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Alternate day fasting aggravates atherosclerosis through the suppression of hepatic ATF3 in Apoe^(-/-)mice

Life Metabolism 2024年第3期3卷 46-59页

作者： Yajuan Deng Xiaoyu Yang Xueru Ye youwen Yuan Yanan Zhang Fei Teng danming you Xuan Zhou Wenhui Liu Kangli Li Shenjian Luo Zhi Yang Ruxin Chen Guojun Shi Jin Li Huijie Zhang Department of Endocrinology and Metabolism Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Guangdong Provincial Key Laboratory of Shock and Microcirculation Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China State Key Laboratory of Organ Failure Research National Clinical Research Center for Kidney DiseaseNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Endocrinology The Second Hospital of Shanxi Medical UniversityShanxi Medical UniversityTaiyuanShanxi 030001China Department of Endocrinology and Metabolism Guangdong Provincial Key Laboratory of DiabetologyThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China

Atherosclerosis is the major contributor to cardiovascular mortality *** day fasting(ADF)has gained growing attention due to its metabolic ***,the effects of ADF on atherosclerotic plaque formation remain inconsistent and controversial in atherosclerotic animal *** present study was designed to investigate the effects of ADF on atherosclerosis in apolipoprotein E-deficient(Apoe^(-/-))***-week-old male Apoe^(-/-)mice fed with Western diet(WD)were randomly grouped into ad libitum(AL)group and ADF group,and ADF aggravated both the early and advanced atherosclerotic lesion formation,which might be due to the disturbed cholesterol profiles caused by ADF *** significantly altered cholesterol metabolism pathways and down-regulated integrated stress response(ISR)in the *** hepatic expression of activating transcription factor 3(ATF3)was suppressed in mice treated with ADF and hepatocyte-specific overexpression of Aft3 attenuated the effects of ADF on atherosclerotic plaque formation in Apoe^(-/-)***,the expression of ATF3 could be regulated by Krüppel-like factor 6(KLF6)and both the expressions of ATF3 and KLF6 were regulated by hepatic cellular ISR *** conclusion,ADF aggravates atherosclerosis progression in Apoe^(-/-)mice fed on *** inhibits the hepatic ISR signaling pathway and decreases the expression of KLF6,subsequently inhibiting ATF3 *** suppressed ATF3 expression in the liver mediates the deteriorated effects of ADF on atherosclerosis in Apoe^(-/-)*** findings suggest the potentially harmful effects when ADF intervention is applied to the population at high risk of atherosclerosis.

关键词： alternate day fasting atherosclerosis cholesterol integrated stress response activating transcription factor 3

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Cytokine receptor-like factor 1(CRLF1)promotes cardiac fibrosis via ERK1/2 signaling pathway

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第8期24卷 682-697页

作者： Shenjian LUO Zhi YANG Ruxin CHEN danming you Fei TENG youwen YUAN Wenhui LIU Jin LI Huijie ZHANG Department of Endocrinology and Metabolism Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of Shock and Microcirculation Southern Medical UniversityGuangzhou 510515China State Key Laboratory of Organ Failure Research Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Endocrinology Shanxi Medical University Affiliated Second HospitalTaiyuan 030001China

Cardiac fibrosis is a cause of morbidity and mortality in people with heart ***-fibrosis treatment is a significant therapy for heart disease,but there is still no thorough understanding of fibrotic *** study was carried out to ascertain the functions of cytokine receptor-like factor 1(CRLF1)in cardiac fibrosis and clarify its regulatory *** found that CRLF1 was expressed predominantly in cardiac *** expression was up-regulated not only in a mouse heart fibrotic model induced by myocardial infarction,but also in mouse and human cardiac fibroblasts provoked by transforming growth factor-β1(TGF-β1).Gain-and loss-of-function experiments of CRLF1 were carried out in neonatal mice cardiac fibroblasts(NMCFs)with or without TGF-β1 ***1 overexpression increased cell viability,collagen production,cell proliferation capacity,and myofibroblast transformation of NMCFs with or without TGF-β1 stimulation,while silencing of CRLF1 had the opposite *** inhibitor of the extracellular signal-regulated kinase 1/2(ERK1/2)signaling pathway and different inhibitors of TGF-β1 signaling cascades,comprising mothers against decapentaplegic homolog(SMAD)-dependent and SMAD-independent pathways,were applied to investigate the mechanisms ***1 exerted its functions by activating the ERK1/2 signaling ***,the SMAD-dependent pathway,not the SMAD-independent pathway,was responsible for CRLF1 up-regulation in NMCFs treated with TGF-β*** summary,activation of the TGF-β1/SMAD signaling pathway in cardiac fibrosis increased CRLF1 ***1 then aggravated cardiac fibrosis by activating the ERK1/2 signaling ***1 could become a novel potential target for intervention and remedy of cardiac fibrosis.

