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Journal of Agricultural Science and Technology(B) 2016年第5期6卷 350-359页

作者： Monica Rodrigues Ferreira Machado] Eliane aparecida de Andrade Estefania de Souza Andrade daniella aparecida de jesus paula Julia Alvarenga Oliveira Adriano Carvalho Costa Ana paula Peconick Luis David Solis Murgas department of Biological Science Federal University of Goias (UFG) Campus Cidade Universitaria CEP 75801-615 JataiGoias Brazil department of Veterinary Medicine Cdmpus Universitario Federal University of Lavras (UFLA) Lavras Minas Gerais CEP3 7200-000 Brazil department of Animal Science Federal Institute of Rio Verde (IFR V) Rio Verde Goias CEP 75901-970 Brazil

Anti-diabetic potential of apigenin,luteolin,and baicalein via partially activating PI3K/Akt/GLUT-4 signaling pathways in insulin-resistant HepG2 cells

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Food Science and Human Wellness 2023年第6期12卷 1991-2000页

作者： Lingchao Miao Haolin Zhang Meng Sam Cheong Ruting Zhong paula Garcia-Oliveira Miguel A.Prieto Ka-Wing Cheng Mingfu Wang Hui Cao Shaoping Nie jesus Simal-Gandara Wai San Cheang Jianbo Xiao Institute of Chinese Medical Sciences University of MacaoMacao 999078China department of Analytical Chemistry and Food Science Faculty of Food Science and TechnologyUniversity of Vigo-Ourense CampusOurense E-32004Spain Institute for Advanced Study Shenzhen UniversityShenzhen 508060China School of Biological Sciences The University of Hong KongHong Kong 999077China College of Food Science and Technology Guangdong Ocean UniversityGuangdong Provincial Key Laboratory of Aquatic Product Processing and SafetyGuangdong Province Engineering Laboratory for Marine Biological ProductsGuangdong Provincial Engineering Technology Research Center of SeafoodKey Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education InstitutionZhanjiang 524088China State Key Laboratory of Food Science and Technology China-Canada Joint Lab of Food Science and Technology(Nanchang)Nanchang UniversityNanchang 330047China International Research Center for Food Nutrition and Safety Jiangsu UniversityZhenjiang 212013China

Dietary flavonoids are abundant in natural plants and possess multiple pharmacological and nutritional *** this study,apigenin,luteolin,and baicalein were chosen to evaluate their anti-diabetic effect in high-glucose and dexamethasone induced insulin-resistant(IR)HepG2 *** flavonoids improves the glucose consumption and glycogen synthesis abilities in IR-HepG2 cells via activating glucose transporter protein 4(GLUT4)and phosphor-glycogen synthase kinase(GSK-3β).These fl avonoids signifi cantly inhibited the production of reactive oxygen species(ROS)and advanced glycation end-products(AGEs),which were closely related to the suppression of the phosphorylation form of NF-κB and *** expression levels of insulin receptor substrate-1(IRS-1),insulin receptor substrate-2(IRS-2)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)pathway in IR-HepG2 cells were all partially activated by the fl avonoids,with variable ***,the intracellular metabolic conditions of the fl avonoids were also evaluated.

关键词： Apigenin Luteolin Baicalein Insulin-resistant HepG2 cells Signaling pathway Reactive oxygen species(ROS) Advanced glycation end-products(AGEs) Glycogen synthase kinase(GSK-3β) Glucose transporter protein 4(GLUT4)

Advanced glycation end product:A potential biomarker for risk stratification of non-alcoholic fatty liver disease in ELSA-Brasil study

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World Journal of Gastroenterology 2021年第29期27卷 4913-4928页

作者： Evelyn Nunes Goulart da Silva Pereira Daniela Polessa paula Beatriz Peres de Araujo Maria de jesus Mendes da Fonseca Maria de Fátima Haueisen Sander Diniz Anissa Daliry Rosane Harter Griep Laboratory of Cardiovascular Investigation Oswaldo Cruz FoundationRio de Janeiro 21040-360Brazil National School of Statistical Sciences Brazilian Institute of Geography and StatisticsRio de Janeiro 20231-050Brazil department of Epidemiology and Quantitative Methods in Health Oswaldo Cruz FoundationRio de Janeiro 21040-360Brazil Faculty of Medicine Universidade Federal de Minas GeraisMinas Gerais 31270-901Brazil Laboratory of Health and Environment Education Oswaldo Cruz FoundationRio de Janeiro 21040-360Brazil

