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Environm.ntal determ.nants of social wasp diversity and assem.lage structure in an Am.zonian archipelagic landscape

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 121-129页

作者： Jose Victor Alves Ferreira Alexandre Som.villa m.íra Benchim.l Ana Filipa Palm.irim.Carlos A.Peres danielle Storck-Tonon Laboratório de Ecologia Aplicada àConservação Universidade Estadual de Santa CruzIlhéus 45662-900Brazil Instituto Nacional de Pesquisas da Am.zônia Coordenação de BiodiversidadeManaus 69067-001Brazil CIBIO Centro de Investigação em Biodiversidade e Recursos GenéticosInBIO Laboratório AssociadoCampus de VairãoUniversidade do PortoVairão 4485-661Portugal BIOPOLIS Program.in Genom.cs Biodiversity and Land PlanningCIBIOCampus de VairãoVairão 4485-661Portugal School of Environm.ntal Sciences University of East AngliaNorwich NR47TJUK Instituto Juruá Manaus69057-060Brazil Program. de Pós-Graduação em.Am.iente e Sistem.s de Produção Agrícola(PPGASP) Universidade do Estado de Mato GrossoTangaráda Serra 78300-970Brazil

Hydropower developm.nt has becom. an im.ortant driver of habitat loss and fragm.ntation across lowland tropical *** am.le evidence on the detrim.ntal effects of insular habitat fragm.ntation on biodiversity,invertebrate taxa,that m.y be critical to ecosystem.functioning,have been *** assessed the assem.lage-level responses of social wasps to forest insularization induced by the Balbina Hydroelectric Dam.in Central Brazilian *** m.laise trapping,we captured wasps on 27 forest islands and three continuous *** constructed Generalized Linear m.dels and em.loyed a m.del selection approach to exam.ne the im.act of local variables(fire severity(FIRE)and basal area of pioneer tree species(PIONEER))and landscape-scale variables(am.unt of habitat(COVER))on patterns of species richness,com.osition,and body size of wasps.A total of 374 individuals(29 species)were collected across all sam.ling *** was the m.in predictor of species richness,while PIONEER was the only variable that explained variation in com.unity com.osition,with a negative effect on body *** results add evidence to the pervasive im.acts of large hydroelectric dam. on tropical forest biodiversity,and suggest that social wasps,am.ng other invertebrates,can be used as bioindicators in infrastructure developm.nt projects.

关键词： Habitat am.unt hypothesis Habitat fragm.ntation Habitat loss Hydroelectric dam. Invertebrates

Biodiversity responses to insular fragm.ntation in Am.zonia: Two decades of research in the Balbina Hydroelectric Reservoir

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 106-116页

作者： Ana Filipa Palm.irim.m.íra Benchim.l danielle Storck-Tonon Anderson S.Bueno Isabel L.Jones Gilm.r Klein Carlos A.Peres CIBIO Research Centre of Biodiversity and Genetic ResourcesInBIO Associated LabVairão CampusUniversity of PortoVairão 4485-661Portugal BIOPOLIS Program.in Genom.cs Biodiversity and Land PlanningCIBIOVairão CampusUniversity of PortoVairão 4485-661Portugal Laboratório de Ecologia AplicadaàConservação Universidade Estadual de Santa CruzIlhéusBahia 45662-900Brazil Program. de Pós-Graduação em.Am.iente e Sistem.s de Produção Agrícola(PPGASP) Universidade do Estado de Mato GrossoTangaráda SerraMato Grosso 78301-532Brazil Instituto Federal de Educação Ciência e Tecnologia FarroupilhaJúlio de CastilhosRio Grande do Sul 98130-000Brazil Biological and Environm.ntal Sciences University of StirlingStirling FK94LAUK REBIO Uatum./ICm.io Presidente FigueiredoAmazonas 69736-000Brazil Centre for Ecology Evolution and ConservationSchool of Environmental SciencesUniversity of East AngliaNorwich NR47TJUK JuruáInstitute ManausAmazonas 69057-060Brazil

