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Diagnostic accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography in gallbladder cancer: A meta-analysis

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World Journal of Gastroenterology 2015年第40期21卷 11481-11488页

作者： Salvatore Annunziata daniele antonio pizzuto Carmelo Caldarella Federica Galiandro Ramin Sadeghi Giorgio Treglia Institute of Nuclear Medicine Department of Bioimaging and Radiological SciencesCatholic University of the Sacred Heart Postgraduate School of General Surgery Catholic University of the Sacred Heart Nuclear Medicine Research Center Mashhad University of Medical Sciences Department of Nuclear Medicine and PET Center Oncology Institute of Southern Switzerland

AIM: To meta-analyze published data about the diagnostic accuracy of fluorine-18-fluorodeoxyglucose(18F-FDG) positron emission tomography(PET) and PET/computed tomography(PET/CT) in the evaluation of primary tumor in patients with gallbladder cancer(GBCa).METHODS: A comprehensive literature search of studies published through 30 th June 2014 regarding the role of 18F-FDG PET and PET/CT in the evaluation of primary gallbladder cancer(GBCa) was performed. All retrieved studies were reviewed. Pooled sensitivity and specificity of 18F-FDG PET or PET/CT in the evaluation of primary GBCa were calculated. The area under the summary receiving operator characteristics curve(AUC) was calculated to measure the accuracy of these methods. Sub-analyses considering the device used(PET vs PET/CT) were carried ***: Twenty-one studies comprising 495 patients who underwent 18F-FDG PET or PET/CT for suspicious GBCa were selected for the systematic review. The meta-analysis of 13 selected studies provided the following results: sensitivity 87%(95%CI: 82%-92%),specificity 78%(95%CI: 68%-86%). The AUC was 0.88. Improvement of sensitivity and specificity was observed when PET/CT was ***: 18F-FDG-PET and PET/CT demonstrated to be useful diagnostic imaging methods in the assessment of primary tumor in GBCa patients,nevertheless possible sources of false-negative and false-positive results should be kept in mind. PET/CT seems to have a better diagnostic accuracy than PET alone in this setting.

关键词： Positron emission tomography Positron emission tom

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Editorial article to:Animal experimental study on magnetic anchor technique-assisted endoscopic submucosal dissection of early gastric cancer

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World Journal of Gastrointestinal Endoscopy 2024年第2期16卷 51-54页

作者： Enrico Fiori Antonietta Lamazza daniele Crocetti antonio V Sterpetti Department of Surgery Sapienza University of RomeRome 00161Italy Department of Surgery University of Rome La SapienzaRome 00161Italy

In this editorial we comment on the article published in the recent issue of the World Journal of Gastrointestinal Endoscopy 2023;15(11):*** cancer(GC)remains the fifth most common malignancy and the fourth leading cause of cancer-related death *** overall prevalence of GC has declined,although that of proximal GC has increased over ***,a significant proportion of GC cases and deaths can be avoided if preventive interventions are *** GC(EGC)is defined as GC confined to the mucosa or *** resection is considered the most appropriate treatment for precancerous gastrointestinal lesions improving patient quality of life,with reduced rates of complications,shorter hospitalization period,and lower costs when compared to surgical *** mucosal resection(EMR)and endoscopic sub-mucosal dissection(ESD)are representative endoscopic treatments for EGC and precancerous gastric *** EMR implies injection of a saline solution into the sub-mucosal space,followed by excision of the lesion using a *** resection rates vary depending on the size and severity of the *** using conventional EMR methods for lesions less than 1 cm in size,the complete resection rate is approximately 60%,whereas for lesions larger than 2 cm,the complete resection rate is low(20%-30%).ESD can be used to remove tumors exceeding 2 cm in diameter and lesions associated with ulcers or submucosal *** with EMR,ESD has higher en bloc resection rates(90.2%vs 51.7%),higher complete resection rates(82.1 vs 42.2%),and lower recurrence rates(0.65%vs 6.05%).Thus,innovative techniques have been introduced.