BACKGROUND Liver diseases are associated with the excess formation of advanced glycation end products(AGEs),which induce tissue inflammation and oxidative ***,the trend of oxidative marker levels according to the steatosis grade in non-alcoholic fatty liver disease(NAFLD)is *** To compare serum AGE levels between participants with NAFLD accordingly to steatosis severity in the baseline ELSA-Brasil *** In 305 individuals at baseline ELSA-Brasil,NAFLD-associated steatosis was classified by ultrasound hepatic *** participants were grouped according to the severity of steatosis:mild and moderate/severe *** measurement of serum fluorescent AGE concentrations was based on spectrofluorimetric *** AGE content and clinical and laboratory characteristics of the participants were compared between *** correlation between serum AGE levels and the grade of steatosis was *** regression analysis was used to investigate the relationship between serum AGE levels and steatosis severity.A P valuedered statistically *** According to the steatosis severity spectrum in NAFLD,from mild to moderate/severe,individuals with the most severe steatosis grade had a higher incidence of metabolic syndrome(63%vs 34%,P≤0.001),diabetes mellitus(37%vs 14%,P≤0.001),and high cholesterol levels(51%vs 33%,Pdex,systolic and diastolic blood pressure,fasting blood glucose,glycated hemoglobin,insulin,triglycerides,alanine aminotransferase,gamma-glutamyl transferase,C-reactive protein,and uric acid levels and lower high-density *** serum AGE content was present in the moderate/severe group of individuals than in the mild group(P=0.008).In addition,the serum AGE levels were correlated with the steatosis grade in the overall sample(rho=0.146,P=0.010).Logistic regres

关键词： Advanced glycation end products Non-alcoholic fatty liver disease Steatosis ELSA-Brasil study Spectroscopy

Obesity in people with diabetes in COVID-19 times: Important considerations and precautions to be taken

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World Journal of Clinical Cases 2021年第20期9卷 5358-5371页

作者： Adriano Alberti Fabiana Schuelter-Trevisol Betine Pinto Moehlecke Iser Eliane Traebert Viviane Freiberger Leticia Ventura Gislaine Tezza Rezin Bruna Becker da Silva Fabiana Meneghetti Dallacosta Leoberto Grigollo paula Dias Gracielle Fin Josiane aparecida de jesus Fabiane Pertille Carina Rossoni Ben Hur Soares Rudy JoséNodari Júnior Clarissa Martinelli Comim Research Group in Neurodevelopment of Childhood and Adolescence Laboratory of Experimental NeurosciencePostgraduate Program in Health SciencesUniversity of South Santa Catarina(Unisul)Palhoça88137-270Santa CatarinaBrazil Brazil Clinical Research Center Postgraduate Program in Health SciencesUniversity of Southern Santa Catarina at TubarãoTubarão88704-900Santa CatarinaBrazil Postgraduate Programme in Health Sciences University of Southern Santa CatarinaPalhoça88137-270Santa CatarinaBrazil Postgraduate Program in Biosciences and Health University of the West of Santa CatarinaJoaçaba89600-000Santa CatarinaBrazil department of Physical Education University of the West of Santa CatarinaJoaçaba89600-000Santa CatarinaBrazil Environmental Health Institute of the Faculty of Medicine of the University of Lisbon Lisboa1649-029Portugal Health Science University of Passo FundoPasso Fundo99052-900Rio Grande do SulBrazil Research department Salus DermatoglifiaLuzerna89609-000Santa CatarinaBrazil

At the end of 2019,a new disease with pandemic potential appeared in *** was a novel coronavirus called coronavirus disease 2019(COVID-19).Later,in the first quarter of 2020,the World Health Organization declared the outbreak of this disease a *** people,people with comorbidities,and health care professionals are more vulnerable to *** has been growing exponentially worldwide,affecting several age *** is a morbidity that is associated with genetic,epigenetic,environment factors and/or interaction between *** is associated with the development of several diseases including diabetes mellitus,mainly type *** affects a significant portion of the global *** and diabetes are among the main risk factors for the development of severe symptoms of COVID-19,and individuals with these conditions constitute a risk *** on a literature review on obesity in people with diabetes in the framework of the COVID-19 pandemic,this study presents updated important considerations and care to be taken with this population.

