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Delivery of theophylline as dry powder for inhalation

Asian Journal of Pharmaceutical Sciences 2015年第6期10卷 520-527页

作者： Bing Zhu Mehra Haghi Anphy Nguyen Mary Goud Stewart Yeung Paul MYoung daniela Traini Respiratory Technology TheWoolcock Institute for Medical Research and Discipline of PharmacologySydney Medical SchoolUniversity of SydneyNSW 2006Australia Faculty of Pharmacy University of Technology SydneyNSW 2007Australia Avans University of Applied Science BredaThe Netherlands

Theophylline(TP)is a very well established orally or intravenously delivered antiasthma drug with many beneficial *** study aims to improve asthma treatment by creating a dry powder inhalable(DPI)formulation of TP to be delivered directly to the lung,avoiding the side effects associated with conventional oral *** DPI TP formulation was investigated for its physico-chemical characteristics using scanning electron microscopy,laser diffraction,thermal analysis and dynamic vapour ***,aerosol performance was assessed using the Multi Stage Liquid Impinger(MSLI).In addition,a Calu-3 cell transport assay was conducted in vitro using a modified ACI to study the impact of the DPI formulation on lung epithelial *** showed DPI TP to be physico-chemically stable and of an aerodynamic size suitable for lung *** aerosolisation performance analysis showed the TP DPI formulation to have a fine particle fraction of 29.70±2.59%(P<0.05)for the TP formulation containing 1.0%(w/w)sodium stearate,the most efficient for *** the deposition of TP DPI on Calu-3 cells using the modified ACI,results demonstrated that 56.14±7.62%of the total TP deposited(13.07±1.69μg)was transported across the Calu-3 monolayer over 180 min following deposition,while 37.05±12.62%of the deposited TP was retained in the *** could be due to the presence of sodium stearate in the current formulation that increased its lipophilicity.A DPI formulation of TP was developed that was shown to be suitable for inhalation.

关键词： Theophylline Powder formulation Aerosol performance Physiochemical characteristics

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In vitro toxicity of particulate matter emissions from residential pellet combustion

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Journal of Environmental Sciences 2022年第5期34卷 215-226页

作者： Estela D.Vicente daniela Figueiredo Catia Goncalves Isabel Lopes Helena Oliveira Nora Kovats Teresa Pinheiro Celia A.Alves Department of Environment and Planning and CESAM-Centre for Environmental and Marine Studies University of Aveiro3810-193 AveiroPortugal Department of Biology and CESAM-Centre for Environmental and Marine Studies University of Aveiro3810-193 AveiroPortugal Centre of Natural Environmental Sciences University of PannoniaEgyetem str.108200 VeszpremHungary Instituto de Bioengenharia e Biociencias Departamento de Engenharia e Ciencias NuclearesInstituto Superior TecnicoUniversidade de LisboaAv.Rovisco Pais 11049-001 LisboaPortugal

Particulate matter emissions(PM10)from the combustion,in a residential stove,of two com-mercial brands of certified(ENplus A1)pellets,a non-certified brand and laboratory made pellets of acacia were tested for their ability to induce ecotoxic,cytotoxic,and mutagenic re-sponses in unicellular organisms and a human cell *** was evaluated through the Vibrio fischeri bioluminescence inhibition ***,cytotoxicity was assessed at two time points(24-and 48-hr)through two complementary techniques in order to evaluate the cellular metabolic activity and membrane integrity of human lung epithelial cells *** Ames test using two Salmonella typhimurium strains(TA100 and TA98)was employed to assess the mutagenic potential of the polycyclic aromatic hydrocarbon fraction extracted from the PM10 *** obtained with the bioluminescent bacteria indicated that only particles from the combustion of acacia pellets were *** samples induced im-pairment on the A549 cells metabolic activity,while no significant release of lactate dehy-drogenase was ***10 emissions from acacia pellets were the most cytotoxic,while samples from both certified pellets evoked significant cytotoxicity at lower ***-icity time-dependency was only observed for PM10 from the combustion of acacia pellets and one of the brands of certified *** activity was not detected in both *** murium *** study emphasises the role of the raw material for pellet manu-facturing on the toxicological profile of PM *** raw materials should be deeply investigated before their use in pelletisation and combustion in residential appli-ances.

