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Speckle spatial correlations aiding optical transmission matrix retrieval:the smoothed Gerchberg–Saxton single-iteration algorithm

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Photonics Research 2022年第10期10卷 2349-2358页

作者： daniele ANCORA LORENZO DOMINICI ANTONIO GIANFRATE paolo CAZZATO MILENA DE GIORGI DARIO BALLARINI daniele SANVITTO LUCA LEUZZI Department of Physics Universitàdi Roma la SapienzaPiazzale Aldo Moro 5I-00185 RomeItaly Institute of Nanotechnology Consiglio Nazionale delle Ricerche(CNR-NANOTEC)Via MonteroniI-73100 LecceItaly Institute of Nanotechnology Soft and Living Matter LaboratoryConsiglio Nazionale delle Ricerche(CNR-NANOTEC)Piazzale Aldo Moro 5I-00185 RomeItaly

The estimation of the transmission matrix of a disordered medium is a challenging problem in disordered ***,its reconstruction relies on a complex inversion that aims at connecting a fully controlled input to the deterministic interference of the light field scrambled by the *** the moment,iterative phase retrieval protocols provide the fastest reconstructing frameworks,converging in a few tens of *** the knowledge of speckle correlations,we construct a new phase retrieval algorithm that reduces the computational cost to a single *** being faster,our method is practical because it accepts fewer measurements than state-of-the-art *** to reducing computation time by one order of magnitude,our result can be a step forward toward real-time optical imaging that exploits disordered devices.

关键词： optical matrix algorithm

Nanotechnology meets atopic dermatitis: Current solutions, challenges and future prospects. Insights and implications from a systematic review of the literature

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Bioactive Materials 2019年第1期4卷 380-386页

作者： Giovanni Damiani Roberto Eggenhöffner paolo daniele Maria Pigatto Nicola Luigi Bragazzi Clinical Dermatology IRCCS Istituto Ortopedico GaleazziMilanItaly Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilanItaly Department of Dermatology Case Western Reserve UniversityClevelandOHUSA Young Dermatologists Italian Network Centro Studi GISEDBergamoItaly Department of Surgical Sciences and Integrated Diagnostics University of GenoaGenoaItaly Postgraduate School of Public Health Department of Health SciencesUniversity of GenoaGenoaItaly Laboratory for Industrial and Applied Mathematics(LIAM) Department of Mathematics and StatisticsYork UniversityTorontoOntarioCanada Department of Neuroscience RehabilitationOphthalmologyGenetics and Maternal/Child Sciences(DINOGMI)University of GenoaGenoaItaly

Atopic dermatitis is a chronic,relapsing,non-contiguous,exudative eczema/dermatitis,which represents a complex,multi-factorial disorder,due to an impairment of the stratum corneum *** available drugs have a low skin bioavailability and may give rise to severe adverse ***,including nanoparticles,liposomes,nano-gels,nano-mixtures,nano-emulsions and other nano-carriers,offer unprecedented solutions to these issues,enabling:i)the management of different clinical forms of atopic dermatitis,especially the recalcitrant ones,i)a better bio-availability and trans-dermal drug targeted delivery at the inflammation site,ii)dose control,iii)significant improvements both in clinical symptoms and immune responses,iv)with less adverse events being reported and a better safety ***,some nano-sized structures could amplify and even worsen symptoms in particularly susceptible ***,most studies included in the present systematic review have been conducted in-vitro or in-vivo,with few randomized controlled clinical trials(RCTs).Future investigations should adopt this design in order to enable scholars achieving robust findings and ***,given the above-mentioned shortcomings,further research in the field is urgently warranted.

关键词： Nanodermatology Nanobiotechnologies Atopic dermatitis

Vascular-confined multi-passage discoidal nanoconstructs for the low-dose docetaxel inhibition of triple-negative breast cancer growth

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Nano Research 2022年第1期15卷 482-491页

作者： Alessia Felici daniele Di Mascolo Miguel Ferreira Simone Lauciello Luca Bono Andrea Armirotti Arunkumar Pitchaimani Anna Lisa Palange paolo Decuzzi Laboratory of Nanotechnology for Precision Medicine Fondazione Istituto Italiano di TecnologiaGenoa 16163Italy Department of Informatics BioengineeringRobotics and System EngineeringUniversity of GenoaGenoa 16126Italy Nanochemistry Laboratory Fondazione Istituto Italiano di TecnologiaGenoa 16163Italy Analytical Chemistry Laboratory Fondazione Istituto Italiano di TecnologiaGenoa 16163Italy

