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Determination of iohexol by capillary blood microsampling and UHPLC-MS/MS

Journal of Pharmaceutical Analysis 2019年第4期9卷 259-265页

作者： Valentin Ion Caroline Legoff Etienne Cavalier Pierre Delanaye Anne-Catherine Servais daniela-lucia muntean Marianne Fillet Laboratory for the Analysis of Medicines (LAM) Center for Interdisciplinary Research on Medicines (CIRM) University of Liege Liege Belgium Analytical Chemistry and Drug Analysis Department Faculty of Pharmacy University of Medicine Pharmacy Science and Technology from Tirgu Mures 540139 Tirgu Mures Romania Department of Clinical Chemistry Center for Interdisciplinary Research on Medicines (CIRM) University of Liege CHU Sart-Tilman Liege Belgium Department of Nephrology-Dialysis-Transplantation University of Liege CHU Sart-Tilman Liege Belgium

One of the most important tools used to evaluate kidney function in the context of chronic kidney disease or other renal function related pathologies is the exploration of glomerular filtration rate (GFR). Iohexol is up to this moment a good candidate molecule for the GFR assessment since it exhibits minimum protein binding rates and minimum extra-renal clearance, being neither secreted nor reabsorbed at the tubular level. This study proposes and evaluates a new LC-MS/MS method for the iohexol determination from capillary blood, prelevated using volumetric absorbative microsampling (VAMS) systems. As an alternative to VAMS, a brand new HemaPEN■ device for micro-prelevation was also tested. A new high throughput sample preparation protocol adapted for iohexol quantification from whole blood VAMS samples was developed. The medium term stability study of iohexol in dried whole blood VAMS samples that was conducted showed a good stability of this molecule for up to 12 days. By collecting only 10 mL of blood, iohexol can be analyzed from dried whole blood VAMS samples for concentration ranges between 1 and 250 mg/mL. Due to the analyte stability in VAMS for up to 12 days, this approach might be successfully applied for GFR assessment for clinical cases allowing minimum invasiveness and even delayed analysis.

关键词： Microsampling Iohexol VAMS LC-MS/MS HemaPEN

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Breaking the brain barrier:cell competition in neural development and disease

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Neural Regeneration Research 2024年第9期19卷 1863-1864页

作者： Patrizia Morciano daniela Grifoni Department of“Life Health and Environmental Sciences”University of L’AquilaItaly “INFN-Laboratori Nazionali del Gran Sasso” AssergiItaly

General information on cell competition:Social behaviors are the basis of biological *** species and populations,cell communities experience Darwinian ecological interactions,and in case space and nutrient availabilit... 详细信息

关键词： neural barrier throughout

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GRP7 phase separation as an interpreter of temperature cues

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Molecular Plant 2024年第6期17卷 842-844页

作者： Sunita Pathak lucia C.Strader Department of Biology Duke UniversityDurhamNCUSA

Plants are exposed to a range of daily and seasonal temperatures and thus are required to regulate their cellular processes under fluctuating temperature *** various temperature-responsive genes,GLYCINE-RICH RNA BINDING PROTEIN7(GRP7)encodes a glycine-rich RNA-binding protein that provides freezing tolerance to plants(Carpenter et al.,1994;Kim et al.,2008)by acting as an RNA chaperone(Kwak et al.,2011).

关键词： al. conditions. separation

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意大利语版护理管理者胜任力测评工具的信效度检验

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International Journal of Nursing Sciences 2024年第3期11卷 338-348页

作者： Dhurata Ivziku lucia Filomeno daniela Forte Rosario Caruso Gianluca Conte Arianna Magon Raffaella Gualandi Marco Di Muzio daniela Tartaglini Department of Health Professions Fondazione Policlinico Universitario Campus Bio-MedicoRomeItaly Department of Biomedicine and Prevention University of Rome Tor VergataRomeItaly Health Professions Research and Development Unit IRCCS San Donato HospitalMilanItaly Department of Biomedical Sciences for Health University of MilanMilanItaly Department of Clinical and Molecular Medicine Sapienza UniversityRomeItaly Vice President Italian Society for the Direction and Management in Nursing(SIDMI) RomeItaly

