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Epidemiological characteristics and genetic alterations in adult diffuse glioma in East Asianpopulations

Cancer Biology & Medicine 2022年第10期19卷 1440-1459页

作者： Zongchao Mo Junyi Xin Ruichao Chai Peter Y.M.Woo danny T.M.Chan Jiguang Wang Division of Life Science and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina HKUST Shenzhen-Hong Kong Collaborative Innovation Research Institute Shenzhen 518000China Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijing 100070China Department of Neurosurgery Kwong Wah HospitalHong Kong SARChina Hong Kong Neuro-Oncology Society Hong Kong SARChina Division of Neurosurgery Department of SurgeryPrince of Wales HospitalHong Kong SARChina Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina Hong Kong Center for Neurodegenerative Diseases Hong Kong Science ParkHong Kong SARChina

Understanding the racial specificities of diseases—such as adult diffuse glioma,the most common primary malignant tumor of the central nervous system—is a critical step toward precision ***,we comprehensively review studies of gliomas in East Asian populations and other ancestry groups to clarify the racial differences in terms of epidemiology and genomic ***,we observed a lower glioma incidence in East Asians than in Whites;notably,patients with glioblastoma had significantly younger ages of onset and longer overall survival than the *** genome-wide association studies of various cohorts have revealed single nucleotide polymorphisms associated with overall and subtype-specific glioma ***,only 3 risk loci—5p15.33,11q23.3,and 20q13.33—were shared between patients with East Asian and White ancestry,whereas other loci predominated only in particular *** instance,risk loci 12p11.23,15q15-21.1,and 19p13.12 were reported in East Asians,whereas risk loci 8q24.21,1p31.3,and 1q32.1 were reported in studies in White *** the somatic mutational profiles of gliomas between East Asians and non-East Asians were broadly consistent,a lower incidence of EGFR amplification in glioblastoma and a higher incidence of 1p19q-IDH-TERT triple-negative low-grade glioma were observed in East Asian *** summarizing large-scale disease surveillance,germline,and somatic genomic studies,this review reveals the unique characteristics of adult diffuse glioma among East Asians,to guide clinical management and policy design focused on patients with East Asian ancestry.

关键词： Glioma East Asian epidemiology germline somatic

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Biliary-colonic fistula caused by cholecystectomy bile duct injury

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Hepatobiliary & Pancreatic Diseases International 2013年第4期12卷 443-445页

作者： Francisco Igor B Macedo Victor J Casillas James S Davis Joe U Levi danny Sleeman Dewitt Daughtry Family Department of Surgery University of Miami Miller School of Medicine and Ryder Trauma Center/Jackson Memorial HospitalMiami Florida USA Department of Radiology University of Miami Miller School of Medicine and Ryder Trauma Center/Jackson Memorial HospitalMiami Florida USA

Biliary-colonic fistula is a rare complication after laparoscopic cholecystectomy. We present a case of post-cholecystectomy iatrogenic biliary injury that resulted in a fistula between the common hepatic duct and large bowel. Magnetic resonance cholangiopancreatography provided good visualization of injury even with concurrent normal level of alkaline phosphatase. Radiologic findings and surgical management of this condition are discussed in detail.

关键词： cholecystectomy magnetic resonance imaging biliary tract disease

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Overexpression of a Potato Sucrose Synthase Gene in Cotton Accelerates Leaf Expansion, Reduces Seed Abortion, and Enhances Fiber Production

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Molecular Plant 2012年第2期5卷 430-441页

作者： Shou-Min Xu Elizabeth Brill danny J. Llewellyn Robert T. Furbank Yong-Ling Ruan CSIRO Plant Industry GPO Box 1600 Canberra ACT 2601 Australia School of Environmental and Life Sciences University of Newcastle Newcastle NSW 2308 Australia

Sucrose synthase （Sus） is a key enzyme in the breakdown of sucrose and is considered a biochemical marker for sink strength, especially in crop species, based on mutational and gene suppression studies. It remains elusive, however, whether, or to what extent, increase in Sus activity may enhance sink development. We aimed to address this question by expressing a potato Sus gene in cotton where Sus expression has been previously shown to be critical for normal seed and fiber development. Segregation analyses at T1 generation followed by studies in homozygous progeny lines revealed that increased Sus activity in cotton （1） enhanced leaf expansion with the effect evident from young leaves emerging from shoot apex; （2） improved early seed development, which reduced seed abortion, hence enhanced seed set, and （3） promoted fiber elongation. In young leaves of Sus overexpressing lines, fructose concentrations were significantly increased whereas, in elongating fibers, both fructose and glucose levels were increased. Since hexoses contribute little to osmolality in leaves, in contrast to developing fibers, it is concluded that high Sus activity promotes leaf development independently of osmotic regulation, probably through sugar signaling. The analyses also showed that doubling the Sus activity in 0-d cotton seeds increased their fresh weight by about 30%. However, further increase in Sus activity did not lead to any further increase in seed weight, indicating an upper limit for the Sus overexpression effect. Finally, based on the observed additive effect on fiber yield from increased fiber length and seed number, a new strategy is proposed to increase cotton fiber yield by improving seed development as a whole, rather than solely focusing on manipulating fiber growth.

