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Pre-osteoblastic MC3T3-E1 cells promote breast cancer growth in bone in a murine xenograft model

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Chinese j.urnal of Cancer 2011年第3期30卷 189-196页

作者： Thomas M. Bodenstine Benj.min H. Beck Xuemei Cao Leah M. Cook Aimen Ismail j. Kent Powers Andrea M. Mastro danny R. Welch Department of Pathology University of Alabama at Birmingham Birmingham AL 35294 USA National Foundation for Cancer Research-Center for Metastasis Research University of Alabama at Birmingham Birmingham AL 35294 USA Department of Biochemistry and Molecular Biology Pennsylvania State University University Park PA 16802 USA Department of Pharmacology/ Toxicology University of Alabama at Birmingham Birmingham AL 35294 USA Cell Biology University of Alabama at Birmingham Birmingham AL 35294 USA Comprehensive Cancer Center University of Alabama at Birmingham Birmingham AL 35294 USA Center for Metabolic Bone Disease University of Alabama at Birmingham Birmingham AL 35294 USA.

The bones are the most common sites of breast cancer metastasis. Upon arrival within the bone microenvironment, breast cancer cells coordinate the activities of stromal cells, resulting in an increase in osteoclast activity and bone matrix degradation. In late stages of bone metastasis, breast cancer cells induce apoptosis in osteoblasts, which further exacerbates bone loss. However, in early stages, breast cancer cells induce osteoblasts to secrete inflammatory cytokines purported to drive tumor progression. To more thoroughly evaluate the role of osteoblasts in early stages of breast cancer metastasis to the bones, we used green fluorescent protein-labeled human breast cancer cell lines MDA-MB-231 and MDA-MB-435, which both induce osteolysis after intra-femoral inj.ction in athymic mice, and the murine pre-osteoblastic cell line MC3T3-E1 to modulate osteoblast populations at the sites of breast cancer metastasis. Breast cancer cells were inj.cted directly into the femur with or without equal numbers of MC3T3-E1 cells. Tumors grew significantly larger when co-inj.cted with breast cancer cells and MC3T3-E1 cells than inj.cted with breast cancer cells alone. Osteolysis was induced in both groups, indicating that MC3T3-E1 cells did not block the ability of breast cancer cells to cause bone destruction. MC3T3-E1 cells promoted tumor growth out of the bone into the extraosseous stroma. These data suggest that breast cancer cells and osteoblasts communicate during early stages of bone metastasis and promote tumor growth.

关键词：乳腺癌细胞成骨细胞肿瘤生长小鼠绿色荧光蛋白标记模型移植早期阶段

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音乐表演速度分析的意义与理论

中央音乐学院学报 2023年第1期 43-53页

作者：周全中央音乐学院音乐学系

一直以来,乐谱都是音乐分析的基础,基于乐谱的分析是音乐学者解读作曲家意图和解释作品结构的主要途径。然而,许多近期的研究发现,乐谱中的记号与实际演奏中发出的声音相差甚远,导致传统的音乐分析不能够全面、完整地解释音乐的内容和... 详细信息

一直以来,乐谱都是音乐分析的基础,基于乐谱的分析是音乐学者解读作曲家意图和解释作品结构的主要途径。然而,许多近期的研究发现,乐谱中的记号与实际演奏中发出的声音相差甚远,导致传统的音乐分析不能够全面、完整地解释音乐的内容和结构。诸多例子表明,速度在对音乐结构的分析中发挥着重要的作用。因此,在音乐分析的过程中,应该纳入更多表演特征的分析,尤其是对于速度的分析。音乐学者需要一套关于速度分析的理论框架,以便更全面、深入地分析演奏中的速度和速度变化。这套框架可以为音乐分析提供更有效的方法和更扎实的理论基础。

关键词：音乐表演研究表演理论速度分析音乐结构

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AntVis:A web-based visual analytics tool for exploring ant movement data

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Visual Informatics 2020年第1期4卷 58-70页

作者： Tianxiao Hu Hao Zheng Chen Liang Sirou Zhu Natalie Imirzian Yizhe Zhang Chaoli Wang David P.Hughes danny Z.Chen Facebook Inc.Menlo ParkCA 94025United States University of Notre Dame Notre DameIN 46556United States Carnegie Mellon University PittsburghPA 15213United States Pennsylvania State University University ParkPA 16802United States

We present AntVis,a web-based visual analytics tool for exploring ant movement data collected from the video recording of ants moving on tree *** goal is to enable domain experts to visually explore massive ant movement data and gain valuable insights via effective visualization,filtering,and *** is achieved through a deep learning framework for automatic detection,segmentation,and labeling of ants,ant movement clustering based on their trace similarity,and the design and development of five coordinated views(the movement,similarity,timeline,statistical,and attribute views)for user interaction and *** demonstrate the effectiveness of AntVis with several case studies developed in close collaboration with domain ***,we report the expert evaluation conducted by an entomologist and point out future directions of this study.

