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The miR-9-5p/CXCL11 pathway is a key target of hydrogen sulfide-mediated inhibition of neuroinflammation in hypoxic ischemic brain injury

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Neural Regeneration Research 2024年第5期19卷 1084-1091页

作者： Yijing Zhao Tong Li Zige Jiang Chengcheng Gai Shuwen Yu danqing Xin Tingting Li Dexiang Liu Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China Maternal and Child Health Care Hospital of Shandong Province Affiliated to Qingdao UniversityJinanShandong ProvinceChina

We previously showed that hydrogen sulfide(H2S)has a neuroprotective effect in the context of hypoxic ischemic brain injury in neonatal mice.However,the precise mechanism underlying the role of H2S in this situation remains unclear.In this study,we used a neonatal mouse model of hypoxic ischemic brain injury and a lipopolysaccharide-stimulated BV2 cell model and found that treatment with L-cysteine,a H2S precursor,attenuated the cerebral infarction and cerebral atrophy induced by hypoxia and ischemia and increased the expression of miR-9-5p and cystathionineβsynthase(a major H2S synthetase in the brain)in the prefrontal cortex.We also found that an miR-9-5p inhibitor blocked the expression of cystathionineβsynthase in the prefrontal cortex in mice with brain injury caused by hypoxia and ischemia.Furthermore,miR-9-5p overexpression increased cystathionine-β-synthase and H2S expression in the injured prefrontal cortex of mice with hypoxic ischemic brain injury.L-cysteine decreased the expression of CXCL11,an miR-9-5p target gene,in the prefrontal cortex of the mouse model and in lipopolysaccharide-stimulated BV-2 cells and increased the levels of proinflammatory cytokines BNIP3,FSTL1,SOCS2 and SOCS5,while treatment with an miR-9-5p inhibitor reversed these changes.These findings suggest that H2S can reduce neuroinflammation in a neonatal mouse model of hypoxic ischemic brain injury through regulating the miR-9-5p/CXCL11 axis and restoringβ-synthase expression,thereby playing a role in reducing neuroinflammation in hypoxic ischemic brain injury.

关键词： chemokine(C-X-C motif)ligand 11 cystathionineβsynthase H2S hypoxic ischemic brain injury inflammation L-cysteine lipopolysaccharide microglia miR-9-5p neuroprotection

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Rapid report of the December 18,2023 M_(S)6.2 Jishishan earthquake,Gansu,China

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Earthquake Research Advances 2024年第2期4卷 14-21页

作者： Guangjie Han danqing Dai Yu Li Nan Xi Li Sun China Earthquake Networks Center Beijing100045China

On December 18,2023,the Jishishan area in Gansu Province was jolted by a M_(S) 6.2 earthquake,which is the most powerful seismic event that occurred throughout the year in China.The earthquake occurred along the NWtrending Lajishan fault(LJSF),a large tectonic transformation zone.After this event,China Earthquake Networks Center(CENC)has timely published several reports about seismic sources for emergency responses.The earthquake early warning system issued the first alert 4.9 s after the earthquake occurrence,providing prompt notification that effectively mitigated panics,injuries,and deaths of residents.The near real-time focal mechanism solution indicates that this earthquake is associated with a thrust fault.The distribution of aftershocks,the rupture process,and the recorded amplitudes from seismic monitoring and GNSS stations,all suggest that the mainshock rupture predominately propagates to the northwest direction.The duration of the rupture process is~12 s,and the largest slip is located at approximately 6.3 km to the NNW from the epicenter,with a peak slip of 0.12 m at~8 km depth.Seismic station N0028 recorded the highest instrumental intensity,which is 9.4 on the Mercalli scale.The estimated intensity map shows a seismic intensity reaching up to IX near the rupture area,consistent with field survey results.The aftershocks(up to December 22,2023)are mostly distributed in the northwest direction within~20 km of the epicenter.This earthquake caused serious casualties and house collapses,which requires further investigations into the impact of this earthquake.