关键词： Ecotoxicity Cytotoxicity Mutagenicity Fuel quality Pellet combustion PM10 emissions

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Silica-quaternary ammonium “Fixed-Quat” nanofilm coated fiberglass mesh for water disinfection and harmful algal blooms control

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Journal of Environmental Sciences 2019年第8期31卷 213-224页

作者： daniela Diaz Jared Church Mikaeel Young Keug Tae Kim Jungsu Park Yun Bin Hwang Swadeshmukul Santra Woo Hyoung Lee Department of Civil Environmental and Construction Engineering University of Central Florida NanoScience Technology Center University of Central Florida Burnett School of Biomedical Sciences University of Central Florida Department of Environmental & Energy Engineering Suwon University K-water Institute Korea Water Resources Corporation Department of Material Science and Engineering 4000 Central Florida Blvd University of Central Florida Department of Chemistry 4111 Libra Drive University of Central Florida

Intensification of pollution loading worldwide has promoted an escalation of different types of disease-causing microorganisms, such as harmful algal blooms(HABs), instigating detrimental impacts on the quality of receiving surface waters. Formation of unwanted disinfection by-products(DBPs) resulting from conventional disinfection technologies reveals the need for the development of new sustainable alternatives. Quaternary Ammonium Compounds(QACs) are cationic surfactants widely known for their effective biocidal properties at the ppm level. In this study, a novel silica-based antimicrobial nanofilm was developed using a composite of silica-modified QAC(Fixed-Quat) and applied to a fiberglass mesh as an active surface via sol–gel technique. The synthesized Fixed-Quat nanocoating was found to be effective against E. coli with an inactivation rate of 1.3 × 10^(-3) log reduction/cm min. The Fixed-Quat coated fiberglass mesh also demonstrated successful control of Microcystis aeruginosa with more than 99% inactivation after 10 hr of *** developed antimicrobial mesh was also evaluated with wild-type microalgal species collected in a water body experiencing HABs, obtaining a 97% removal efficiency. Overall,the silica-functionalized Fixed-Quat nanocoating showed promising antimicrobial properties for water disinfection and HABs control, while decreasing concerns related to DBPs formation and the possible release of toxic nanomaterials into the environment.

关键词： Fiberglass mesh HAB mitigation Nanocoating Quaternary ammonium compounds(QACs) Silica-functionalization Water disinfection

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Characterization and catalytic activity of soft-templated Ni0-CeO_(2) mixed oxides for CO and CO_(2) co-methanation

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Frontiers of Chemical Science and Engineering 2021年第2期15卷 251-268页

作者： Luciano Atzori Maria Giorgia Cutrufello daniela Meloni Barbara Onida Delia Gazzoli Andrea Ardu Roberto Monaci Maria Franca Sini Elisabetta Rombi Department of Chemical and Geological Sciences University of Cagliari09042 Monserrato(CA)Italy Department of Materials Science and Chemical Engineering CR-INSTM for Materials with Controlled PorosityPolytechnic of Turin10129 TurinItaly Department of Chemistry University of Rome“La Sapienza”00185 RomeItaly

Nanosized NiO,CeO_(2) and NiO-CeO_(2) mixed oxides with different Ni/Ce molar ratios were prepared by the soft template *** the samples were characterized by different techniques as to their chemical composition,structure,morphology and *** the catalysts submitted to the same reduction pretreatment adopted for the activity tests the surface basic properties and specific metal surface area were also *** and CeO_(2) nanocrystals of about 4 nm in size were obtained,regardless of the Ni/Ce molar *** Raman and X-ray photoelectron spectroscopy results proved the formation of defective sites at the NiO-CeO_(2) interface,where Ni species are in strong interaction with the *** microcalorimetric and Fourier transform infrared analyses of the reduced samples highlighted that,unlike metallic nickel,CeO_(2) is able to effectively adsorb CO_(2),forming carbonates and hydrogen *** reduction in H2 at 400°C for 1 h,the catalytic performance was studied in the CO and CO_(2) co-methanation *** tests were performed at atmospheric pressure and 300°C,using CO/CO_(2)/H_(2) molar compositions of 1/1/7 or 1/1/5,and space velocities equal to 72000 or 450000 cm^(3)∙h^(-1)∙gcat^(-1).Whereas CO was almost completely hydrogenated in any investigated experimental conditions,CO_(2) conversion was strongly affected by both the CO/CO_(2)/H_(2) ratio and the space *** faster and definitely preferred CO hydrogenation was explained in the light of the different mechanisms of CO and CO_(2) *** a selected sample,the influence of the reaction temperature and of a higher number of space velocity values,as well as the stability,were also *** that the Ni content is optimized,the NiCe system investigated was very promising,being highly active for the CO_(x) co-methanation reaction in a wide range of operating conditions and stable(up to 50 h)also when submitted to thermal stress.