关键词： Gastric cancer Early gastric cancer Endoscopic resection Endoscopic mucosal resection Endoscopic sub-mucosal dissection

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Impact of neoadjuvant multimodal therapy in the setting of locally advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第28期30卷 3452-3455页

作者： daniele Ferraro Federica Falaschi Luca Nazzaro Giovanni Vennarecci Hepato-biliary and Liver Transplant Centre Department of General Surgery and Woman’s HealthAORN Antonio CardarelliNaples 80131Italy

Immunotherapy and the implementation of more aggressive treatment schemes for locally advanced hepatocellular carcinomas have expanded the boundaries of curative *** of these advancements,patients who were once consid... 详细信息

关键词： Hepatocellular carcinoma Immunotherapy Radioembolization Chemoembolization Liver transplantation Liver resection

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On “Over-Sized” High-Gain Practical Observers for Nonlinear Systems

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IEEE/CAA Journal of Automatica Sinica 2018年第3期5卷 691-698页

作者： daniele Carnevale Corrado Possieri antonio Tornambè Dipartimento di Ingegneria Civile e Ingegneria Informatica Universita di Roma Tor Vergata

In this paper,it is shown that the performances of a class of high-gain practical observers can be improved by estimating the time derivatives of the output up to an order that is greater than the dimension of the system, which is assumed to be in observability form and, possibly, time-varying. Such an improvement is achieved without increasing the gain of the observers, thus allowing their use in a wide variety of control and identification applications.

关键词： Filtering properties nonlinear systems observability observer design

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Testicular ultrasound inhomogeneity is an informative parameter for fertility evaluation

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Asian Journal of Andrology 2020年第3期22卷 302-308页

作者： Giorgia Spaggiari antonio R M Granata daniele Santi Unit of Endocrinology Department of BiomedicalMetabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModena 41126Italy Unit of Endocrinology Department of Medical SpecialtiesAzienda Ospedaliero-Universitaria of ModenaOspedale Civile of BaggiovaraModena 41126Italy.

Testicular volume(TV)is proposed to be a positive predictor of male fertility status,because of the relation known between the TV and the seminiferous tubule *** of the measurement methodology,the role of TV and testicular ultrasound(US)assessments is still debated in andrological clinical *** this retrospective cohort study,we evaluated TV and testis US role in the diagnostic workup of andrological *** consecutive outpatients undergoing single-operator testis US(Modena,Italy)from March 2012 to March 2018 were enrolled,matching sonographic,hormonal,and seminal data.A total of 302 men were referred and evaluated for gynecomastia,suspected hypogonadism,couple infertility(Cl),or sexual *** the hypogonadal group,TV was lower compared to that in other groups(P<0.001),and a significant,direct correlation between TV and testosterone level was observed in nonandrogen-treated patients(R=0.911,P<0.001),suggesting that testicular size could be related to the testosterone-secreting *** the Cl group,normozoospermic patients showed higher TV compared to men with impaired semen quality(P=0.003)and azoospermia(P=0.003).However,TV was not able to discriminate between patients presenting normal and altered semen *** the contrary,testis US inhomogeneity was more frequent in patients with impaired sperm quality(55.0%;P=0.007)and azoospermia(40.0%;P=0.012),compared to patients with normozoospermia(5%),identifying thereby the sonographic pattern as an informative parameter of the fertility ***,in the Cl workup,US evaluation seems to be more informative than the TV assessment alone.

关键词： male hypogonadism male infertility testicular diseases testis

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Oral frailty and neurodegeneration in Alzheimer’s disease

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Neural Regeneration Research 2021年第11期16卷 2149-2153页

作者： Vittorio Dibello Madia Lozupone daniele Manfredini antonio Dibello Roberta Zupo Rodolfo Sardone antonio daniele Frank Lobbezoo Francesco Panza Department of Orofacial Pain and Dysfunction Academic Centre for Dentistry Amsterdam(ACTA)University of Amsterdam and Vrije Universiteit AmsterdamAmsterdamThe Netherlands Neurodegenerative Disease Unit Department of Basic MedicineNeuroscienceand Sense OrgansUniversity of Bari Aldo MoroBariItaly School of Dentistry Department of Biomedical TechnologiesUniversity of SienaSienaItaly Azienda Sanitaria Locale(ASL)Bari BariItaly Frailty Phenotypes Research Unit “Salus in Apulia Study”National Institute of Gastroenterology“Saverio de Bellis”Research HospitalCastellana GrotteBariItaly Institute of Neurology Catholic University of Sacred HeartRomeItaly Institute of Neurology Fondazione Policlinico Universitario A.Gemelli IRCCSRomeItaly

