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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第8期20卷 687-692页

作者： Radoslaw Wieczór Anna Maria Wieczór Arleta Kulwas Grzegorz Pulkowski Jacek Budzyński danuta rosc Department of Pathophysiology Faculty of Pharmacy Nicolaus Copernicus University in Toruń Ludwik Rydygier Collegium Medicum in Bydgoszcz Bydgoszcz PL 85-094 Poland Clinic of Vascular and Internal Medicine Dr Jan Biziel University Hospital No. 2 in Bydgoszcz Bydgoszcz PL 85-168 Poland Department of Vascular and Internal Medicine Faculty of Health Sciences Nicolaus Copernicus University in Toruń Ludwik Rydygier Collegium Medicum in Bydgoszcz Bydgoszcz PL 85-168 Poland

The objective of this study was to assess the angiogenic potential expressed as a quotient of vascular endothelial growth factor A (VEGF-A), as an indicator of proangiogenic activity, and the circulating receptors (soluble VEGF receptor protein R1 (sVEGFR-1) and sVEGFR-2), as indicators of the effect of angiogenic inhibition, depending on the concentrations of matrix metalloproteinase 2 (MMP-2) and MMP-9 and their tissue inhibitor 1 (TIMP-1) and TIMP-2 in the plasma of patients with lower extremity artery disease (LEAD). These blood parameters in patients with intermittent claudication (IC) and critical limb ischemia (CLI) were compared for select clinical and biochemical features. Stimulation of angiogenesis in the plasma of individuals with LEAD was evident as indicated by the significant increase in VEGF-A concentration along with reduced inhibition depending on circulating receptors sVEGFR-1 and sVEGFR-2. Critical ischemia was associated with higher VEGF-A, MMP-9, TIMP-1, and TIMP-2 concentrations than in the case of IC.

关键词：严重肢体缺血间歇性跛行血管内皮生长因子金属蛋白酶

Overweight and obesity versus concentrations of VEGF-A, sVEGFR-1, and sVEGFR-2 in plasma of patients with lower limb chronic ischemia

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2016年第11期17卷 842-849页

作者： Radoslaw WIECZóR Anna Maria WIECZóR Grazyna GADOMSKA Katarzyna STANKOWSKA Jacek FABISIAK Karol SUPPAN Grzegorz PULKOWSKI Jacek BUDZYNSKI danuta rosc Department of Pathophysiology Faculty of PharmacyNicolaus Copernicus University in ToruhLudwik Rydygier Collegium Medicum in BydgoszczBydgoszcz PL 85-094Poland Clinic of Vascular and Internal Medicine Dr.Jan Biziel University Hospital No.2 in BydgoszezBydgoszcz PL 85-168Poland Department of Vascular and Internal Medicine Faculty of Health SciencesNicolaus Copernicus University in ToruhLudwik Rydygier Collegium Medicum in BydgoszezBydgoszcz PL 85-168Poland

Objective： Being overweight or obese comprises a significant risk factor for atherosclerosis. Fat tissue also generates factors stimulating angiogenesis, the process by which new blood vessels form. The purpose of this paper is to assess concentrations of the vascular endothelial growth factor A （VEGF-A） and its soluble type-1 and type-2 re- ceptors （sVEGFR-1 and sVEGFR-2） in plasma of patients with peripheral arterial disease （PAD） depending on the level of nutrition according to body mass index （BMI）. Methods： The study group included patients suffering from symptomatic PAD （n=46） in Fontaine classes Ila-lV without any history of neoplastic disease and who have a normal BMI （n=15）, are overweight （n=21） or are obese （n=10）. The control group （n=30） consisted of healthy non-smoking volunteers who were neither overweight nor obese. Venous blood plasma samples were collected from both groups at rest in the morning to determine plasma concentrations of VEGF-A, sVEGFR-1, and sVEGFR-2 using the enzyme- linked immunosorbent assay （ELISA） method. Results： The group of patients with PAD co-existent with being over- weight or obese tended to have higher mean concentration levels of VEGF-A and sVEGFR-2 when compared with patients suffering from PAD with normal BMIo A statistically significant positive correlation was obtained between BMI and average plasma concentrations of sVEGFR-2 （R=0.37, P=-0.0103）. However, no significant correlation was no- ticed between BMI and VEGF-A or sVEGFR-1 concentrations. Conclusions： A positive correlation determined be- tween the level of antiangiogenic factor and BMI value may be indicative of the linearly growing prevalence of some antiangiogenic factors in patients with metabolic disorders, which may be one of numerous factors contributing to incomplete efficiency of collateral circulation development in patients with PAD.