关键词： soft template method Ni0-CeO_(2)catalystss CO and CO_(2)co-mtharation synthetic natural gas production

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Effectiveness of Acupuncture on Pain, Physical Function and Health-Related Quality of Life in Patients with Rheumatoid Arthritis: A Systematic Review of Quantitative Evidence

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Chinese Journal of Integrative Medicine 2019年第9期25卷 704-709页

作者： Susana Seca Diana Miranda daniela Cardoso Bernice Nogueira Henry J.Greten Antonio Cabrita Manuel Alves Rodrigues Faculty of Medicine University of CoimbraInstitute of Science Biomedicine Abel Salazar University of Porto Porto PortugalHeidelberg School of Chinese Medicine Heidelberg Germany Institute of Science Biomedicine Abel Salazar University of Porto Porto Portugal Health Sciences Research Unit:Nursing (UICISA: E) Nursing School of Coimbra (ESEnfC) Portugal Centre for Evidenee Based Practice: A Joanna Briggs Institute Centre of Excellence Coimbra Portugal School of Health Sciences Macao Polytechnic Institute Macao SAR China Institute of Science Biomedicine Abel Salazar University of PortoHeidelberg School of Chinese Medicine Heidelberg Germany Faculty of Medicine University of Coimbra Portugal Health Sciences Research Unit: Nursing (UICISA:E) Nursing School of Coimbra (ESEnfC)Portugal Centre for Evidence Based Practice: A Joanna Briggs Institute Centre of Excellence Portugal

Objective: To identify and synthesize the most recent available evidence of effectiveness of acupuncture on pain, physical function and health-related quality of life(HRQoL) in patients with rheumatoid arthritis(RA). Methods: A comprehensive search of 12 Western and Chinese databases was undertaken from their inception up to end of 2016. Randomized controlled trials(RCTs), concerning patients with RA treated with needle acupuncture, written in English, Portuguese, German or Chinese were included. Primary outcomes included pain, physical function and HRQoL. Secondary outcomes included morning stiffness, functional impairment, number of tender and swollen joints and serum concentrations of inflamatory markers. Methodological quality was assessed by three independent reviewers using the standardized critical appraisal instrument from the Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument. Results: Twenty-two studies met the inclusion criteria. Of those, 9 studies were excluded after assessment of their methodological quality. The remaining 13 original RCTs included 974 patients. Ten of these studies published in China, showed favorable statistical significant effects of acupuncture in relieving symptoms of RA compared with controls. Conclusions: Evidence suggests that acupuncture interventions may have a positive effect in pain relief, physical function and HRQo L in RA patients. However, due to the heterogeneity and methodologic limitations of the studies included in this systematic review, evidence is not strong enough to produce a best practice guideline.

关键词： acupuncture rheumatoid arthritis quality of life pain physical function randomized clinical trial

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Transforming growth factor-β1 induces intestinal myofibroblast differentiation and modulates their migration

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World Journal of Gastroenterology 2009年第12期15卷 1431-1442页

作者： Julia Brenmoehl Sandra Nicole Miller Claudia Hofmann daniela Vogl Werner Falk Jrgen Schlmerich Gerhard Rogler Department of Internal Medicine Ⅰ University of Regensburg93055 Regensburg Germany Department of Internal Medicine Ⅱ University of Jena07747 Jena Germany Clinic of Gastroenterology and Hepatology Department of Internal MedicineUniversity Hospital of Zurich8091 ZurichSwitzerland

