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Recent progress on multifunctional electromagnetic interference shielding polymer composites

Journal of Materials Science & Technology 2023年第3期134卷 106-131页

作者： Ke Tian danrong hu Quan Wei Qiang Fu hua Deng College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China Rehabilitation Medicine Center and Institute of Rehabilitation Medicine Key Laboratory of Rehabilitation Medicine in Sichuan ProvinceWest China HospitalSichuan UniversityChengdu 610041China

The explosive development of electronic devices and wireless communication technology gives rise to the issue of electromagnetic pollution,known as electromagnetic interference(EMI).The accumulation of undesirable electromagnetic radiation in space disturbs the normal function of unshielded electronic appliances and poses seriously threat to human health.Thus,the development of EMI shielding materials have emerged to solve the grim problem.Considering the complex application contexts,EMI shielding materials have evolved from traditional single-function to multi-functions to meet the ever-increasing application requirements in recent few years.This paper provides detailed insight into the current re-search status and future challenges in the advancement of polymer-based EMI shielding materials with various functions.First,the basic theory of EMI shielding,factors influencing results and the dominating characterization technologies for EMI shielding properties are summarized.Then,the comprehensive descriptions of the seven types of multifunctional EMI shields are provided with respect to their structures,fabrication methods and specific functions.Meanwhile,the corresponding critical scientific and technical issues are proposed.Based on our comprehensive analysis,the main challenges in the development of multifunctional EMI shielding materials are presented.This review aims to provide some guidance and inspire more efforts toward functional EMI shielding material research to satisfy the growing requirements for next-generation electronic systems.

关键词： Polymer-based composites Electromagnetic interference shielding Multiple losses Multifunctionality

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Newly developed gas-assisted sonodynamic therapy in cancer treatment

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药学学报:英文版 2023年第7期13卷 2926-2954页

作者： Meng Pan danrong hu Liping Yuan Yan Yu Yicong Li Zhiyong Qian State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan UniversityCollaborative Innovation Center of BiotherapyChengdu 610041China Rehabilitation Medicine Center and Institute of Rehabilitation Medicine Key Laboratory of Rehabilitation Medicine in Sichuan ProvinceWest China HospitalSichuan UniversityChengdu 610041China

Sonodynamic therapy(SDT) is an emerging noninvasive treatment modality that utilizes lowfrequency and low-intensity ultrasound(US) to trigger sensitizers to kill tumor cells with reactive oxygen species(ROS).Although SDT has attracted much attention for its properties including high tumor specificity and deep tissue penetration,its anticancer efficacy is still far from satisfactory.As a result,new strategies such as gas-assisted therapy have been proposed to further promote the effectiveness of SDT.In this review,the mechanisms of SDT and gas-assisted SDT are first summarized.Then,the applications of gas-assisted SDT for cancer therapy are introduced and categorized by gas types.Next,therapeutic systems for SDT that can realize real-time imaging are further presented.Finally,the challenges and perspectives of gas-assisted SDT for future clinical applications are discussed.

关键词： Sonodynamic therapy Gas therapy Cancer therapy US imaging Sonotheranostics

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A review on recent advances in hydrogen peroxide electrochemical sensors for applications in cell detection

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Chinese Chemical Letters 2022年第9期33卷 4133-4145页

作者： Yan Yu Meng Pan Jinrong Peng danrong hu Ying Hao Zhiyong Qian State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengdu 610065China

Hydrogen peroxide(H_(2)O_(2))is a very simple bioactive small molecule.In living organisms,H_(2)O_(2)plays an important role in intracellular signaling.It is involved in many physiological processes including cellular physiology,intracellular signaling,oxidative damage and disease progression.The tumor microenvironment enriched with H_(2)O_(2).Several electrochemical sensors have been developed and some have been put on the market.Such electrochemical sensors provide efficient,cost-effective,rapid and highly selective method of H_(2)O_(2)detection.So far,much progress has been made in the designing of materials and construction of H_(2)O_(2)sensors.This review describes the advances in the application of H_(2)O_(2)electrochemical sensors in cell detection.Enzyme-based sensors have been applied in diverse applications.In addition,recent advancements in nanotechnology have improved the development of nanozymes-based sensors.The application of noble metals,metal oxides,polymers,carbon materials and other two-dimensional materials in the design of H_(2)O_(2)sensors are discussed in detail.Moreover,the bio-stimulant types of H_(2)O_(2)sensor are summarized.Finally,the challenges and future perspectives in the application of H_(2)O_(2)electrochemical sensors in biological detection are discussed.

