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Impact of climate change on outdoor design conditions and implications to peak loads

Building Simulation 2022年第12期15卷 2051-2065页

作者： Xujie Huo liu Yang danny hin wa li Isaac Lun Siwei Lou Yuan Shi School of Architecture&Urban Planning Shenzhen UniversityShenzhen 518060China BenYuan Design and Research Center Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Architecture for Health&Well-being(in preparation) Shenzhen 518060China School of Architecture Xi’an University of Architecture and TechnologyXi’an 710055China Building Energy Research Group Department of Architecture and Civil EngineeringCity University of Hong KongHong KongChina Centre for Sustainable Energy Technologies University of Nottingham Ningbo ChinaNingbo 315100China School of Civil Engineering Guangzhou UniversityGuangzhou 510006China

This study exams the impact of climate change on outdoor design conditions and peak loads of five Chinese cities over the five major climate zones for the winter and summer *** design dry-bulb temperature(DDBT)and the coincident wet-bulb temperature(CWBT)for two 30-year periods;1971–2000 and 1984–2013 were *** was found that the DDBT of the period 1984–2013 was higher than that of the period 1971–2000,whereas the CWBT and the corresponding outdoor enthalpy of the period 1984–2013 was lower than that of 1971–2000 at the various cumulative *** trend implies that the increment in conductive heat gain through the building envelope due to the rising temperature can be lower than the reduction in fresh air load due to the lower outdoor air *** this case,the peak cooling loads may reduce in all five cities under study,and this is different from the widely held view that global warming will lead to more stringent outdoor design conditions,higher peak cooling loads and larger heating,ventilation and air conditioning(HVAC)plants than the current or historical *** implications to the“free-cooling”of HVAC systems with enthalpy control are discussed as well.

关键词： outdoor design conditions outdoor air enthalpy climate change peak loads

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MOF-mediated synthesis of novel PtFeCoNiMn high-entropy nanoalloy as bifunctional oxygen electrocatalysts for zinc-air battery

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Nano Research 2024年第6期17卷 5288-5297页

作者： Mingkuan Xie Xin Xiao Duojie Wu Cheng Zhen Chunsheng Wu Wenjuan wang Hao Nian Fayan li Meng danny Gu Qiang Xu Shenzhen Key Laboratory of Micro/Nano-Porous Functional Materials(SKLPM) Shenzhen 518055China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China SUSTech-Kyoto University Advanced Energy Materials Joint Innovation Laboratory(SKAEM-JIL) Shenzhen 518055China Key University Laboratory of Highly Efficient Utilization of Solar Energy and Sustainable Development of Guangdong Southern University of Science and TechnologyShenzhen 518055China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingbo 315200China

High-entropy alloy(HEA)-based materials are expected to be promising oxygen electrocatalysts due to their exceptional *** electronic structure regulation of HEAs plays a pivotal role in enhancing their elctrocatalytic ***,PtFeCoNiMn nanoparticles(NPs)with subtle lattice distortions are constructed on metal-organic framework-derived nitrogen-doped carbon by an ultra-rapid Joule heating *** to the modulated electronic structure and the inherent cocktail effect of HEAs,the as-synthesized PtFeCoNiMn/NC exhibits superior bifunctional electrocatalytic performance with a positive half-wave potential of 0.863 V *** hydrogen electrode(RHE)for oxygen reduction reaction and a low overpotential of 357 mV at 10 mA·cm^(-2)for oxygen evolution *** assembled quasi-solid-state zinc-air battery using PtFeCoNiMn/NC as air electrode shows a high peak power density of 192.16 mW·cm^(-2),low charge−discharge voltage gap,and excellent durability over 500 cycles at 5 mA·cm^(-2).This work demonstrates an effective route for rational design of bifunctional nanostructured HEA electrocatalysts with favorable electronic structures,and opens up a fascinating directions for energy storage and conversion,and beyond.

关键词： oxygen reduction reaction oxygen evolution reaction high-entropy nano-alloy zinc-air battery

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Efficient C-N coupling in electrocatalytic urea generation on copper carbonate hydroxide electrocatalysts

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Journal of Energy Chemistry 2024年第6期93卷 289-298,I0008页

作者： Yinuo wang Yian wang Qinglan Zhao Hongming Xu Shangqian Zhu Fei Yang Ernest P.Delmo Xiaoyi Qiu Chi Song Juhee Jang Tiehuai li Ping Gao Mdanny Gu Minhua Shao Advanced Materials Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400GuangdongChina Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Department of Materials Science and Engineering Southern University of Science and Technology of Chin11088 Xueyuan BoulevardShenzhen 518055GuangdongChina Energy Institute and Chinese National Engineering Research Center for Control&Treatment of Heavy Metal PollutionThe Hong Kong University of Science and TechnologyKowloonHong KongChina Department of Chemistry City University of Hong KongTat Chee AvenueKowloonHong KongChina

