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Knowledge and awareness of glaucoma in Mexican patients with and without glaucoma diagnosis in an Ophthalmology Referral Center

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 990-996页

作者： Valeria Becerril-Ledezma daniela Alvarez-Ascencio Clarisa Esther del Hierro-Gutiérrez Alejandra Hernandez-Oteyza Jesús Jiménez-Román Association to Prevent Blindness in Mexico Private Assistance Institution(APEC)Mexico City 04030Mexico

AIM: To assess and compare knowledge and awareness of glaucoma in subjects with and without glaucoma diagnosis attending an Ophthalmology Referral ***: This cross-sectional study was conducted at Asociación Para Evitar la Ceguera in Mexico City, using a questionnaire formulated by a group of experts following the Delphi panel rules, and pre-tested in a pilot *** questionnaire was applied and compared between:glaucoma patients, relatives of glaucoma patients and patients without glaucoma. Socio-demographic data was collected to assess correlation with the level of knowledge using Logistic regression models, estimating the odds ratios(OR), 95% confidence intervals, and P<***: Three hundred and ninety-four subjects were enrolled;with a median age of 61y. One hundred and thirty-four(34%) were patients with glaucoma, 152(38.6%)patients without glaucoma, and 108(27.4%) relatives of patients with glaucoma. Two hundred and ninety-one(73.9%) participants were aware of the term “glaucoma”.Regarding knowledge 46.7% had moderate knowledge,37.8% had poor knowledge, and 15.5% good ***, relatives of glaucoma patients had the highest scores, and patients without glaucoma got the lowest scores. A positive correlation was found between better knowledge and frequent ophthalmological examinations OR 2.24(P=0.02), higher education level OR 4.17(P=0.00) and having a family member with glaucoma OR 3.28(P=0.00).CONCLUSION: Awareness and knowledge of glaucoma in subjects attending an Ophthalmology Referral Center is predominantly moderate or poor. This has important implications regarding attitudes that can result in lack of follow up in ophthalmological care.

关键词： glaucoma awareness knowledge vision loss treatment

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How Learning from Trauma Benefits the Obstetric Population?Damage Control Surgery

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Maternal-Fetal Medicine 2023年第4期5卷 248-252页

作者： María Fernanda Escobar Vidarte daniela Nasner Albaro José Nieto-Calvache María Paula Echavarría Javier Andrés Carvajal Department of Obstetrics and Gynecology High Complexity Obstetric UnitFundación Valle del LiliCali 760032Colombia Department of Obstetrics and Gynecology School of MedicineUniversidad IcesiCali 760032Colombia Clinical Research Center Fundación Valle del LiliCali 760032Colombia

The recent implementation of trauma-validated damage control strategies in severe postpartum hemorrhage proves the importance of interdisciplinary management in the obstetric *** hemorrhage control techniques and damage control surgery are clear examples of how learning from trauma can benefit the obstetric ***,most obstetric programs do not include training in this type of ***,it has been shown that these interventions are useful in the management of severe postpartum *** aim of this article is to introduce the application of damage control surgery principles in the management of massive obstetric *** propose to include appropriate training and the implementation of damage control surgery in obstetric management *** prompt application of damage control principles can be considered in patients with persistent hemodynamic instability despite control of the source of bleeding.

关键词： Postpartum hemorrhage Damage control Obstetric hemorrhage Critical care Maternal mortality

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Evidence-based approach to the treatment of esophagogastric junction tumors

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World Journal of Clinical Oncology 2022年第3期13卷 159-167页

作者： Francisco Schlottmann María A Casas daniela Molena Department of Surgery Hospital Alemán of Buenos AiresBuenos Aires C1118AATArgentina Department of Surgery Memorial Sloan Kettering Cancer CenterNew YorkNY 10065United States

The incidence of esophagogastric junction(EGJ)adenocarcinoma is increasing in developed nations due to the rising prevalence of obesity and gastroesophageal reflux *** to the peculiar location in a histological transition zone between the esophagus and the stomach,the management of EGJ tumors is *** main surgical approaches exist:total gastrectomy with distal esophagectomy or esophagectomy by either transhiatal or transthoracic *** operations differ significantly in the extent of *** addition,patients with locally advanced disease can receive either preoperative chemoradiation or perioperative *** evidence-based review analyzes current evidence regarding the management of EGJ tumors in order to help defining the best surgical and systemic treatment of these patients.

关键词： Esophagogastric junction tumors Esophagectomy Gastrectomy Esophageal adenocarcinoma Chemotherapy Chemoradiation

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Can leukocyte telomere shortening be a possible biomarker to track Huntington’s disease progression?

