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Geomechanical design of a room and rib pillar granite mine

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Journal of University of Science and Technology Beijing 2008年第2期15卷 97-103页

作者： daniele Peila Claudia Guardini Sebastiano Pelizza Tunnelling Underground Space Center Department of EnvironmentLand and Geotechnology Engineering Politecnico di Torino Tunnelling Underground Space Center Department of EnvironmentLand and Geotechnology EngineeringPolitecnico di TorinoTorinoItaly

The geomechanical and stability design of an underground granite mine located in Canal San Bovo （Trento district, Northeastern Italy） was described. The exploitation of the granite, which is used in the ceramic industry, was carried out by the rooms and rib pillars method. The rooms are 12 m wide while the pillars are 11 m wide and they cross the main discontinuity set of the rock mass in the perpendicular direction. To verify the stability condition of an underground mine, it is necessary to carry out the calcula- tions that are able to check both the local and global stability of the rock mass. In the studied example, this approach has been applied with the development of analytical and numerical parametric analyses and it has permitted to get the best orientation and to design the size of rooms and pillars.

关键词： mining room and pillar rock mechanics stability analysis

CUBE, a Cable-driven Device for Limb Rehabilitation

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Journal of Bionic Engineering 2019年第3期16卷 492-502页

作者： daniele Cafolla Matteo Russo Giuseppe Carbone IRCCS Neuromed Via delFelettronica 86077 Pozzilli IS Italy University of Nottingham Advanced Manufacturing Building C47 Nottingham NG8 IBB UK DIMEG University of Calabria Via Bucci Cubo 46C 87036 Rende Italy CESTER Technical University of Cluj-Napoca MunciiAve. 103-105 400641 Cluj-Napoca Romania

In this paper, a novel cable-driven parallel robot, CUBE, is introduced for the assistance of patients in rehabilitation exercising of both upper and lower limbs. The system is characterized by a lightweight structure that is easy to set-up and operate, for both clinical and home usage for both pre-determined and customized exercises, with control over the position of the end-effector while locking its rotation around the horizontal axes. Its cable-driven design makes it inherently safe in human/robot interactions also due to the extremely low inertia. While a novel end-effector design makes the device wearable both on the upper and lower limbs without having to disassemble any part of the structure. The design is presented with its kinematic analysis. Then, the manufacturing through 3D?printing and commercial components of a first prototype is reported. Finally, the system is validated through motion tests along simple trajectories and two different spatial exercises.

关键词： cable-driven robots medical robots parallel robots rehabilitation devices

Myelin positron emission tomography(PET) imaging in multiple sclerosis

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Neural Regeneration Research 2020年第10期15卷 1842-1843页

作者： daniele de Paula Faria Laboratory of Nuclear Medicine (LIM-43) Departamento de Radiologia e Oncologia Faculdade de Medicina Universidade de Sao Paulo

Multiple sclerosis(MS)is a neurodegenerative disease characterized by inflammation and *** are focused on encountering remyelination therapies that can be applied to delaying,or even decreasing,the motor and cognitive disabilities caused by the *** cellular/molecular changes in MS are dynamic,with inflammation,demyelination and remyelination inducing progressive neurodegenerative changes in the central nervous system,as a ***,the imaging methods for accompanying the process are,as yet,shortcoming.

关键词： inflammation sclerosis myelin

Pull the fuzes:Processing protein precursors to generate apoplastic danger signals for triggering plant immunity

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Plant Communications 2024年第8期5卷 113-136页

作者： daniele Del Corpo daniele Coculo Marco Greco Giulia De Lorenzo Vincenzo Lionetti Department of Biology and Biotechnology“Charles Darwin ”Sapienza University of RomeRomeItaly

The apoplast is one of the first cellular compartments outside the plasma membrane encountered by phytopathogenic microbes in the early stages of plant tissue *** have developed sophisticated surveillance mechanisms to sense danger events at the cell surface and promptly activate ***,a fine tuning of the activation of immune pathways is necessary to mount a robust and effective defense *** endogenous proteins and enzymes are synthesized as inactive precursors,and their post-translational processing has emerged as a critical mechanism for triggering alarms in the *** this review,we focus on the precursors of phytocytokines,cell wall remodeling enzymes,and *** physiological events that convert inactive precursors into immunomodulatory active peptides or enzymes are *** review also explores the functional synergies among phytocytokines,cell wall damage-associated molecular patterns,and remodeling,highlighting their roles in boosting extracellular immunity and reinforcing defenses against pests.

