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Impact of modern antiviral therapy of chronic hepatitis B and C on clinical outcomes of liver disease

World Journal of Gastroenterology 2021年第29期27卷 4831-4845页

作者： Tiffany Khoo danielle lam John K Olynyk Department of Gastroenterology and Hepatology Fiona Stanley HospitalMurdoch 6150Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalup 6027Australia

Chronic infections with the hepatitis B and C viruses have significant worldwide health and economic *** treatments for hepatitis C such as interferon and ribavirin therapy were ineffective and poorly tolerated by *** introduction of directly acting curative antiviral therapy for hepatitis C and the wider use of nucleos(t)ide analogues for suppression of chronic Hepatitis B infection have resulted in many positive *** the prevalence of hepatitis B and C have concurrently reduced transmission rates and hence,the number of new *** treatments have decreased the rates of liver decompensation and as a result,lowered hospitalisation and mortality rates for both chronic hepatitis B and C *** quality of life of chronically infected patients has also been improved significantly by modern *** therapy has stopped the progression of liver disease to cirrhosis in certain patient cohorts and prevented ongoing hepatocellular damage in patients with existing *** term benefits of antiviral therapy include a reduced risk of developing hepatocellular carcinoma and decreased number of patients requiring liver *** review article assesses the literature and summarises the impact of modern antiviral therapy of chronic hepatitis B and C on clinical outcomes from liver disease.

关键词： Hepatitis B Hepatitis C Nucleotide analogues Directly acting antiviral therapy Clinical outcomes Liver disease

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