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Intraoperative cholangio-ultrasonography(IOCUS)during hepatectomy with resection of the biliary confluence:An effective alternative to intraoperative cholangiography

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 417-420页

作者： daniele del Fabbro Fabio Procopio Jacopo Galvanin Guido Costa Simone Famularo Angela Palmisano Matteo Donadon Guido Torzilli Division of Hepatobiliary Surgery Department of SurgeryIRCCS Humanitas Research HospitalVia A.Manzoni 56Rozzano 20089MilanItaly Department of Biomedical Sciences Humanitas UniversityVia Rita Levi Montalcini 4Pieve Emanuele 20072MilanItaly

Intraoperative ultrasonography(IOUS)in hepatobiliary surgery is well known as an essential tool for radical and safe hepatectomies,allowing to perform parenchymal sparing surgery and,as consequence,to expand the surgical indications for patients otherwise considered ***,since many years,despite its effectiveness in the study of vascular anatomy of the liver,the gold standard for the assessment of biliary anatomy during surgery is intraoperative cholangiography(IOC),which is used for the validation of preoperative imaging as well as for guiding reconstruction in case of bile duct injury or resection.

关键词： anatomy biliary ultrasonography

Hazelnut mapping detection system using optical and radar remote sensing:Benchmarking machine learning algorithms

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Artificial Intelligence in Agriculture 2024年第2期12卷 97-108页

作者： daniele Sasso Francesco Lodato Anna Sabatini Giorgio Pennazza Luca Vollero Marco Santonico Mario Merone Department of Engineering Research Unit of Computer Systems and BioinformaticsUniversitàCampus Bio-Medico di RomaviaÁlvaro del PortilloRome 00128Italy Department of Science and Technology for Sustainable Development and One Health Research Unit of Electronics for Sensor SystemsUniversitàCampus Bio-Medico di RomaviaÁlvaro del PortilloRome 00128Italy Department of Engineering Research Unit of Electronics for Sensor SystemsUniversitàCampus Bio-Medico di RomaviaÁlvaro del PortilloRome 00128Italy Department of Biology University of Naples FedericoⅡNaples 80138Italy

Mapping hazelnut orchards can facilitate land planning and utilization policies,supporting the development of cooperative precision farming *** present work faces the detection of hazelnut crops using optical and radar remote sensing data.A comparative study of Machine Learning techniques is *** system proposed utilizes multi-temporal data from the Sentinel-1 and Sentinel-2 datasets extracted over several years and processed with cloud *** provide a dataset of 62,982 labeled samples,with 16,561 samples belonging to the‘hazelnut’class and 46,421 samples belonging to the‘other’class,collected in 8 heterogeneous geograph-ical areas of the Viterbo *** different comparative tests are conducted:firstly,we use a Nested 5-Fold Cross-Validation methodology to train,optimize,and compare different Machine Learning algorithms on a single *** a second experiment,the algorithms were trained on one area and tested on the remaining seven geo-graphical *** developed study demonstrates how AI analysis applied to Sentinel-1 and Sentinel-2 data is a valid technology for hazelnut *** the results,it emerges that Random Forest is the classifier with the highest generalizability,achieving the best performance in the second test with an accuracy of 96%and an F1 score of 91%for the‘hazelnut’class.

关键词： Remote sensing Crop detection Hazelnut Machine learning Classification

Metal-Halide Perovskite Submicrometer-Thick Films for Ultra-Stable Self-Powered Direct X-Ray Detectors

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Nano-Micro Letters 2024年第9期16卷 410-431页

作者： Marco Girolami Fabio Matteocci Sara Pettinato Valerio Serpente Eleonora Bolli Barbara Paci Amanda Generosi Stefano Salvatori Aldo Di Carlo daniele M.Trucchi CNR‑ISM Consiglio Nazionale delle RicercheIstituto di Struttura della MateriaSede Secondaria di MontelibrettiDiaTHEMA LabStrada Provinciale 35D900010 MontelibrettiRomeItaly CHOSE–Centre for Hybrid and Organic Solar Energy Department of Electronic EngineeringUniversity of Rome“Tor Vergata”Via del Politecnico 100133 RomeItaly Faculty of Engineering Universita degli Studi Niccolo CusanoVia don Carlo Gnocchi 300166 RomeItaly SpecXLab CNR‑ISMConsiglio Nazionale Delle RicercheIstituto di Struttura Della MateriaArea della Ricerca di Tor VergataVia del Fosso del Cavaliere 10000133 RomeItaly

Metal-halide perovskites are revolutionizing the world of X-ray detectors,due to the development of sensitive,fast,and cost-effective ***-powered operation,ensuring portability and low power consumption,has also been recently demonstrated in both bulk materials and thin ***,the signal stability and repeatability under continuous X-ray exposure has only been tested up to a few hours,often reporting degradation of the detection *** it is shown that self-powered direct X-ray detectors,fabricated starting from a FAPbBr_(3)submicrometer-thick film deposition onto a mesoporous TiO_(2)scaffold,can withstand a 26-day uninterrupted X-ray exposure with negligible signal loss,demonstrating ultra-high operational stability and excellent *** structural modification is observed after irradiation with a total ionizing dose of almost 200 Gy,revealing an unexpectedly high radiation hardness for a metal-halide perovskite thin *** addition,trap-assisted photoconductive gain enabled the device to achieve a record bulk sensitivity of 7.28 C Gy^(−1)cm^(−3)at 0 V,an unprecedented value in the field of thin-film-based photoconductors and photodiodes for“hard”***,prototypal validation under the X-ray beam produced by a medical linear accelerator for cancer treatment is also introduced.