关键词： apoplast immunity activation post-translational processing cell wall proteases pro-peptides proenzymes phytocytokines cell-wall remodeling enzymes phytopathogenic microbes plant immunity

Structure Polynomials and Subgraphs of Rooted Regular Trees

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Algebra Colloquium 2018年第1期25卷 45-70页

作者： daniele D'Angeli Alfredo Donno Institut ffir Diskrete Mathematik Technische Universitat Graz Steyrergasse 30 8010 Graz Austria Universitg degli Studi Niccolo Cusano - Via Don Carlo Gnocchi 300166 Roma Italia

We introduce an algebraic structure allowing us to describe subgraphs of a regular rooted tree. Its elements are called structure polynomials, and they are in a one- to-one correspondence with the set of all subgraphs of the tree. We define two operations, the sum and the product of structure polynomials, giving a graph interpretation of them. Then we introduce an equivalence relation between polynomials, using the action of the full automorphism group of the tree, and we count equivalence classes of subgraphs modulo this equivalence. We also prove that this action gives rise to symmetric Gelfand pairs. Finally, when the regularity degree of the tree is a prime p, we regard each level of the tree as a finite dimensional vector space over the finite field Fp, and we are able to completely characterize structure polynomials corresponding to subgraphs whose leaf set is a vector subspace.

关键词： rooted tree structure polynomial rooted subtree automorphism group of a tree Gelfand pair

＇Hot stuff＇： inflammatory lymphocyte populations in acute coronary syndrome

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Cellular & Molecular Immunology 2015年第4期12卷 513-514页

作者： Natale daniele Brunetti FESC Departement of Medical & SurgicalSciences University of Foggia Foggia Italy

Acute myocardial infarction and co- ronary unstable plaque： definitely＇hot stuff to address. However, it is not just a pun. Atherosderosis and acute coronary syndrome are both characterized by active inflammation） Increased levels of C-react- ive protein and inflammatory cytokines have been found during the very early phases of acute myocardial infarction2 and are associated with a worse prognosis.

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Comparison between the seismic response of 2D and 3D models of rigid blocks

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Earthquake Engineering and Engineering Vibration 2014年第1期13卷 151-162页

作者： Angelo Di Egidio daniele Zulli Alessandro Contento Department of Civil Engineering Architecture and Environment(DICEAA)University of L'Aquila

A three-dimensional rigid body on the shape of a parallelepiped is modelled in order to rock on a side or a vertex of the base,in order to evaluate the seismic response of rigid blocks lying on a horizontal *** center of mass of the body is considered as eccentric with respect to its geometric *** seismic input,three Italian recorded accelerograms,with different spectral content,are *** study is mainly conducted to highlight the differences between the seismic response of 2D and 3D models of rigid blocks,with the aim to understand if,in some cases,the use of the 3D model of rigid block is required to obtain safer *** fact,the outcomes show that in some ranges of the geometrical and mechanical parameters that characterize the excitation and the body,a two-dimensional model,which is not able to consider the 3D rocking on a vertex,can provide unsafe *** particular,it is found that the overturning process of the three-dimensional block can occur under excitations which are lower than those which overturn a corresponding two-dimensional block.

关键词： seismic excitation 3D rigid block rectangular base rocking overturning

Systemic therapy of hepatocellular carcinoma:Current status and future perspectives

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World Journal of Gastroenterology 2014年第12期20卷 3087-3099页

作者： Domenico Germano Bruno daniele Oncology Unit A.O. "G.Rummo"

The management of hepatocellular carcinoma (HCC) has substantially changed in the past few decades, the introduction of novel therapies (such as sorafenib) have improved patient survival. Nevertheless, HCC remains the third most common cause of cancer-related deaths worldwide. Decision-making largely relies on evidence-based criteria, as showed in the US and European clinical practice guidelines, which endorse five therapeutic recommendations:resection; transplantation; radiofrequency ablation; chemoembolization; and sorafenib. Many molecularly targeted agents that inhibit angiogenesis, epidermal growth factor receptor, and mammalian target of rapamycin are at different stages of clinical development in advanced HCC. Future research should continue to unravel the mechanism of hepatocarcinogenesis and to identify key relevant molecular targets for therapeutic intervention. Identification and validation of potential surrogate and predictive biomarkers hold promise to individualize patient’s treatment to maximize clinical benefit and minimize the toxicity and cost of targeted agents.

关键词： Hepatocellular Carcinoma Molecular agents Targheted therapy Sorafenib

An Experimental Investigation of the Dissipation Mechanisms in the Suction Side Boundary Layer of a Turbine Blade

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Journal of Thermal Science 2008年第4期17卷 289-297页

作者： Francesca Satta daniele Simoni Marina Ubaldi Pietro Zunino Dipartimento di Macchine Sistemi Energetici e Trasporti-Università di Genova

The present work is part of an extensive experimental activity carried out by the authors in recent years aimed at investigating the boundary layer transition phenomenon in turbine blades. The large scale of the cascade and the use of advanced LDV instrumentation and precision probe traversing mechanism resulted in high degree of spatial resolution and high accuracy of measurements. The main dissipation mechanism determining the profile losses in turbomachinery blades is the work of deformation of the mean motion within the boundary layer operated by both viscous and turbulent shear stresses. In the present paper, the local viscous and turbulent deformation works have been directly evaluated from the detailed measurements of boundary layer mean velocity and Reynolds shear stress. The results show the distributions and the relative importance of the viscous and turbulent contributions to the loss production, in relation with the boundary layer states occurring along the turbine profile.

关键词： Axial flow turbines Profile boundary layer Energy dissipation mechanism Boundary layer transition Laser Doppler measurements.