关键词： cotton fiber invertase leaf expansion seed abortion seed development sucrose synthase sugar signaling.

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Supramolecular approaches for insulin stabilization without prolonged duration of action

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2281-2290页

作者： Rolande Meudom Yanxian Zhang Michael A.VandenBerg Lei Zou Yi Wolf Zhang Matthew J.Webber danny Hung-Chieh Chou Division of Endocrinology and Diabetes Department of PediatricsSchool of MedicineStanford UniversityPalo AltoCA 94305USA Department of Biochemistry School of MedicineUniversity of UtahSalt Lake CityUT 84112USA Department of Chemical Engineering University of Notre DameNotre DameIN 46556USA

Aggregation represents a significant challenge for the long-term formulation stability of insulin *** supramolecular PEGylation of insulin with conjugates of cucurbit[7]uril and polyethylene glycol(CB[7]-PEG)has been shown to stabilize insulin formulations by reducing aggregation *** prolonged in vivo duration of action,arising from sustained complex formation in the subcutaneous depot,limits the application scope for meal-time insulin uses and could increase hypoglycemic risk several hours after a *** affinity of CB[7]in binding the B1-Phe residue on insulin is central to supramolecular PEGylation using this ***,here we synthesized N-terminal acid-modified insulin analogs to reduce CB[7]interaction affinity at physiological pH and reduce the duration of action by decreasing the subcutaneous depot effect of the *** insulin analogs show weak to no interaction with CB[7]-PEG at physiological pH but demonstrate high formulation stability at reduced ***,N-terminal modified analogs have in vitro and in vivo bioactivity comparable to native ***,in a rat model of diabetes,the acid-modified insulin formulated with CB[7]-PEG offers a reduced duration of action compared to native insulin formulated with CB[7]-*** work extends the application of supramolecular PEGylation of insulin to achieve enhanced stability while reducing the risks arising from a subcutaneous depot effect prolonging in vivo duration of action.

关键词： Diabetes mellitus Insulin aggregation Supramolecular PEGylation Selective N-Terminal modification N-terminal acid-modified insulin Subcutaneous depot Hypoglycemia Subcutaneous administration

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A Fluorescent Alternative to the Synthetic Strigolactone GR24

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Molecular Plant 2013年第1期6卷 100-112页

作者： Amanda Rasmussen Thomas Heugebaert Cedrick Matthys Rik Van Deun Francois-Didier Boyer1 Sofie Goormachtig Christian Stevens danny Geelen Plant Production Faculty of Bioscience Engineering Ghent University Coupure links 653 Ghent 9000 Belgium Research Group SynBioC Department of Sustainable Organic Chemistry and Technology Faculty of Bioscience Engineering Ghent University Coupurelinks 653 B-9000 Gent Belgium Department of Plant Systems Biology VIB Ghent 9052 Belgium Department of Plant Biotechnologyand Bioinformatics Ghent University Ghent 9052 Belgium f-element Coordination Chemistry Lab Inorganic and Physical Chemistry Department Ghent University Krijgslaan 281--$3 9000 Gent Belgium Centre de Recherche de Gif Institut de Chimie des Substances Naturelles UPR2301 CNRS INRA 1 avenue de la Terrasse F-91198 Gif-sur-Yvette Cedex France

Strigolactones have recently been implicated in both above- and below-ground developmental pathways in higher plants. To facilitate the molecular and chemical properties of strigolactones in vitro and in vivo, we have devel- oped a fluorescent strigolactone molecule, CISA-1, synthesized via a novel method which was robust, high-yielding, and used simple starting materials. We demonstrate that CISA-1 has a broad range of known strigolactone activities and further report on an adventitious rooting assay in Arabidopsis which is a highly sensitive and rapid method for testing biological activity of strigolactone analogs. In this rooting assay and the widely used Orobanche germination assay, CISA-1 showed stronger biological activity than the commonly tested GR24. CISA-1 and GR24 were equally effective at inhibiting branching in Arabidopsis inflorescence stems. In both the branching and adventitious rooting assay, we also demonstrated that CISA-1 activity is dependent on the max strigolactone signaling pathway. In water methanol solu- tions, CISA-1 was about threefold more stable than GR24, which may contribute to the increased activity observed in the various biological tests.

关键词： strigolactones adventitious rooting branching fluorescent markers parasitic weed seed germination.

