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Structural evolution and reaction mechanism of lithium nickelate(LiNiO_(2))during the carbonation reaction

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Journal of Materiomics 2018年第1期4卷 56-61页

作者： daniela gonzalez-varela Brenda Alcantar-Vazquez Heriberto Pfeiffer Laboratorio de Fisicoquímica y Reactividad de Superficies(LaFReS) Instituto de Investigaciones en MaterialesUniversidad Nacional Autonoma de MexicoCircuito exterior s/nCUDel.CoyoacanCP 04510Ciudad de MexicoMexico Instituto de Ingenieria Coordinacion de Ingeniería AmbientalUniversidad Nacional Autonoma de MexicoCircuito Escolar s/nCUDel.CoyoacanCP 04510Ciudad de MexicoMexico

Lithium nickelate(LiNiO_(2))was synthesized using the lithium excess method,and then characterized by X-ray diffraction,scanning electron microscopy and N_(2) adsorption-desorption.Finally,differential thermal and thermogravimetric analyses were performed in CO_(2)presence,at high temperatures.Results show that LiNiO_(2)is able to react with CO_(2)through a complex structural evolution process,where lithium atoms are released to produce Li_(2)CO_(3),while some nickel atoms are rearranged on different Li_(1-x)Ni_(1+x)O_(2)crystalline phases.LiNiO_(2)-CO_(2)reaction kinetic parameters were determined assuming a first-order reaction,where kinetic constants tended to increase as a function of temperature.However,kinetic constant values did not follow a linear trend.This atypical behavior was attributed to LiNiO_(2)sintering and crystalline evolution performed as a function of temperature.

关键词： Lithium nickelate CO_(2)chemisorption Lithium diffusion coefficient Phase transition

Understanding the function and dysfunction of the immune system in lung cancer: the role of immune checkpoints

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Cancer Biology & Medicine 2015年第2期12卷 79-86页

作者： Niki Karachaliou Maria gonzalez Cao Cristina Teixidó Santiago Viteri daniela Morales-Espinosa Mariacarmela Santarpia Rafael Rosell Instituto Oncológico Dr Rosell Quiron Dexeus University Hospital Pangaea Biotech Medical Oncology Unit Human Pathology Department University of Messina Catalan Institute of Oncology Hospital Germans Trias i Pujol Molecular Oncology Research (MORe) Foundation Germans Trias i Pujol Health Sciences Institute and Hospital

Survival rates for metastatic lung cancer, including non-small cell lung cancer(NSCLC) and small cell lung cancer(SCLC), are poor with 5-year survivals of less than 5%. The immune system has an intricate and complex relationship with tumorigenesis; a groundswell of research on the immune system is leading to greater understanding of how cancer progresses and presenting new ways to halt disease progress. Due to the extraordinary power of the immune system—with its capacity for memory, exquisite specificity and central and universal role in human biology—immunotherapy has the potential to achieve complete, long-lasting remissions and cures, with few side effects for any cancer patient, regardless of cancer type. As a result, a range of cancer therapies are under development that work by turning our own immune cells against tumors. However deeper understanding of the complexity of immunomodulation by tumors is key to the development of effective immunotherapies, especially in lung cancer.

关键词：非小细胞肺癌免疫系统检查点癌症患者肿瘤发生免疫治疗人类生物学癌症治疗

Ovarian Follicle Disaggregation to Assess Granulosa Cell Viability

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International Journal of Clinical Medicine 2018年第5期9卷 377-399页

作者： Mohammad Asaduzzaman daniela Figueroa gonzalez Fiona Young Medical Biotechnology Flinders University Adelaide South Australia

Background: Mammalian ovaries contain follicles containing an oocyte enclosed by layers of granulosa cells (GC). Follicle growth and oocyte maturation are largely dependent on GC numbers and viability, but there is no established, reliable method for assessing the number of viable GC within an isolated follicle. Methods: Centrifugation conditions and the Trypan Blue (TB) Exclusion assay were optimised for low cell densities compatible with the numbers of GC in follicles. Mouse ovarian follicles were disaggregated to produce a single cell suspension of GC which were examined by TB (n = 4), but also by crystal violet assay in a 96-well plate format after 24 h in vitro (n = 3). GC viability in vitro was characterised further by using enzyme-linked immunoassays to quantify GC production of anti-Mullerian hormone (AMH) and estrogen. Results: The centrifugation and low cell density TB protocol could accurately measure the viability of 78 GC in 10 μL, with an intra-assay coefficient of variation (CoV) 22%, and inter-assay CoV 7%. The best follicle disaggregation method (30 min 37°C exposure to 2 mg/mL collagenase prior to 30 min exposure to 0.025% hyaluronidase) yielded (656 ±87) GC per antral follicle of which 82% ±5% were viable. Culturing 312 - 20,000 GC per well for 24 hours and assessing viability by crystal violet assay generated a linear correlation between OD value and viable GC number (R2 = 0.98) and estrogen concentration per well (R2 = 0.92). 20,000 GC per well produced 143 ±16 pg/mL estrogen during 24 hours in vitro, but no detectable AMH. Conclusion: This is the first report describing the isolation of viable, estrogen-producing GC from murine follicles, and their subsequent culture. These procedures are transferrable to other species including humans and can be applied to screening the reproductive toxicity of pharmaceutical agents.

关键词： Ovarian Follicle Granulosa Cells Viability Collagenase Hyaluronidase

Violence Towards Migrants

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Psychology Research 2018年第8期8卷 355-366页

作者： Patricia Martinez Lanz Maria Domenica Ravelo Ladron de Guevara daniela Ayari Moreno Landeta Maria Fernanda Gen Lortia Ixchel Aditi gonzalez Gutierrez Elsa Paulina Alanis Cazares Universidad Anauac Mexico Mexico City Mexico