Frailty is a critical intermediate status of the aging process with a multidimensional and multisystem nature and at higher risk for adverse health-related outcomes,including falls,disability,hospitalizations,institutionalization,mortality,dementia,and Alzheimer’s *** different frailty phenotypes,oral frailty has been recently suggested as a novel construct defined as a decrease in oral function with a coexisting decline in cognitive and physical *** briefly reviewed existing evidence on operational definitions of oral frailty,assessment and screening tools,and possible relationships among oral frailty,oral microbiota,and Alzheimer’s disease *** underlying mechanism may explain the oral health-frailty links including undernutrition,sarcopenia linked to both poor nutrition and frailty,psychosocial factors,and the chronic inflammation typical of oral *** microbiota may influence Alzheimer’s disease risk through circulatory or neural access to the brain and the interplay with periodontal disease,often causing tooth loss also linked to an increased Alzheimer’s disease *** this bases,COR388,a bacterial protease inhibitor targeting Porphyromonas gingivalis implicated in periodontal disease,is now being tested in a double-blind,placebocontrolled Phase II/III study in mild-to-moderate Alzheimer’s ***,oral status may be an important contributor to general health,including Alzheimer’s disease and latelife cognitive disorders,suggesting the central role of preventive strategies targeting the novel oral frailty phenotype and including maintenance and improvement of oral function and nutritional status to reduce the burden of both oral dysfunction and frailty.

关键词： biomarkers cognitive frailty dementia diet mild cognitive impairment nutritional frailty oral health oral microbiota periodontal disease tooth loss

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Current concepts in hepatic resection for hepatocellular carcinoma in cirrhotic patients

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World Journal of Gastroenterology 2012年第44期18卷 6398-6408页

作者： Alessandro Cucchetti Matteo Cescon Franco Trevisani antonio daniele Pinna General Surgery and Transplant Unit Department of General Surgery and Organ TransplantationAlma Mater StudiorumUniversity of Bologna40138 BolognaItaly Department of Clinical Medicine Semeiotica MedicaS.Orsola-Malpighi HospitalAlma Mater StudiorumUniversity of BolognaVia Massarenti 940138 BolognaItaly

Hepatocellular carcinoma(HCC) is one of the most frequent neoplasms worldwide and in most cases it is associated with liver *** resection is considered the most potentially curative therapy for HCC patients when liver transplantation is not an option or is not immediately *** review is aimed at investigating the current concepts that drive the surgical choice in the treatment of HCC in cirrhotic patients;Eastern and Western perspectives are *** extensive literature review of the last two decades was performed,on topics covering various aspects of hepatic *** post-operative and long-term outcome measures adopted were firstly analyzed in an attempt to define an optimal standardization useful for research *** need to avoid the development of post-hepatectomy liver failure represents the "conditio sine qua non" of surgical choice and the role of the current tools available for the assessment of liver function reserve were *** of hepatic resection in relationship with tumor burden were compared with those of available competing strategies,namely,radiofrequency ablation for early stages,and trans-arterial chemoembolization for intermediate and advanced ***,the choice for anatomical versus non-anatomical,as well as the role of laparoscopic approach,was *** literature review suggests that partial hepatectomy for HCC should be considered in the context of multi-disciplinary evaluation of cirrhotic *** research on HCC has moved,in recent years,from surgical therapy toward non-surgical approaches and most of the literature regarding topics debated in the present review is represented by observational studies,whereas very few well-designed randomized controlled trials are currently available;thus,no robust recommendations can be derived.

