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Schizophrenia-associated microRNA–Gene Interactions in the Dorsolateral Prefrontal Cortex

Genomics, Proteomics & Bioinformatics 2019年第6期17卷 623-634页

作者： danielle m.santarelli Adam P.Carroll Heath m.Cairns Paul A.Tooney murray J.Cairns School of Biomedical Sciences and Pharmacy The University of NewcastleCallaghanNSW 2308Australia Centre for Brain and mental Health Research Hunter Medical Research InstituteNewcastleNSW 2305Australia

Schizophrenia-associated anomalies in gene expression in postmortem brain can be attributed to a combination of genetic and environmental influences. Given the small effect size of common variants, it is likely that we may only see the combined impact of some of these at the pathway level in small postmortem studies. At the gene level, however, there may be more impact from common environmental exposures mediated by influential epigenomic modifiers, such as microRNA(miRNA). We hypothesise that dysregulation of miRNAs and their alteration of gene expression have significant implications in the pathophysiology of schizophrenia. In this study, we integrate changes in cortical gene and miRNA expression to identify regulatory interactions and networks associated with the disorder. Gene expression analysis in post-mortem prefrontal dorsolateral cortex(BA 46)(n = 74 matched pairs of schizophrenia, schizoaffective, and control samples)was integrated with miRNA expression in the same cohort to identify gene–miRNA regulatory networks. A significant gene–miRNA interaction network was identified, including miR-92 a, miR-495,and miR-134, which converged with differentially expressed genes in pathways involved in neurodevelopment and oligodendrocyte function. The capacity for miRNA to directly regulate gene expression through respective binding sites in BCL11 A, PLP1, and SYT11 was also confirmed to support the biological relevance of this integrated network model. The observations in this study support the hypothesis that mi RNA dysregulation is an important factor in the complex pathophysiology of schizophrenia.

关键词： Schizophrenia microRNA Dorsolateral prefrontal cortex Network Neuropathology

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Phosphorylation of the Pseudomonas Effector AvrPtoB by Arabidopsis SnRK2.8 Is Required for Bacterial Virulence

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molecular Plant 2020年第10期13卷 1513-1522页

作者： Lei Lei danielle m.Stevens Gitta Coaker Department of Plant Pathology University of CaliforniaDavisDavisCAUSA

A critical component controlling bacterial virulence is the delivery of pathogen effectors into plant cells during *** alter host metabolism and immunity for the benefit of *** effectors are phosphorylated by host kinases,and this posttranslational modification is important for their *** sought to identify host kinases involved in effector *** phosphorylated effector residues matched the proposed consensus motif for the plant calcium-dependent protein kinase(CDPK)and Snf1-related kinase(SnRK)*** conserved Pseudomonas effector AvrPtoB acts as an E3 ubiquitin ligase and promotes bacterial *** this study,we identified a member of the Arabidopsis SnRK family,SnRK2.8,which interacts with AvrPtoB in yeast and in *** showed that SnRK2.8 was required for AvrPtoB virulence functions,including facilitating bacterial colonization,suppression of callose deposition,and targeting the plant defense regulator NPR1 and analyses receptor *** spectrometry analysis revealed that AvrPtoB phosphorylation occurs at multiple serine residues in planta,with S258 phosphorylation significantly reduced in the snrk2.8 *** phospho-'null'mutants exhibited compromised virulence functions and were unable to suppress NPR1 accumulation,FLS2 accumulation,or inhibit FLS2-BAK1 complex formation upon flagellin *** together,these data identify a conserved plant kinase utilized by a pathogen effector to promote disease.

关键词： Arabidopsis Pseudomonas syringae effector AvrPtoB kinase SnRK2.8

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Pseudocapacitive Vanadium-based materials toward High-Rate Sodium-Ion Storage

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Energy & Environmental materials 2020年第3期3卷 221-234页

作者： Qiulong Wei Ryan H.De Block danielle m.Butts Christopher Choi Bruce Dunn Department of materials Science and Engineering Fujian Key Laboratory of Materials GenomeCollege of MaterialsXiamen UniversityXiamen Fujian 361005China National Research Council Postdoctoral Associate U.S.Naval Research LaboratoryWashington DC 20375USA Department of materials Science and Engineering University of California Los AngelesLos Angeles CA 90095–1595USA

Sodium-ion battery materials and devices are promising candidates for largescale applications,owing to the abundance and low cost of sodium *** sodium-ion pseudocapacitive materials provide one approach for achieving high capacity at high rates,but are currently not well ***,a comprehensive overview of the fundamentals and electrochemical behaviors of vanadium-based pseudocapacitive materials for sodium-ion storage is *** insight of sodium-ion storage mechanisms for various vanadium-based materials,including vanadium oxides,vanadates,vanadium sulfides,nitrides,and carbides are systematically discussed and *** particular,areas for further development to improve fundamental understanding of electrochemical and structural properties of materials are ***,we provide a perspective on the application of pseudocapacitive materials in high-power and high-energy sodium-ion storage devices(e.g.,sodium-ion capacitors).

