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A novel approach to the dynamic response analysis of Euler-Bernoulli beams resting on a Winkler soil model and subjected to impact loads

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 389-401页

作者： Adolfo Foriero filippo Santucci de Magistris Giovanni Fabbrocino Département de génie civil et de génie des eaux Pavillon Adrien-PouliotUniversitéLavalQuébecCanada Dipartimento di Bioscienze e Territorio Universitàdegli Studi del MoliseCampobassoItaly Construction Technologies Institute National Research CouncilITC-CNRL’AquilaItaly

This work presents a novel approach to the dynamic response analysis of a Euler-Bernoulli beam resting on a Winkler soil model and subjected to an impact *** approach considers that damping has much less importance in controlling the maximum response to impulsive loadings because the maximum response is reached in a very short time,before the damping forces can dissipate a significant portion of the energy input into the *** development of two sine series solutions,relating to different types of impulsive loadings,one involving a single concentrated force and the other a distributed line load,are *** study revealed that when a simply supported Euler-Bernoulli beam,resting on a Winkler soil model,is subject to an impact load,the resulting vertical displacements,bending moments and shear forces produced along the span of the beam are considerably *** particular,the quantification of this effect is best observed,relative to the corresponding static solution,via an amplification *** computed impact amplification factors,for the sub-grade moduli used in this study,were in magnitude greater than 2,thus confirming the multiple-degree-of-freedom nature of the problem.

关键词： beam-Winkler-soil model sub-grade moduli impact load impact distributed line load dynamic solution impact amplification factor

The AMS measurement of ^236U at CIRCE

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Nuclear Science and Techniques 2017年第7期28卷 47-51页

作者： Yong-Jing Guan Hui-Juan Wang Mario de Cesare filippo Terrasi Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science & Technology Guangxi University Nanning 530004 China department of Diagnostic Methodologies and Measurement Techniques Italian Aerospace Research Centre (CIRA) 81043 Capua (CE) Italy INFN 80126 Naples Italy CIRCE Department of Mathematic and Physics Ⅱ University of Naples 81100 Caserta Italy

Accelerator mass spectrometry(AMS) is an ultrasensitive technique for measuring long-lived actinides,e.g.,^(236)U,^(237)Np and Pu *** order to improve the detection limit for actinides abundance,and to increase the detection efficiency in actinides AMS measurement,a 16-strip silicon detector was used to identify actinides at the Center for Isotopic Research on Cultural and Environmental heritage in Caserta,*** sensitivity of ^(236)U/^(238)U was 1×10^(-11) by special resolution and 5.0×10^(-12) by time *** pulse height defect of^(236)U in an ion-implanted silicon detector in the low-energy range with 17.26 MeV is presented.

关键词： AMS 测量锕系元素钚同位素硅探测器加速器质谱时间分辨率元素丰度

Managements of recurrent hepatocellular carcinoma after liver transplantation: A systematic review

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World Journal of Gastroenterology 2015年第39期21卷 11185-11198页

作者： Nicola de'Angelis filippo Landi Maria Clotilde Carra Daniel Azoulay Unit of Digestive Hepato-Pancreato-Biliary Surgery and Liver Transplantation Henri-Mondor Hospital Inserm Unité 4394-MACBEth 94010 Créteil France department of Advanced Biomedical Sciences University Federico Ⅱ of Naples University Paris 7 Denis Diderot Rothschild Hospital Inserm Unité 955-IMRB 94010 Créteil France

AIM: To investigate the efficacy(survival) and safety of treatments for recurrent hepatocellular carcinoma(HCC) in liver transplantation(LT) ***: Literature search was performed on available online databases without a time limit until January 2015. Clinical studies describing survival after HCC recurrence in LT patients were retrieved for a fulltext evaluation. A total of 61 studies were selected: 13 case reports, 41 retrospective case series, and 7 retrospective comparative ***: Based on all included studies, the mean HCC recurrence rate was 16% of all LTs for HCC. A total of 1021 LT patients experienced HCC recurrence. The median time from LT to HCC recurrence was 13 mo(range 2-132 mo). The majority of patients(67%) presented with HCC extra-hepatic recurrences, involving lung, bone, adrenal gland, peritoneal lymph nodes, and rarely the brain. Overall survival after HCC recurrence was 12.97 mo. Surgical resection of localized HCC recurrence and Sorafenib for controlling systemic spread of HCC recurrence were associated with the higher survival rates(42 and 18 mo, res-pectively). However, Sorafenib, especially when combined with m TOR, was frequently associated with severe side effects that required dose reduction or discontinuation CONCLUSION: Management of recurrent HCC in LT patients is challenging and associated with poor prognosis independently of the type of treatment.