关键词： Metal-halide perovskite thin films Direct X-ray detectors Self-powered devices Operational stability Medical linear accelerator

Design of a Novel Exoskeleton with Passive Magnetic Spring Self-locking and Spine Lateral Balancing

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Journal of Bionic Engineering 2024年第1期21卷 236-255页

作者： Jhon F.Rodríguez-León Betsy D.M.Chaparro-Rico daniele Cafolla Francesco Lago Eduardo Castillo-Castañeda Giuseppe Carbone Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada Unidad Querétaro MecatronicaInstituto Politécnico NacionalCerro Blanco 14176090 Colinas del CimatarioQuerétaroMexico Department of Mechanical Energy and Management EngineeringUniversity of CalabriaVia P.Bucci Cubo 46 C87036 RendeItaly Faculty of Science and Engineering Department of Computer ScienceSwansea UniversitySwanseaUK CESTER University of Cluj-NapocaCluj-NapocaRomania

This paper proposes a new upper-limb exoskeleton to reduce worker physical *** proposed design is based on a novel PRRRP(P-Prismatic;R-Revolute)kinematic chain with 5 passive Degrees of Freedom(DoF).Utilizing a magnetic spring,the proposed mechanism includes a specially designed locking mechanism that maintains any desired task *** proposed exoskeleton incorporates a balancing mechanism to alleviate discomfort and spinal torsional effects also helping in limb weight *** paper reports specific models and simulations to demonstrate the feasibility and effectiveness of the proposed *** experimental characterization is performed to validate the performance of the mechanism in terms of forces and physical strain during a specific application consisting of ceiling-surface drilling *** obtained results preliminarily validate the engineering feasibility and effectiveness of the proposed exoskeleton in the intended operation task thereby requiring the user to exert significantly less force than when not wearing it.

关键词： Assistive mechanism Exoskeleton Locking mechanism Bionic robot

Commentary on“Effect of green-Mediterranean diet on intrahepatic fat:the DIRECT PLUS randomised controlled trial”

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 699-701页

作者： Francesco Baratta daniele Pastori Maria del Ben Department of Clinical Internal Anesthesiological and Cardiovascular SciencesSapienza University of RomeRomeItaly

Non-alcoholic fatty liver disease(NAFLD)represents the most prevalent liver disease worldwide with a high spread in Western *** high spread is due to the typical Western *** fact,western diet,characterized by the high intake of red meat,processed meat,high-fat dairy products and high-sugar drinks and sedentary lifestyles are the principal factors promoting the growing prevalence of obesity and NAFLD together(1).

关键词： NAFLD intake obesity

Modern approach to the clinical management of non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第26期20卷 8341-8350页

作者： Maria del Ben Licia Polimeni Francesco Baratta daniele Pastori Lorenzo Loffredo Francesco Angelico Department of Internal Medicine and Medical Specialities Department of Public Health and Infectious Diseases Sapienza University

Non-alcoholic fatty liver disease (NAFLD) is the most common and emerging form of chronic liver disease worldwide. It includes a wide spectrum of liver diseases ranging from simple fatty liver to steatohepatitis, which may progress to cirrhosis, liver cancer, and liver mortality. Common metabolic diseases, which are well established cardiovascular risk factors, have been associated to NAFLD and cardiovascular disease is the single most important cause of morbidity and mortality in this patient population. The pathogenesis of NAFLD appears multifactorial and many mechanisms have been proposed as possible causes of fatty liver infiltration. Management of fatty liver has become a major challenge to healthcare systems as the consequence of the increasing rates of obesity worldwide. First-line management focuses on lifestyle modifications. Moderate weight reduction either by dietary restriction or by increased habitual physical activity is safe and highly recommended. Several therapeutic interventions have been proposed. These include insulin sensitizer agents, lipid lowering drugs, antioxidants such as vitamin E and supplementation of vitamin D3. However, therapeutic strategies have been largely empirical so far, and experimental trials have mostly been carried out in uncontrolled settings with small sample sizes. Metabolic conditions such as diabetes mellitus, obesity, hypertension and hyperlipidemia, should be strongly considered and a multidisciplinary approach should be personalized for individual patients. Treatment of co-morbidities should be regarded as of paramount importance in the management of these patients. The purpose of this review is to examine different approaches for the clinical management of non-alcoholic fatty liver disease.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Insulin resistance Oxidative stress Cardiovascular risk Statins Vitamin D Vitamin E Pioglitazone