关键词： Cytokine receptor-like factor 1(CRLF1) TGF-β1/SMAD signaling pathway ERK1/2 signaling pathway Cardiac fibrosis Myofibroblast transformation Extracellular matrix(ECM)

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某铝盘地铁项目制动噪声原因分析

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城市轨道交通研究 2024年第5期27卷 110-112,117页

作者：王芬吴旦鸣中车南京浦镇车辆有限公司南京211800

[目的]某项目制动盘在制动最后停车阶段产生较大噪声,造成的环境噪声污染影响到车辆段周围住户休息及乘客乘车舒适度,故需对其噪声形成的原因进行相关分析。[方法]选取1列典型噪声车,在其转向架夹钳吊耳和闸片托上安装振动加速度传感器... 详细信息

[目的]某项目制动盘在制动最后停车阶段产生较大噪声,造成的环境噪声污染影响到车辆段周围住户休息及乘客乘车舒适度,故需对其噪声形成的原因进行相关分析。[方法]选取1列典型噪声车,在其转向架夹钳吊耳和闸片托上安装振动加速度传感器;在夹钳上安装声音传感器,对其进行试验。根据不同工况下,对不同转向架发生噪声及夹钳振动频率的关系进行分析。[结果及结论]经过检测发现:噪声制动盘在制动时产生约300 Hz的振动,振动伴随着整个噪声过程;噪声原因为制动盘与夹钳在制动时产生共振导致。解决其噪声的方法:在制动过程中充分采用电制动,以减少气制动使用,使制动噪声降低;通过闸片倒角或更换制动夹钳固定螺栓等改变制动夹钳振动频率,降低制动盘与夹钳制动的共振。

关键词：地铁:噪声共振制动盘

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肠道菌群在肿瘤免疫治疗中的新作用

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重庆医学 2020年第20期49卷 3486-3490页

作者：斯伃恬应昊轩游丹铭张健南方医科大学珠江医院肿瘤中心广州510280

共生微生物菌群的活动对人类健康有重大的影响,并与包括癌症在内的许多疾病的发展相关。无菌动物模型表明,微生物菌群可以对宿主的生理活动产生许多影响,包括免疫应答的形成和调节。最近的研究表明,微生物菌群可以对癌症免疫治疗的结果... 详细信息

共生微生物菌群的活动对人类健康有重大的影响,并与包括癌症在内的许多疾病的发展相关。无菌动物模型表明,微生物菌群可以对宿主的生理活动产生许多影响,包括免疫应答的形成和调节。最近的研究表明,微生物菌群可以对癌症免疫治疗的结果产生更特别的影响。本文就宿主微生物菌群相互作用的基本方法和注意事项,肠道微生物菌群组成与免疫治疗效果之间存在的因果关系,调控微生物菌群对免疫治疗效果影响的可能机制进行综述,并对潜在生物学机制深入的了解,将微生物菌群效应与其他参与调节免疫治疗过程的因素相结合,从而优化治疗效果。

关键词：免疫治疗肠道微生物菌群亚基因组学无菌小鼠基于微生物菌群的治疗

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不烧滑板磨削加工用Fe-Ni-Cu-Sn金属基金刚石工具的制备与性能

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材料导报 2024年第10期38卷 175-181页

作者：呼丹明段锋丁冬海李杰尹育航彭凯西安建筑科技大学材料科学与工程学院西安710055 广东奔朗新材料股份有限公司广东佛山528313

Al_(2)O_(3)-C不烧滑板作为连铸功能耐火材料在炼钢领域中受到广泛应用,而金属结合剂金刚石工具在滑板磨削加工中起到关键作用。本工作通过热压烧结法制备Fe-Ni-Cu-Sn金属基胎体和Fe-Ni-Cu-Sn金属基金刚石工具,首先研究烧结温度、保温... 详细信息