关键词： charge-storage mechanism nanomaterials pseudocapacitance sodium-ion capacitors vanadium-based materials

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Advances in targeted nanotherapeutics： From bioconjugation to biomimicry

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Nano Research 2018年第10期11卷 4999-5016页

作者： danielle m. Valcourt Jenna Harris Rachel S. Riley megan Dang Jianxin Wang Emily S. Day 161 Colburn L ab Department of Biomedical Engineering University of Delaware Newark DE 19716 USA 201 DuPont Hall Department of Materials Science & Engineering University o f Delaware Newark DE 79716 USA 4701 Ogletown Stanton Road Helen F. Graham Cancer Center & Research Institute Newark DE 19713 USA

Since the emergence of cancer nanomedicine, researchers have had intense interest in developing nanoparticles （NPs） that can specifically target diseased sites while avoiding healthy tissue to mitigate the off-target effects seen with conventional treatments like chemotherapy. Initial endeavors focused on the bioconjugation of targeting agents to NPs, and more recently, researchers have begun to develop biomimetic NP platforms that can avoid immune recognition to maximally accumulate in tumors. In this review, we describe the advantages and limitations of each of these targeting strategies. First, we review developments in bioconjugation strategies, where NPs are coated with biomolecules such as antibodies, aptamers, peptides, and small molecules to enable cell-specific binding. While bioconjugated NPs offer many exciting features and have improved pharmacokinetics and biodistribution relative to unmodified NPs, they are still recognized by the body as ＂foreign＂, resulting in their clearance by the mononuclear phagocytic system （mPS）. To overcome this limitation, researchers have recently begun to investigate biomimetic approaches that can hide NPs from immune recognition and reduce clearance by the mPS. These biomimetic NPs fall into two distinct categories： synthetic NPs that present naturally occurring structures, and NPs that are completely disguised by natural structures. Overall bioconjugated and biomimetic NPs have substantial potential to improve upon conventional treatments by reducing off-target effects through site-specific delivery. and they show great promise for future standards of care. Here, we provide a summary of each strategy, discuss considerations for their design moving forward, and highlight their potential clinical impact on cancer therapy.

关键词： targeting nanoparticles cancer biomimicry bioconjugation delivery

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Juvenile polyposis syndrome

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World Journal of Gastroenterology 2011年第44期17卷 4839-4844页

作者： Lodewijk AA Brosens danielle Langeveld W Arnout van Hattem Francis m Giardiello G Johan A Offerhaus Department of Pathology University Medical Centre Utrecht Department of Pathology Academic Medical Centre Division of Gastroenterology Department of Medicine The Johns Hopkins University School of Medicine

Juvenile polyposis syndrome is a rare autosomal dominant syndrome characterized by multiple distinct juvenile polyps in the gastrointestinal tract and an increased risk of colorectal *** cumulative life-time risk of colorectal cancer is 39% and the relative risk is *** polyps have a distinctive histology characterized by an abundance of edematous lamina propria with inflammatory cells and cystically dilated glands lined by cuboidal to columnar epithelium with reactive ***,juvenile polyposis syndrome is defined by the presence of 5 or more juvenile polyps in the colorectum,juvenile polyps throughout the gastrointestinal tract or any number of juvenile polyps and a positive family history of juvenile *** about 50%-60% of patients diagnosed with juvenile polyposis syndrome a germline mutation in the SmAD4 or BmPR1A gene is *** genes play a role in the BmP/TGF-beta signalling *** has been suggested that cancer in juvenile polyposis may develop through the socalled "landscaper mechanism" where an abnormal stromal environment leads to neoplastic transformation of the adjacent epithelium and in the end invasive *** of this rare disorder is important for patients and their families with regard to treatment,follow-up and screening of at risk *** clinician confronted with the diagnosis of a juvenile polyp should therefore consider the possibility of juvenile polyposis *** addition,juvenile polyposis syndrome provides a unique model to study colorectal cancer pathogenesis in general and gives insight in the molecular genetic basis of *** review discusses clinical manifestations,genetics,pathogenesis and management of juvenile polyposis syndrome.