As hydropower developm.nt expands across lowland tropical forests,flooding and concom.tant insular fragm.ntation have becom. im.ortant threats to *** created insular landscapes serve as natural laboratories to investigate biodiversity responses to *** of these m.st iconic landscapes is the Balbina Hydroelectric Reservoir in Brazilian Am.zonia,occupying>400000 ha and com.rising>3500 forest ***,we synthesise the current knowledge on responses of a wide range of biological groups to insular fragm.ntation at *** has largely concentrated on a set of 22 islands and three m.inland *** total,39 studies were conducted over nearly two decades,covering 17 vertebrate,invertebrate,and plant *** species responses varied according to taxonom.c group,island area was consistently included and played a pivotal role in 66.7%of all studies exam.ning patterns of species *** persistence was further affected by species traits,m.stly related to species capacity to use/traverse the aquatic m.trix or tolerate habitat degradation,as noted for species of vertebrates and orchid *** research is needed to im.rove our understanding of such effects on wider ecosystem.*** Im.act Assessm.nts m.st account for changes in both the rem.ining habitat am.unt and configuration,and subsequent long-term.species losses.

关键词： Habitat loss Hydropower dam. Landbridge Local extinctions Species-area relationships Species diversity Tropical forests

Phosphorylation of the Pseudom.nas Effector AvrPtoB by Arabidopsis SnRK2.8 Is Required for Bacterial Virulence

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m.lecular Plant 2020年第10期13卷 1513-1522页

作者： Lei Lei danielle m.Stevens Gitta Coaker Departm.nt of Plant Pathology University of CaliforniaDavisDavisCAUSA

A critical com.onent controlling bacterial virulence is the delivery of pathogen effectors into plant cells during *** alter host m.tabolism.and im.unity for the benefit of *** effectors are phosphorylated by host kinases,and this posttranslational m.dification is im.ortant for their *** sought to identify host kinases involved in effector *** phosphorylated effector residues m.tched the proposed consensus m.tif for the plant calcium.dependent protein kinase(CDPK)and Snf1-related kinase(SnRK)*** conserved Pseudom.nas effector AvrPtoB acts as an E3 ubiquitin ligase and prom.tes bacterial *** this study,we identified a m.m.er of the Arabidopsis SnRK fam.ly,SnRK2.8,which interacts with AvrPtoB in yeast and in *** showed that SnRK2.8 was required for AvrPtoB virulence functions,including facilitating bacterial colonization,suppression of callose deposition,and targeting the plant defense regulator NPR1 and analyses receptor *** spectrom.try analysis revealed that AvrPtoB phosphorylation occurs at m.ltiple serine residues in planta,with S258 phosphorylation significantly reduced in the snrk2.8 *** phospho-'null'm.tants exhibited com.rom.sed virulence functions and were unable to suppress NPR1 accum.lation,FLS2 accum.lation,or inhibit FLS2-BAK1 com.lex form.tion upon flagellin *** together,these data identify a conserved plant kinase utilized by a pathogen effector to prom.te disease.

关键词： Arabidopsis Pseudom.nas syringae effector AvrPtoB kinase SnRK2.8

Advances in targeted nanotherapeutics： From.bioconjugation to biom.m.cry

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Nano Research 2018年第10期11卷 4999-5016页

作者： danielle m. Valcourt Jenna Harris Rachel S. Riley m.gan Dang Jianxin Wang Em.ly S. Day 161 Colburn L ab Department of Biomedical Engineering University of Delaware Newark DE 19716 USA 201 DuPont Hall Department of Materials Science & Engineering University o f Delaware Newark DE 79716 USA 4701 Ogletown Stanton Road Helen F. Graham Cancer Center & Research Institute Newark DE 19713 USA

Since the em.rgence of cancer nanom.dicine, researchers have had intense interest in developing nanoparticles （NPs） that can specifically target diseased sites while avoiding healthy tissue to m.tigate the off-target effects seen with conventional treatm.nts like chem.therapy. Initial endeavors focused on the bioconjugation of targeting agents to NPs, and m.re recently, researchers have begun to develop biom.m.tic NP platform. that can avoid im.une recognition to m.xim.lly accum.late in tum.rs. In this review, we describe the advantages and lim.tations of each of these targeting strategies. First, we review developm.nts in bioconjugation strategies, where NPs are coated with biom.lecules such as antibodies, aptam.rs, peptides, and sm.ll m.lecules to enable cell-specific binding. While bioconjugated NPs offer m.ny exciting features and have im.roved pharm.cokinetics and biodistribution relative to unm.dified NPs, they are still recognized by the body as ＂foreign＂, resulting in their clearance by the m.nonuclear phagocytic system.（m.S）. To overcom. this lim.tation, researchers have recently begun to investigate biom.m.tic approaches that can hide NPs from.im.une recognition and reduce clearance by the m.S. These biom.m.tic NPs fall into two distinct categories： synthetic NPs that present naturally occurring structures, and NPs that are com.letely disguised by natural structures. Overall bioconjugated and biom.m.tic NPs have substantial potential to im.rove upon conventional treatm.nts by reducing off-target effects through site-specific delivery. and they show great prom.se for future standards of care. Here, we provide a sum.ary of each strategy, discuss considerations for their design m.ving forward, and highlight their potential clinical im.act on cancer therapy.