Al_(2)O_(3)-C不烧滑板作为连铸功能耐火材料在炼钢领域中受到广泛应用,而金属结合剂金刚石工具在滑板磨削加工中起到关键作用。本工作通过热压烧结法制备Fe-Ni-Cu-Sn金属基胎体和Fe-Ni-Cu-Sn金属基金刚石工具,首先研究烧结温度、保温时间和烧结压力对金刚石工具胎体力学性能的影响,获得优化的胎体烧结工艺参数并为后续制备金刚石工具奠定基础;其次研究不同的金刚石磨料对金刚石工具力学性能及磨削不烧滑板性能的影响,通过研究金刚石的浓度、粒度、品级与加工工具磨削效率、寿命及锋利度的关系,从而得到磨削加工不烧滑板的金刚石工具中金刚石磨料的优化参数,通过SEM对金刚石工具表面胎体与金刚石磨料的结合状态、金刚石的磨损情况进行表征。实验结果表明:金刚石工具胎体的最佳烧结工艺参数是烧结温度、烧结压力和保温时间分别为785℃、170 MPa、240 s;金刚石工具中的金刚石磨料最优选择为金刚石浓度25%、粒度45/50、品级SMD35。

关键词：烧结工艺金刚石磨料不烧滑板磨削性能

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Piezoelectric Nanogenerator Based on Electrospun Cellulose Acetate/Nanocellulose Crystal Composite Membranes for Energy Harvesting Application

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Chemical Research in Chinese Universities 2022年第4期38卷 1005-1011页

作者： SUN Bolun CHAO danming WANG Ce Alan G.MacDiarmid Institute Jilin UniversityChangchun130012P.R.China

Nanogenerators,as the typical conversion of mechanical energy to electrical energy devices,have great potential in the application of providing sustainable energy sources for powering miniature *** this work,cellulose acetate/cellulose nanocrystal(CA/CNC)composite nanofiber membranes were prepared by electrospinning method and then utilized to manufacture a flexible pressure-driven *** addition of CNC not only increased the content of piezoelectric cellulose I crystallization but also strengthened the mechanical deformation of the nanofiber membranes,which could greatly enhance the piezoelectric performance of CA/CNC composite *** CA/CNC composite nanofiber membrane with 20%(mass fraction)of CNC(CA/CNC-20%)showed optimal piezoelectric conversion performance with the output voltage of 1.2 V under the force of 5 N(frequency of 2 Hz).Furthermore,the output voltage of the CA/CNC-20%nanogenerator device exhibited a linear relationship with applied impact force,indicating the great potential in pressure sensors.

关键词： Piezoelectric Nanogenerator Electrospinning Cellulose acetate Nanocellulose crystal

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Interface Reversible Electric Field Regulated by Amphoteric Charged Protein-Based Coating Toward High-Rate and Robust Zn Anode

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Nano-Micro Letters 2022年第12期14卷 535-548页

作者： Meihua Zhu Qing Ran Houhou Huang Yunfei Xie Mengxiao Zhong Geyu Lu Fu-Quan Bai Xing-you Lang Xiaoteng Jia danming Chao College of Chemistry Jilin UniversityChangchun 130012People’s Republic of China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Key Laboratory of Automobile Materials Ministry of EducationSchool of Materials Science and EngineeringJilin UniversityChangchun 130022People’s Republic of China

Metallic interface engineering is a promising strategy to stabilize Zn anode via promoting Zn^(2+) uniform ***,strong interactions between the coating and Zn^(2+) and sluggish transport of Zn^(2+) lead to high anodic ***,we present a bio-inspired silk fibroin(SF)coating with amphoteric charges to construct an interface reversible electric field,which manipulates the transfer kinetics of Zn^(2+) and reduces anodic *** alternating positively and negatively charged surface as a build-in driving force can expedite and homogenize Zn^(2+) flux via the inter-play between the charged coating and adsorbed ions,endowing the Zn-SF anode with low polarization voltage and stable plating/*** analyses with theo-retical calculations suggest that SF can facilitate the desolvation of[Zn(H_(2)O)_(6)]^(2+) and provide nucleation sites for uniform ***,the Zn-SF anode delivers a high-rate performance with low voltage polarization(83 mV at 20 mA cm^(−2)) and excellent stability(1500 h at 1 mA cm^(−2);500 h at 10 mA cm^(−2)),realizing exceptional cumulative capacity of 2.5 Ah cm^(−2).The full cell coupled with Zn_(x)V_(2)O_(5)·nH_(2)O(ZnVO)cathode achieves specific energy of~270.5/150.6 Wh kg^(−1)(at 0.5/10 A g^(−1))with-99.8% Coulombic efficiency and retains~80.3%(at 5.0 A g^(−1))after 3000 cycles.

