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Metastasis-associated lung adenocarcinoma transcript 1 molecular mechanisms in gastric cancer progression

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World Journal of Gastrointestinal Oncology 2023年第9期15卷 1520-1530页

作者： Daniel Mateus de Oliveira Batista Jessica Manoelli Costa da Silva Carolina de Oliveira Gigek Marilia de Arruda Cardoso Smith Paulo Pimentel de Assumpcao danielle Queiroz Calcagno Nucleo de Pesquisas em Oncologia Universidade Federal do ParaBelem 66073-000ParaBrazil Departamento de Patologia Universidade Federal de São PauloSao Paulo 04023-062São PauloBrazil Disciplina de Genetica Departamento de Morfologia e GeneticaUniversidade Federal de São PauloSão Paulo 04023-900Sao PauloBrazil

Gastric cancer(GC)remains among the most common cancers worldwide with a high mortality-to-incidence *** evidence suggests that long noncoding RNAs(lncRNAs)are involved in gastric *** transcripts are longer than 200 nucleotides and modulate gene expression at multiple molecular levels,inducing or inhibiting biological processes and ***-associated lung adenocarcinoma transcript 1(MALAT1)is one of the best-studied lncRNAs with comprehensive actions contributing to cancer *** lncRNA regulates gene expression at the transcriptional and posttranscriptional levels through interactions with microRNAs and *** the present review,we discussed the molecular mechanism of MALAT1 and summarized the current knowledge of its expression in ***,we highlighted the potential use of MALAT1 as a biomarker,including liquid biopsy.

关键词： Long noncoding RNA Gastric carcinogenesis Transcriptional levels Posttranscriptional levels Prognostic biomarker Liquid biopsy

Clickers and Deep Learning： An Oxymoron？

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Computer Technology and Application 2013年第1期4卷 69-78页

作者： danielle Morin Jennifer D.E. Thomas Robert Cassidy John Molson School of Business Concordia University Montreal QC H3G 1M8 Canada Seidenberg School of Computer Science and Information Systems Pace University New York NY 10038 USA Department of Psychology Faculty of Arts and Science Concordia University Montreal QC H4B 1R6 Canada

The use of clicker technology as a tool for promoting learning, let along deep learning, is hotly debated and has its proponents and opponents. With the question still open, this paper examines the use of this technology in fostering critical thinking and other higher-order learning and team-building skills, in the context of two entry-level psychology courses. The results obtained indicate that from the perspectives of both the student and the instructor, the integration of this technology was positively perceived to enhance the learning process and the acquisition of these skills. It would seem these concepts are, after all, not antithetical.

关键词： Clickers critical thinking technology and learning higher-order skills.

Reducing psychiatric illness in the perinatal period:A review and commentary

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World Journal of Psychiatry 2023年第4期13卷 149-160页

作者： Jessica Rohr Farhaan S Vahidy Nicole Bartek Katelynn A Bourassa Namrata R Nanavaty danielle D Antosh Konrad P Harms Jennifer L Stanley Alok Madan Department of Psychiatry and Behavioral Health Houston MethodistHoustonTX 77030United States Department of Neurosurgery Houston MethodistHoustonTX 77030United States Department of Obstetrics and Gynecology Houston MethodistHoustonTX 77030United States

This brief overview highlights the global crisis of perinatal psychiatric illness(PPI).PPI is a major contributor to many adverse pregnancy,childbirth,and childhood development *** contributes to billions of dollars in spending worldwide each year and has a significant impact on the individual,their family,and their *** is also highly *** recommendations for intervention and management of PPI are limited and vary considerably from country to ***,there are several significant challenges associated with implementation of these *** challenges are magnified in number and consequence among women of color and/or minority populations,who experience persistent and negative health disparities during pregnancy and the postpartum *** paper aims to provide a broad overview of the current state of recommendations and implementation challenges for PPI and layout a framework for overcoming these *** equityinformed model of care that provides universal intervention for pregnant women may be one solution to address the preventable consequences of PPI on child and maternal ***,this model emphasizes the importance of managing and eliminating known barriers to traditional health care *** and contextually specific challenges must be overcome to fully realize the impact of improved management of PPI.

