检索结果-南通市图书馆

国土资源情报 2006年第7期 13-14页

作者： danielle Murray 兰月

巴西圣保罗的消费者有两种燃油选择：石油或乙醇。20世纪70年代中期以来，巴西就致力于从当地生产的甘蔗中蒸馏提取乙醇来取代进口石油。如今乙醇能源在巴西市场的占有率已经达到40％。

关键词：玉米生产乙醇 20世纪70年代燃油选择消费者巴西占有率石油

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HARRT对肾衰竭的快速逆转

中国处方药 2006年第5期5卷 49-51页

作者： danielle Scheurer 杨麟

人类免疫缺陷病毒相关性肾病(HIVAN)主要表现为蛋白尿和进行性肾衰竭,是HIV感染的常见并发症。从组织学上来看,肾脏通常表现为塌陷性、局灶性、节段性肾小球硬化,并且伴有中度增大,CD4细胞计数较少的HIV长期感染者多发,急性HIV感染者偶... 详细信息

人类免疫缺陷病毒相关性肾病(HIVAN)主要表现为蛋白尿和进行性肾衰竭,是HIV感染的常见并发症。从组织学上来看,肾脏通常表现为塌陷性、局灶性、节段性肾小球硬化,并且伴有中度增大,CD4细胞计数较少的HIV长期感染者多发,急性HIV感染者偶见。研究对象不同,该疾病的发生率也不一样,如在临床检出有蛋白尿的患者中,为3.5%,而尸检中为12%。该疾病在非裔及西班牙裔中发病率高。据调查,824例HIVAN患者中,94%的为非裔。糖皮质激素、ACEI和高效抗逆转录病毒治疗(HARRT)均能改善其预后。在使用HAART之前,该病预后不佳,2年存活率为36%。有报道称HAART能改善肾功能,但是尚未有前瞻性研究对其证实,而且肌酐水平好转所需要的时间无记载。本例所述为1例经肾组织活检确诊为HIVAN的患者在接受HAART治疗后其终末期肾衰竭快速逆转的案例。

关键词：肾衰竭 HARRT 人类免疫缺陷病毒相关性肾病快速逆转 HIV感染者 CD4细胞计数常见并发症肾小球硬化研究对象蛋白尿

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汽车巨变下的两个女人

经营者(汽车商业评论) 2019年第12期 188-198页

作者：叶无极 danielle Bochove ABR

十多年前,她们加入通用汽车,如今,汽车行业转型让其中一人被抛在了后面15年前,阿曼达·卡尔霍斯(Amanda Kalhous)和丽贝卡·基奇(Rebecca Keetch)先后入职通用汽车加拿大公司,这么多年过去了,她们在裁员、政府救助和公司破产等一系列危... 详细信息

十多年前,她们加入通用汽车,如今,汽车行业转型让其中一人被抛在了后面15年前,阿曼达·卡尔霍斯(Amanda Kalhous)和丽贝卡·基奇(Rebecca Keetch)先后入职通用汽车加拿大公司,这么多年过去了,她们在裁员、政府救助和公司破产等一系列危机之中坚持了下来。如今,两人又将面临新的挑战,只不过这回更彻底,她们对抗的将是自装配线被发明以来汽车业发生的最大变化——自动驾驶与电动化。这一次,只有一个人能继续待在队列中,另一个人很有可能会被抛弃。

关键词：丽贝卡加拿大阿曼达奥沙瓦

Analysis of 12 variants in the development of gastric and colorectal cancers

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World Journal of Gastroenterology 2017年第48期23卷 8533-8543页

作者： Giovanna C Cavalcante Marcos AT Amador Andre M Ribeiro dos Santos Darlen C Carvalho Roberta B Andrade Esdras EB Pereira Marianne R Fernandes danielle F Costa Ney PC Santos Paulo P Assumpcao Andrea Ribeiro dos Santos Sidney Santos Laboratório de Genética Humana e Médica Universidade Federal do Pará Núcleo de Pesquisas em Oncologia Universidade Federal do Pará