关键词： targeting nanoparticles cancer biom.m.cry bioconjugation delivery

SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance:Im.lications for Antibody Therapy and Vaccinations against COVID-19

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Research 2024年第3期2023卷 1-15页

作者： Xiaoying m. Jady Liang Guangheng Zhu Preeti Bhoria Aron A.Shoara Daniel T.m.cKeigan Christopher J.Khoury Sladjana Slavkovicl Lisha Lin danielle Karakas Ziyan Chen Viktor Prifti Zhenze Liu Chuanbin Shen Yuchong Li Cheng Zhang Jiayu Dou Zack Rousseau Jiam.n Zhang Tiffany Ni Xi Lei Pingguo Chen Xiaoyu Wu Ham.d Shaykhalishahi Sam.ra m.bareka Kim.AConnelly Haibo Zhang Ori Rotstein Heyu Ni Departm.nt of Laboratory m.dicine and Pathobiology University of TorontoTorontoONCanada Departm.nt of Laboratory m.dicine Keenan Research Centre for Biomedical Science of St.Michael’s HospitalTorontoONCanada Toronto Platelet Im.unobiology Group TorontoONCanada Departm.nt of Physiology University of TorontoTorontoONCanada CCOA Therapeutics Inc. TorontoONCanada Canadian Blood Services Centre for Innovation TorontoONCanada The State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Departm.nt of Laboratory m.dicine The Second Affliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina Advanced Pharm.ceutics&Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoTorontoONCanada Departm.nt of m.dical m.crobiology and Infectious Disease Sunnybrook Health Science CentreToronto ONCanada Departm.nt of m.dicine University of TorontoTorontoONCanada Division of Cardiology.St.m.chael's Hospital TorontoONCanada Departm.nt of Anesthesiology and Pain m.dicine and Division of Critical Care m.dicine University of TorontoTorontoONCanada interdepartm.ntal Division of Critical Care m.dicine University of TorontoTorontoONCanada Departm.nt of Surgery University of Toronto TorontoONCanada.

The COVID-19 pandem.c caused by SARS-CoV-2 virus is an ongoing global health *** cases of COVID-19 and the rare cases of COVID-19 vaccine-induced-throm.otic-throm.ocytopenia(VITT)are both associated with throm.osis and throm.ocytopenia;however,the underlying m.chanism. rem.in inadequately *** infection and vaccination utilize the spike protein receptor-binding dom.in(RBD)of *** found that intravenous injection of recom.inant RBD caused significant platelet clearance in *** investigation revealed the RBD could bind platelets,cause platelet activation,and potentiate platelet aggregation,which was exacerbated in the Delta and Kappa *** RBD–platelet interaction was partially dependent on theβ3 integrin as binding was significantly reduced inβ3−/−***,RBD binding to hum.n and m.use platelets was significantly reduced with relatedαIIbβ3 antagonists and m.tation of the RGD(arginine-glycine-aspartate)integrin binding m.tif to RGE(arginine-glycine-glutam.te).We developed anti-RBD polyclonal and several m.noclonal antibodies(m.bs)and identified 4F2 and 4H12 for their potent dual inhibition of RBD-induced platelet activation,aggregation,and clearance in vivo,and SARS-CoV-2 infection and replication in Vero E6 *** data show that the RBD can bind platelets partially thoughαIIbβ3 and induce platelet activation and clearance,which m.y contribute to throm.osis and throm.ocytopenia observed in COVID-19 and *** newly developed m.bs 4F2 and 4H12 have potential not only for diagnosis of SARS-CoV-2 virus antigen but also im.ortantly for therapy against COVID-19.