关键词： Juvenile polyposis syndrome Hamartoma Colorectal cancer SmAD4 BmPR1A

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澳大利亚danielle mazza教授全科医疗案例分析--异位妊娠

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中国全科医学 2015年第1期18卷 8-10页

作者： danielle m 澳大利亚monash 大学医学、护理和卫生科学部全科医学系

1病例简介：她没有＂怀孕＂反应Haslinda,32岁,按着右下腹来见全科医生。她解释说持续剧烈的疼痛把她从睡眠中疼醒。进一步询问,全科医生发现Haslinda 4个月之前已经停用口服避孕药,希望怀第二个孩子。她最后一次正常月经是7周前,但是... 详细信息

1病例简介：她没有＂怀孕＂反应Haslinda,32岁,按着右下腹来见全科医生。她解释说持续剧烈的疼痛把她从睡眠中疼醒。进一步询问,全科医生发现Haslinda 4个月之前已经停用口服避孕药,希望怀第二个孩子。她最后一次正常月经是7周前,但是她并不确定自己是怀孕了,因为过去几周里她有过4~5次不规则出血而且没有妊娠反应。尿人绒膜促性腺激素（β-HCG）试验阳性。Haslinda血压、脉搏平稳,没有强迫体位。窥器检查阴道内没有血,宫颈口闭合。子宫如孕6周大,附件无压痛,未及包块。全科医生考虑Haslinda可能是异位妊娠,所以即刻安排做阴道超声。扫描显示没有见到宫内妊娠,于是Haslinda因可疑异位妊娠被送到当地的妇产科医院进一步就诊。

关键词：妊娠,异位全科医疗

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Valorization of the agro-industrial by-products of bacupari(Garcinia brasiliensis(mart.))through production of flour with bioactive properties

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Food Bioscience 2022年第1期45卷 377-385页

作者： Anely maciel de melo Rafaela Cristina Turola Barbi Bruno Patrício Costa mˆonica Ikeda danielle Carpine Rosemary Hoffmann Ribani Food Engineering Graduate Program Federal University of ParanaDepartment of Chemical Engineering81531-990CuritibaPRBrazil

Brazil has a wide variety of fruits that remain insufficiently *** encourage the use of one such fruit,the bacupari((Garcinia brasiliensis(mart.)),the current study produced flours from its by-products(the peel and seed)at two maturation stages and subsequently evaluated their proximate composition,physical,antioxidant,bioactive,microstructural and thermal *** results revealed that the flours have a high in fiber content(>15%)and are a potential source of protein(>5%).Seed flour has an energy value similar to that of wheat flour and other conventional *** flour micrographs indicate the presence of starch,a fact confirmed by viscosity *** flours contain phenolic compounds and exhibit antioxidant activity,especially the unripe peel *** the compounds identified by chromatography,those present in the greatest concentrations were quinine(≅111μg/g),p-coumaric acid(≅25μg/g),m-coumaric acid(≅15μg/g),and formononetin(≅21μg/g),all of which are known to have several human health *** flour crystallinity diminished as the fruit *** flour exhibited similar thermal transitions but less thermal stability than seed *** summary,this study revealed that flours produced from the peel and seeds of bacupari,which are generated in large quantities as agro-industrial by-products,can be used as alternative ingredients in various sectors of the food industry.

关键词： Antioxidant activity Bacupari fruit Seed Peel Phenolic compounds

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Cortical and spinal evoked potential response to electrical stimulation in human rectum

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World Journal of Gastroenterology 2010年第43期16卷 5440-5446页

作者： Brian Garvin Lisa Lovely Alex Tsodikov danielle minecan Shaungson Hong John W Wiley Department of Internal medicine University of Michigan Michigan Clinical Research Unit Level 1 Room 1702 Cardiovascular Center 1500E Medical Center Drive Ann Arbor MI 48109 United States Department of Neurology University of Michigan Ann Arbor MI 48109 United States Department of Biostatistics University of Michigan Ann Arbor MI 48109 United States

AIm: To study a novel technique to record spinal and cortical evoked potentials (EPs) simultaneously in response to electrical stimulation in the human rectum. mETHODS: Eight male and nine female healthy volunteers participated. Stimulating electrodes were attached to the rectal mucosa at 15 cm and 12 cm above the dentate line. Recording skin electrodes were positioned over vertebrae L4 through S2. The electrical stimulus was a square wave of 0.2 ms duration and the intensity of the stimulus varied between 0 and 100 mA. EP responses were recorded using a Nicolet Viking IV programmable signal ***: Simultaneous recording of cortical and spinal EPs was obtained in > 80% of the trials. The EP responses increased with the intensity of the electrical stimulation, were reproducible overtime, and were blocked by application of Lidocaine jelly at the site of stimulation. The morphology (N1/P1), mean ± SD for latency (spinal N1, 4.6 ± 0.4 ms; P1, 6.8 ± 0.5 ms; cortical N1, 136.1 ± 4.2 ms; P1, 233.6 ± 12.8 ms) and amplitude (N1/P1, spinal, 38 ± 7 μV; cortical 19 ± 3 μV) data for the EP responses were consistent with those in the published literature. Reliable and reproducible EP recordings were obtained with the attachment of the electrodes to the rectal mucosa at predetermined locations between 16 and 8 cm above the anal verge, and the distance between the attachment sites of the electrodes (the optimal distance being approximately 3.0 cm between the two electrodes). CONCLUSION: This technique can be used to assess potential abnormalities in primary afferent neural pathways innervating the rectum in several neurodegenerative and functional pain disorders.