关键词： Hepatocellular carcinoma Hepatic resec-tion Surgical therapy Ablation techniques Transplan-tation Survival Liver failure

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Antimicrobial management of intra-abdominal infections:Literature's guidelines

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World Journal of Gastroenterology 2012年第9期18卷 865-871页

作者： Massimo Sartelli Fausto Catena Federico Coccolini antonio daniele Pinna Department of General Surgery Macerata Hospital Department of General Emergency and Transplant SurgerySant'Orsola-Malpighi University Hospital

Antimicrobial management of severe intra-abdominal infections (IAIs) involves a delicate balance of optimizing empirical therapy,which has been shown to improve clinical outcomes,while simultaneously reducing unnecessary antimicrobial *** sets of guidelines for the management of intra-abdominal infections were recently *** 2010,the Surgical Infection Society and the Infectious Diseases Society of America (SIS-IDSA) created guidelines for the diagnosis and management of complicated *** new SIS-IDSA guidelines replace those previously published in 2002 and *** World Society of Emergency Surgery (WSES) guidelines represent additional contributions,made by specialists worldwide,to the debate regarding proper antimicrobial drug *** guidelines represent the conclusions of the consensus conference held in Bologna,Italy,in July 2010 during the first congress of the WSES.

关键词： Intra-abdominal infections Antimicrobial the-rapy Literature's guidelines

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Gastrointestinal stromal tumor and mitosis,pay attention

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World Journal of Gastroenterology 2012年第6期18卷 587-588页

作者： Federico Coccolini Fausto Catena Luca Ansaloni antonio daniele Pinna General and Emergency Surgery Department Ospedali Riuniti 24128 BergamoItaly General and Transplant Surgery Department Sant'Orsola-Malpighi University Hospital24128 BolognaItaly

The difference between stages I and ]]I of gastric gas- trointestinal stromal tumor depends principally on the number of mitosis. According with TNM classification, the presence in the tumor of high mitotic rate deter- mines the upgrading. Many studies exposed different count techniques in evaluating the number of mitosis. An international standardized method to assess mitotic rate is needed.

关键词： Gastrointestinal stromal tumor Mitosis Clas-sification Gastroesophageal Enudeation

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Investigation of droplet breakup in liquid–liquid dispersions by CFD–PBM simulations：The influence of the surfactant type

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Chinese Journal of Chemical Engineering 2017年第10期25卷 1369-1380页

作者： Dongyue Li antonio Buffo Wioletta Podgórska daniele L.Marchisio Zhengming Gao State Key Laboratory of Chemical Resource Engineering School of Chemical Engineering Beijing University of Chemical Technology Beijing 100029 China Aalto University Department of Biotechnology and Chemical Technology Espoo Finland Faculty of Chemical and Process Engineering Warsaw University of Technology Warsaw Poland Institute of Chemical Engineeriag Department of Applied Science and Technology Politecnico di Torino Torino Italy

The accurate prediction of the droplet size distribution(DSD)in liquid–liquid turbulent dispersions is of fundamental importance in many industrial applications and it requires suitable kernels in the population balance *** a surfactant is included in liquid–liquid dispersions,the droplet breakup behavior will change as an effect of the reduction of the interfacial ***,also the dynamic interfacial tension may be different with respect to the static,due to the fact that the surfactant may be easily desorbed from the droplet surface,generating additional disruptive *** this work,the performance of five breakup kernels from the literature is assessed,to investigate their ability to predict the time evolution of the DSD and of the mean Sauter diameter,when different surfactants are *** are performed with the Quadrature Method of Moments for the solution of the population balance model coupled with the two-fluid model implemented in the compressible Two Phase Euler Foam solver of the open-source computational fluid dynamics(CFD)code Open FOAM *** time evolution of the mean Sauter diameter predicted by these kernels is validated against experimental data for six test cases referring to a stirred tank with different types of surfactants(Tween 20 and PVA 88%)at different concentrations operating under different stirrer *** results show that for the dispersion containing Tween 20 additional stress is generated,the multifractal breakup kernel properly predicts the DSD evolution,whereas two other kernels predict too fast breakup of droplets covered by adsorbed *** derived originally for bubbles completely fail.

关键词： Breakup Stirred tank Liquid–liquid dispersions Interfacial tension CFD–PBM

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