Taxane efficacy in triple negative breast cancer(TNBC)is limited by insufficient tumor accumulation and severe off-target *** offer a unique opportunity to enhance the anti-cancer potency of this ***,1,000 nm×400 nm discoidal polymeric nanoconstructs(DPN)encapsulating docetaxel(DTXL)and the near infrared compound Iipid-Cy5 were *** were obtained by filling multiple times cylindrical wells in a poly(vinyl alcohol)template with a polymer mixture comprising poly(lactic-co-glycolic acid)(PLGA)and poly(ethylene glycol)diacrylate(PEG-DA)chains together with therapeutic and imaging *** resulting“multi-passage”DPN exhibited higher DTXL loading,Iipid-Cy5 stability,and stiffness as compared to the conventional"single-passage"*** microscopy confirmed that DTXL-DPN were not taken up by MDA-MB-231 cells but would rather sit next to the cell membrane and slowly release DTXL *** DPN had no toxicity on TNBC cells,whereas DTXL-DPN presented a cytotoxic potential comparable to free DTXL(IC_(50)=2.6 nM±1.0 nM vs.7.0 nM±1.09 nM at 72 h).In orthotopic murine models,DPN accumulated in TNBC more efficiently than *** only 2 mg/kg DTXL,intravenously administered every 2 days for a total of 13 treatments,DTXL-DPN induced tumor regression and were associated to an overall 80%survival rate as opposed to a 30%survival rate for free-DTXL,at 120 *** untreated mice succumbed before 90 ***,this data demonstrates that vascular confined multi-passage DPN,biomimicking the behavior of circulating platelets,can efficiently deliver chemotherapeutic molecules to malignant tissues and effectively treat orthotopic TNBC at minimal taxane doses.

关键词： hydrogel particles template strategy vascular targeting biomimicry cancer therapy

Long term follow-up and outcome of liver transplantation from hepatitis B surface antigen positive donors

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World Journal of Gastroenterology 2017年第12期23卷 2095-2105页

作者： Roberto Ballarin Alessandro Cucchetti Francesco paolo Russo paolo Magistri Matteo Cescon Umberto Cillo Patrizia Burra Antonio daniele Pinna Fabrizio Di Benedetto Hepatopancreatobiliary Surgery and Liver Transplant Unit University Hospital "Policlinico" University of Modena and Reggio Emilia Department of Medical and Surgical Sciences DIMEC S. Orsola-Malpighi Hospital Alma Mater Studiorum University of Bologna Gastroenterology/Multivisceral Transplant Unit Department of Surgery Oncology and Gastroenterology Padua University Hospital Department of Medical and Surgical Sciences and Translational Medicine Sapienza University of Rome

Liver transplant for hepatitis B virus(HBV) currently yields excellent outcomes: it allows to rescue patients with an HBV-related advanced liver disease, resulting in a demographical modification of the waiting list for liver transplant. In an age of patient-tailored treatments, in liver transplantation as well the aim is to offer the best suitable graft to the patient who can benefit from it, also expanding the criteria for organ acceptance and allocation. With the intent of developing strategies to increase the donor pool, we set-up a multicenter study involving 3 Liver Transplant Centers in Italy: patients undergoing liver transplantation between March 03, 2004, and May 21, 2010, were retrospectively evaluated. 1408 patients underwent liver transplantation during the study period, 28(2%) received the graft from hepatitis B surface antigen positive(HBs Ag)-positive deceased donors. The average follow-up after liver transplantation was 63.7 mo [range: 0.1-119.4; SD ± 35.8]. None Primary nonfunction, re-liver transplantation, early or late hepatic artery thrombosis occurred. The 1-, 3-and 5-year graft and patient survival resulted of 85.7%, 82.1%, 78.4%. Our results suggest that the use of HBs Agpositive donors liver grafts is feasible, since HBV can be controlled without affecting graft stability. However, the selection of grafts and the postoperative antiviral therapy should be managed appropriately.

关键词： Liver transplantation Hepatitis B virus Hepatitis B surface antigen Hepatocellular carcinoma Organ allocation Organ procurement Multicenter study

Intraductal papillary neoplasm of the bile duct:The new frontier of biliary pathology

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World Journal of Gastroenterology 2023年第38期29卷 5361-5373页

作者： Federico Mocchegiani paolo Vincenzi Grazia Conte daniele Nicolini Roberta Rossi Andrea Benedetti Cacciaguerra Marco Vivarelli Department of Experimental and Clinical Medicine Polytechnic University of MarcheAncona 60126Italy Department of Gastroenterology and Transplant United Hospital of MarcheAncona 60126Italy

Intraductal papillary neoplasms of the bile duct(IPNBs)represent a rare variant of biliary tumors characterized by a papillary growth within the bile duct *** their first description in 2001,several classifications have been proposed,mainly based on histopathological,radiological and clinical features,although no specific guidelines addressing their management have been *** duct neoplasms generally develop through a multistep process,involving different precursor pathways,ranging from the initial lesion,detectable only microscopically,*** intraepithelial neoplasia,to the distinctive grades of IPNB until the final stage represented by invasive *** and advanced investigations,mainly relying on magnetic resonance imaging(MRI)and cholangioscopy,are required to reach a correct diagnosis and to define an adequate bile duct mapping,which supports proper *** recently introduced subclassifications of types 1 and 2 highlight the histopathological and clinical aspects of IPNB,as well as their natural evolution with a particular focus on prognosis and *** surgical resection,including hepatectomy,pancreaticoduodenectomy or both,represents the treatment of choice,yielding optimal results in terms of survival,although several endoscopic approaches have been *** are newly recognized preinvasive neoplasms of the bile duct with high malignant *** novel subclassification of types 1 and 2 defines the histological and clinical aspects,prognosis and *** is mainly based on MRI and *** resection represents the mainstay of treatment,although endoscopic resection is currently applied to nonsurgically fit *** frontiers in genetic research have identified the processes underlying the carcinogenesis of IPNB,to identify targeted therapies.