关键词： Spinal evoked potentials Cortical evoked potentials Rectum Electrical stimulation Primary afferent neurons Visceral sensation

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An examination of the population dynamics of syngnathid fishes within Tampa Bay,Florida,USA

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Current Zoology 2010年第1期56卷 118-133页

作者： Heather D.mASONJONES Emily ROSE Lori Benson mcRAE danielle L.DIXSON Biology Department University of Tampa Biology Department Texas A & M University School of marine and Tropical Biology James Cook University

Seagrass ecosystems worldwide have been declining, leading to a decrease in associated fish populations, especially those with low mobility such as syngnathids （pipefish and seahorses）. This two-year pilot study investigated seasonal patterns in density, growth, site fidelity, and population dynamics of Tampa Bay （FL） syngnathid fishes at a site adjacent to two marinas under construction. Using a modified mark-recapture technique, fish were collected periodically from three closely located sites that varied in seagrass species （Thalassia spp., Syringodium spp., and mixed-grass sites） and their distance from open water, but had consistent physical/chemical environmental characteristics. Fish were marked, photographed for body size and gender measurements, and released the same day at the capture site. Of the 5695 individuals surveyed, 49 individuals were recaptured, indicating a large, flexible population. Population density peaks were observed in July of both years, with low densities in late winter and late summer. Spatially, syngnathid densities were highest closest to the mouth of the bay and lowest near the shoreline. Seven species of syngnathid fishes were observed, and species-specific patterns of seagrass use emerged during the study. However, only two species, Syngnathus scovelli and Hippoeampus zosterae, were observed at high frequencies. For these two species, body size decreased across the study period, but while S. scovelli＇s population density decreased, H. zosterae＇s increased. Across six of the seven species, population size declined over the course of this preliminary study; however, seasonal shifts were impossible to distinguish from potential anthropogenic effects of construction [Current Zoology 56 （1）： 118-133, 2010].

关键词： Syngnathids Habitat-use Seahorse Pipefish Population density mark-recapture

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From hardware store to hospital:a COVID-19-inspired,cost-effective,open-source,in vivo-validated ventilator for use in resource-scarce regions

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Bio-Design and manufacturing 2022年第1期5卷 133-140页

作者： matthew H.Park Yuanjia Zhu Hanjay Wang Nicholas ATran Jinsuh Jung michael JPaulsen Annabel m.Imbrie‑moore Samuel Baker Robert Wilkerson mateo marin‑Cuartas danielle m.mullis Y.Joseph Woo Department of Cardiothoracic Surgery Stanford UniversityFalk Cardiovascular Research Building CV-235300 Pasteur DriveStanfordCA 94305-5407USA Department of mechanical Engineering Stanford UniversityStanfordCAUSA Department of Bioengineering Stanford UniversityStanfordCAUSA Department of Comparative medicine Stanford UniversityStanfordCAUSA University Department of Cardiac Surgery Leipzig Heart CenterLeipzigGermany

Resource-scarce regions with serious COVID-19 outbreaks do not have enough ventilators to support critically ill patients,and these shortages are especially devastating in developing *** help alleviate this strain,we have designed and tested the accessible low-barrier in vivo-validated economical ventilator(ALIVE Vent),a COVID-19-inspired,cost-effective,open-source,in vivo-validated solution made from commercially available *** ALIVE Vent operates using compressed oxygen and air to drive inspiration,while two solenoid valves ensure one-way flow and precise cycle *** device was functionally tested and profiled using a variable resistance and compliance artificial lung and validated in anesthetized large *** functional test results revealed its effective operation under a wide variety of ventilation conditions defined by the American Association of Respiratory Care guidelines for ventilator *** large animal test showed that our ventilator performed similarly if not better than a standard ventilator in maintaining optimal ventilation *** FiO2,respiratory rate,inspiratory to expiratory time ratio,positive-end expiratory pressure,and peak inspiratory pressure were successfully maintained within normal,clinically validated ranges,and the animals were recovered without any *** regions with limited access to ventilators,the ALIVE Vent can help alleviate shortages,and we have ensured that all used materials are publicly *** this pandemic has elucidated enormous global inequalities in healthcare,innovative,cost-effective solutions aimed at reducing socio-economic barriers,such as the ALIVE Vent,can help enable access to prompt healthcare and life saving technology on a global scale and beyond COVID-19.

关键词： COVID-19 Ventilator Open-source

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