关键词： Obesity Diabetes COVID-19 Population World Disease

Late diagnosis and TCD8 immune response profile of cutaneous tuberculosis: A case report

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Open Journal of Immunology 2012年第3期2卷 125-131页

作者： Bruna daniella de Souza Silva Sueli Lemes de ávila Alves André Kipnis Ana paula Junqueira-Kipnis departamento de Microbiologia Imunologia Patologia e Parasitologia Instituto de Patologia Tropical e Saúde Pública Universidade Federal de Goiás Goiania/GO Brazil Laboratório Central de Saúde Pública Dr. Giovanni Cysneiros LACEN/GO Goiania/GO Brazil

Introduction: Cutaneous tuberculosis (CTB) is a rare form of extra-pulmonary tuberculosis that, when associated with late diagnosis, worsen the quality of life of the sick individuals. This report presents a case of late diagnosis of CTB. Unusual clinical manifestations retarded the correct tuberculosis diagnosis for more than a year. The immune response elicited by this type of tuberculosis as well as the factors that might contribute to the delay in diagnosis was evaluated and discussed. Methodology: Clinical evaluation and flow cytometric analyses of PBMC were realized for a case of CTB and a healthy individual as a control. Results: M. tuberculosis specific TCD8+ cell response was analyzed by flow cytometry and revealed positive cells for IL-17, IL-10, TGF-β and IDO. The CTB patient presented higher percentage of those cells when compared to a healthy donor. However, TCD8 cells positive for the important protective cytokine, IFN-γ was decreased in the CTB patient. Conclusion. The assessment of the M. tuberculosis specific TCD8+ immune response showed a regulatory/modulatory phenotype with a reduced IFN-γ response when compared to the healthy control that could have contributed to the CTB infection.

关键词： Cutaneous tuberculosis Late Diagnosis CD8+ T Cells

Quality of Drugs Based on Ferrous Sulfate Dispensed in a Basic Health and Commercial Pharmacy in a City in the Amazon Region

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Pharmacology & Pharmacy 2022年第9期13卷 331-339页

作者： Amanda Gabryelle Nunes Cardoso Mello Marceonia Costa dos Santos Ana Gabriela Lisboa Santos Danila Teresa Valeriano Alves daniella Paternostro de Araújo Grisolia Alan Barroso Araújo Grisólia Mariceli Baia Leão Barros Fabrícia de jesus Paiva da Fonseca Manoel Samuel da Cruz Neto Faculty of Pharmacy FIBRA University Center Belém Brazil Faculty of Biotechnology Federal University of Pará Belém Brazil Biological Sciences Center Federal University of Pará Belém Brazil FACI WYdeN Faculty Belém Brazil

Background: For the WHO, anemia is a serious public health problem, with an emphasis on deprivation anemia, which has socioeconomic conditions as determining factors for its development. Among nutritional anemias, the most relevant is iron deficiency, whose main form of prevention and treatment is supplementation with ferrous sulfate dispensed in the public health system, with the need to periodically check whether the drug has the quality required by regulatory health agencies. Thus, the objective of this study was to analyze the quality of the ferrous sulfate medication, from the same laboratory, and dispensed in a basic health unit (BHU) and a commercial pharmacy (CF). Materials and Methods: An analytical, qualitative and quantitative study of ferrous sulfate heptahydrate (25 mg/mL in 100 mL syrup), carried out on 20 BHU and 10 from CF, both from the same laboratory, but in different batches. Samples were subjected to organoleptic analysis and verification of iron content, pH, volume and density. Data were compared with values recommended by the Brazilian pharmacopoeia 5th edition. Results: Three batches were evaluated: 4659 of from the CF;4574 from the BHU1, and 4576 from the BHU2, stored in accordance with RDC 304/19 of ANVISA. All showed compliance with some organoleptic characteristics;and stable values in pH (3.61 - CF;3.67 - BHU1;3.65 - BHU2), density (1.079 - CF;1.088 - BHU1;1.086 - BHU2) and individual volume (not less than 95% of the declared value). However, it was not possible to detect the odor of herbs;the average volume of batch BHU1 was below the declared value, and the iron content of both BHUs was above the maximum value of pharmacopoeia standards. Conclusion: Samples did not show full compliance with the physical and chemical parameters evaluated, suggesting deviation in the quality of the medication.