关键词： Earthquake early warning Focal mechanism Rupture process Real-time intensity Coseismic deformation

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Boosting solar hydrogen production via electrostatic interaction mediated E.coli-TiO_(2−x)biohybrid system

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Nano Research 2024年第6期17卷 5390-5398页

作者： Xingxing Lv Weicheng Huang Ya Gao Rui Chen Xiaowei Chen danqing Liu Ling Weng Liangcan He Shaoqin Liu School of Material Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150040China School of Medicine and Health and Key Laboratory of Micro-systems and Micro-structures Manufacturing of Ministry of EducationHarbin Institute of TechnologyHarbin 150001China Department of Physics School of ScienceJimei UniversityXiamen 361021China Zhengzhou Research Institute Harbin Institute of TechnologyZhengzhou 450046China

Hydrogen is garnering growing attention as a green energy source with zero carbon emissions.However,most hydrogen production technologies still rely on the consumption of fossil fuels and are therefore unsustainable.This has driven the search for more environmentally friendly methods of hydrogen production.In this work,we present an innovative approach to enhance hydrogen generation via electrostatic interaction in the Escherichia coli and defective titanium dioxide(TiO_(2−x))biohybrids.Our method involves narrowing the forbidden bandwidth of TiO2 while introducing defect bands into its conduction band to facilitate visible light absorption and efficient charge separation.This biohybrid system,consisting of E.coli and TiO_(2−x),demonstrates a remarkable capability to produce 1.25 mmol of hydrogen within a 3-h timeframe under visible light irradiation.This accomplishment signifies a 3.31-fold rise in hydrogen production in comparison to E.coli,signifying a substantial enhancement in hydrogen production efficiency.Furthermore,we delve into the alterations in biological metabolites associated with hydrogen production and the changes in electron transfer in different biohybrid systems.It provides valuable insights into the understanding of the intrinsic mechanisms that drive the process.This work introduces a novel and promising avenue for achieving this exciting goal.

关键词： Escherichia coli TiO_(2−x)nanoparticles biohybrid system hydrogen production

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Chemical construction and anti-HCoV-OC43 evaluation of novel 10,12-disubstituted aloperine derivatives as dual cofactor inhibitors of TMPRSS2 and SR-B1

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Chinese Chemical Letters 2024年第5期35卷 201-206页

作者： Yulong Shi Fenbei Chen Mengyuan Wu Xin Zhang Runze Meng Kun Wang Yan Wang Yuheng Mei Qionglu Duan Yinghong Li Rongmei Gao Yuhuan Li Hongbin Deng Jiandong Jiang Yanxiang Wang danqing Song Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Pharmacy Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJining 272000China

Thirty-one new 10,12-disubstituted aloperine derivatives were subtly constructed through a selective oxidation on the 10-α-C-H induced by sulfonyl and a nucleophilic substitution with the stereoselectivity and scalability.Of them,compound 6b displayed a moderate anti-human coronavirus OC43(HCoV-OC43)potency and blocked the viral entry stage through a host mechanism of action.Using chemoproteomic techniques,both transmembrane serine protease 2(TMPRSS2)and scavenger receptor class B type 1(SR-B1)proteins,which act as host cofactors of viral entry,were identified to be the direct targets of 6b against HCoV-OC43.Furthermore,6b may deactivate the TMPRSS2 by inducing a change in protein conformation,rather than binding to its catalytic center,thus suppressing the viral membrane fusion.Accordingly,our study provided key scientific data for the development of aloperine derivatives into a new class of antiviral candidates against humanβ-coronavirus,including severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).

关键词： Aloperine SARS-CoV-2 TMPRSS2 SR-B1 Synthesis

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外资进入促进了企业全球价值链嵌入吗?——基于中国微观企业的经验证据

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北京理工大学学报（社会科学版） 2024年第2期26卷 193-206页

作者：郑丹青河南大学经济学院河南开封475004

外资进入是否改变了中国企业的全球价值链嵌入模式?利用中国工业企业数据库和海关贸易数据库在刻画企业全球价值链嵌入模式的动态演进基础上,探讨了外资进入对中国企业全球价值链嵌入模式的影响。研究表明:2000—2013年中国企业上游嵌... 详细信息

