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Effectiveness of rotavirus vaccines against rotavirus infection and hospitalization in Latin America: systematic review and metaanalysis

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Infectious Diseases of poverty 2016年第1期5卷 764-775页

作者： Victor S.Santos daniella p.marques paulo R.S.Martins-Filho Luis E.Cuevas Ricardo Q.Gurgel postgraduate program in Health Sciences Federal University of SergipeRua Cláudio Batista s/nAracajuSergipe Zip code:49060-108Brazil Department of Medicine Federal University of SergipeAracajuSergipeBrazil Investigative pathology Laboratory Federal University of SergipeAracajuSergipeBrazil Liverpool School of Tropical Medicine LiverpoolUK

Background:Rotavirus was the leading cause of childhood diarrhoea-related hospitalisations and death before the introduction of rotavirus ***:We describe the effectiveness of rotavirus vaccines to prevent rotavirus infections and hospitalizations and the main rotavirus strains circulating before and after vaccine introduction through a systematic review and meta-analysis of studies published between 1990 and 2014.203 studies were included to estimate the proportion of infections due to rotavirus and 10 to assess the impact of the vaccines.41 of 46 studies in the post-vaccination period were used for meta-analysis of genotypes,20 to calculate VE against infection,eight for VE against hospitalisation and seven for VE against severe ***:24.3%(95%CI 22.1–26.5)and 16.1%(95%CI 13.2–19.3)of cases of diarrhoea were due to rotavirus before and after vaccine introduction,*** most prevalent G types after vaccine introduction were G2(51.6%,95%CI 38–65),G9(14.5%,95%CI 7–23)and G1(14.2%,95%CI 7–23);while the most prevalent p types were p[4](54.1%,95%CI 41–67)and p[8](33%,95%CI 22–46).G2p[4]was the most frequent genotype combination after vaccine *** was 53%(95%CI 46–60)against infection,73%(95%CI,66–78)against hospitalisation and 74%(95%CI,68.0–78.0)against severe *** in hospitalisations and mortality due to diarrhoea were observed in countries that adopted universal rotavirus ***:Rotavirus vaccines are effective in preventing rotavirus-diarrhoea in children in Latin *** vaccines were associated with changes in genotype distribution.

关键词： Rotavirus vaccines Rotavirus vaccine effectiveness Rotavirus genotype Meta-analysis Latin America

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