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Neural Regeneration Research 2019年第10期14卷 1709-1710页

作者： Elide Mantuano Martina Peconi daniela Scarabino CNR Institute of Translational Pharmacology RomeItaly CNR Institute of Molecular Biology and Pathology Rome Italy

Huntington's disease (HD): HD is an autosomal dominant neurodegenerative disease, caused by a CAG trinucleotide repeat expansion in the first exon of the HTT gene encoding the huntingtin protein. The mutant protein contains an expanded polyglutamine sequence that confers a toxic gain-of-function and causes neurodegeneration. Moreover, several studies indicate that loss of the normal protein beneficial functions, contribute to the pathology (Schulte and Littleton 2011). Triplet expansion over 40 repeats are fully penetrant and invariably lead to manifest HD in the fourth or fifth decade of life.

关键词： Huntington's disease(HD) neurodegenerative disease fifth decade of life

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The potential of natural products for targeting PPARα

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Acta Pharmaceutica Sinica B 2017年第4期7卷 427-438页

作者： daniela Rigano Carmina Sirignano Orazio Taglialatela-Scafati Department of Pharmacy University of Naples Federico IINaples I-80131Italy

Peroxisome proliferator activated receptors(PPARs) α,-γ and-β/δ are ligand-activated transcription factors and members of the superfamily of nuclear hormone receptor. These receptors play key roles in maintaining glucose and lipid homeostasis by modulating gene expression. PPARs constitute a recognized druggable target and indeed several classes of drugs used in the treatment of metabolic disease symptoms, such as dyslipidemia(fibrates, e.g. fenofibrate and gemfibrozil) and diabetes(thiazolidinediones, e.g. rosiglitazone and pioglitazone) are ligands for the various PPAR isoforms. More precisely, antidiabetic thiazolidinediones act on PPARγ, while PPARα is the main molecular target of antidyslipidemic fibrates. Over the past few years, our understanding of the mechanism underlying the PPAR modulation of gene expression has greatly increased. This review presents a survey on terrestrial and marine natural products modulating the PPARα system with the objective of highlighting how the incredible chemodiversity of natural products can provide innovative leads for this "hot" target.

关键词： PPAR 自然产品行动的机制 Dyslipidemia 新陈代谢的症候群

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Green Synthesis of Titanium Oxide Nanoparticles Using Natural Extracts

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Journal of Materials Science and Chemical Engineering 2023年第2期11卷 29-40页

作者： Maribel Santiago daniela Rivera Agustín Torres Chemical Engineering Department Tecnológico Nacional de México Atitalaquia Campus Atitalaquia México Basic Sciences Department Tecnológico Nacional de México Atitalaquia Campus Atitalaquia México

Green synthesis is an alternative method for obtaining nanoparticles for environmentally friendly purposes. The present work describes the synthesis and characterization of titanium oxide nanoparticles, starting from three natural sources: orange peel, hibiscus rosa sinensis and Aloe vera. Titanium (IV) tetrabutoxide in ethanol solution was used as precursor. The methodology used was based on the sol-gel technique, through which TiO2 nanoparticles were obtained in the anatase phase. The characterization of the nanoparticles was carried out by means of x-ray diffraction (XRD), scanning electron microscopy (SEM) and infrared spectrophotometry (FTIR), which allowed the identification of a good degree of purity and crystallinity of the samples obtained.

关键词： TiO2 Nanoparticles Green Synthesis Sol-Gel Methodology Natural Sources

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Scientific Study Reveals that Electroacupuncture Technique Can Treat PCOS Symptoms

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Chinese Medicine and Culture 2020年第4期3卷 225-231页

作者： daniela Donoso Paredes Life Flow UbudBaliIndonesia

The efficiency of traditional Chinese medicine theory and acupoints shows once more its accurate regulatory capacity by improving women biological cycles with the use of electroacupuncture(EA).Results presented in a research study that preformed ovulation induction in women with anovulation due to polycystic ovary syndrome(PCOS),successfully provided data supporting acupuncture as a natural treatment for infertile women,with no significant side *** purpose of this study is to demonstrate how EA treatment can induce ovulation related to the hormonal and neuronal system in women affected by *** study introduces proof of effectivity and improvement based on the research of the University of Gothenburg,Sweden,that presents a study on how EA can be an alternative to ovulation-inducing drugs,to be considered as a possible holistic regulator of PCOS and *** study covered 24 women with PCOS and oligo-/amenorrhea who received EA in a low frequency of 2 Hz with a total of 14 treatments applied for 3 *** were taken three times during the study to see fluctuations in hormonal,ovulatory,and symptomatic behavior of *** demonstrated effective regular ovulatory inductions in more than a third of women.