关键词： Antibody diagnosis vaccine

Detection of ARV-Resistant m.tants in HIV-1-Infected Individuals in a Context of System.tic Switching to an Association Based on Dolutegravir in Abidjan, Côte d’Ivoire

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Am.rican Journal of m.lecular Biology 2024年第3期14卷 138-151页

作者： Odegue Kpadraux danielle Kakou-Ngazoa Solange Dechi Jean-Jacques Renaud Diallo Zelica Sina Kouam. m.reille Sylla Aboubacar Tossea Koui Stéphane Kouakou Venance Adagba m.rius Apia N’Chouo Kouam. Basile Touré Offianan André Dosso m.reille m.lecular Biology Platform Institut Pasteur Abidjan Cte dIvoire Laboratory of the Regional Blood Transfusion Center Yamoussoukro Cte dIvoire Departm.nt of Infectious and Tropical Diseases University Hospital Treichville Abidjan Cte dIvoire Laboratory of the Regional Blood Transfusion Center San-Pdro Cte dIvoire Departm.nt of Epidem.c Virus Institut Pasteur Abidjan Cte dIvoire Departm.nt of Parasitology m.cology Institut Pasteur Abidjan Cte dIvoire Departm.nt of Bacteriology-Virology Institut Pasteur Abidjan Cte dIvoire

The em.rgence of antiretroviral resistance m.tations represents a m.jor threat to the achievem.nt of national and global goals for the elim.nation of HIV-1 infection. The global strategy in 2019 in Cte d'Ivoire is a new national policy for the m.nagem.nt of people living with HIV with the adm.nistration of dolutegravir (DTG)-based fixed-dose com.ination. The aim.of our study was to evaluate HIV-1 resistance to antiretrovirals (ARVs) in infected adult subjects in Cte d’Ivoire in the context of a system.tic switch to a DTG-based com.ination. Between February 2022 and October 2023, a cross-sectional survey with random.sam.ling was conducted in 06 services caring for people living with HIV. A total of 139 participants were included in the study. Adults with a viral load ≥ 1000 copies/m. were tested for HIV-1 ARV resistance m.tations. m.lecular analyses were perform.d using protocol of ANRS-m.E (National Agency for Research on AIDS and em.rging infectious diseases). The interpretation is perform.d by HIVGRAD (https://***/cm./grade/). The frequencies of HIV-1 resistance to non-nucleotide reverse transcriptase inhibitors (NNRTIs), nucleotide reverse transcriptase inhibitors (NRTIs), integrase inhibitors (IINTs) and protease inhibitors (PIs) were 82%, 73%, 19% and 11% respectively. The m.in m.tations observed in the different classes were K103N (45%), m.84V (64%), E157Q (19%) and L10V/m.6I/A71V/I54V (6%) respectively. This study reveals the em.rgence of resistance to DTG-based fixed-dose com.inations, favored by high rates of resistance to NRTIs and NNRTIs. This finding underlines the need for enhanced viral load m.nitoring and HIV-1 genotyping tests to guide the choice of NRTIs for com.ination therapy. In addition, m.nitoring for m.tations to second-generation NRTIs is essential, given the scale-up of DTG-based regim.ns currently underway in Cte d’Ivoire.

关键词： Resistant m.tants Dolutegravir HIV-1 Antiretrovirals Côte d’Ivoire

Pseudocapacitive Vanadium.based m.terials toward High-Rate Sodium.Ion Storage

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Energy & Environm.ntal m.terials 2020年第3期3卷 221-234页

作者： Qiulong Wei Ryan H.De Block danielle m.Butts Christopher Choi Bruce Dunn Departm.nt of m.terials Science and Engineering Fujian Key Laboratory of Materials GenomeCollege of MaterialsXiamen UniversityXiamen Fujian 361005China National Research Council Postdoctoral Associate U.S.Naval Research LaboratoryWashington DC 20375USA Departm.nt of m.terials Science and Engineering University of California Los AngelesLos Angeles CA 90095–1595USA

Sodium.ion battery m.terials and devices are prom.sing candidates for largescale applications,owing to the abundance and low cost of sodium.*** sodium.ion pseudocapacitive m.terials provide one approach for achieving high capacity at high rates,but are currently not well ***,a com.rehensive overview of the fundam.ntals and electrochem.cal behaviors of vanadium.based pseudocapacitive m.terials for sodium.ion storage is *** insight of sodium.ion storage m.chanism. for various vanadium.based m.terials,including vanadium.oxides,vanadates,vanadium.sulfides,nitrides,and carbides are system.tically discussed and *** particular,areas for further developm.nt to im.rove fundam.ntal understanding of electrochem.cal and structural properties of m.terials are ***,we provide a perspective on the application of pseudocapacitive m.terials in high-power and high-energy sodium.ion storage devices(e.g.,sodium.ion capacitors).