关键词： Overweight Obesity Angiogenesis Vascular endothelial growth factor Soluble type-1 and type-2receptors Peripheral arterial disease

A preliminary evaluation of VEGF-A, VEGFR1 and VEGFR2 in patients with well-controlled type 2 diabetes mellitus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第6期15卷 575-581页

作者： Barbara RUSZKOWSKA-CIASTEK Alina SOKUP Maciej W. SOCHA Zofia RUPRECHT Lidia HALAS Barbara GóRALCZYK Krzysztof GóRALCZYK Grazyna GADOMSKA danuta rosc Department of Pathophysiology Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Toruń Department of Obstetrics Gynecology and Oncological Gynecology Collegium Medicum in BydgoszczNicolaus Copernicus University in Toruń Department of Endocrinology and Diabetology Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Toruń

Objective： Decompensated chronic hyperglycemia often leads to late microvascular complications such as retinopathy, diabetic foot syndrome, and diabetic kidney disease. The aim of this study was to determine the concentration of vascular endothelial growth factor A （VEGF-A） and its receptors in patients with well-controlled diabetes. Methods： The study was conducted on 31 patients with well-controlled type 2 diabetes without microor macroangiopathy. Thirty healthy volunteers were enrolled in a control group. Serum concentrations of VEGF-A, VEGF receptors 1 and 2 （VEGFR1 and VEGFR2）, fasting glucose, and lipid profiles were measured, and the plasma concentration of glycated hemoglobin （HbAlc） was determined. Results： No significant differences were observed between the concentration of VEGF-A, VEGFR1 or VEGFR2 in the subject group and that in the control group. Positive correlations were noted between the levels of VEGF-A, VEGFR2, and triglyceride, and there was a negative correlation between the levels of VEGFR2 and high-density lipoprotein （HDL）-cholesterel in the study group. Conclusions： The concentrations of VEGF-A and its receptors 1 and 2 in patients with well-controlled diabetes are comparable to those of healthy individuals, which may indicate that appropriate control of glucose levels delays the occurrence of vascular complications. A negative correlation between VEGFR2 and HDL-cholesterol levels, and positive correlations between VEGF-A, VEGFR2, and triglyceride levels, suggest that lipid abnormalities occurring in diabetes may be involved in the modulation of angiogenesis.

关键词： Type 2 Diabetes Angiogenesis Lipid abnormalities Glycated hemoglobin (HbA1c)

Low-grade risk of hypercoagulable state in patients suffering from diabetes mellitus type 2

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第9期16卷 788-795页

作者： Barbara RUSZKOWSKA-CIASTEK Alina SOKUP Tomasz WERNIK Piotr RHONE Krzysztof GORALCZYK Kornel BIELAWSKI Agata FIJALKOWSKA Aleksandra NOWAKOWSKA Elzbieta RHONE danuta rosc Department of Pathophysiology Faculty of PharmacyNicolaus Copernicus University in TorunCollegium Medicum in Bydgoszcz