AIM To evaluate the relation between 12 polymorphisms and the development of gastric cancer(GC) and colorectal cancer(CRC).METHODS In this study,we included 125 individuals with GC diagnosis,66 individuals with CRC diagnosis and 475 cancer-free individuals. All participants resided in the North region of Brazil and authorized the use of their samples. The 12 polymorphisms(in CASP8,CYP2 E1,CYP19 A1,IL1 A,IL4,MDM2,NFKB1,PAR1,TP53,TYMS,UGT1 A1 and XRCC1 genes) were genotyped in a single PCR for each individual,followed by fragment analysis. To avoid misinterpretation due to population substructure,we applied a previously developed set of 61 ancestryinformative markers that can also be genotyped by multiplex PCR. The statistical analyses were performed in Structure v.2.3.4,R environment and SPSS *** After statistical analyses with the control of confounding factors,such as genetic ancestry,three markers(rs79071878 in IL4,rs3730485 in MDM2 and rs28362491 in NFKB1) were positively associated with the development of GC. One of these markers(rs28362491) and the marker in the UGT1 A1 gene(rs8175347) were positively associated with the development of CRC. Therefore,we investigated whether the joint presence of the deleterious alleles of each marker could affect the development of cancer and we obtained positive results in all analyses. Carriers of the combination of alleles RP1 + DEL(rs79071878 and rs28361491,respectively) are at 10-times greater risk of developing GC than carriers of other combinations. Similarly,carriers of the combination of DEL + RARE(rs283628 and rs8175347) are at about 12-times greater risk of developing CRC than carriers of other *** These findings are important for the comprehension of gastric and CRC development,particularly in highly admixed populations,such as the Brazilian population.

关键词： Inflammatory processes Immune response Genomic and cellular stability Gastric cancer Colorectal cancer Amazon

Leptin-induced Notch and IL-1 signaling crosstalk in endometrial adenocarcinoma is associated with invasiveness and chemoresistance

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World Journal of Clinical Oncology 2019年第6期10卷 222-233页

作者： danielle Daley-Brown Adriana Harbuzariu Ann Anu Kurian Gabriela Oprea-Ilies Ruben Rene Gonzalez-Perez Department of Microbiology Biochemistry and Immunology Morehouse School of Medicine Atlanta GA 30310 United States Department of Pathology and Laboratory Medicine Emory University Atlanta GA 30322 United States

BACKGROUND Obesity is a recognized risk factor for endometrial cancer (EmCa) and other cancer types. Leptin levels are significantly increased in obese individuals. Leptin-induced signaling crosstalk [Notch, Interleukin-1 (IL-1) and leptin outcome, NILCO] has been associated with breast cancer progression. This complex signaling crosstalk affects cancer cell proliferation, migration, invasion, angiogenesis, apoptosis and chemoresistance. NILCO expression was previously detected in human EmCa. However, it is unknown whether leptin regulates NILCO and alters EmCa’s response to chemotherapeutics. It is hypothesized that leptin induces NILCO and increases aggressiveness and chemoresistance in EmCa cells. AIM To determine whether leptin induces NILCO molecules in EmCa affecting cell proliferation, aggressiveness and chemoresistance. METHODS Leptin’s effects on the expression of NILCO molecules [mRNAs and proteins for Notch receptors (Notch1-4), ligands (JAG1 and DLL4) and downstream effectors (survivin, Hey2), and leptin (OB-R) and IL-1 (IL-1R tI) receptors] was examined in EmCa cells (type I: Ishikawa, and HEC-1A, and type II: An3Ca and KLE) using Real-time PCR and Western blot analysis, respectively. In addition, the effects of leptin on cell cycle, proliferation and cell invasion were determined using cytometric analysis (Cellometer Vision CBA system), MTT cell proliferation and Matrigel-based invasion assays, respectively. Inhibitors of leptin (nanoparticlebound leptin peptide receptor antagonist-2, IONP-LPrA2), IL-1 (anti-IL-1R tI antibody) and Notch (siRNA interference RNA) were used to investigate NILCO’s effects on cell proliferation and invasion. Leptin’s effects on Paclitaxel cytotoxicity in EmCa cells was determined by the CCK8 and Cellometer-based Annexin V assays. RESULTS For the first time it was shown that leptin is an inducer of Notch in EmCa. Experimental data suggest that leptin induced the expression of NILCO molecules, promoted proliferation and S- ph

关键词： Endometrial cancer Leptin Notch Interleukin-1 Notch, IL-1 and Leptin crosstalk outcome Chemoresistance

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时尚复兴者

商学院 2008年第5期 33-35页

作者： danielle Sacks 邓小莉

“拿出你们最有创造力的设计，”他回忆说，“他们的脸上呈现出从监狱里重返自由的表情。”

关键词：时尚创造力企业管理经营理念

Sleep Quality on Maintenance Hemodialysis Patients in Douala General Hospital in Cameroon

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Open Journal of Nephrology 2017年第3期7卷 61-68页