关键词： Hydrogen peroxide Electrochemical sensors Cells detection Enzyme Nanozyme

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Tumor-targeted/reduction-triggered composite multifunctional nanoparticles for breast cancer chemo-photothermal combinational therapy

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Acta Pharmaceutica Sinica B 2022年第6期12卷 2710-2730页

作者： Yun Yang danrong hu Yi Lu Bingyang Chu Xinlong He Yu Chen Yao Xiao Chengli Yang Kai Zhou Liping Yuan Zhiyong Qian State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan UniversityCollaborative Innovation Center of BiotherapyChengdu 610041China West China School of Pharmacy Sichuan UniversityChengdu 610041China

Breast cancer has become the most commonly diagnosed cancer type in the world.A combination of chemotherapy and photothermal therapy(PTT) has emerged as a promising strategy for breast cancer therapy.However,the intricacy of precise delivery and the ability to initiate drug release in specific tumor sites remains a challenging puzzle.Therefore,to ensure that the therapeutic agents are synchronously delivered to the tumor site for their synergistic effect,a multifunctional nanoparticle system(PCRHNs) is developed,which is grafted onto the prussian blue nanoparticles(PB NPs) by reductionresponsive camptothecin(CPT) prodrug copolymer,and then modified with tumor-targeting peptide cyclo(Asp-D-Phe-Lys-Arg-Gly)(cRGD) and hyaluronic acid(HA).PCRHNs exhibited nano-sized structure with good monodispersity,high load efficiency of CPT,triggered CPT release in response to reduction environment,and excellent photothermal conversion under laser irradiation.Furthermore,PCRHNs can act as a photoacoustic imaging contrast agent-guided PTT.In vivo studies indicate that PCRHNs exhibited excellent bio compatibility,prolonged blood circulation,enhanced tumor accumulation,allow tumor-specific che mo-photo thermal therapy to achieve synergistic antitumor effects with reduced systemic toxicity.Moreover,hyperthermia-induced upregulation of heat shock protein 70 in the tumor cells could be inhibited by CPT.Collectively,PCRHNs may be a promising therapeutic way for breast cancer therapy.

关键词： Breast cancer Chem-photothermal combinational therapy Camptothecin Prussian blue nanoparticles Reduction-responsive prodrugs

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Macrophage Membrane-Camouflaged shRNA and Doxorubicin:A pH-Dependent Release System for Melanoma Chemo-Immunotherapy

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Research 2022年第2期2022卷 161-178页

作者： Chengli Yang Yang Ming Kai Zhou Ying Hao danrong hu Bingyang Chu Xinlong He Yun Yang Zhiyong Qian State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation Center of BiotherapyChengduSichuan 610041China Departiment of Pharmacy The Affiliated Hospital of Guizhon Medical UniversityGuiyangGuizhou 550000China

mproving the eficacy of melanoma treatment remains an important global challenge.Here,we combined chemotherapy with protein tyrosine phosphatase nonreceptor type 2(Ptpn2)based immunotherapy in an effort to address this challenge.Shorthairpin RNA(shRNA)targeting Ptpn2 was coencapsulated with doxorubicin(DOX)in the cell membrane of MI macrophages(MIHD@RPR).The prepared nanoparticles(NPs)were effectively phagocytosed by B16F10 cells and MI macrophages,but not by MOmacrophages.Hence,NPevasion from the reticuloendothelial system(RES)was improved and NPenrichment in tumor sites increased.MIHD@RPR can directly kill tumor cells and stimulate immunogenic cell death(ICD)by DOX and downregulate Ptpn2.It can promote Ml macrophage polarization and dendritic cell maturation and increase the proportion of CD8+T cells.MIHD@RPR killed and inhibited the growth of primary melanoma and lung metastatic tumor celis without harming the surrounding tssue.These findings establish MIHD@RPR as a safe multifunctional nanoparticle capable of effectively combining chemotherapy and gene immunotherapies against melanoma.

关键词： chemotherapy inhibited melanoma

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Current research progress of photopolymerized hydrogels in tissue engineering

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Chinese Chemical Letters 2021年第7期32卷 2117-2126页

作者： Ao Sun Xinye He Xiao Ji danrong hu Meng Pan Linghong Zhang Zhiyong Qian State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy West China HospitalWest China Medical SchoolSichuan University

Owing to the special fo rmation of photopolymerized hydrogels,they can effectively control the formation of hydrogels in space and time.Moreover,the photopolymerized hydrogels have mild formation conditions and biocompatibility;therefore,they can be widely used in tissue engineering.With the development and application of manufacturing technology,photopolymerized hydrogels can be widely used in cell encapsulation,scaffold materials,and other tissue engineering fields through more elaborate manufacturing methods.This review covers the types of photoinitiators,manu facturing technologies for photopolymerized hydrogels as well as the materials used,and a summary of the applications of photopolymerized hydrogels in tissue engineering.