关键词： Perinatal psychiatric illness Postpartum depression Equity-oriented care Minority populations Maternal mortality Pregnancy

Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation

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World Journal of Hepatology 2019年第2期11卷 208-216页

作者： Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes Department of Pediatrics Section of GastroenterologyHepatologyand NutritionBaylor College of Medicine College of Arts and Sciences Washington University in St.Louis Outcomes and Impact Service Texas Children’s Hospital Dan L.Duncan Institute for Clinical and Translational Research Baylor College of Medicine Department of Pediatrics Section of Infectious DiseaseBaylor College of Medicine

BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in *** with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be *** PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of *** To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver *** Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were *** compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of *** Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia *** sole polymicrobial infection grew Enterobacter cloacae and Klebsiella *** organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,*** demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver *** clinical,demographic,or laboratory factor we

关键词： Parenteral nutrition Central line-associated bloodstream infection Pediatric Microbiology Central venous catheter

Teacher Self-Efficacy & Student Success in Mathematics at Kiski Area High School

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Teacher Self-Efficacy & Student Success in Mathematics at Ki...

Systematic Review of HPV Prevalence in Penile Cancer and Penile Intraepithelial Neoplasia

作者： Greg S.Goodman danielle Pugliese Clarion University of Pennsylvania

Teacher Self-Efficacy and Student Success in Mathematics at Kiski Area High School assessed the self-efficacy of six teachers from the mathematics department of Kiski Area High School,Vandergrift,PA,in an attempt to provide a focused application of Tschannen-Moran and Woolfolk Hoy’s Teacher’s Sense of Efficacy *** research primarily exists to answer the question;In what specific and measureable ways does teacher self-efficacy impact the academic success of students within the mathematics department of Kiski Area High School?An answer to this question shall be reached via analysis of teacher observations,Teacher Sense of Efficacy Scale responses,follow-up questionnaire,and comparison to recent PSSA *** included relative homogeneity of teacher self-efficacy scale responses,with some variance among *** of the small sample size,no relation between teacher self-efficacy as measured by Tschannen-Moran and Woolfolk Hoy’s Teacher’s Sense of Efficacy Scale and student achievement on 11

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Systematic Review of HPV Prevalence in Penile Cancer and Pen...

The unique degradation pathway of the PTS2 receptor,Pex7,is dependent on the PTS receptor/co-receptor,Pex5 and Pex20.

24th International Papillomavirus Conference and Clinical Workshop

作者： danielle Backes Robert Kurman Jennifer Smith Department of Epidemiology School of Public HealthUniversity of North CarolinaChapel HillNC Departments of Pathology Gynecology and ObstetricsJohns Hopkins Medical InstitutionsBaltimoreMD Department of Epidemiology School of Public HealthUniversity of North CarolinaChapel HillNC

＜正＞Background:Type-specific prevalence data of human papitlomavirus（HPV）DNA in penile carcinoma and penile intraepithelial neoplasia（PIN）are needed to determine the potential impact of HPV prophytactic vaccines...

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The unique degradation pathway of the PTS2 receptor,Pex7,is ...

R eview of Soil and Water Assessment Tool(SWAT)applications in Brazil:C hallenges and prospects

2014年第七届中国模式真菌研讨会

作者：马长乐 danielle Hagstrom Suresh Subramani College of Life Sciences Shandong Normal University Section of Molecular Biology Division of Biological SciencesUniversity of California

Peroxisomal matrix protein import uses two peroxisomal targeting signals(PTSs).Most matrix proteins use the PTS 1 pathway and its cargo receptor,*** PTS2 pathway is dependent on another receptor,Pex7,and its co-receptor,*** found that during the matrix protein import cycle,the stability and dynamics of Pex7 differ from that of Pex5 and *** Pichia pastoris,unlike Pex5 and Pex20,Pex7 is constitutively degraded in wild-type cells but is stabilized in pex mutants affecting matrix protein *** of Pex7 is more prevalent in cells grown in methanol,wherein the PTS2 pathway is non-essential,in comparison with oleate,suggesting

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International Journal of Agricultural and Biological Engineering 2015年第3期8卷 9-35,F0002,I0001页

作者： danielle de Almeida Bressiani Philip W.Gassman Josimar Gurgel Fernandes Luis Hamilton Pospissil Garbossa Raghavan Srinivasan Nadia Bernard i Bonumá Eduardo Mario Mendiondo University of São Paulo EESCSHS-São Carlos/SP 13566-590Brazil Department of Ecosystem Science and Management SSLTexas A&M UniversityCollege StationTX 77843USA Center for Agricultural and Rural Development Iowa State University-AmesIA 50011-1070USA Agronomic Institute of Pernambuco-IPA-Recife/PE 50761-000Brazil Federal University of Pernambuco-UFPE-Recife/PE 50670-901Brazil Santa Catarina Agricultural Research and Extension Corporation-Epagri/Ciram-Florianópolis/SC 88034-901Brazil Federal University of Santa Catarina-UFSC-Florianópolis/SC 88040-900Brazil Brazilian Center of Monitoring and Early Wa rning of Natural Disasters CEMADEN/MCTISão Josédos Campos/SP12247-016 Brazil