关键词： Ant movement Obj.ct detection Image segmentation Visual analytics Knowledge discovery

Serum Mac-2 binding protein glycosylation isomer level predicts hepatocellular carcinoma development in E-negative chronic hepatitis B patients

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World j.urnal of Gastroenterology 2019年第11期25卷 1398-1408页

作者： Lung-Yi Mak Wai-Pan To danny Ka-Ho Wong j.mes Fung Fen Liu Wai-Kay Seto Ching-Lung Lai Man-Fung Yuen Department of Medicine Queen Mary Hospital Department of Medicine The University of Hong Kong State Key Laboratory for Liver Research The University of Hong Kong

BACKGROUND Liver cirrhosis is a maj.r risk factor for hepatocellular carcinoma(HCC)development in chronic hepatitis B(CHB). Serum Mac-2 binding protein glycosylation isomer(M2 BPGi) is a novel serological marker for fibrosis. The role of M2 BPGi in prediction of HCC is *** To examine the role of serum M2 BPGi in predicting HCC development in hepatitis B e antigen(HBeAg)-negative *** Treatment-naive CHB patients with documented spontaneous HBeAg seroconversion were recruited. Serum M2 BPGi was measured at baseline(within3 years from HBeAg seroconversion), at 5 years and 10 years after HBeAg seroconversion and expressed as cut-off index(COI). Multivariate cox regression was performed to identify predictors for HCC development. ROC analysis was used to determine the cut-off value of M2 *** Among 207 patients(57% male, median age at HBeAg seroconversion 40 years old) with median follow-up of 13.1(11.8-15.5) years, the cumulative incidence of HCC at 15 years was 7%. Median M2 BPGi levels were significantly higher in patients with HCC compared to those without HCC(baseline: 1.39 COI vs 0.38 COI, P < 0.001; 5-year: 1.45 COI vs 0.47 COI, P < 0.001; 10-year: 1.20 COI vs 0.55 COI, P = 0.001). Multivariate analysis revealed age at HBeAg seroconversion[odds ratio(OR) = 1.196, 95% confidence interval(CI): 1.034-1.382, P = 0.016] and baseline M2 BPGi(OR = 4.666, 95%CI: 1.296-16.802, P = 0.018) were significant factors predictive of HCC. Using a cut-off value of 0.68 COI, baseline M2 BPGi yielded AUROC of 0.883 with 91.7% sensitivity and 80.8% *** High serum M2 BPGi within 3 years after HBeAg seroconversion was a strong predictor for subsequent HCC development in treatment-naive HBeAg-negative CHB patients.

关键词： Hepatocellular carcinoma Hepatitis B Liver fibrosis Mac-2 binding protein glycosylation isomer Biomarker

Morphometric Comparison of White Tambaqui （Piaractus brachypomus） in Lentic and Lotic Environments

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j.urnal of Environmental Science and Engineering(A) 2013年第8期2卷 520-522页

作者： danny Villegas Rivas Tonny Garcia Ruj.no Agriculrural Science Program and Sea UNELLEZ Guanare Portuguesa 3350 Venezuela Decanate of Agronomy UCLA Barquisimeto Lara 3023 Venezuela

The purpose of this paper is looking for associations between environmental factors and morphological parameters in tambaqui （Piaractus brachypomus） individuals to differentiate this species in lentic environments （lake） and lotic （river）. In this, regard studied 30 specimens, 15 from lentic environment （lake） and 15 from lotic （river）. Also, on right profile of these 25 morphometric variables were measured. On data matrix a PCA （principal components analysis） based on morphometric correlations matrix, which was defined in the new morphologic space of these specimens （3 principal components） which explain 73.23% of variability. Fish proj.ction in first two principal components showed a morphological differentiation between two environments （lentic and lotic）, with variables as, horizontal eye diameter, length maxilla, suggesting greater response of these fish in lotic environment by their adaptation to light conditions, predators threat and food distribution. Finally, in lotic environment these fish have thinner caudal peduncle, indicating greater plasticity, namely stylized fish.

关键词： Morphometric comparison tambaqui environments and principal components.