关键词： Silk fibroin coating Zn anode Amphoteric charge Interfacial engineering Aqueous zinc-ion batteries

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数字经济背景下潍坊市农业高质量发展研究

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山东纺织经济 2024年第8期41卷 15-21页

作者：李丹明刘西敏孙皓山东经贸职业学院山东潍坊261011

实现农业高质量发展是全面推进乡村振兴的重要环节,数字经济为农业高质量发展提供了新的动力源泉。为探究潍坊市农业高质量发展的提升路径,本文选取了潍坊市2015—2021年的年度数据,采用熵值TOPSIS法构建潍坊市农业高质量发展评价指标... 详细信息

实现农业高质量发展是全面推进乡村振兴的重要环节,数字经济为农业高质量发展提供了新的动力源泉。为探究潍坊市农业高质量发展的提升路径,本文选取了潍坊市2015—2021年的年度数据,采用熵值TOPSIS法构建潍坊市农业高质量发展评价指标体系。实证研究发现:农业产出效益指标对潍坊市农业高质量发展水平影响最大;农业数字化发展和农业基础设施建设能够推动潍坊市农业高质量发展;数字技术与农业产业融合还需要进一步提升;近三年,潍坊市农业高质量发展水平呈现增长趋势。基于研究结论,提出建议:优化农业科技投入,提高农业产出效益;建立农业数据共享机制,促进数字技术与农业农村深度融合;发展农村电商新模式,推动农村一二三产业融合。

关键词：数字经济农业高质量发展熵值法 TOPSIS法

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Failure mode investigation of fuel cell for vehicle application

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Frontiers in Energy 2017年第3期11卷 318-325页

作者： Zhongjun HOU Renfang WANG Keyong WANG Weiyu SHI danming XING Hongchun JIANG Sunrise Power Co. Ltd. & National Engineering Research Centre of Fuel cell and H2 Technology Dalian 116085 China

The durability of proton exchange membrane fuel cells （PEMFCs） has been posing a key technical challenge to commercial spread of fuel cell vehicles （FCVs）. To improve the durability, it is necessary to optimize the fuel cell system （FCS） design against failure modes. The fuel cell durability research method at FCS scale was exhibited, and the failure modes of fuel cell were experimentally investigated in this paper. It is found that the fuel cell dry operation, start/stop cycle and gas diffusion layer （GDL） flooding are typical failure modes of fuel cells. After the modifications against the failure modes, the durability of FCSs is improved to over 3000 h step by step.

关键词： proton exchange membrane fuel cell (PEMFC) fuel cell system (FCS) durability failure mode fuel cell vehicle (FCV) carbon corrosion water management

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Synthesis and Electrochemical Properties of a Novel Poly（ether sulfone） with Oligoaniline Pendants

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Chemical Research in Chinese Universities 2015年第6期31卷 1066-1071页

作者： LI Fangfei WANG Jiayu ZHOU Mingjuan LIU Xincai WANG Ce CHAO danming State Key Laboratory of Superhard Materials Jilin University Changchun 130012 R R. China College of Chemistry Jilin University Changchun 130012 P. R. China

A novel poly（ether sulfone） with oligoaniline pendants（PESOP） was prepared by KaCO3-mediated nucleophilic polycondensation and characterized with Fourier-transform infrared spectrometry（FTIR）, 1H nuclear magnetic resonance（1H NMR） and gel permeation chromatography（GPC）. The cyclic voltammetry（CV） curve of PESOP reveals the reversible electroactivity. In the electrochromism study, PESOP film exhibited good electroch- romic properties with a high contrast value, moderate switching time and acceptable coloration efficiency. After running 1000 cycles, the PESOP/indium-tin oxide（ITO） electrochromic device remained unchanged except for the drifting of base line, which certified its good electro-photo stability of the fabricated electrochromic device. Moreover, the polarization technique and electrochemical impedance spectroscopy（EIS） were used to study the anticorrosion performance of PESOP coatings on the cold rolled steel（CRS） in a 5%（mass fraction） NaCI solution. All the results indicate that the obtained PESOP is a competitive candidate as anticorrosion material.

关键词： Electroactive Oligoaniline Electrochromism Anticorrosion

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