Objective： Diabetes, including type 1 and type 2, is associated with the hypercoagulable state. The aim of this study is to evaluate the concentration of selected hemostatic parameters and vascular endothelial growth factor-A （VEGF-A） in diabetic subjects. Methods： The study was conducted in 62 patients with diabetes. Group I consisted of 27 patients having uncontrolled diabetes with microalbuminuria and Group II included 35 well-controlled diabetic patients. The control group was made up of 25 healthy volunteers. In the citrate plasma, the concentrations of tissue factor （TF）, tissue factor pathway inhibitor （TFPI）, thrombin-antithrombin （TAT） complexes, and D-dimer were assayed. Serum concentrations of VEGF-A, lipid profile, creatinine, and plasma fasting glucose were measured and in the versene plasma the concentration of HbAlc was determined. Results： In the patients with uncontrolled diabetes, higher con- centrations of TF, TFPI, and VEGF-A were observed, as compared with the well-controlled diabetics group and the control group. A significantly lower activity of antiplasmin was reported in patients from Group I as compared with the control group. In Group I, using the multivariate regression analysis, the glomerular filtration rate was independently associated with VEGF-A and dependently associated with total cholesterol. Conclusions： The study showed higher concentrations of TF and TFPI in the patients with uncontrolled diabetes with microalbuminuria, which is associated with rapid neutralization of the thrombin formation, since TFPI inhibits the complex of TF/VIIa/Ca2＋. The manifestation of the above suggestions is the correct TAT complexes and D-dimer, which indicates a low grade of prothrombotic risk in this group of patients, but a higher risk of vascular complications.

关键词： Diabetes Extrinsic coagulation pathway Angiogenesis Glomerular filtration rate

Movement in the Fight against Diseases of the Future

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Journal of Environmental Science and Engineering(B) 2024年第3期13卷 114-123页

作者： Janina danuta Rzeszot Higher School of Social and Natural Sciences named after Wincentego Pola Choiny 220-816 LublinPoland

“Motion”(philosophy)(Latin:motus,motio)—in modern philosophy,is a change in the place of space in relation to a fixed point or consideration as *** the classical metaphysics of Aristotle’s time,motion is an actualization of what is possible,motion is a change:quantitative or local action is *** on the literature of various sources,it seems that exercise is indicated for people with these *** activity,according to ***,focused on the functioning of dopanin signaling.D2 receptor deficiency is enough to explain inactivity in obese people—people with obesity are less socially *** may contribute to this condition more and more often in the third or even fourth decade of *** 50%of fifty-year-olds and 60%-70%of seventy-year-olds struggle with *** problems are the most common cause of disability among people under the age of *** is a serious disease,if left untreated and poorly regulated,it can lead to very serious complications and even *** physical activity and education in this direction is very necessary.

关键词： Physical activity obesity joint degeneration diabetes

Foraminiferal micro-buildups(“reefs”)in the Wuchiapingian basin facies of the basal Zechstein carbonates in western Poland

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Journal of Palaeogeography 2021年第4期10卷 463-481页

作者： Tadeusz Marek Peryt danuta Peryt Polish Geological Institute-National Research Institute Rakowiecka 400-975WarszawaPoland Institute of Paleobiology Polish Academy of SciencesTwarda 51/5500-818WarszawaPoland

Encrusting foraminifers locally can play an essential reef-forming role such as in the Carnian fossiliferous Hallstatt Limestones of Austria where a dense succession of hardgrounds occurs with numerous small buildups(up to 2 cm high)composed of sessile *** foraminiferal micro-buildups occur in a 10-cm-thick bed in the basinal facies in the basal Zechstein(Upper Permian)strata in the Radlin 60 borehole,in western *** micro-buildups of presumably columnar habit account for up to a half of the *** growth of columns was interrupted by hiatal surfaces,although usually the growth of columns was restored *** the upper part of the bed with foraminiferal micro-buildups,the foraminiferal encrustations become visibly less abundant,and in most cases,they have a shape of less regular *** bed with foraminiferal micro-buildups abounds in closely spaced discontinuity(hiatal)surfaces,occasionally encrusted by *** foraminifers in the bed with foraminiferal micro-buildups are accompanied by various encrusting organisms,possibly microbes;they are grouped under the name *** the intercolumnar spaces,common Midiella *** deposition,the conditions were mostly suboxic,and various types of ferruginous morphs,common in the lower part of the bed,suggest that dysoxic-anoxic interfaces produced various microaerophilic environments for *** environmental conditions during the deposition of the upper part of the bed were very similar to those characterizing the starved basin environment in which the bioclastic-peloidal and oncoidal sediments in the Zechstein Limestone have been *** turn,the lower part of the bed registers the transition from normal(=not starved)marine conditions,with a clear chemocline,to the starved basin *** deposition of the bed was coeval with the Kupferschiefer deposition based on the correlation ofδ13C curves,which implies that the previous str