目的旨在翻译Chase护理管理者胜任力测评工具(the Chase Nurse Manager Competency Instrument,CNMCI)为意大利语,并对其进行信度和效度检验。方法对英文版CNMCI进行翻译,并通过横断面研究验证其信效度。采用预翻译(建立等效)、初始翻... 详细信息

目的旨在翻译Chase护理管理者胜任力测评工具(the Chase Nurse Manager Competency Instrument,CNMCI)为意大利语,并对其进行信度和效度检验。方法对英文版CNMCI进行翻译,并通过横断面研究验证其信效度。采用预翻译(建立等效)、初始翻译、预测试、审查和管理5个步骤的问卷翻译方法,将英文版工具翻译为意大利语版。于2022年8月到2023年6月,选取意大利3个地区31所医疗机构349名护理管理者进行调查。采用内容效度、结构效度评估工具的效度;采用Cronbach'sα系数、重测信度评估工具的信度。结果意大利语版CNMCI,包括“知识理解”和“实施和/或使用能力”两个分量表,每个分量表包括53个条目。工具的条目内容效度指数(I-CVI)为0.83~1.00,两个分量表的内容效度指数(S-CVI)均为0.97。经验证性因子分析显示该工具各项拟合指数表现良好。工具中“知识理解”分量表的Cronbach'sα系数为0.978,“实施和/或使用能力”分量表的Cronbach'sα系数为0.976。各个维度之间的相关系数为0.494~0.908重测信度为0.820,表明工具的一致性较好。结论意大利语版CNMCI在测量护理管理者胜任力方面显示出良好的信度和效度,并支持该工具的多维度结构。此外,研究结果支持了这些因素的层次性质,进一步支持了该工具的有效性。

关键词：胜任力护理管理者信度调查及问卷效度

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Experimental Exclusion of Guanaco Grazing Increases Cover, Diversity, Land Function and Plant Recruitment in Patagonia

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1383-1401页

作者： Carla Cepeda Gabriel Oliva daniela Ferrante INTA Instituto Nacional de Tecnología Agropecuaria Santa Cruz9400Rio GallegosArgentina Universidad Nacional de la Patagonia Austral Santa Cruz9400Rio GallegosArgentina

Semiarid Patagonia represents 25%of the rangeland area in Argentina,and sheep overgrazing has degraded about a third of it in the *** this century,depleted domestic stocks have mostly stabilized,but Guanaco populations have *** native camelids share habitat and diets with sheep,but their effect on vegetation is poorly understood and has long been *** set up an exclusion experiment in Monte León and Cañadón Vaca,a semiarid shrubland grassland in southern Patagonia,currently grazed only by *** baselines were studied in 2016 in twelve plots,and half of them were protected from guanaco ***-six plots were cleared to study *** was reassessed in 2021,and changes were evaluated using a paired *** protected plots,vegetation cover increased,bare soil diminished,and vegetated patches grew in size,but the density of the patch-interpatch arrangement did not ***,measured by richness and the Shan-non-Wiener(SW)index,grew signiﬁ*** recycling increased,as did the Stability and Inﬁltration Land Function indexes,although these last differences were not signiﬁ*** cover under guanaco grazing also increased,mainly due to the growth of dwarf shrubs,a typical tendency in sheep grazing-induced transitions in the *** patches under grazing fragmented,resulting in smaller patches and denser patch struc-tures,while diversity and land function indexes remained *** plants established in cleared plots without guanacos showed higher cover density and individual *** effects are similar to those observed in numerous experimental sheep *** grazing may thus prevent restoration and contribute to the generalized land degradation processes that overgrazing has been causing in Patagonia for over a century.

关键词： Rangelands herbivory biodiversity overgrazing carrying capacity fauna

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Climate change impacts on eutrophication in the Po River(Italy):Temperature-mediated reduction in nitrogen export but no effect on phosphorus

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Journal of Environmental Sciences 2024年第9期143卷 148-163页

作者： Elisa Soana Maria Pia Gervasio Tommaso Granata daniela Colombo Giuseppe Castaldelli Department of Environmental and Prevention Sciences University of FerraraVia Luigi Borsari 4644121 FerraraItaly CESI-Italian Electrical and Technical Experimental Center via Rubattino 5420134MilanoItaly