外资进入是否改变了中国企业的全球价值链嵌入模式?利用中国工业企业数据库和海关贸易数据库在刻画企业全球价值链嵌入模式的动态演进基础上,探讨了外资进入对中国企业全球价值链嵌入模式的影响。研究表明:2000—2013年中国企业上游嵌入度不断提升但程度较小,下游嵌入度相对较大却持续下降,企业全球价值链分工地位整体为负但攀升态势明显;外资进入推动了企业上游环节的嵌入度,对下游环节嵌入度产生明显锁定效应,整体上外资进入的企业全球价值链地位效应表现出显著负向作用;一般贸易企业、外资企业、劳动密集型及低技术水平企业同行业外资进入的全球价值链地位负向效应明显;进一步的动态效应和影响机制分析发现,外资进入对企业全球价值链地位表现出显著动态抑制作用,会通过融资约束效应对企业全球价值链地位产生显著的正向调节效应,从而有利于缓解外资进入的全球价值链“低端锁定”风险。

关键词：外资进入企业全球价值链地位上游嵌入度下游嵌入度

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基于改进交替迁移学习的滚动轴承故障诊断算法

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振动与冲击 2024年第5期43卷 239-249页

作者：王鹏李丹青王恒南通大学机械工程学院江苏南通226019

针对不同型号滚动轴承监测信号之间特征分布差异大、故障数据样本少,导致轴承故障精度低的问题,提出了一种基于改进交替迁移学习的滚动轴承故障诊断算法。为了充分发挥卷积神经网络(convolutional neural network, CNN)对二维数据优秀... 详细信息

针对不同型号滚动轴承监测信号之间特征分布差异大、故障数据样本少,导致轴承故障精度低的问题,提出了一种基于改进交替迁移学习的滚动轴承故障诊断算法。为了充分发挥卷积神经网络(convolutional neural network, CNN)对二维数据优秀的特征提取能力,首先将一维振动信号转化为二维图像,输入到深度卷积神经网络中学习;其次,为了减少源域与目标域数据间的特征分布差异,提出了改进的交替迁移学习(improved alternately transfer learning, IATL),通过交替计算域间的CORAL损失函数和最大均值差异(maximum mean discrepancy, MMD)损失函数,并反向传播更新各层网络权重与偏置参数,以实现变工况、跨轴承型号和小故障样本条件下轴承特征迁移适配;最后,在全连接层使用Softmax函数对目标域数据进行故障诊断。为了验证该算法的有效性,采用凯斯西储大学(Case Western Reserve University, CWRU)的滚动轴承数据集进行了迁移试验验证。结果表明,与仅计算CORAL损失函数和MMD损失函数等算法对比可知,该算法有效地减少了领域数据之间的特征分布差异,具有较高的故障分类准确率。

关键词：滚动轴承故障诊断迁移学习(TL) 损失函数深度卷积神经网络

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Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期 1776-1788页

作者： Zige Jiang Dexiang Liu Tingting Li Chengcheng Gai danqing Xin Yijing Zhao Yan Song Yahong Cheng Tong Li Zhen Wang Department of Physiology School of Basic Medical Sciences Cheeloo College of Medicine Shandong University Department of Medical Psychology and Ethics School of Basic Medicine Sciences Cheeloo College of Medicine Shandong University Department of Neurosurgery Surgery Qingdao Municipal Hospital

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

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Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells

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Genes & Diseases 2021年第3期8卷 344-352页

作者： Lu Yang Yukai Jing danqing kang Panpan Jiang Na Li Xinrong Zhou Yan Chen Lisa S.Westerberg Chaohong Liu Department of Pathogen Biology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei Province430030PR China Department of Immunology School of MedicineYangtze UniversityJingzhouHubei Province434023PR China Department of Endocrinology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei Province430030PR China The Second Department of Pediatrics Affiliated Hospital of Zunyi Medical UniversityZunyiGuiZhou Province563000PR China Department of Microbiology Tumor and Cell Biology Karolinska InstitutetStockholm17177Sweden

