Barr virus infection Haploidentical hematopoietic stem cell transplantation Prognosis Graft versus host diseases Thrombotic microangiopathy

Asymmetric　Tetrahedral　Cadmium　Complex：Bis［triphenylphosphine］cadmium（Ⅱ）Diiodide

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Chinese Journal of Structural Chemistry 1996年第4期15卷 270-272页

作者： Gou Shao-hua Lu Jian-Ping zeng Qin-dao You Xiao-zeng(Coordination Chemistry Institute and State Key Laborataory of Coordination Chemistry,Nanjing University, Hanjing 210093)Yu Kai-Bei(Chengdu Center of Analysis and Determination, Academia Sinica,Cheng Coordination Chemistry Institute State Key Lab. of Coord. Chemistry Nanjing University Nanjing 210093 Chengdu Ctr. Anal. and Determination Academia Sinica Chengdu 610051

The structure of the title complex, [Cd (PPh_3)_2I_2], was determined by X-ray diffraction with crystallographic data as follows: C_36H_30CdI_2P_2, Mr=890. 75, monoclinic, space group P2_1/a, a=18. 367(3), b=10. 300(3), c=19.339 (3) A, β=111. 68(1)°; V=3400(1) A￣3, z=4, D_x= 1. 74 g/cm￣3, P=25. 5 cm￣(-1),F(000)=1720, R=0. 0470, R_w=0. 049. The coordination polyhedron of each Cd atom is a distorted tetrahedron consisting of two P atoms from two triphenylphosphine groups and two iodine anions. The molecule has no C_2 symmetry with two unequal Cd -P bonds due to the presence of the bulky size of triphosphine.

关键词： crystal structure Cd(Ⅱ) complex triphenylphosphine

The Lower Order and Type of Solutions of Second Order Differential Equation

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Chinese Quarterly Journal of Mathematics 2014年第1期29卷 14-21页

作者： z.ang Shao-hua WU zhao-jun SUN dao-chun School of Mathematics and Statistics Hubei University of Science and Technology Xianning 437100China School of Mathematics South China Normal University Guangzhou 510631 China

The main purpose of this paper is to study the lower order and type of second order differential equation w"(z)-A(z)w=0,where A(z)is a *** the case of A(z)=a_dz^d,the authors prove that the lower order and the type of all non-trivial solutions w of w"(z)-A(z)w=0 are equal to(d+2)/2 and(2(|a_d|)^(1/2))/(d+2)*** the case of A(z)=a_dz^d+a_(d-1)z^(d-1)+…a_1z+a_0,a_d>0,a_(d-1)>0,…,a_1≥0,a_0≥0,the authors prove that the lower order of all non-trivial solutions w of w"(z)-A(z)w=0 is(d+2)/2.

关键词： type order lower order differential equation

hTERT-targeted *** purine nucleoside phosphorylase gene/ 6-methylpurine deoxyribose therapy for pancreatic cancer

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Chinese Medical Journal 2007年第15期120卷 1348-1352页

作者： zHOU Jia-hua Tang Bo LIU Xun-liang HE dao-wei Yang De-tong Department of Biliary-Pancreatic Surgery First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China National Key Opening Laboratory of Biology and Medicine and Pharmacology Technology Nanjing University Nanjing 210008 China Clinical Medicine School of Southeast University Nanjing 210009 China Department of Biliary-Pancreatic Surgery Zhongda Hospital of Southeast University Nanjing 210009 China

Background Pancreatic cancer is one of the most common tumors and has a 5-year survival for all stages of less than 5%. Most patients with pancreatic cancer are diagnosed at an advanced stage and therefore are not candidates for surgical resection. In recent years, investigation into alternative treatment strategies for this aggressive disease has led to advances in the field of gene therapy for pancreatic cancer. E. coil purine nucleoside phosphorylase/6-methylpurine deoxyribose （ePNP/MePdR） is a suicide gene/prodrug system where PNP enzyme cleaves nontoxic MePdR into cytotoxic membrane-permeable compounds 6-methylpurine （MeP） with high bystander activity, hTERT is expressed in cell lines and tissues for telomerase activity. In this study we examined the efficacy of ePNP under the control of hTERT promoter sequences and assessed the selective killing effects of the ePNP/prodrug MePdR system on pancreatic tumors. Methods Recombinant pET-PNP was established. The protein of E. coil PNPase was expressed and an antibody to E. coil PNPase was prepared. Transcriptional activities of hTERT promoter sequences were analyzed using a luciferase reporter gene. A recombinant phTERT-ePNP vector was constructed. The ePNP/MePdR system affects SW1990 human pancreatic cancer cell lines in vitro. Results The hTERT promoter had high transcriptional activity and conferred specificity on cancer cell lines. The antibody to E. coil PNPase was demonstrated to be specific for the ePNP protein. The MePdR treatment induced a high in vitro cytotoxicity on the sole hTERT-ePNP-producing cell lines and affected SW1990 cells in a dose-dependent manner. Conclusions The hTERT promoter control of the ePNP/MePdR system can provide a beneficial anti-tumor treatment in pancreatic cancer cell lines including a good bystander killing effect.

关键词： hTERT promoter Escherichia coli purinenucleoside phosphorylase pancreatic cancer gene therapy