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Frontiers in Energy 2014年第4期8卷 459-463页

作者： chang CHEN danmei XIE Yangheng XIONG Hengliang ZHANG School of Power and Mechanical Engineering Wuhan University Wuhan 430072 China

The operation condition of the cold-end system of a steam turbine has a direct impact on the economy and security of the unit as it is an indispensible auxiliary system of the thermal power unit. Many factors influence the cold- end operation of a steam turbine; therefore, the operation mode needs to be optimized. The optimization analysis of a 1000 MW ultra-supercritical （USC） unit, the turbine cold- end system, was performed utilizing the back propagation （BP） neural network method with genetic algorithm （GA） optimization analysis. The optimized condenser pressure under different conditions was obtained, and it turned out that the optimized parameters were of significance to the performance and economic operation of the system.

关键词： optimization turbine cold-end system BP neural network genetic algorithm

Interaction of Hepatitis B Virus X Protein with the Pregnane X Receptor Enhances the Synergistic Effects of Aflatoxin B1 and Hepatitis B Virus on Promoting Hepatocarcinogenesis

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Journal of Clinical and Translational Hepatology 2021年第4期9卷 466-476页

作者： Yongdong Niu Shaohua Fan Qin Luo Liming Chen danmei Huang Wenjun chang Wenxin Qin Ganggang Shi Department of Pharmacology Shantou University Medical CollegeShantouGuangdongChina Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life ScienceJiangsu Normal UniversityXuzhouJiangsuChina State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Oncology First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdongChina Department of Environmental Hygiene Second Military Medical UniversityShanghaiChina

Background and Aims:Hepatitis B virus(HBV)infection has been found to increase hepatocellular sensitivity to carcinogenic xenobiotics,by unknown mechanisms,in the generation of hepatocellular *** pregnane X receptor(PXR)is a key regulator of the body’s defense against xenobiotics,including xenobiotic carcinogens and clinical *** this study,we aimed to investigate the molecular mechanisms of HBV X protein(HBx)-PXR signaling in the synergistic effects of chemical carcinogens in HBV-associated ***:The expression profile of PXR-cytochrome p4503A4(CYP3A4)signaling was determined by PCR,western blotting,and tissue *** viability and aflatoxin B1(AFB1)cytotoxicity were measured using the cell counting kit-8 *** gene expression was evaluated using transient transfection and real *** genotoxicity of AFB1 was assessed in newborn mice with a single dose of ***:HBx enhanced the hepatotoxicity of AFB1 by activating CYP3A4 and reducing glutathione Stransferase Mu 1(GSTM1)in cell *** of PXR by pregnenolone 16α-carbonitrile increased AFB1-induced liver tumor incidence by up-regulating oncogenic KRAS to enhance interleukin(IL)-11:IL-11 receptor subunit alpha-1(IL11RA-1)-mediated inflammation in an HBx transgenic ***:Our finding regarding AFB1 toxicity enhancement by an HBx-PXR-CYP3A4/GSTM1-KRASIL11:IL11RA signaling axis provides a rational explanation for the synergistic effects of chemical carcinogens in HBV infection-associated hepatocarcinogenesis.

关键词： Liver cancer Hepatitis B virus X protein Pregnane X receptor Aflatoxin B1 Hepatotoxicity

Deciphering chemical and metabolite profiling of chang-Kang-Fang by UPLC-Q-TOF-MS/MS and its potential active components identification

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Chinese Journal of Natural Medicines 2023年第6期21卷 459-480页

作者： YANG Fengge ZHANG Sihao TIAN danmei ZHOU Guirong TANG Xiyang MIAO Xinglong HE Yi YAO Xinsheng TANG Jinshan Institute of Traditional Chinese Medicine and Natural Products College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drug Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of ChinaJinan UniversityGuangzhou 510632China State Key Laboratory of Core Technology in Innovative Chinese Medicine Tasly Pharmaceutical Group Co.Ltd.Tianjin 300410China Tasly Pharmaceutical Group Co. Ltd.Tianjin 300410China

chang-Kang-Fang(CKF)formula,a Traditional Chinese Medicine(TCM)prescription,has been widely used for the treatment of irritable bowel syndrome(IBS).However,its potential material basis and underlying mechanism remain ***,this study employed an integrated approach that combined ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UPLC-Q/TOF-MS)with network pharmacology to systematically characterize the phytochemical components and metabolites of CKF,as well as elucidating its underlying *** this comprehensive analysis,a total of 150 components were identified or tentatively characterized within the CKF ***,six N-acetyldopamine oligomers from Cicadae Periostracum and eight resin glycosides from Cuscutae Semen were characterized in this formula for the first ***,149 xenobiotics(58 prototypes and 91 metabolites)were detected in plasma,urine,feces,brain,and intestinal contents,and the in vivo metabolic pathways of resin glycosides were elaborated for the first ***,network pharmacology and molecular docking analyses revealed that alkaloids,flavonoids,chromones,monoterpenes,N-acetyldopamine dimers,p-hydroxycinnamic acid,and Cus-3/isomer might be responsible for the beneficial effects of CKF in treating IBS,and CASP8,MARK14,PIK3C,PIK3R1,TLR4,and TNF may be its potential *** discoveries offer a comprehensive understanding of the potential material basis and clarify the underlying mechanism of the CKF formula in treating IBS,facilitating the broader application of CKF in the field of medicine.