作者： Fouda Menye Ebana Hermine danielle Maimouna Mahamat Kaze Folefack Francois Halle Marie-Patrice Ashuntantang Gloria Department of Internal Medicine Faculty of Medicine and Biomedical Sciences of Yaoundé Yaoundé Cameroon Department of Internal Medicine Faculty of Medicine and Pharmaceutic Sciences of Douala Douala Cameroon

Background: Poor sleep quality is reported to be common in hemodialysis patients. However, limited data are available about its prevalence in sub-Saha-ran region. The aim of this study was to assessed sleep quality and its predictors among hemodialysis patients. Methods: We conducted a cross sectional study of 2 weeks in the Douala General Hospital hemodialysis center of Cameroon involving 46 chronic hemodialyzed patients for at least six months with arteriovenous fistula. Quality of sleep was measured using the Pittsburgh Sleep Quality Index (PSQI) and laboratory data were collected in patients’’ fields. Result: Thirty-five (76.1%) subjects reported poor sleep quality. The most frequent abnormal sleep components were subjective sleep quality, sleep disturbances and sleep latency (87%, 85% and 76% respectively). In univariate linear regression, hemoglobin level, sleep quality, sleep latency, sleep duration, habitual sleep efficiency and sleep disturbance were associated with poor sleep quality. In multivariate linear regression only hemoglobin level (p = 0.004) and sleep latency (p = 0.002) were associated with poor sleep quality. Conclusion: Poor sleep quality is frequent in our hemodialysis patients and hemoglobin seems to be a good predictor of sleep quality in these patients.

关键词： Sleep Quality Hemodialysis Cameroon Anemia

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甲流疫苗与“情绪流行病学”

中国医院院长 2009年第24期5卷 86-87页

作者： danielle Ofri 戴廉

记录下情绪流行病学和疾病流行病学，并且以同等的紧迫性对二者进行治疗，是当前流感季节的基本临床工具。2009年春天，当甲型H1N1流感首次受到关注时，我的病人们陷入了恐慌。我们的诊所不断接到电话以及来访的病人，他们部问了同一个... 详细信息

记录下情绪流行病学和疾病流行病学，并且以同等的紧迫性对二者进行治疗，是当前流感季节的基本临床工具。2009年春天，当甲型H1N1流感首次受到关注时，我的病人们陷入了恐慌。我们的诊所不断接到电话以及来访的病人，他们部问了同一个问题：“什么时候会有疫苗？”

关键词：流行病学情绪疫苗流感季节临床工具 H1N1

Comparison of total immunoglobulin A levels in different samples in Leghorn and broiler chickens

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Asian Pacific Journal of Tropical Biomedicine 2017年第2期7卷 116-120页

作者： Rubén Merino-Guzmán Juan David Latorre Ramiro Delgado Xochitl Hernandez-Velasco Amanda Desha Wolfenden Kyle Dean Teague Lucas Elzie Graham Brittany danielle Mahaffey Mikayla Francis Ann Baxter Billy Marshall Hargis Guillermo Tellez College of Veterinary Medicine National Autonomous University of Mexico Department of Poultry Science University of Arkansas Nutriavicola

Objective: To standardize an ELISA protocol to quantify total immunoglobulin A(IgA)from different biological ***: Two independent experiments were conducted. In Experiment 1, total IgA levels were quantified from the lachrymal fluid, tracheal swab, and cloacal swab at various time points from Days 30 to 89 in white Leghorn chickens. Experiment 2 was conducted to evaluate the effect of 50 or 500 ppb of aflatoxin B1(AFB1) on total IgA quantified in samples from the lachrymal fluid, tracheal swab, gut content and cloacal swab in broiler chickens at 21 days of ***: Lachrymal fluid contained the highest level of IgA; however, the sampling procedure was time consuming and stressful to the bird, and the sample volume depends largely on the size of the chicken. Cloacal swabs also contained a high concentration of IgA; this sampling procedure was faster than lachrymal fluid sampling and was not affected by the age of the bird. Tracheal sampling was more difficult than cloacal sampling; the age of the bird limited the sampling, and the IgA concentration was the lowest detected at all sampling ages. 500 ppb of AFB1 significantly reduced total IgA concentration in the gut content compared with control or 50 ppb of AFB1 treated ***, a significant reduction in total IgA was also observed in those chickens that received 50 ppb of AFB1 in gut rinse when compared with cloacal ***: The results of this study suggest that cloacal swab is an easy and reliable way to evaluate mucosal IgA concentration in both Leghorn and broiler chickens.

关键词： Immunoglobulin A ELISA Chicken Lachrymal fluid