关键词： Physical and Chemical Quality Control Ferrous Sulfate Heptahydrate Syrup

Populational description of Patients with Diabetes Mellitus Attended in a Family Health Center in Cuiabá, Mato Grosso

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Open Journal of Endocrine and Metabolic Diseases 2017年第1期7卷 1-11页

作者： Erick Tiago de jesus Assunç &atilde o Ana paula Brianezi Danyelle Mariaca de Melo Paloma de Oliveira Luciana Graciela de Oliveira Boiç a Larissa Bianca Paiva Cunha de Sá Alberto Krayyem Arbex Division of Endocrinology IPEMED Medical School S&atilde o Paulo Brazil Family and Community Health Cuiabá Brazil Diabetology department Malteser Krankenhaus St. Franziskus-Hospital Flensburg Germany

Diabetes mellitus (DM) represents one of the most serious current health problems nowadays, considering the number of people affected, its complications and morbidities. A broad analysis was performed among diabetic patients attended in the Family Health Center from the district of Baú, in Cuiabá, Mato Grosso State (Center-east Brazil), to examine the patterns of occurrence of overweight or obesity, values of glycated hemoglobin and the diagnostic of metabolic syndrome. The results show ahead a wide work that is necessary to prevent and early diagnose concerning DM, since only an intensive control will make it possible to alter the reality of the unfavorable prognosis documented.

关键词： Diabetes Mellitus Obesity Metabolic Syndrome

Dunnigan-Type Familial Partial Lipodystrophy: Understanding and Treating the Syndrome

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Open Journal of Endocrine and Metabolic Diseases 2017年第1期7卷 22-34页

作者： Ana Raisa Jatahy Santos Sabrina Pinto Ferreira Moacir Benazzi Mara Capra Helen paula Apparicio Medeiros Ana Luísa de jesus Mirella Hansen de Almeida Larissa Bianca Paiva Cunha de Sá Alberto Krayyem Arbex Division of Endocrinology IPEMED Medical School Rio de Janeiro Brazil Porto Velho Garrison Hospital—HGuPV Porto Velho Brazil Division of Endocrinology Central Air Force Hospital Rio de Janeiro Brazil Diabetology department Malteser Krankenhaus St. Franziskus-Hospital Flensburg Germany

Dunnigan-type partial lipodystrophy, which is characterized by a number of metabolic alterations, change in body fat distribution, and autosomal dominant inheritance pattern, is rare in the general population. Objective: To report the case of an adolescent with clinical and laboratory findings suggestive of Dunnigan-type partial lipodystrophy. Methods: Case report and literature review. Results: A 15-year-old adolescent presented at the clinic complaining of darkening of skin folds on her trunk and back. During physical examination, the presence of serious acanthosis nigricans in her cervical region, axillae, and intergluteal space was noted. Hirsutism in androgen-dependent areas was also observed, as well as relevant reduction of subcutaneous adipose tissue in the limbs, gluteal region, abdomen, and trunk and fat accumulation in the face and chin. Discussion. Dunnigan-type familial partial lipodystrophy is a rare dominant autosomal disease resulting from a heterozygous missense mutation in the LMNA gene, known as LPF type 2 (Dunnigan variant), which encodes the nuclear protein A/C-type lamin. It is characterized by the progressive disappearance of the subcutaneous adipose tissue in the limbs, gluteal region, abdomen, and trunk, with onset in puberty, followed by fat accumulation in other areas such as the face, chin, labia majora, and intra-abdominal region, leading to hypertrophy that may mimic the Cushing’s syndrome phenotype. Affected patients display marked insulin resistance and may consequently develop diabetes mellitus, acanthosis nigricans, hirsutism, and polycystic ovary syndrome. Conclusion: This case report highlights the importance of suspecting Dunnigan-type familial partial lipodystrophy in clinical practice. Early clinical diagnosis allows for measures that minimize the severe metabolic disorders associated with this disease and, consequently, these adolescents’ self-esteem issues.