关键词： chang-Kang-Fang Chemical profile Metabolites profile UPLC-Q-TOF/MS Network pharmacology Molecular docking

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基于BP神经网络的汽轮机排汽干度在线计算

热力发电 2014年第9期43卷 39-42,47页

作者：谢诞梅陈畅熊扬恒高尚王纯武汉大学动力与机械学院湖北武汉430072

对于大型凝汽式汽轮机,其汽轮机末级的排汽状态点处于湿蒸汽区,由于缺乏实时有效的测量手段,汽轮机末级排汽干度难以直接确定,其计算取值一直是火电机组热力系统热经济性在线分析的难点。利用BP神经网络的非线性映射能力,以某台N1000-25... 详细信息

对于大型凝汽式汽轮机,其汽轮机末级的排汽状态点处于湿蒸汽区,由于缺乏实时有效的测量手段,汽轮机末级排汽干度难以直接确定,其计算取值一直是火电机组热力系统热经济性在线分析的难点。利用BP神经网络的非线性映射能力,以某台N1000-25/600/600型汽轮机为研究对象,建立了汽轮机末级排汽干度(排汽干度)与机组负荷和汽轮机末级排汽压力(排汽压力)的BP神经网络关系模型。将该模型通过典型工况的学习训练及校验后,用于排汽干度的全工况在线计算。结果表明,所建模型最大训练误差和最大校验误差分别为-0.006 1和-0.001 0,满足工程计算的精度要求,可用于排汽干度在线计算和预测。

关键词：汽轮机排汽干度 BP神经网络在线计算

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冠心病伴慢性失眠患者中医证候临床分析

山西中医药大学学报 2023年第7期24卷 736-739页

作者：付丽娟乔丹妹常中飞首都医科大学北京100043 首都医科大学石景山教学医院北京市石景山医院中医科北京100043 首都医科大学中西医结合学系北京100050

目的:分析冠心病伴慢性失眠患者的常见中医证型及临床特点,以期指导临床选择有效的治疗方法。方法:回顾性分析49例冠心病伴慢性失眠患者的中医四诊资料,对中医辨证分型、伴随疾病及临床特点进行分析。结果:49例冠心病伴慢性失眠患者中... 详细信息

目的:分析冠心病伴慢性失眠患者的常见中医证型及临床特点,以期指导临床选择有效的治疗方法。方法:回顾性分析49例冠心病伴慢性失眠患者的中医四诊资料,对中医辨证分型、伴随疾病及临床特点进行分析。结果:49例冠心病伴慢性失眠患者中属于阳证(肝火扰心型和痰热扰心型)8例(16.20%),属于阴证(心脾两虚型、心肾不交型和心胆气虚型)41例(83.80%);阴证患者中以心肾不交证最多见,占全部病例的53.00%(26/49)。冠心病伴慢性失眠中最常见的伴随疾病/症状前5位分别是健忘(40/49,81.63%)、高血压(38/49,77.55%)、高脂血症(31/49,63.27%)、易怒(29/49,59.18%)及多梦(27/49,55.10%)。结论:冠心病伴慢性失眠患者阴证居多,阴证以心肾不交证多见;最常见的伴随疾病/症状分别是健忘、高血压、高脂血症、易怒和多梦。

关键词：失眠冠心病中医证型症状临床流行病学调查

149例青年女性慢性失眠患者中医证型及临床特点回顾性分析

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山西中医药大学学报 2022年第6期23卷 549-553页

作者：常中飞骆佳莹王煜童付丽娟乔丹妹郭俊宏首都医科大学石景山教学医院北京市石景山医院中医科北京100043 首都医科大学中西医结合学系北京100050 首都医科大学北京100043

目的:分析青年女性慢性失眠患者的常见中医证型及临床特点。方法:运用回顾性分析,对149例青年女性慢性失眠患者的中医四诊资料进行辨证分型、伴随疾病及临床特点的分析。结果:149例青年女性慢性失眠患者中属于阳证(包括肝火扰心型和痰... 详细信息

目的:分析青年女性慢性失眠患者的常见中医证型及临床特点。方法:运用回顾性分析,对149例青年女性慢性失眠患者的中医四诊资料进行辨证分型、伴随疾病及临床特点的分析。结果:149例青年女性慢性失眠患者中属于阳证(包括肝火扰心型和痰热扰心型)95例(63.76%),阴证(包括心脾两虚型、心肾不交型和心胆气虚型)54例(36.24%);阳证患者中以肝火扰心证最多见,占全部病例的53.02%(79/149),阴证患者以心肾不交证多见,占16.11%(24/149)。青年女性慢性失眠中最常见的伴随疾病/症状前5位分别是:月经不调(66/149,44.3%)、多梦(58/149,38.93%)、胃肠功能紊乱(39/149,26.17%)、肥胖(38/149,25.50%)及心悸(29/149,19.46%)。失眠伴随多梦者58例,其中肝火扰心型最常见(20/58,34.48%),其次为心肾不交型(14/58,24.14%)。结论:青年女性慢性失眠患者阳证居多,阳证以肝火扰心证多见;阴证以心肾不交证多见。最常见的伴随疾病/症状分别是月经不调、多梦、胃肠功能紊乱、肥胖及心悸。

关键词：慢性失眠中医证型症状临床流行病学调查