Urea generation through electrochemical CO_(2) and NO_(3)~-co-reduction reaction(CO_(2)NO_(3)RR)is still limited by either the low selectivity or yield rate of ***,we report copper carbonate hydroxide(Cu_2(OH)_2CO_(3))as an efficient CO_(2)NO_(3)RR electrocatalyst with an impressive urea Faradaic efficiency of45.2%±2.1%and a high yield rate of 1564.5±145.2μg h~(-1)mg_(cat)~(-1).More importantly,H_(2) evolution is fully inhibited on this electrocatalyst over a wide potential range between-0.3 and-0.8 V versus reversible hydrogen *** thermodynamic simulation reveals that the first C-N coupling follows a unique pathway on Cu_2(OH)_2CO_(3) by combining the two intermediates,~*COOH and~**** work demonstrates that high selectivity and yield rate of urea can be simultaneously achieved on simple Cu-based electrocatalysts in CO_(2)NO_(3)RR,and provide guidance for rational design of more advanced catalysts.

关键词： Copper carbonate hydroxide Co-reduction Urea generation C-N coupling DFT calculation

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The effects of hydrogen bonding on the shear viscosity of liquid water

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International Journal of Sediment Research 2019年第1期34卷 8-13页

作者： Hongwei Fang Ke Ni Jian Wu Jun li Lei Huang danny Reible State Key Laboratory of Hydro-science and Engineering Department of Hydraulic EngineeringTsinghua University State Key Laboratory of Low-Dimensional Quantum Physics Department of PhysicsTsinghua University Key Laboratory of Organic Optoelectronics and Molecular Engineering of Ministry of Education Department of ChemistryTsinghua University Department of Civil & Environmental Engineering Texas Tech University

As one of the fundamental physical properties of fluids, viscosity is considered to be the result of intermolecular forces and molecular momentum exchange. In this paper, we assume that hydrogen bonds, as the dominant intermolecular force, dominate the shear viscosity of liquid water and a relationship between the shear viscosity and hydrogen bonding is developed using dimensional analysis,which is further validated by computational chemistry methods. water, methanol and ethanol are taken as examples to illustrate shear viscosity accounting for intermolecular forces and momentum exchange and their temperature dependence as a result of molecular thermal motions. The calculated shear viscosity of water is consistent with experimental data, which supports the idea that we can use the conceptual model to reveal the nature of shear viscosity.

关键词： Viscosity Hydrogen bonding liquid water Dimensional analysis

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Facile synthesis of insulin fusion derivatives through sortase A ligation

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2719-2725页

作者： Maria M.Disotuar Jake A.Smith Jinze li Steve Alam Nai-Pin lin danny Hung-Chieh Chou Department of Biochemistry School of MedicineUniversity of UtahSalt Lake CityUT 84112USA Division of Endocrinology and Diabetes Department of PediatricsSchool of MedicineStanford UniversityPalo AltoCA 94305USA

Insulin derivatives such as insulin detemir and insulin degludec are *** and Drug Administration(FDA)-approved long-acting insulin currently used by millions of people with *** derivatives are modified in C-terminal B29 lysine to retain insulin *** and efficient methods for facile synthesis of insulin derivatives may lead to new discovery of therapeutic ***,we report a new method using sortase A(SrtA)-mediated ligation for the synthesis of insulin derivatives with high efficiency and functional group tolerance in the C-terminal B *** new insulin molecule(Ins-SA) with an SrtA-recognizing motif can be conjugated to diverse groups with N-terminal oligoglycines to generate new insulin *** further demonstrated that a new insulin derivative synthesized by this SrtA-mediated ligation shows strong cellular and in vivo *** enzymatic method can therefore be used for future insulin design and development.

关键词： Diabetes mellitus Insulin synthesis Sortase A(SrtA)ligation Albumin-binding peptide SA21 Long-acting insulin

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Bevacizumab for neovascular age-related macular degeneration in Chinese patients in a clinical setting

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 424-430页

作者： danny Siu-Chun Ng Alvin Kwan-Ho Kwok Justin Man-Kit Tong Clement wai-Nang Chan walton wai-Tat li Department of Ophthalmology & Visual Sciences the Chinese University of Hong Kong Department of Ophthalmology Hong Kong Sanatorium and Hospital Department of Ophthalmology United Christian Hospital