关键词： Dunnigan-Type Familial Partial Lipodystrophy Insulin Resistance Heterozygous Mutation

Case Report: Clinical and Diagnostic Aspects of Mayer-Rokitansky-Kuster-Hauser Syndrome

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Health 2019年第10期11卷 1367-1372页

作者： Lucas Ferreira de paula Filho Guilherme Carolino Neves Laís Figueira Bandoli Lucas Caraline de Almeida Coelho Nathália de Souza Ferreira Feital Renan Vieira Murad Ana Luísa Conceiç o de jesus Diana Aristótelis de Sá Larissa Bianca Cunha de Sá Jonathan Mwambire Alberto Krayyem Arbex IPEMED Medical School/AFYA Educational Postgraduation in Endocrinology Rio de Janeiro Brazil UNIFESO Medical School Teresópolis Brazil department of Pediatrics Medical School University of So Paulo (USP) So Paulo Brazil Medical Clinic in Endocrinology and Diabetology Schleswig-Flensburg Germany.

Mayer-Rokitansky-Kuster-Hauser Syndrome (MRKH) is a rare disease characterized by total or partial vagina agenesis, karyotype 46, XX with normal secondary sexual characters. Still, it is the second leading cause of primary amenorrhea. The absence of obvious signs and symptoms often causes the syndrome to be diagnosed only after puberty. The case presented here highlights exactly this difficulty of early diagnosis, which meets the objective of the study, and is precisely to provide reliable material that facilitates the diagnosis and management of patients with MRKH syndrome.

关键词： Mayer-Rokitansky-Kuster-Hauser Syndrome Primary Amenorrhea Gonadal Dysgenesis

Bacterial Fecal Microbiota in Healthy Subjects and Inpatients with <i>Clostridium difficile</i>Infection

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Advances in Microbiology 2017年第1期7卷 10-21页

作者： Thaís Flecher Barbosa Danielle Angst Secco Raquel Silva Peixoto Alexandre Soares Rosado Flavia Lima do Carmo Hugo Emiliano de jesus Leandro Araujo Lobo Luis Caetano Martha Antunes Karla Rodrigues Miranda Geraldo Renato de paula Regina Maria Cavalcanti Pilotto Domingues Instituto de Microbiologia Paulo de Goes Universidade Federal do Rio de Janeiro Rio de Janeiro RJ Brazil Escola Nacional de Saúde Pública Sergio Arouca Fundacao Oswaldo Cruz Rio de Janeiro RJ Brazil Faculdade de Farmácia Universidade Federal do Rio de Janeiro—Campus Macaé Macaé RJ Brazil departamento de Tecnologia Farmacêutica Universidade Federal Fluminense Niterói RJ Brazil

Clostridium difficile is a nosocomial enteric pathogen, considered the main etiological agent of antibiotic-associated diarrhea in hospitals. C. difficile is resistant to several antimicrobial agents used in empiric treatment protocols, which confers selective advantages to this species as compared with other members of the intestinal microbiota. The aim of this study was to evaluate and identify possible alterations of the intestinal microbiota population resulting from the use of antimicrobials associated with infections by C. difficile (CDI). denaturing Gradient Gel Electrophoresis (DGGE) was used to evaluate fecal samples from two groups: healthy subjects and patients with C. difficile-associated diarrhea (CDAD). A decrease in bacterial diversity was highlighted by the low number of bands in samples from CDAD patients, compared with healthy subjects. This may indicate that antibiotic treatment would affect bacterial diversity, leading to a significant difference between the intestinal microbiota of these two groups, but further studies are still needed. Firmicutes and Verrucomicrobia phyla were detected mainly in healthy individuals, and these could be related to protection factors against the CDI. Klebsiella variicola/K. pneumoniae were found mostly in samples from CDI patients. This study shows the effects of antimicrobials and the CDI itself on human intestinal microbiota.

关键词： Clostridium difficile DGGE Microbiota CDAD Antimicrobials