A novel distributed architecture for unmanned aircraft systems based on Robot Operating System 2

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IET Cyber-Systems and Robotics 2023年第1期5卷 9-23页

作者： Lorenzo Bianchi daniele Carnevale Fabio del Frate Roberto Masocco Simone Mattogno Fabrizio Romanelli Alessandro Tenaglia Department of Civil Engineering and Computer Science Engineering University of Rome“Tor Vergata”RomeItaly

A novel distributed control architecture for unmanned aircraft system (UASs) based on thenew Robot Operating System (ROS) 2 middleware is proposed, endowed with industrialgradetools that establish a novel standard for high-reliability distributed systems. Thearchitecture has been developed for an autonomous quadcopter to design an inclusivesolution ranging from low-level sensor management and soft real-time operating systemsetup and tuning to perception, exploration, and navigation modules orchestrated by afinite-state machine. The architecture proposed in this study builds on ROS 2 with itsscalability and soft real-time communication functionalities, while including security andsafety features, optimised implementations of localisation algorithms, and integrating aninnovative and flexible path planner for UASs. Finally, experimental results have beencollected during tests carried out both in the laboratory and in a realistic environment,showing the effectiveness of the proposed architecture in terms of reliability, scalability, andflexibility.

关键词： navigation robot perception slam(robots) unmanned aerial vehicle

Surgical treatment of synchronous colorectal liver and lung metastases： the usefulness of thoracophrenolaparotomy for single stage resection

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Hepatobiliary & Pancreatic Diseases International 2016年第2期15卷 216-219页

作者： daniele del Fabbro Marco Alloisio Fabio Procopio Matteo Cimino Matteo Donadon Angela Palmisano Luca Viganò Guido Torzilli Department of Hepatobiliary Surgery Humanitas Research HospitalUniversity of Milan School of MedicineRozzanoMilanItaly Department of Thoracic Surgery Humanitas Research HospitalUniversity of Milan School of MedicineRozzanoMilanItaly

When suitable, surgery still remains the therapeutic option to be preferred for patients carrier of colorectal liver and lung metastases. Since thoracophrenolaparotomy should be helpful during liver resection for some of these patients, simultaneous removal of right lung metastases can be proposed through this approach. Eleven consecutive patients（median age of 53 years） carrier of colorectal liver and lung metastases, underwent single session surgical resection of both liver and right lung lesions by means of J-shaped thoracophrenolaparotomy. The median number of liver metastases removed was 5（range 2-30） and of lung metastases removed was 2（range 1-3）. Lung metastases were located in the upper lobe in 1 patient, in the middle lobe in 2, in the lower lobe in 6, and in the upper and lower lobe in 2. Mortality and major morbidity were nil. Two patients had a minor morbidity： one had wound infection and bile leakage treated conservatively and the other had transient fever. Mean overall survival was 24.4 months. An aggressive surgical approach should be undertaken for colorectal metastases： in case of multifocal liver disease with complex presentations, J-shaped thoracophrenolaparotomy could be considered as safe approach for combined liver and right lung metastasectomies.

关键词： colorectal carcinoma liver metastases lung metastases thoracophrenolaparotomy

Reduced lysosomal acid lipase activity: A new marker of liver disease severity across the clinical continuum of non-alcoholic fatty liver disease?

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World Journal of Gastroenterology 2019年第30期25卷 4172-4180页

作者： Francesco Baratta daniele Pastori Domenico Ferro Giovanna Carluccio Giulia Tozzi Francesco Angelico Francesco Violi Maria del Ben Department of Internal Medicine and Medical Specialties Sapienza-University of RomeRome 00155Italy Hepatogastroenterology and Nutrition Unit-Pediatric Department Bambino GesùChildren’s HospitalRome 00156Italy Department of Public Health and Infectious Disease Sapienza-University of RomeRome 00161Italy

Lysosomal acid lipase(LAL)plays a key role in intracellular lipid *** LAL activity promotes increased multi-organ lysosomal cholesterol ester storage,as observed in two recessive autosomal genetic diseases,Wolman disease and Cholesterol ester storage *** liver steatosis and accelerated liver fibrosis are common features in patients with genetic LAL *** contrast,few reliable data are available on the modulation of LAL activity in vivo and on the epigenetic and metabolic factors capable of regulating its activity in subjects without homozygous mutations of the Lipase A *** the last few years,a less severe and non-genetic reduction of LAL activity was reported in children and adults with non-alcoholic fatty liver disease(NAFLD),suggesting a possible role of LAL reduction in the pathogenesis and progression of the *** with NAFLD show a significant,progressive reduction of LAL activity from simple steatosis to non-alcoholic steatohepatitis and cryptogenic *** cirrhosis of different etiologies,those with cryptogenic cirrhosis show the most significant reductions of LAL *** findings suggest that the modulation of LAL activity may become a possible new therapeutic target for patients with more advanced forms of ***,the measurement of LAL activity may represent a possible new marker of disease severity in this clinical setting.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Lysosomal acid lipase Cirrhosis Wolman disease Cholesterol ester storage disease