AIM：To determine the outcome of non-investigational treatment with intravitreal bevacizumab（IVB） in neovascular age-related macular degeneration（AMD）patients.· METHODS：Retrospective chart review of 81 eyes with neovascular AMD followed-up for at least 12 mo and received 3-monthly loading IVB ***-treat was based upon the individual clinician＇s *** visual acuity（BCVA） and optical coherence tomography measurements of central foveal thickness outcomes were evaluated at 12,24 mo.· RESULTS：Eighty-one eyes（of 75 patients） completed12 mo of follow-up and 44 eyes（of 41 patients） completed24 mo of *** mean baseline logMAR BCVA significantly improved from 0.94±0.69 to 0.85±0.68 at12mo（P〈0.001） and from 0.91±0.65 to 0.85±0.60（P=0.004）at 24 *** proportion of eyes that lost 〈15 logMAR letters at 12 mo was 90.1%and at 24 mo was 81.8%.IVB was effective in improving visual acuity in both treatment naive and previous photodynamic therapy（PDT）-treated *** naive patients required significantly fewer injections than patients with prior *** regression analysis identified that poorer baseline visual acuity was associated with greater improvement in visual acuity（P=0.015）.· CONCLUSION：Fewer injections in clinical practice may result in suboptimal visual outcomes compared with clinical trials of IVB in neovascular AMD *** baseline visual acuity and prior PDT treatment may also improve vision after *** safety and durability of effect was maintained at 24 mo.

关键词： bcvacizumab age-related maculardegeneration Chinese

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Mechanistic-empirical pavement design guide(MEPDG):a bird's-eye view

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Journal of Modern Transportation 2011年第2期19卷 114-133页

作者： Qiang li danny X. XIAO Kelvin C. P. waNG Kevin D. HALL Yanjun QIU Department of Civil and Environmental Engineering University of Delaware Newark DE 19 711 USA Department of Civil Engineering University of Arkansas Fayetteville AR 72701 USA School of Civil Engineering Southwest Jiaotong University Chengdu 610031 China

Past editions of the American Association of State Highway and Transportation Officials （AASHTO） Guide for Design of Pavement Structures have served well for several decades; nevertheless, many serious limitations exist for their continued use as the nation＇s primary pavement design procedures. Researchers are now incorporating the latest advances in pavement design into the new Mechanistic-Empirical Pavement Design Guide （MEPDG）, developed under the National Cooperative Highway Research Program （NCHRP） 1-37A project and adopted and published by AASHTO. The MEPDG procedure offers several dramatic improvements over the current pavement design guide and presents a new paradigm in the way pavement design is performed. However, MEPDG is substantially more complex than the AASHTO Design Guide by considering the input parameters that influence pavement performance, including traffic, climate, pavement structure and material properties, and applying the principles of engineering mechanics to predict critical pavement responses. It requires significantly more input from the designer. Some of the required data are either not tracked previously or are stored in locations not familiar to designers, and many data sets need to be preprocessed for use in the MEPDG. As a result, tremendous research work has been conducted and still more challenges need to be tackled both in federal and state levels for the full implementation of MEPDG. This paper, for the first time, provides a comprehensive bird＇s eye view for the MEPDG procedure, including the evolvement of the design methodology, an overview of the design philosophy and its components, the research conducted during the development, improvement, and implementation phases, and the challenges remained and future developments directions. It is anticipated that the efforts in this paper aid in enhancing the mechanistic-empirical based pavement design for future continuous improvement to keep up with changes in trucking, materials, c

关键词： design of pavement structures mechanistic-empirical pavement design guide (MEPDG) local calibration implementation challenges

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Traditional Chinese herbal medicine Astragalus Radix and its effects on intestinal absorption of aconite alkaloids in rats

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Chinese Herbal Medicines 2021年第2期13卷 235-242页

作者： Xin-li liang Miao-miao Ji Lai Chen Ye liao Xiao-qiang Kong Xi-qiang Xu Zheng-gen liao danny W.Wilson Key Laboratory of Modern Preparation of Chinese Meteria Medica Ministry of EducationJiangxi University of Traditional Chinese MedicineNanchang 330004China Laboratory of Animal Research Center for Science and Technology Jiangxi University of Traditional Chinese MedicineNanchang 210023China Shengjing Hospital of China Medical University Shenyang 110122China Research Centre for Infectious Diseases(RCID) University of AdelaideAdelaide SA5005Australia

Objective:Astragalus Radix(AR,Huangqi in Chinese) has been widely used as a qi(energy) restoring herb that is thought to act through reinvigorating the spleen and *** is used to rebalance the body temperature during illness and played an irreplaceable role in disease control since ancient times,but it is limited by its strong neuro and *** the Song Dynasty(1227),the two herbs have been commonly used as herbal pairs including in the famous Qifu Decotion,from the "Wei's Family Prescription".However,many ancient texts also record that they are not compatible using together,suggesting they can have negative outcomes when *** study investigated whether Astragali Radix had either positive or negative effects on absorption of six different active alkaloids derived from ***:Single intestinal perfusion model was used to study the effects of Astragali Radix on aconite alkaloids *** of ABC transporters and distribution of three tight junction proteins on the surface of intestinal enothelium were assessed by Reverse Transcription-Polymerase Chain Reaction(RT-PCR),Western blot and immunofluorescence microscopy,***:The results showed that aconite alkaloids absorption could be inhibited,and different concentrations of Astragali Radix considerably increased the expression levels of the ABC transporters and tight junction proteins with Astragali Radix ***:These results suggest that Astragali Radix can block absorption of aconite alkaloids through the upregulation expression of ATP-binding cassette transporters(ABC transporters) and tight junction *** demonstrates that co-administration of Astragali Radix with other drugs might change the absorption profile of the second drug which is important to know in clinic therapy.