关键词： Condensed Zechstein Limestone Micro-buildups Encrusting foraminifers Stable isotopes Depositional environment Zechstein stratigraphy Hiatal surfaces

Role of quantum dots nanoparticles in the chemical treatment of colored wastewater: Catalysts or additional pollutants

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Journal of Environmental Sciences 2011年第9期23卷 1479-1485页

作者： Hrvoje Kusic danuta Leszczynska Natalija Koprivanac Igor Peterne Civil and Environmental Engineering Department Jackson State University Faculty of Chemical Engineering and Technology University of Zagreb

The objective of the study was to investigate the presence and the activity of quantum dots nanoparticles in colored *** special interest is devoted to the investigation of their role in the typical treatment of water or wastewater,studying their influence on the effectiveness of applied treatments *** standard chemical processes for water treatment and disinfection （direct UV photolysis and direct ozonation） were applied for the degradation of colored organic pollutant,reactive azo dye,in the presence/absence of CdSe/ZnS core-shells quantum *** obtained results indicated that investigated nanoparticles inhibit the overall efficiency of applied processes,especially in the case of direct UV photolysis,although catalytic effect might be expected in part due to the semiconductor nature of quantum *** results lead to a conclusion that CdSe/ZnS nanoparticles behave as additional pollutants in the *** should be removed from the system prior the treatment,because their presence could decrease the efficiency,i.e.,prolong the time of treatment and correspondingly increase the costs of the treatment process.

关键词： wastewater treatment CdSe/ZnS core-shells reactive azo dye UV irradiation ozone

Marine transgression(s) to evaporite basin:The case of middle Miocene (Badenian) gypsum in the Central Paratethys, SE Poland

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Journal of Palaeogeography 2020年第3期9卷 335-352页

作者： danuta Peryt Przemyslaw Gedl Tadeusz Marek Peryt Institute of Paleobiology Polish Academy of SciencesTwarda 51/5500-818 WarszawaPoland institute of Geological Sciences Polish Academy of SciencesResearch Centre in CracowSenacka 131-002 KrakowPoland Polish Geological Institute-National Research Institute Rakowiecka 400-975 WarszawaPoland

The middle Miocene Badenian evaporite basin of the Carpathian Foredeep Basin was a saline lake, separated by a barrier from the sea and supplied with seawater seeping through the barrier or overflowing it occasionally in the form of short-lived marine transgressions. Such transgressions could leave behind marine microfossils in marly clay intercalations. One of them(2.3 m thick) occurs in the uppermost part of the sulphate sequence, in the unit ‘o’, in the Babczyn 2 borehole section. It contains marine palynomorphs(dinoflagellate cysts) and foraminiferal assemblages indicating a marine environment. The low-diversity benthic foraminiferal assemblages are dominated by opportunistic, shallow infaunally living species, preferring muddy or clayey substrate for thriving, brackish to normal marine salinity, and inner shelf environment. Dinoflagellate cyst assemblages, although taxonomically impoverished, consist of marine species;euryhaline forms that tolerate increased salinity are missing. Relatively common microfossils found in clay intercalations within gypsum have important palaeogeographical implications:they strongly suggest that there existed an additional inflow channel supplying the Polish Carpathian Basin from the south during the evaporite deposition and afterwards.