Rivers worldwide are under stress from eutrophication and nitrate pollution,but the ecological consequences overlap with climate change,and the resulting interactions may be unexpected and still *** Po River basin(northern Italy)is one of the most agriculturally productive and densely populated areas in *** remains unclear whether the climate change impacts on the thermal and hydrological regimes are already affecting nutrient dynamics and transport to coastal *** present work addresses the long-term trends(1992-2020)of nitrogen and phosphorus export by investigating both the annual magnitude and the seasonal patterns and their relationship with water temperature and discharge *** the constant diffuse and point sources in the basin,a marked decrease(-20%)in nitrogen export,mostly as nitrate,was recorded in the last decade compared to the 1990 s,while no significant downward trend was observed for *** water temperature of the Po River has warmed,with the most pronounced signals in summer(+0.13℃/year)and autumn(+0.16℃/year),together with the strongest increase in the number of warm days(+70%-80%).An extended seasonal window of warm temperatures and the persistence of low flow periods are likely to create favorable conditions for permanent nitrate removal via denitrification,resulting in a lower delivery of reactive nitrogen to the *** present results show that climate change-driven warming may enhance nitrogen processing by increasing respiratory river metabolism,thereby reducing export from spring to early autumn,when the risk of eutrophication in coastal zones is higher.

关键词： Nutrient export Eutrophication Climate change Water temperature Denitrification Po River

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Advancing pediatric exercise research:A focus on immunomics and cutting-edge technologies

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Journal of Sport and Health Science 2024年第5期13卷 679-681页

作者： Abel Plaza-Florido Alejandro lucia Shlomit Radom-Aizik Pediatric Exercise and Genomics Research Center Department of PediatricsSchool of MedicineUniversity of California at IrvineIrvineCA 92617USA Faculty of Sport Sciences Universidad Europea de MadridMadrid 28670Spain Physical Activity Health Research Group(“PaHerg”) Research Institute of Hospital 12 de Octubre(“imas12”)Madrid 28041Spain

*** importance of immunomics in pediatric exercise research The profound effect that"acute"or"regular"exercise(i.e.,a single exercise session or repeated sessions over time,respectively)exerts on the immune system has been widely recognized.1 Acute exercise is largely"immuno-enhancing"(e.g.,it may even improve vaccine responses in"at-risk"patients),whereas regular exercise reduces the risk of chronic conditions(not only obesity,diabetes,or cardiovascular diseases,but also several types of cancer)partly due to its anti-inflammatory effects.

关键词： pediatric Acute vaccine

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High CO_(2)permeation using a new Ce_(0.85)Gd_(0.15)O_(2-δ)-LaNiO_(3)composite ceramic–carbonate dual-phase membrane

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Journal of Environmental Sciences 2024年第6期140卷 219-229页

作者： daniela González-Varela JFrancisco Gómez-García Gustavo Tavizon Heriberto Pfeiffer Instituto de Investigaciones en Materiales Universidad Nacional Autónoma de MéxicoCd.UniversitariaDel.CoyoacánCP 04510Ciudad de MéxicoMéxico Departamento de Física y Química Teórica Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoCd.UniversitariaDel.CoyoacánCP 04510Ciudad de MéxicoMéxico 不详

This work shows the synthesis,characterization and evaluation of dense-ceramic membranes made of Ce_(0.85)Gd_(0.15)O_(2-δ)-LaNiO_(3)(CG-LN)composites,where the fluorite-perovskite ratio(CG:LN)was varied as follows:75:25,80:20 and 85:15 wt.%.Supports were initially characterized by XRD,SEM and electrical conductivity(using vacuum and oxygen atmospheres),to determine the composition,microstructural and ionic-electronic conductivity ***,supports were infiltrated with an eutectic carbonates mixture,producing the corresponding dense dual-phase membranes,in which CO_(2)permeation tests were ***,CO_(2)permeation experiments were performed from 900 to 700℃,in the presence and absence of oxygen(flowed in the sweep membrane side).Results showed that these composites possess high CO_(2)permeation properties,where the O_(2)addition significantly improves the ionic conduction on the sweep membrane ***,the GC80-LN20 composition presented the best results due to the following physicochemical characteristics:high electronic and ionic conductivity,appropriate porosity,interconnected porous channels,as well as thermal and chemical stabilities between the composite support and carbonate phases.