Ubiquitin-specific peptidase 18(USP18)plays an important role in the development of CD11b^(+)dendritic cells(DCs)and Th17 cells,however,its role in the differentiation of other T cell subsets,especially in regulatory T(Treg)cells,is unknown.In our study,we used Usp18 K0 mice to study the loss of USP18 on the impact of Treg cell differentiation and function.We found that USP18 deficiency upregulates the differentiation of Treg cells,which may lead to disrupted homeostasis of peripheral T cells,and downregulates INF-y,IL-2,IL-17A producing CD4^(+)T cells and INF-γproducing CD8^(+)T cells.Mechanistically,we also found that the upre-gulation of Tregs is due to elevated expression of CD25 in Usp18 KO mice.Finally,we found that the suppressive function of Usp18 KO Tregs is downregulated.Altogether,our study was the first to identify the role of USP18 in Tregs differentiation and its suppressive function,which may provide a new reference for the treatment of Treg function in many autoimmune diseases,and USP18 can be used as a new therapeutic target for precise medical treatment.

关键词： CD25 Foxp3 ICOS Regulator T cell USP18

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无人潜航器锂电池安全设计及测试验证

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船舶工程 2024年第3期46卷 109-116页

作者：何丹青谢坤义乌工商职业技术学院浙江金华322000 中国舰船研究设计中心武汉430064

为有效解决无人潜航器密闭环境下大规模锂电池上艇存在的安全性问题,将“磷酸铁锂正极-固态电解质-铌钛氧负极”本质安全性锂电池技术引入无人潜航器锂电池设计中。对无人潜航器锂电池的功能定位进行分析,提出“磷酸铁锂正极-固态电解质... 详细信息

为有效解决无人潜航器密闭环境下大规模锂电池上艇存在的安全性问题,将“磷酸铁锂正极-固态电解质-铌钛氧负极”本质安全性锂电池技术引入无人潜航器锂电池设计中。对无人潜航器锂电池的功能定位进行分析,提出“磷酸铁锂正极-固态电解质-铌钛氧负极”本质安全性锂电池。在联调试验中和船舶上实际应用该锂电池,结果表明:“磷酸铁锂正极+固态电解质+钛铌氧负极”锂电池的电压平台、能量密度、功率密度等功性能指标满足上艇需求,循环寿命可提高至数千次,热失控、短路、跌落、低气压、非正常充电和海水浸泡等试验测试过程中均未发生热失控,且具有良好的环境适应性、适装性和匹配性,能提升无人潜航器的安全性。

关键词：无人潜航器磷酸铁锂正极固态电解质铌钛氧负极安全性

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多数恒牙先天缺失多学科联合诊疗1例

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中华口腔医学杂志 2024年第4期59卷 378-382页

作者：江丽斌杨静文何丹青北京大学口腔医学院·口腔医院正畸科、国家口腔医学中心、国家口腔疾病临床医学研究中心、口腔生物材料和数字诊疗装备国家工程研究中心、口腔数字医学北京市重点实验室北京100081 北京大学口腔医学院·口腔医院修复科、国家口腔医学中心、国家口腔疾病临床医学研究中心、口腔生物材料和数字诊疗装备国家工程研究中心、口腔数字医学北京市重点实验室北京100081

本文报道1例以多数恒牙先天缺失、余留牙不齐为临床表现的患者的多学科联合诊疗过程。通过多学科联合诊疗确定前牙位置并进行美学设计,正畸治疗排齐牙列,调整修复间隙,并通过数字化设计预测种植位点,最终完成种植修复并获得良好的疗效... 详细信息

本文报道1例以多数恒牙先天缺失、余留牙不齐为临床表现的患者的多学科联合诊疗过程。通过多学科联合诊疗确定前牙位置并进行美学设计,正畸治疗排齐牙列,调整修复间隙,并通过数字化设计预测种植位点,最终完成种植修复并获得良好的疗效。文内总结并探讨以正畸-种植修复为核心的多学科联合诊疗多数恒牙先天缺失患者过程中的诊疗要点。

关键词：种植修复正畸治疗多学科联合诊疗余留牙恒牙先天缺失美学设计数字化设计诊疗要点

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