关键词： ABC transporter alkaloids of aconite Astragali Radix intestinal absorption tight junction

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Percutaneous Radiofrequency Ablation of Hepatocellular Carcinoma against the Diaphragm: Is Artificial Ascites Necessary?

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Open Journal of Radiology 2014年第1期4卷 32-43页

作者： Kathleen Khong Ho Nguyen Chin-Shang li danny Cheng John P. McGahan Department of Radiology University of California Davis Sacramento USA

Purpose: To evaluate the utility of artificial ascites induction for radiofrequency ablation (RFA) of peridiaphragmatic hepatocellular carcinoma (HCC) through retrospective cohort analysis comparing characteristics and complications of peridiaphragmatic HCC without the use of artificial ascites to non-peridiaphragmatic HCC. Materials and Methods: IRB approval was obtained. From September 2003 to December 2008, 150 consecutive patients with hepatic tumors received percutaneous RFA. 110 patients had presumed HCC, and of those 21 had lesions abutting the diaphragm. Of the remaining 89 patients with non-peridiaphragmatic HCC lesions, 21 were randomly selected for the comparison group. RFA volume, major and minor complication rates, pain, technical success, and recurrence rates were compared between the two groups. Results: There was no statistical difference in RFA volume (P = 0.962), overall major complication rate (P = 0.343) and minor complication rate (P = 0.118) between the two groups. However, the peridiaphragmatic group that underwent RFA with a clustered-needle demonstrated a statistically significant higher proportion of major complications compared to the non-peridiaphragmatic clustered-needle group (P = 0.033). There was no statistical difference in pain severity (P = 0.8802) or pain location (P = 0.15). There was no statistical difference in technical success rates (P = 1), local tumor progression rates (P = 1), or time to local tumor recurrence (P = 0.67). Conclusion: Artificial ascites induction for RFA of HCC lesions adjacent to the diaphragm may not be necessary, although clustered electrode technique should be avoided in this location as they present with a higher complication rate.

关键词： Radiofrequency Ablation Hepatocellular Carcinoma Hepatoma Artificial Ascites Diaphragm

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A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration

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Bioactive Materials 2022年第3期7卷 281-298页

作者： Peng Guo Xizhe liu Penghui Zhang Zhongyuan He Zhen li Mauro Alini RGeoff Richards Sibylle Grad Martin J.Stoddart Guangqian Zhou Xuenong Zou danny Chan Wei Tian Dafu Chen Manman Gao Zhiyu Zhou Shaoyu liu Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury Department of Orthopaedic SurgeryThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenChina Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina AO Research Institute Davos DavosSwitzerland Shenzhen Key Laboratory of Anti-aging and Regenerative Medicine Department of Medical Cell Biology and GeneticsHealth Sciences CenterShenzhen UniversityShenzhenChina School of Biomedical Sciences LKS Faculty of MedicineThe University of Hong KongHong Kong SARChina Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing JiShuiTan HospitalBeijingChina Department of Sport Medicine Inst Translat MedThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhenChina

The osteogenic microenvironment of bone-repairing materials plays a key role in accelerating bone regeneration but remains incompletely defined,which significantly limits the application of such bioactive ***,the transcriptional landscapes of different osteogenic microenvironments,including three-dimensional(3D)hydroxyapatite(HA)scaffolds and osteogenic medium(OM),for mesenchymal stromal cells(MSCs)in vitro were mapped at single-cell *** findings suggested that an osteogenic process reminiscent of endochondral ossification occurred in HA scaffolds through sequential activation of osteogenic-related signaling pathways,along with inflammation and angiogenesis,but inhibition of adipogenesis and ***,we revealed the mechanism during OM-mediated osteogenesis involves the ZBTB16 and WNT signaling *** of MSCs was also *** vitro ossification of LRRC75A+MSCs was shown to have better utilization of WNT-related ossification process,and PCDH10+MSCs with superiority in hydroxyapatite-related osteogenic *** findings provided further understanding of the cellular activity modulated by OM conditions and HA scaffolds,providing new insights for the improvement of osteogenic *** atlas provides a blueprint for research on MSC heterogeneity and the osteogenic microenvironment of HA scaffolds and a database reference for the application of bioactive materials for bone regeneration.

关键词： inflammation bioactive finding

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