关键词： Recurrent hepatocellular carcinoma Liver transplan

Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatoceiluiar carcinoma

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World Journal of Gastroenterology 2005年第44期11卷 6920-6925页

作者： Umberto Cillo Alessandro Vitale filippo Navaglia daniela Basso Umberto Montin Marco Bassanello Francesco D'Amico Francesco Antonio Ciarleglio Alberto Brolese Giacomo Zanus Vito de Pascale Mario Plebani Davide Francesco D'Amico Clinica Chirurgica Ⅰ Dipartimento di Medicina di Laboratono Dipartimento Assistenziale di Chirurgia Generale ed Emergenze Chirurgiche Dipartimento di Medicina di Laboratorio Clinica Chirurgica I

AIM： To explore the potential prognostic role of preoperative tumor grade and blood AFP mRNA in a cohort of patients with hepatocellular carcinoma （HCC） eligible for radical therapies according to a well-defined treatment algorithm not including nodule size and number as absolute selection criteria. METHODS： Fifty patients with a diagnosis of HCC were prospectively enrolled in the study. Inclusion criteria were：（1） histological assessment of tumor grade by means of percutaneous biopsies; （2） determination of AFP mRNA status in the blood; （3） patient＇s eligibility for radical therapies. RESULTS： At preoperative evaluation, 54% of the study group had a well-differentiated HCC, 42% had AFP mRNA in the blood, 40% had a tumor larger than 5 cm and 56% had more than one nodule. Surgery （resection or liver transplantation） was performed in 29 patients, while 21 had percutaneous ablation procedures. After a median follow-up of 28 too, 12-, 24-, and 36-mo survival rates were 78%, 58%, and 51%, respectively. Surgical therapy, performance status and three tumor-related variables （AFP mRNA, HCC grade and gross vascular invasion） resulted as significant survival predictors at univariate analysis. Nodule size and number did not perform as significant prognosticators. Multivariate study selected only surgical therapy and a biologically early HCC profile （AFP mRNA negative and well-differentiated tumor without gross vascular invasion） as independent survival variables. CONCLUSION： The preoperative determination of tumor grade and blood AFP mRNA status may potentially refine the prognostic evaluation of HCC patients and improve the selection process for radical therapies.

关键词： Hepatocellular carcinoma Prognosis Treatment policy Biomarker Tumor biology

Autoimmune pancreatitis not otherwise specified(NOS): Clinical features and outcomes of the forgotten type

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Hepatobiliary & Pancreatic Diseases International 2019年第6期18卷 576-579页

作者： Nicolò de Pretis filippo Vieceli Alessandro Brandolese Lorenzo Brozzi Antonio Amodio Luca Frulloni Gastroenterology Unit Pancreas Center University of Verona

Background:Autoimmune pancreatitis(AIP)is a well-recognized fibroinflammatory disease of the *** the significant number of studies published on AIP type 1 and 2,no studies have been focused on AIP type not otherwise specified(NOS)and therefore very little is known about clinical features and long-term outcomes of these *** aim of this study was to investigate clinical and radiological features of AIP type ***:Patients classified as AIP type NOS at clinical onset included in our database prospectively maintained since 1995 were ***,clinical data were collected and ***:Forty-six patients were included in the *** clinical onset was mainly characterized by weight loss,jaundice and acute *** patients(17.4%)were reclassified as AIP type 2 during follow-up because of the development of ulcerative *** patients(15.2%)experienced relapse after steroid treatment but only one(2.2%)needed immunosuppressive drugs because of recurrent ***:AIP type NOS shares clinical features similar to AIP type 2 and a relevant proportion of patients was reclassified as AIP type 2 during follow-up because of the development of ulcerative *** risk of relapse is low but not irrelevant.

关键词： Autoimmune pancreatitis Not otherwise specified Outcome Follow-up Therapy

Bacterial cell-free expression technology to in vitro systems engineering and optimization

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Synthetic and Systems Biotechnology 2017年第2期2卷 97-104页

作者： filippo Caschera Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris(ESPCI Paris) CNRS UMR 708310 Rue Vauquelin75231 Paris Cedex 05France

Cell-free expression system is a technology for the synthesis of proteins in *** system is a platform for several bioengineering projects,***-free metabolic engineering,evolutionary design of experiments,and synthetic minimal cell *** cell-free protein synthesis system(CFPS)is a robust tool for synthetic *** bacteria lysate,the DNA,and the energy module,which are the three optimized sub-systems for in vitro protein synthesis,compose the integrated ***,an optimized *** cell-free expression system can produce up to^2.3 mg/mL of a fluorescent reporter ***,I will describe the features of ATP-regeneration systems for in vitro protein synthesis,and I will present a machine-learning experiment for optimizing the protein yield of *** cell-free protein synthesis ***,I will introduce experiments on the synthesis of a minimal cell using liposomes as dynamic containers,and *** cell-free expression system as biochemical platform for metabolism and gene *** can be further integrated with other technologies for novel applications in environmental,medical and material science.