关键词： Evaporite basins Transgression Microfossils Badenian Palaeogeography Paratethys

Effect of interferon alpha2b plus ribavirin treatment on selected growth factors in respect to inflammation and fibrosis in chronic hepatitis C

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World Journal of Gastroenterology 2005年第12期11卷 1854-1858页

作者： Panasiuk Anatol Flisiak Robert Prokopowicz danuta Department of Infectious Diseases

AIM: Growth factors (GF) that participate in regeneration and apoptosis have an important role in chronic liver diseases. We analyzed serum GF concentration during antiviral treatment and correlated it with morphological liver failure in chronic hepatitis C. METHODS: The levels of GF were determined in sera by ELISA method in 0,16,32 and 48 wk of therapy in 40 patients treated with IFNα2b (9 MU sc/wk) and RBV (1.2 g/d) and in 25 healthy subjects. Blind liver biopsies were done before treatment with histological grading and staging examination. RESULTS: The hepatocyte growth factor (HGF) and epidermal growth factor (EGF) were markedly elevated prior the treatment and decreased during the therapy, although they did not reach the normal level. In non-responding (NR) patients, HGF and EGF were higher than that in responders (R), however differences were not significant. Before the treatment thrombopoietin (TPO) level was significantly lower in R than in NR (P<0.03). Platelet-derived growth factor (PDGF) concentration was lower in chronic hepatitis C than in healthy subjects and decreased during the treatment. A significant positive correlation was observed between inflammatory activity in the liver tissue and the concentration of HGF (in R: r= 0.4, in NR: r= 0.5), TPO (R: r= 0.6), and a significant negative correlation between this activity and EGF (R: r = -0.6) and PDGF (R: r= -0.5). Serum HGF concentration was higher in more advanced fibrosis (R: r = 0.5, P<0.05; NR: r=0.4, P<0,03). CONCLUSION: The decrease in PDGF can be an effective prognostic marker of the treatment and HCV elimination. Decreasing HGF, EGF, and PDGF can influence the inhibition of inflammatory and fibrotic processes in the liver during the antiviral treatment.

关键词： Growth factor Chronic hepatitis C Liver biopsy Interferon alfa 2b Ribivirin

Expression of bcl-2 protein in chronic hepatitis C:Effect of interferon alpha 2b with ribavirin therapy

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World Journal of Gastroenterology 2005年第19期11卷 2949-2952页

作者： Panasiuk Anatol Prokopowicz danuta Dzieciol Janusz Panasiuk Bozena Department of Infectious Diseases Medical University of Bialystok Zurawia Str.1415-540 BialystokPoland Department of Human Anatomy Medical University of Bialystok Zurawia Str.1415-540 BialystokPoland

AIM: Mechanisms responsible for persistence of HCV infection and liver damage in chronic hepatitis C are not clear. Apoptosis is an important form of host immune response against viral infections. Anti-apoptotic protein bcl-2 expression on liver tissue as well as the influence of interferon alpha 2b (IFNa2b) and ribavirin (RBV) were analyzed in patients with chronic hepatitis C. METHODS: In 30 patients with chronic hepatitis C (responders - R and non-responders - NR) treated with IFNα2b+RBV, protein bcl-2 was determined in hepatocytes and in liver associated lymphocytes before and after the treatment. RESULTS: The treatment diminished bcl-2 protein accumulation in liver cells in_patients with hepatitis C (P<0.05). Before and after the therapy, we detected bcl-2 protein in R in 87±15% and 83±20% of hepatocytes and in 28±18% and 26±10% of liver-associated lymphocytes, respectively. In NR, the values before treatment decreased from 94±32% to 88±21% of hepatocytes and 39±29% to 28±12% of lymphocytes with bcl-2 expression. There was no statistical correlation between bcl-2 expression on liver tissue with inflammatory activity, fibrosis and biochemical parameters before and after the treatment. CONCLUSION: IFNα2b+RBV treatment, by bcl-2 protein expression decrease, enables apoptosis of hepatocytes and associated liver lymphocytes, which in turn eliminate hepatitis C viruses.

关键词： Bcl-2 Chronic hepatitis C Interferon alpha Ribavirin Hepatitis C virus