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铁胆雄山

铁胆雄山

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作者：丹尼·勒纳 danny·Lerner导演

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Incidence and mortality of female breast cancer in the AsiaPacific region

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Cancer Biology & Medicine 2014年第2期11卷 101-115页

作者： danny R.Youlden Susanna M.Cramb Cheng Har Yip Peter D.Baade Cancer Council Queensland School of Mathematical Sciences Queensland University of Technology Faculty of Medicine University of Malaya Griffith Health Institute Griffith University School of Public Health and Social Work Queensland University of Technology

Objective: To provide an overview of the incidence and mortality of female breast cancer for countries in the Asia-Pacific ***: Statistical information about breast cancer was obtained from publicly available cancer registry and mortality databases(such as GLOBOCAN), and supplemented with data requested from individual cancer registries. Rates were directly age-standardised to the Segi World Standard population and trends were analysed using joinpoint ***: Breast cancer was the most common type of cancer among females in the region, accounting for 18% of all cases in 2012, and was the fourth most common cause of cancer-related deaths(9%). Although incidence rates remain much higher in New Zealand and Australia, rapid rises in recent years were observed in several Asian countries. Large increases in breast cancer mortality rates also occurred in many areas, particularly Malaysia and Thailand, in contrast to stabilising trends in Hong Kong and Singapore, while decreases have been recorded in Australia and New Zealand. Mortality trends tended to be more favourable for women aged under 50 compared to those who were 50 years or older. Conclusion: It is anticipated that incidence rates of breast cancer in developing countries throughout the Asia-Pacific region will continue to increase. Early detection and access to optimal treatment are the keys to reducing breast cancerrelated mortality, but cultural and economic obstacles persist. Consequently, the challenge is to customise breast cancer control initiatives to the particular needs of each country to ensure the best possible outcomes.

关键词： Asia-Pacific region female breast cancer epidemiology incidence mortality

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LINKING SEDIMENT EXPOSURE WITH EFFECTS: MODELING TECHNIQUES, ORGANIC AVAILABILITY AND UPTAKE

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International Journal of Sediment Research 2003年第2期 208-213页

作者： Xiaoxia LU ,danny REIBLE Hazardous Substance Research Center/S&SW Louisiana State University Baton Rouge LA 70803

The release or degradation of organic contaminants in soils and sediments often shows a period of relatively rapid change followed by a period of slow or no change due to limited desorption rates or extent. This desorption-resistance has been attributed to sequestration of the contaminants in the soil or sediment matrix. Studies have suggested that this sequestration may be associated with the nature of the sorbing media or due to conformational or other changes of the contaminants in the media. Regardless of the cause, however, desorption-resistance may influence the extent or rate of uptake of contaminants into receptor organisms. Deposit-feeding benthic worms represent an intense sediment-processing environment that can contribute significantly to the transport of contaminants from sediments to the overlying water and the food chain. This paper will focus on the availability of the desorption-resistant organic contaminants to benthic worms. The research to-date suggested that desorption-resistance might reduce but not eliminate contaminant uptake and accumulation, and the decrease in the availability was proportional to the reduction in the pore water concentration for a given compound. A model using the sediment-water partition coefficient to predict uptake was applied to describe the accumulation data for several organic contaminants. The results of this study suggested that a less conservative sediment quality criterion might be established in risk assessment and sediment remediation

关键词： Sediment exposure Desorption resistance Organic contaminants Bioavailability

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大学英语视听说教程 3

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丛书名：大学英语立体化网络化系列教材

2012年

作者： danny Yu总

本书是与大学英语教程配套的听说教程，为教师教学提供参考，可以有针对性地加强培养学生的实用听说能力。本书为3。

ISBN: (纸本)9787301182055

本书是与大学英语教程配套的听说教程，为教师教学提供参考，可以有针对性地加强培养学生的实用听说能力。本书为3。

关键词：听说教学

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Bacillus subtilis produces(p)ppGpp in response to the bacteriostatic antibiotic chloramphenicol to prevent its potential bactericidal effect

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mLife 2022年第2期1卷 101-113页

作者： Jin Yang Jessica T.Barra danny K.Fung Jue D.Wang Department of Bacteriology University of WisconsinMadisonUSA

Antibiotics combat bacteria through their bacteriostatic(by growth inhibition)or bactericidal(by killing bacteria)***,it has been proposed that bactericidal antibiotics trigger cellular damage,while bacteriostatic antibiotics suppress cellular ***,we demonstrate how the difference between bacteriostatic and bactericidal activities of the antibiotic chloramphenicol can be attributed to an antibiotic-induced bacterial protective response:the stringent *** targets the ribosome to inhibit the growth of the Gram-positive bacterium Bacillus ***,we found that chloramphenicol becomes bactericidal in *** mutants unable to produce(p)*** observed a similar(p)ppGpp-dependent bactericidal effect of chloramphenicol in the Gram-positive pathogen Enterococcus *** ***,chloramphenicol treatment induces(p)ppGpp accumulation through the action of the(p)ppGpp synthetase RelA.(p)ppGpp subsequently depletes the intracellular concentration of GTP and antagonizes GTP *** GTP regulation is critical for preventing chloramphenicol from killing ***,as bypassing(p)ppGpp-dependent GTP regulation potentiates chloramphenicol killing,while reducing GTP synthesis increases ***,chloramphenicol treatment protects cells from the classical bactericidal antibiotic vancomycin,reminiscent of the clinical phenomenon of antibiotic *** together,our findings suggest a role of(p)ppGpp in the control of the bacteriostatic and bactericidal activity of antibiotics in Gram-positive bacteria,which can be exploited to potentiate the efficacy of existing antibiotics.

关键词： antibiotic tolerance bactericidal antibiotic bacteriostatic antibiotic GTP (p)ppGpp

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