关键词： Hydrogels Photopolymerization Photoinitiators Biofabrication Tissue engineering

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Adhesive chitosan-based hydrogel assisted with photothermal antibacterial property to prompt mice infected skin wound healing

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Chinese Chemical Letters 2023年第12期34卷 415-423页

作者： Shuang Cheng Meng Pan danrong hu Ruxia Han Lang Li Zhongwu Bei Yicong Li Ao Sun Zhiyong Qian State Key Laboratory of Biotherapy and Cancer Center and Collaborative Innovation Center for BiotherapyWest China HospitalSichuan UniversityChengdu610041China Rehabilitation Medicine Center and Institute of Rehabilitation Medicine Key Laboratory of Rehabilitation Medicine in Sichuan Province West China HospitalSichuan UniversityChengdu610041China Department of Pediatric Surgery West China HospitalSichuan UniversityChengdu 610041China

Bacterial infection of wounds is an escalating medical problem,issuing threats to both global public health and personal health.Photothermal antibacterial technology as a novel sterilization strategy has outstanding sterilization efficiency,high safety and low risk of emergence of drug-resistant bacteria.By combining inherent antibacterial activity and light-assisted antibacterial treatment,developing novel multifunctional dressings with synergistic high-efficiency antibacterial effects and also promoting wound healing possesses attractive advantages in the field of treating bacterial wound infections in clinical care.Herein,a multifunctional hydrogel formed by in situ photo-cross linking was designed and prepared by first grafting methacrylic anhydride as a photosensitizer onto chitosan,and then introducing oxidatively synthesized polydopamine(PDA).The physicochemical characterizations of the synthesized hydrogels demonstrated their tunability certainly associated with PDA concentration,including pore size,water swelling,rheological properties and in vitro degradability.In addition,the composite hydrogels exhibited good adhesion,anti-oxidation and photothermal properties due to the existence of PDA.Within 10min upon exposure to 808 nm near-infrared(NIR)light irradiation,this hydrogel system displayed outstanding antibacterial activity against Staphylococcus aureus with almost 100%killing efficiency,of which rapid efficient sterilization plays a significant role in wound healing.Moreover,the hydrogel is capable of cytocompatibility and has low toxicity to murine fibroblasts(L929 and NIH/3T3).In the full-thickness wound defect infection model in mice,the wound closure ratio,inflammatory response,fibroblasts,neovascularization and epithelialization were measured.Animal experiments also reveal that the hydrogel assisted with NIR laser irradiation can inhibit effectively infection at an early stage and accelerate the wound healing process.In summary,this novel multifunctional injectable hydrogel exhibits excellent sw

关键词： Hydrogel Adhesion Photothermal therapy Antibacterial Wound infection

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Palladium Nanoparticles/Graphdiyne Oxide Nanocomposite with Excellent Peroxidase-like Activity and Its Application for Glutathione Detection

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Chemical Research in Chinese Universities 2022年第2期38卷 529-534页

作者： LAN Weifei hu Ruifeng huANG danrong DONG Xu SHEN Gangyi CHANG Shan DAI Dongsheng School of Pharmacy Minzu University of ChinaBeijing 100081P.R.China Institute of Chemistry Chinese Academy of SciencesBeijing 100190P.R.China Institute of Bioinformatics and Medical Engineering School of Electrical and Information EngineeringJiangsu University of TechnologyChangzhou 213001P.R.China

In this study, palladium nanoparticles loaded graphdiyne oxide (Pd/GDYO) nanocomposite were fabricated by in-situ reduction of palladium chloride in the dispersion of GDYO, and characte-rized by Raman spectra, transmission electron microscopy, X-ray diffraction and X-ray photoelectron spectroscopy. The synthesized Pd/GDYO was first found to have catalytic activities similar to those of the peroxidase enzyme, which can catalyze the oxidation of peroxidase substrate 3,3',5,5'-tetramethylbenzidine(TMB) in the presence of hydrogen peroxide(H2O2). Steady-state kinetic studies showed that the catalytic reaction of Pd/GDYO follows a ping-pong mechanism, and Pd/GDYO has a stronger activity to TMB with a Michaelis constant(Km) value of 5.32×10-4 mmol/L. Based on the shielding effect of glutathione(GSH) on the Pd/GDYO-H2O2-TMB reaction system, a colorimetric detection method for GSH was deve-loped with a wide linear range from 0.1 μmol/L to 40 μmol/L and a limit of detection of 0.1 μmol/L. The method was successfully applied for fast and accurate detection of GSH in injection powder drugs. It was expected that this peroxidase-like Pd/GDYO nano- composite would have wide applications in the fields of biomedicine and environmental chemistry.