关键词： Cell-free protein synthesis Engineering Optimization Polysaccharide ATP-regeneration Machine-learning Synthetic minimal cell

“Noisy”issues in road acoustics:A white paper

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Journal of Road Engineering 2022年第1期2卷 61-69页

作者： filippo Giammaria Praticò DIIES department University Mediterranea of Reggio CalabriaReggio Calabria 89124Italy

despite almost a century of studies dealing with traffic noise,researchers and practitioners still face old and new issues when designing a low-noise *** that,this manuscript aims at focusing on a number of unsolved questions,namely theoretical or technological.1)Is it viable to balance diverse road-related needs(i.e.,noise,expected life,texture levels,and friction)?2)How much does the pavement material affect its acoustic performance(the remaining factors being constant)?3)How much reliable is the relationship between road texture and mixture aggregate gradation?Based on the analysis of these issues,it emerges that:1)optimal pavement design involves complex mix optimization and there are theoretical and practical bases to set up a balanced approach to address the complexity of pavement design;2)high percentages of crumb rubber could optimise road acoustic response but this latter has a relationship with the tyre/road noise(expressed,for example,in terms of close proximity index)that calls for further investigation;3)aggregate gradation appears to be a reliable basis to predict surface texture and therefore,under given boundary conditions,tyre/road noise;and 4)further studies and investigations are needed in terms of local calibration of deterioration curves and setting up of a sound method to assess the frequency response of asphalt concretes and to govern on-site noise indicators based on mixture properties.

关键词： Aggregate gradation Complex design Noise Surface texture Tyre/road interaction

Fatigue strength of Al7075 notched plates based on the local SED averaged over a control volume

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Science China(Physics,Mechanics & Astronomy) 2014年第1期57卷 30-38页

作者： BERTO filippo LAZZARIN Paolo University of Padova Department of Management and Engineering Stradella San Nicola 3 36100 Vicenza Italy

When pointed V-notches weaken structural components, local stresses are singular and their intensities are expressed in terms of the notch stress intensity factors （NSIFs）. These parameters have been widely used for fatigue assessments of welded struc- tures under high cycle fatigue and sharp notches in plates made of brittle materials subjected to static loading. Fine meshes are required to capture the asymptotic stress distributions ahead of the notch tip and evaluate the relevant NSIFs. On the other hand, when the aim is to determine the local Strain Energy density （SED） averaged in a control volume embracing the point of stress singularity, refined meshes are, not at all, necessary. The SED can be evaluated from nodal displacements and regular coarse meshes provide accurate values for the averaged local SED. In the present contribution, the link between the SED and the NSIFs is discussed by considering some typical welded joints and sharp V-notches. The procedure based on the SED has been also proofed to be useful for determining theoretical stress concentration factors of blunt notches and holes. In the second part of this work an application of the strain energy density to the fatigue assessment of A17075 notched plates is presented. The experimental data are taken from the recent literature and refer to notched specimens subjected to different shot peening treatments aimed to increase the notch fatigue strength with respect to the parent material.

关键词： strain energy density control volume coarse mesh

Use of the RegCM System over East Asia： Review and Perspectives

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Engineering 2017年第5期3卷 766-772页

作者： Xuejie Gao filippo Giorgi Climate Change Research Center Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China The Abdus Salam International Center.for Theoretical Physics Trieste 34151 Italy

The Abdus Salam International Center for Theoretical Physics （ICTP） RegCM system is one of the most commonly used regional climate models （RCMs） over the East Asia region, In this paper, we present a brief review of the RegCM system and its applications to the East Asia region. The model history and plans for future development are described, Previous and ongoing applications, as well as the advantages and biases found in the model system over the East Asia region, are summarized, The model biases that exist are mainly found in the cold seasons, and are characterized by a warm bias at high latitudes and underestimation of precipitation in the south. These biases are similar to those of most global climate models （GCMs）, Finally, future plans on the application and development of the model, and specifically on those within the context of the Coordinated Regional Climate Downscaling Experiment （CORdeX）, are introduced. This paper is intended to serve as a reference for future users of the RegCM system within the East Asia region.

关键词： Regional climate model China Climate change Community land model