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The action of ethanol on G protein. <i>In silico</i>and cellular/molecular evidences

Advances in Bioscience and Biotechnology 2013年第5期4卷 665-673页

作者： Pamela Fernandez Jessica Moreno Claudio Barrientos Sergio A. Aguila daniela leon Sebastián Ortiz Ramon Silva Francisco Rodriguez Maritza leonardi Violeta Morin Ximena Romo Departamento de Bioquimica y Biologia Molecular Facultad de Ciencias Biologicas Universidad de Concepción Concepcion Chile Departamento de Ciencias Biologicas Facultad de Ciencias Biologicas Universidad Andres Bello Sede Concepcion Talcahuano Chile Laboratorio de Virus Oncológicos en Reproducción BIOREN-CEGIN Universidad de La Frontera Temuco Chile Universidad Nacional Autonoma de Mexico Centro de Nanociencias y Nanotecnologia Ensenada Mexico

Ethanol (EtOH) enhances glycinergic currents in the central nervous system (CNS). Because evidence for an interaction between the α1 subunit of the glycine receptor (α1GlyR) and the G protein Gβγ subunit exists in vitro and because cAMP levels are known to increase in response to EtOH, we wanted to investigate the interaction between Gβγ and α1GlyR in response to EtOH treatment in HEK293 cells and to explore the possible sites of interaction between EtOH and the Gαs subunit. His pull-down assays in GlyR-His6-transfected HEK293 cells incubated with ethanol or propofol revealed that only EtOH treatment increased the binding of Gβγ heterodimers to α1GlyR. Using molecular modelling (protein structure prediction), was modelled the hGαs protein for the first time and validated this model by site-directed mutagenesis. By molecular docking, we identified some potential regions of interaction between hGαs and EtOH that are located on the SIII and SI regions of the Gαs. Therefore, we conclude that ethanol increases the interaction between α1GlyR and Gβγ in HEK293 cells, an effect that might be attributed to the interaction between EtOH and hGαs, which consequently stimulates hGαs.

关键词： Alcoholism Ethanol Glycine Receptor G Proteins Signals Transduction

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Therapeutic effectiveness of a single exercise session combined with WalkAide functional electrical stimulation in post-stroke patients:a crossover design study

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Neural Regeneration Research 2021年第5期16卷 805-812页

作者： Viviane Rostirola Elsner Lucieli Trevizol Isadora de leon Marcos da Silva ThaynáWeiss Milena Braga daniela Pochmann Amanda Stolzenberg Blembeel Caroline Dani Elenice Boggio Curso de Fisioterapia do Centro Universitário Metodista-IPA Porto AlegreRSBrasil Programa de Pós-Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA Porto AlegreRSBrasil Programa de Pós-Graduação em Ciências Biológicas:Fisiologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrasil

A growing body of evidence has suggested that the imbalance of epigenetic markers and oxidative stress appears to be involved in the pathophysiology and progression of ***,strategies that modulate these biomarkers might be considered targets for neuroprotection and novel therapeutic opportunities for these *** exercise has been reported to induce changes in these epigenetic markers and improve clinical outcomes in different ***,little is reported on this in post-stroke *** purpose of this study was to investigate the effect of a single exercise session with WalkAide functional electrical stimulation(FES)on cognitive performance,clinical functional parameters,oxidative stress and epigenetic modulation in post-stroke *** this crossover design study,12 post-stroke individuals aged 54–72 years of either sexes were included and subjected to a single session of exercise(45 minutes)without WalkAide functional electrical stimulation(EXE alone group),followed by another single session of exercise(45 minutes)with WalkAide functional electrical stimulation(EXE+FES group).The clinical functional outcome measures,cognitive performance and blood collections for biomarker measurements were assessed pre-and *** intervention,higher Berg Balance Scale scores were obtained in the EXE+FES group than in the EXE alone *** was no significant difference in the Timed Up and Go test results post-intervention between EXE alone and EXE+FES *** intervention,a better cognitive performance was found in both groups compared with before the *** intervention,the Timed Up and Go test scores were higher in the EXE+FES group than in the EXE alone *** addition,the intervention induced lower levels of lipid *** intervention,carbonyl level was lower,superoxide dismutase activity and superoxide dismutase/catalase activity ratio were higher in the EXE+FES group,compared with the

关键词： cognition epigenetic exercise functional electrical stimulation functional mobility oxidative stress stroke WalkAide

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中东现代艺术博物馆

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中国建筑装饰装修 2010年第8期 108-119页

作者： Ben van Berkel Caroline Bos Gerard Loozekoot Lars Nixdorff Wouter de Jonge Ramon van der Heijden daniela Hake Shany Barath Ioana Suela Hendrik Biesenbach Wouter Hilhorst Tom Minderhoud Patrik Noome Jordi Calvera Mark Hopperman leon Bloemendaal UNStudio

中东现代艺术博物馆（MOMEMA）的项目正在进行当中。项目旨在打造阿拉伯联合酋长国（UAE）的多元文化中心。对于世界城市KhorDUbai（迪拜河）成为迪拜的又一文化中心来说．这座博物馆．无疑凸显了它的熏要性。这个新的文化中心．又被称... 详细信息

中东现代艺术博物馆（MOMEMA）的项目正在进行当中。项目旨在打造阿拉伯联合酋长国（UAE）的多元文化中心。对于世界城市KhorDUbai（迪拜河）成为迪拜的又一文化中心来说．这座博物馆．无疑凸显了它的熏要性。这个新的文化中心．又被称之为“文化村“，将坐落于历史上著名的Jadaf地区的40，000，000平方英尺的土地上。

关键词：现代艺术博物馆中东阿拉伯联合酋长国文化中心世界城市迪拜

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