关键词： Palladium nanoparticle/graphdiyne oxide nanocomposite Peroxidase-like activity Colorimetric detection Glutathione

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番泻苷B通过Wnt/β-catenin通路抑制视网膜母细胞瘤HXO-Rb44细胞增殖、凋亡和侵袭

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医学分子生物学杂志 2024年第2期21卷 141-145,153页

作者：孙蒙蒙崔博坤贾梦冉柳王丹荣冯素婷张虎郝建章保定市第一医院手术室河北省保定市071000 保定市第一医院眼科河北省保定市071000

目的探究番泻苷B对视网膜母细胞瘤HXO-Rb44细胞增殖、凋亡、侵袭及Wnt/β-catenin信号通路的影响。方法通过采用不同剂量(0、5、10、20μmol/L)番泻苷B处理HXO-Rb44细胞,将细胞随机分为4组:Control组,番泻苷B 5、10、20μmol/L组。MTT... 详细信息

目的探究番泻苷B对视网膜母细胞瘤HXO-Rb44细胞增殖、凋亡、侵袭及Wnt/β-catenin信号通路的影响。方法通过采用不同剂量(0、5、10、20μmol/L)番泻苷B处理HXO-Rb44细胞,将细胞随机分为4组:Control组,番泻苷B 5、10、20μmol/L组。MTT法检测细胞活力;克隆形成实验检测克隆形成率;流式细胞仪检测细胞凋亡率;Transwell检测侵袭细胞数;细胞成球实验检测细胞成球直径和细胞成球数目;蛋白质印迹检测cleaved caspase-3、caspase-3、MMP-2、MMP-9、SOX2、OCT4、CD44、Wnt1、β-catenin蛋白表达。结果与Control组比较,番泻苷B 10、20μmol/L组细胞活力、克隆形成率显著降低(P<0.05),细胞凋亡率和cleaved caspase-3/caspase-3表达显著升高(P<0.05),侵袭细胞数和MMP-2、MMP-9蛋白表达显著降低(P<0.05),细胞成球直径、细胞成球数目和SOX2、OCT4、CD44蛋白表达显著降低(P<0.05),Wnt1、β-catenin蛋白表达显著降低(P<0.05)。结论番泻苷B可抑制视网膜母细胞瘤HXO-Rb44细胞增殖、侵袭和干细胞样特性,诱导细胞凋亡,抑制Wnt/β-catenin信号通路的活化。

关键词：视网膜母细胞瘤番泻苷B 干细胞样特性 Wnt/β-catenin信号通路

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低介电常数甲基倍半硅氧烷多孔膜的制备及表征

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华中科技大学学报（自然科学版） 2008年第2期36卷 104-107页

作者：胡一帆章瑛付丹蓉华中科技大学物理系湖北武汉430074

利用甲基三甲氧基硅烷(MTMS)水解缩合生成低聚甲基倍半硅氧烷(O-MSSQ)溶胶,经旋转涂胶和热解制备了多孔低介电常数薄膜.用FTIR,AFM和MIM等方法分别对化学结构、表面粗糙度和介电性能等进行表征.FTIR研究表明:薄膜中Si—O—Si键呈笼状和... 详细信息

利用甲基三甲氧基硅烷(MTMS)水解缩合生成低聚甲基倍半硅氧烷(O-MSSQ)溶胶,经旋转涂胶和热解制备了多孔低介电常数薄膜.用FTIR,AFM和MIM等方法分别对化学结构、表面粗糙度和介电性能等进行表征.FTIR研究表明:薄膜中Si—O—Si键呈笼状和网状两种不同的结构,笼状/网状结构的比例会随着烧结温度的升高而明显降低,从而导致了介电常数升高.针对这一情况,使用了正十四烷(tetradecane)作为发泡剂以增加孔隙率,由于孔隙率的提高,其介电常数可达1.9.

关键词：薄膜介电常数甲基倍半硅氧烷多孔材料制备

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