关键词： Intraductal neoplasm of the bile duct Bile duct neoplasms Cholangiocarcinoma Intraductal papilloma Classification Treatment

Follow-up after gastrectomy for cancer:results of an international web round table

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World Journal of Gastroenterology 2014年第34期20卷 11966-11971页

作者： Gian Luca Baiocchi Yasuhiro Kodera daniele Marrelli Fabio Pacelli paolo Morgagni Franco Roviello Giovanni De Manzoni Department of Medical and Surgical Sciences Surgical ClinicBrescia UniversityBrescia 25123Italy Department of Gastroenterological Surgery Surgery ⅡNagoya UniversityNagoya 452-0813Japan Department of Human Pathology and Oncology Surgical OncologySiena UniversitySiena 53011Italy Department of Surgical Sciences Digestive SurgeryCatholic UniversityRome 00118Italy Department of General Surgery MorgagniPierantoni HospitalForlì 47121Italy 1~(st) Department of General Surgery Borgo Trento HospitalUniversity of VeronaVerona 37121Italy

Oncological follow-up after radical gastrectomy for cancer still represents a discrepancy in the field, with many retrospective series demonstrating that early diagnosis of recurrence does not result in an improvement in patient survival; yet, many centers with high quality of care still provide routine patient follow-up after surgery by clinical and instrumental controls. This was the topic for a web round table entitled “Rationale and limits of oncological follow-up after gastrectomy for cancer” that was launched one year before the 10th International Gastric Cancer Congress. Authors having specific expertise were invited to comment on their previous publications to provide the subject for an open debate. During a three-month-long discussion, 32 authors from 12 countries participated, and 2299 people visited the dedicated web page. Substantial differences emerged between the participants: authors from Japan, South Korea, Italy, Brazil, Germany and France currently engage in instrumental follow-up, whereas authors from Eastern Europe, Peru and India do not, and British and American surgeons practice it in a rather limited manner or in the context of experimental studies. Although endoscopy is still considered useful by most authors, all the authors recognized that computed tomography scanning is the method of choice to detect recurrence; however, many limit follow-up to clinical and biochemical examinations, and acknowledge the lack of improved survival with early detection.

关键词： Gastric cancer Recurrence Follow-up Diagnosis Prognosis Surgery Chemotherapy

Impact of immunosuppression minimization and withdrawal in long-term hepatitis C virus liver transplant recipients

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World Journal of Gastroenterology 2014年第34期20卷 12217-12225页

作者： Tommaso Maria Manzia Roberta Angelico paolo Ciano Jon Mugweru Kofi Owusu daniele Sforza Luca Toti Giuseppe Tisone Department of Experimental Medicine and Surgery Section of TransplantationTor Vergata University of Rome00133 RomeItaly Wake Forest School of Medicine Winston-SalemNC 27106United States

AIM: To investigate the effects of different immunosuppressive regimens and avoidance on fibrosis progression in hepatitis C virus (HCV) liver transplant (LT) recipients.

关键词： Liver transplantation Hepatitis C virus recurrence Immunosuppression withdrawal Micofenolate mofetil Clinical operational tolerance Minimization of immunosuppression

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An daniele paolo anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

Lumbar ganglion cyst:Nosology, surgical management and proposal of a new classification based on 34 personal cases and literature review

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World Journal of Orthopedics 2017年第9期8卷 697-704页

作者： Maurizio Domenicucci Alessandro Ramieri daniele Marruzzo paolo Missori Massimo Miscusi Roberto Tarantino Roberto Delfini Department of Neurological and Psychiatric Sapienza University of Rome Orthopedic Division Don Gnocchi Foun-dation Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of Rome

AIM To analyze different terms used in literature to identify lumbar extradural cysts and propose a common scientific terminology; to elaborate a new morphological classification of this pathology, useful for clinical and surgical purposes; and to describe the best surgical approach to remove these cysts, in order to avoid iatrogenic instability or treat the pre-existing one. METHODS We retrospectively reviewed 34 patients with symptomatic lumbar ganglion cysts treated with spinal canal decompression with or without spinal fixation. Microsurgical approach was the main procedure and spinal instrumentation was required only in case of evident preoperative segmental instability. RESULTS The complete cystectomy with histological examination was performed in all cases. All patients presented an improvement of clinical conditions, evaluated by Visual Analogic Scale and Japanese Orthopaedic Association scoring. CONCLUSION Spinal ganglion cysts are generally found in the lumbar spine. The treatment of choice is the microsurgical cystectomy, which generally does not require *** need for fusion must be carefully evaluated: Preoperative spondylolisthesis or a wide joint resection, during the operation, are the main indications for spinal instrumentation. We propose the terms "ganglion cyst" to finally identify this spinal pathology and for the first time its morphological classification, clinically useful for all specialists.

关键词： Synovial cyst Lumbar spine Instability Surgery Ganglion