关键词： CO_(2)permeation Doped CeO_(2) LaNiO_(3) Impedance Ceramic carbonate membrane

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Litter production and leaf nutrient concentration and remobilization in response to climate seasonality in the central Amazon

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Journal of Forestry Research 2024年第3期35卷 131-141页

作者： Ricardo Antonio Marenco Saul Alfredo Antezana-Vera daniela Pereira Dias Luiz Antonio Candido Instituto Nacional de Pesquisas da Amazonia Coordenagao de Uso da Terra e Mudanca ClimaticaAv.Andre Araujo 2936ManausAM69067-375Brazil Programa de pos-Graduagao em Agricultura no Tropico Umido Instituto Nacional de Pesquisas da Amazonia-INPAManausAMBrazil Unidade Academica de Ciencias Agrarias Universidade Federal de JataiBR 364km 195JataiGO 75801-615Brazil

Litterfall is the largest source of nutrients to for-est soils of tropical ***,variability in lit-terfall production,nutrient remobilization,and changes in leaf nutrient concentration with climate seasonality remain largely unknown for the central *** study meas-ured litterfall production,leaf nutrient remobilization,and leaf area index on a forest plateau in the central *** was measured at monthly intervals during 2014,while nitrogen,phosphorus,potassium,calcium and mag-nesium concentrations of leaf litter and canopy leaves were measured in the dry and rainy seasons,and remobilization rates *** area index was also recorded in the dry and rainy *** litterfall varied from 33.2(in the rainy season)to 87.6 g m^(-2) in the dry season,while leaf area index increased slightly in the rainy *** seasonality had no effect on concentrations of nitrogen,calcium,and magnesium,whereas phosphorous and potassium responded to rainfall seasonality *** phosphorous increased,potassium decreased during the dry *** seasons,nitrogen,potassium,and phosphorous decreased in leaf litter;calcium increased in leaf litter,while magnesium remained unaffected with leaf ***,the five nutrients had similar remobilization rates over the *** absence of climate seasonality on nutrient remobilization suggests that the current length of the dry season does not alter nutrient remobilization rates but this may change as dry periods become more prolonged in the future due to climate change.

关键词： Throughfall Nutrient cycling Climatic seasonality Leaf mass per area

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Improving colorectal cancer screening programs

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World Journal of Gastroenterology 2024年第22期30卷 2849-2851页

作者： Oscar J Cordero lucia Mosquera-Ferreiro Iria Gomez-Tourino Department of Biochemistry and Molecular Biology University of Santiago de CompostelaSantiago de Compostela 15782Spain Centre for Research in Molecular Medicine and Chronic Diseases(CiMUS) University of Santiago de CompostelaSantiago de Compostela 15782GaliciaSpain

In this editorial we comment on the article by Agatsuma et al published in the World Journal of *** suggest policies for more effective colorectal *** is the main policy that has led to lower mortality rates in later years among the population that was eligible for *** is the gold standard tool for screening and has preventive effects by removing precancerous or early malignant ***,colonoscopy is an invasive process,and fecal tests such as the current hemoglobin immunodetection were developed,followed by endoscopy,as the general tool for population screening,avoiding logistical and economic *** so,participation and adherence rates are *** screening options are being developed with the idea that if people could choose between the ones that best suit them,participation in population-based screening programs would *** tests,such as a recent one that detects cell-free DNA shed by tumors called circulating tumor DNA,showed a similar accuracy rate to stool tests for cancer,but were less sensitive for advanced precancerous *** the time when the crosstalk between the immune system and cancer was being established as a new hallmark of cancer,novel immune system-related biomarkers and information on patients’immune parameters,such as cell counts of different immune populations,were studied for the early detection of colorectal cancer,since they could be effective in asymptomatic people,appearing earlier in the adenoma-carcinoma development compared to the presence of fecal ***26,for example,detected 80.37%of advanced *** reach as many eligible people as possible,starting at an earlier age than current programs,the direction could be to apply tests based on blood,urine or salivary fluid to samples taken during routine visits to the primary health system.

关键词： Mortality rates Colorectal cancer Screening Biomarker Fecal hemoglobin immunodetection Soluble sCD26 Colonoscopy Immunoscores

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