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开口就会旅游英语

An Algorithm for Optimal Firewall Placement in IEC61850 Substations

2013年

作者：黄静悦 danny O. Neal

本书共分为：基本对话；机场与飞机；入境；住宿；交通；餐饮；观光；购物；邮电；银行；麻烦事；回国几部分，主要内容包括：打招呼及问候、道别等。

ISBN: (数字)9787562834588

ISBN: (纸本)9787562834588

关键词：旅游口语英语

来源：畅想之星图书光盘版（南... 评论

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j.urnal of Power and Energy Engineering 2015年第4期3卷 16-22页

作者： Hermes Eslava Luis Alej.ndro Roj.s danny Pineda Universidad Distrital Bogotá Colombia Openlink Sistemas De Redes De Datos S.A.S Bogotá Colombia

Recently, most electric power substations have adopted production control systems, such as SCADA systems, which communicate with field devices and remotely control processes from a computer screen. However, these systems together with protection measures and additional control actions (using protocol IEC61850) seem not to be enough to free substations of security attacks (e.g. virus, intruders, forgery or unauthorized data manipulation). This paper analyzes the main features of an electric power substation together with the aspects that might be significantly affected by cyber-attacks. The paper also presents the implementation of a specific security system (i.e. firewall-wise system) intended to protect a target distribution network.

关键词： Firewall Security Substations Electric Power IEC61850

代谢相关药物对3T3-L1脂肪细胞促酰化蛋白分泌的影响

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细胞与分子免疫学杂志 2012年第10期28卷 1051-1054页

作者：高颖 Katherine Cianflone danny Gauvreau Wei Cui 马依彤新疆医科大学第一附属医院心脏中心新疆乌鲁木齐830011 Centre de Recherche Institut Universitaire de Cardiologie et dePneumologie de Quebec(CRIUCPQ) Laval UniversityQuebecQuebecCanada

目的:建立使用3T3-L1脂肪细胞评价药物影响促酰化蛋白(ASP)分泌的细胞模型和测定ASP分泌的ELISA方法,观察代谢相关药物二甲双胍、罗格列酮钠及立莫那班对ASP分泌的影响及机制,以及与补体C3、非酯化脂肪酸(NE-FA)释放、甘油三酯总量(TG m... 详细信息

目的:建立使用3T3-L1脂肪细胞评价药物影响促酰化蛋白(ASP)分泌的细胞模型和测定ASP分泌的ELISA方法,观察代谢相关药物二甲双胍、罗格列酮钠及立莫那班对ASP分泌的影响及机制,以及与补体C3、非酯化脂肪酸(NE-FA)释放、甘油三酯总量(TG mass)、脂肪酸摄取量的关系。方法:以3T3-L1前脂肪细胞为实验对象,诱导细胞分化,分别加入乳糜微粒、二甲双胍、罗格列酮钠及立莫那班作用48 h。采用ELISA法测定ASP、C3含量,使用酶标比色法测定NEFA含量,脂肪细胞FA摄取速度在荧光酶标仪进行动力学方法测量,采用分光光度法测定TG含量,考马斯亮蓝染料结合法测定细胞总蛋白。结果:乳糜微粒刺激ASP分泌(达411%±133%P<0.05);罗格列酮钠和立莫那班抑制ASP产生(-53%～-85%,P<0.05),同时抑制前体蛋白C3分泌(-37%～-65%,P<0.05);二甲双胍抑制ASP分泌(-54%～-100%,P<0.05),对前体蛋白C3分泌无影响;二甲双胍降低TG含量(达-60%,P<0.05)和FA摄取速度(达-75%,P<0.05)。结论:成功建立了评价药物影响促酰化蛋白(ASP)分泌的3T3-L1前脂肪细胞模型,并建立了测定ASP分泌的ELISA方法。

关键词： 3T3-L1脂肪细胞促酰化蛋白药物

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Q Fever in Pregnancy—Case Presentation and Literature Review

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International j.urnal of Clinical Medicine 2013年第8期4卷 364-368页

作者： Kugler Eitan Amital Howard Alon danny Rabin Medical Center Beilinson Hospital Department of Medicine B Petah Tikva Israel Rabin Medical Center Beilinson Hospital Department of Medicine F Petah Tikva Israel Sheba Medical Center Department of Medicine B Tel Hashomer Israel

Q fever is a widespread zoonotic infection caused by Coxiella burnetii. During acute infection, three clinical patterns are commonly encountered—self limited, flu like disease, atypical pneumonia or hepatits. Chronic infection almost always implies endocarditis. Acute infection during pregnancy may result in obstetrical complications, and predispose to chronic transformation. Treatment during pregnancy is more complex, and the duration of treatment was debatable up until recently. We describe a 31 years old patient with acute Q fever infection during pregnancy. We review the medical treatment, complications and follow up of acute and chronic Q fever during pregnancy.

关键词： Q Fever Coxiella burnetii Pregnancy