The geographical extent of Brazil exceeds 8.5 million km2 and encompasses a complex mix of biomes and other environmental *** decision support tools are needed to help support management of these diverse Brazilian natural resources including ecohydrological *** use of the Soil and Water Assessment Tool(SWAT)ecohydrological watershed-scale model in Brazil has increased greatly during the past *** over 100 SWAT studies were identified in this review which have been published during 1999 to 2015 in Brazilian and international journals,conference proceedings,and as theses or dissertations,many of which are written in *** majority of these studies(102 total)are reviewed here as part of an extensive survey covering the 1999 to 2013 time *** and spatial distributions,a summary of hydrologic calibration and validation results and a synopsis of the types of applications that were performed are reported for the surveyed studies.A smaller subset of recent Brazilian studies published in English between 2012 and 2015 in scientific journals are also reviewed,with emphasis on hydrologic and sediment transport testing results as well as scenario applications that were *** majority of the surveyed SWAT studies was performed for watersheds located in the South and Southeast regions of Brazil(67%)and was conducted in the context of academic *** 50%of the surveyed studies reported only hydrologic *** trends were found for the subset of more recent English *** studies have been reported that describe applications of SWAT in Brazil by private firms or government agencies;this review indicates that the potential exists for increased numbers of such studies in the ***,there is evidence that a lack of accessibility to adequate quality input data is a possible hindrance to the more general use of SWAT for watershed applications in Brazil.

关键词： SWAT models mapping applications review Brazil

Characterization of patients with both alcoholic and nonalcoholic fatty liver disease in a large United States cohort

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World Journal of Hepatology 2019年第10期11卷 710-718页

作者： George Khoudari Amandeep Singh Mazen Noureddin danielle Fritze Rocio Lopez Imad Asaad Eric Lawitz Fred Poordad Kris V Kowdley Naim Alkhouri Department of Hospital Medicine Cleveland Clinic FoundationClevelandOH 44195United States Department of Gastroenterology and Hepatology Cleveland ClinicClevelandOH 44195United States Department of Gastroenterology and Hepatology Cedars Sinai Medical CenterLos AngelesCA 90048United States Department of General Surgery Texas Liver Institute and University of Texas HealthSan AntonioTX 78215United States Department of Quantitative Health Sciences Cleveland ClinicClevelandOH 44195United States Department of Gastroenterology Metro Health SystemClevelandOH 44109United States Texas Liver Institute and University of Texas Health San AntonioTX 78215United States Swedish Liver Care Network Swedish Medical CenterSeattleWA 98122United States

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is the hepatic manifestation of the metabolic syndrome(MetS)and is characterized by steatosis in the absence of significant alcohol ***,MetS and significant alcohol intake coexist in certain individuals which may lead to the development of *** To assess the clinical characteristics of patients with both alcoholic and NAFLD(BAFLD)in a large cohort in the United *** Adults from the National Health and Nutrition Examination Survey between 2003-2014 were *** was diagnosed based on elevated alanine aminotransferase(ALT)and being overweight or obese in the absence of other liver *** patients met the criteria for NAFLD but also had either MetS or type 2 diabetes and consumed excessive amounts of *** and multivariable analysis were performed to assess differences between NAFLD and BAFLD and to compare severity based on a validated fibrosis score(FIB4 index).RESULTS The prevalence of NAFLD was at 25.9%(95%CI;25.1-26.8)and that of BAFLD was 0.84%(0.67,1.02)which corresponds to an estimated 1.24 million Americans affected by *** to NAFLD,patients with BAFLD were more likely to be male,smokers,have higher ALT,aspartate aminotransferase,triglycerides,and lower platelets;P2.67 was 3.2(1.4,7.0),P=0.004].CONCLUSION A significant percentage of the American general population is afflicted by BAFLD and these patients tend to have more advanced liver fibrosis.

关键词： Non-alcoholic fatty liver disease Alcoholic liver disease Fatty liver disease