关键词： Amenorrhea irregular menstruation oligomenorrhea ovulation polycystic ovarian syndrome uterus

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Prevalence of functional gastrointestinal disorders in children with celiac disease on different types of gluten-free diets

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World Journal of Gastroenterology 2022年第46期28卷 6589-6598页

作者： Francesca Fiori Nastro Maria Rosaria Serra Sabrina Cenni daniela Pacella Massimo Martinelli Erasmo Miele Annamaria Staiano Carlo Tolone Renata Auricchio Caterina Strisciuglio Department of Translational Medical Science Section of PediatricsUniversity of Naples“Federico Ⅱ”Naples 80100Italy Department of Experimental Medicine University of Campania“Luigi Vanvitelli”Naples 80100Italy Department of Public Health University of Naples“Federico Ⅱ”Naples 80100Italy Department of Woman Child and General and Specialistic SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy

BACKGROUND Functional gastrointestinal disorders(FGIDs)are common during the pediatric *** are not related to biochemical or structural ***,since they have a high prevalence,several studies have evaluated an overlap between FGIDs and organic *** with celiac disease(CD)have been shown to be at an increased risk for functional abdominal pain,even if they adhere well to a gluten-free diet(GFD).Little information is available for the pediatric age *** aims of our study were to evaluate the prevalence of FGIDS in CD children 1 year after diagnosis and to compare the prevalence of FGIDs in CD children on a GFD with processed foods compared with those on a GFD with natural *** To assess the prevalence of FGIDs in children with CD after 1 year of follow-up and to compare the prevalence of FGIDs in children with CD on a GFD with processed foods and in children on a GFD with natural *** We recruited pediatric patients aged 1-18 years with a new CD *** were randomized to two groups:Group A on a GFD with processed foods(diet 1);and group B on a GFD with natural products(diet 2).Clinical monitoring,diet assessment and the questionnaire on pediatric gastrointestinal symptoms-Rome IV version were performed at diagnosis(T0)and after 12 mo of follow-up(T1).Dietary intake was assessed using a 3-d food diary *** from the diaries were evaluated using WinFood nutrient analysis *** assessed the prevalence of FGIDs at T1 and the correlation with the type of *** We registered 104 CD children,with 55 patients in group A(53.0%)and 49 patients in group B(47.0%).Initially,30 of the 55(54.5%)CD children were symptomatic in group A,while 25 of 49(51.0%)were symptomatic in group *** T1,in spite of a low or negative serology for CD,FGIDs prevalence was 10/55(18.0%)in group A and 8/49(16.3%)in group B,with no statistically significant difference between the two groups(P=0.780).At T1 the

关键词： Functional gastrointestinal disorders Celiac disease Gluten free diet Gastrointestinal symptoms Children

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Finding the semantic similarity in single-particle diffraction images using self-supervised contrastive projection learning

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npj Computational Materials 2023年第1期9卷 2118-2126页

作者： Julian Zimmermann Fabien Beguet Daniel Guthruf Bruno Langbehn daniela Rupp ETH Zürich ZürichSwitzerland Technische Universität Berlin BerlinGermany Max-Born-Institut BerlinGermany

Single-shot coherent diffraction imaging of isolated nanosized particles has seen remarkable success in recent years,yielding in-situ measurements with ultra-high spatial and temporal *** progress of high-repetition-rate sources for intense X-ray pulses has further enabled recording datasets containing millions of diffraction images,which are needed for the structure determination of specimens with greater structural variety and dynamic *** size of the datasets,however,represents a monumental problem for their ***,we present an automatized approach for finding semantic similarities in coherent diffraction images without relying on human expert *** introducing the concept of projection learning,we extend self-supervised contrastive learning to the context of coherent diffraction imaging and achieve a dimensionality reduction producing semantically meaningful embeddings that align with physical *** method yields substantial improvements compared to previous approaches,paving the way toward real-time and large-scale analysis of coherent diffraction experiments at X-ray free-electron lasers.

关键词： projection coherent similarity

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Equity issues and the PeCUS index:an indirect analysis of community severance

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Geo-Spatial Information Science 2020年第4期23卷 293-304页

作者： daniela Vanessa Rodriguez Lara Antonio Nelson Rodrigues da Silva Department of Transportation Engineering São Carlos School of EngineeringUniversity of São PauloSão PauloBrazil

Urban barriers are often a consequence of the unplanned expansion of transport infrastructures,housing growth nearby existing transport infrastructures,and the vehicular traffic *** process,also known as“community severance”,is a problem that affects the travel patterns of the population and causes negative impacts to adjacent communities,but it is not easy to *** an alternative to the costly technologies and restricted-access data sometimes used to analyze urban barriers,we propose an analytical approach that assesses community severance levels by classifying the quality of Pedestrian Crossings on Urban Streets(the PeCUS index).Additionally,the approach is used to identify possible inequities nearby the different classification groups regarding demographic *** used the chi-square(χ^(2))test of independence and the standardized Pearson residuals to indicate deficits and excesses of residents regarding the demographic characteristics studied surrounding the urban *** found the following evidences of associations:residents with low-income or those aged up to 19 tend to live close to the worst crossings,whereas residents with permanent mobility constraints or the elderly tend to live near the crossings with the best ***,the study shows that the assessment of community severance by the analysis of the PeCUS index is ***,it reveals that the distribution of residents surrounding the distinct classes of quality of crossings is equitable for vulnerable social groups,except for low-income or young residents.

关键词： Community severance transport barriers pedestrian crossings equity open data geographic information systems(GIS)

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