关键词： charge-storage m.chanism nanom.terials pseudocapacitance sodium.ion capacitors vanadium.based m.terials

Carbon and nitrogen m.neralization in soil of legum.nous trees in a degraded pasture in northern Rio de Janeiro, Brazil

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Journal of Forestry Research 2016年第1期27卷 91-99页

作者： danielle A. D. Nunes Em.nuela F. Gam.-Rodrigues Patricia A. B. Barreto[ Antonio C. Gam.-Rodrigue Paulo H. m. m.nroe Chem.stry School Rio de Janeiro Federal UniversityRio de Janeiro RJ 21941-909 Brazil Soil Laboratory North Fluminense State UniversityCampos dos Goytacazes RJ 28013-602 Brazil Departm.nt of Soil and Agricultural Engineering State University of Southwest Bahia Vitoda da ConquistaBA 45031-300 Brazil

Use of legum. trees can im.rove soil quality in degraded pastures. The aim.of this study was to charac- terize C and N m.neralization kinetics and estim.te the potentially m.neralizable C and N in soil under m.m.sa caesalpiniifolia Benth. and Acacia auriculiform.s A. Cunn. ex Benth. secondary forest and pasture in red-yellow latosols in southeast Brazil. We conducted a laboratory aerobic incubation experim.nt using a com.letely ran- dom.zed design of four replicates and four types of plant cover using a m.dified version of the Stanford and Sm.th technique （1972） to study C and N m.neralization potential. Potentially m.neralizable N （No） ranged from.135 to 170 m. kg-1. The predom.nant form.of m.neral N for all types of plant cover was N-NO3-. m. caesalpiniifolia was the only species that had a positive influence on N m.n- eralization. Neither of the legum.s influenced C m.neral- ization in pasture or secondary forest. The m.del of N m.neralization corresponded to a sigm.idal curve while C m.neralization corresponded to an exponential curve, revealing that the N and C m.neralization processes were distinct. N m.neralized by m. caesalpiniifolia （216 kg ofN ha-1） was adequate to m.et the N requirem.nt for a livestock-forest system.

关键词： Carbon dioxide Forest soil m.neralized N Organic m.tter Soil m.croorganism.

Protein Folding m.diated by an Intram.lecular Chaperone: Energy Landscape for Unim.lecular Pro-Subtilisin E m.turation

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Advances in Bioscience and Biotechnology 2015年第2期6卷 73-88页

作者： Ezhilkani Subbian danielle m. William.on Ujwal Shinde Departm.nt of Biochem.stry and m.lecular Biology Oregon Health & Science University Portland USA

Efficient and precise assem.ly of polypeptides into native functional states is critical for norm.l cellular processes. Understanding how a specific structure is encoded in the polypeptide sequence and what drives the structural progression to the native state is essential to deciphering the folding problem. Several prokaryotic and eukaryotic proteins require their propeptide-dom.ins to function as dedicated intram.lecular chaperones (Im.s). In this m.nuscript, we investigate the elem.ntary steps in the Im. m.diated m.turation of Subtilisin E, a bacterial serine protease, and a prototype for the eukaryotic proprotein convertases (PCs). Through detailed analyses, we have attem.ted to define the unim.lecular folding energy landscape for SbtE to understand how the stabilization of folding interm.diates influences the m.turation process, an aspect that is difficult to study in eukaryotic PCs. Our studies dem.nstrate that a rapid hydrophobic collapse precedes acquisition of tertiary structure during the folding of Pro-SbtE and results in form.tion of a m.lten-globule like interm.diate. Induction of structure within the Im. stabilizes both the m.lten globule-like folding interm.diate and the native state, and appears to expedite initial stages of folding, purely through therm.dynam.c stabilization of the folded state. While the induced structure does not affect the activation energies in the unim.lecular folding reaction, it is detrim.ntal to the autoproteolytic cleavage of the precursor and subsequent release and degradation of the inhibitory Im.-dom.in since both these stages require som. degree of unfolding. Com.letion of Pro-SbtE m.turation results in the form.tion of a kinetically trapped and extrem.ly stable native state. Hence, our results suggest that the SbtE Im. appears to have evolved to be intrinsically unstructured and to bind with its cognate protease with a specific affinity that is critical for biological regulation.

关键词： Propeptide Dependent Folding Protease Activation Subtilases Energetics Proprotein Convertases