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Hypoallergenicity of a thickened hydrolyzed formula in children with cow’s milk allergy

World Journal of Clinical Cases 2019年第16期7卷 2256-2268页

作者： danilo rossetti Salvatore Cucchiara AlessANDra Morace Beatrice Leter Salvatore Oliva Department of Pediatrics Sapienza University of Rome

BACKGROUND Allergy to cow’s milk is the most frequent allergy occurring in infants and young *** dietary management of these patients consists of the elimination of any cow’s milk proteins from the diet,and for formula-fed infants,the substitution of the usual infant formula with an adapted formula that is generally based on extensively hydrolyzed cow’s milk *** American Academy of Pediatrics has established specific criteria to confirm the hypoallergenicity of a formula intended for these *** To assess the hypoallergenicity of a new thickened extensively hydrolyzed casein-based formula (TeHCF) in children with cow’s milk allergy (CMA).METHODS Children diagnosed with CMA through a double-blind placebo-controlled food challenge (DBPCFC) were randomly administered increased doses of a placebo formula or the TeHCF [Allernova,new thickener including fibres (Novalac)] under double-blind conditions and medical surveillance on two separate ***,both of these formulas and a cow’s milk-based formula were randomly introduced to children who were highly suspected of having CMA on three separate *** and late reactions occurring after the introduction of any of these formulas were thoroughly recorded by the physician at the hospital and reported by parents to the physician after hospital discharge,*** the children tolerated the TeHCF during the DBPCFC,they were exclusively fed this formula during a 3-mo period where potential allergic symptoms,anthropometric parameters,as secondary outcomes,and adverse events were *** Cow’s Milk-related Symptoms Score (CoMiSSTM) was assessed and anthropometric parameters were compared to World Health Organization (WHO) reference *** Of the 30 children included in the study,the CMA diagnosis of 29 (mean age: 8.03 ± 7.43 mo) patients was confirmed by a *** children all tolerated the TeHCF during both the challenge and the subsequent 3-mo feeding period,which the

关键词： Cow's milk allergy Hypoallergenicity Tolerance Thickened extensively hydrolyzed formula Digestive comfort Dietary management

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