AIM： To investigate the effects of transforming growth factor β1 （TGF-β1） on the differentiation of colonic lamina propria fibroblasts （CLPF） into myofibroblasts in vitro.METHODS： Primary CLPF cultures were incubated with TGF-β1 and analyzed for production of m-smooth muscle actin （α-SMA）, fibronectin （FN） and FN isoforms. Migration assays were performed in a modified 48-well Boyden chamber. Levels of total and phosphorylated focal adhesion kinase （FAK） in CLPF were analyzed after induction of *** not change α-SMA levels, while TGF-β1 treatment for 6 d significantly increased α-SIVlA production. Short term incubation （6 h） with TGF-β1 enhanced CLPF migration, while long term treatment （6 d） of CLPF with TGF-β1 reduced migration to 15%-37% compared to untreated cells. FN and FN isoform mRNA expression were increased after short term incubation with TGF-β1 （2 d） in contrast to long term incubation with TGF-β1 for 6 d. After induction of migration, TGF-β1-preincubated CLPF showed higher amounts of FN and its isoforms and lower levels of total and phosphorylated FAK than untreated cells.CONCLUSION： Long term incubation of CLPF with TGF-β1 induced differentiation into myofibroblasts with enhanced α-SMA, reduced migratory potential and FAK phosphorylation, and increased FN production. In contrast, short term contact （6 h） of fibroblasts with TGF-β1 induced a dose-dependent increase of cell migration and FAK phosphorylation without induction of α-SMA production.

关键词： Transforming growth factor β1 Colonicfibroblasts Myofibroblasts Migration Fibronectin

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Laparoscopic retrosternal gastric pull-up for fistulized mediastinal mass

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World Journal of Gastrointestinal Surgery 2017年第3期9卷 92-96页

作者： Benedetto Mungo Arianna Barbetta Anne O Lidor Miloslawa Stem daniela Molena Division of Thoracic Surgery Department of Surgery Johns Hopkins University School of Medicine Thoracic Surgery Service Department of Surgery Memorial Sloan Kettering Cancer Center Department of Surgery Johns Hopkins University School of Medicine Baltimore

We describe the case of a patient successfully reconstructed with laparoscopic retrosternal gastric pull-up after esophagectomy for unresectable posterior mediastinal inflammatory myofibroblastic tumor, eroding into the esophagus and compressing the airways. A partial esophagectomy with esophagostomy was performed for treatment of esophageal pleural fistula and empyema, while the airways were managed with the placement of an endobronchial stent. Gastrointestinal reconstruction was performed using a laparoscopic approach to create a retrosternal tunnel for gastric conduit pull-up and cervical anastomosis. The patient was discharged uneventfully after 6 d, and has done very well at home with normal diet.

关键词： Esophageal surgery Minimally invasive surgery Esophageal fistula Laparoscopic retrosternal bypass Gastric conduit

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Statistical Medical Pattern Recognition for Body Composition Data Using Bioelectrical Impedance Analyzer

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Computers, Materials & Continua 2021年第5期67卷 2601-2617页

作者： Florin Valentin Leuciuc Maria daniela Craciun Iulian Stefan Holubiac Mazin Abed Mohammed Karrar Hameed Abdulkareem Gheorghe Pricop Stefan cel Mare University of Suceava Suceava720229Romania The Interdisciplinary Research Center for Human Motricity and Health Sciences Suceava720229Romania College of Computer Science and Information Technology University of AnbarRamadi31001Iraq College of Agriculture Al-Muthanna UniversitySamawah66001Iraq

Identifying patterns,recognition systems,prediction methods,and detection methods is a major challenge in solving different medical *** categories of devices for personal and professional assessment of body composition are *** impedance analyzer is a simple,safe,affordable,mobile,non-invasive,and less expensive alternative device for body composition *** the body composition pattern of different groups with varying age and gender is a major challenge in defining an optimal level because of the body shape,body mass,energy requirements,physical fitness,health status,and metabolic ***,this research aims to identify the statistical medical pattern recognition of body composition data by using a bioelectrical impedance *** previous studies,a pattern was identified for four indicators that concern body composition(e.g.,body mass index(BMI),body fat,muscle mass,and total body water).The novelty of our study is the fact that we identified a recognition pattern by using medical statistical methods for a body composition that contains seven indicators(e.g.,body fat,visceral fat,BMI,muscle mass,skeletal muscle mass,sarcopenic index,and total body water).The youth that exhibited the body composition pattern identified in our study could be considered *** deviation of one or more parameters outside the margins of the pattern for body composition could be associated with health issues,and more medical investigations would be needed for a *** is considered a valid and reliable device to assess body composition along with medical statistical methods to identify a pattern for body composition according to the age,gender,and other relevant parameters.

关键词： Statistical method pattern recognition body composition assessment

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Motivating Teachers

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Sociology Study 2012年第6期2卷 445-457页

作者： daniela Martinek College of Education Salzburg Austria

Teachers can motivate their pupils by fostering autonomous learning or---especially if they feel under pressure themselves--teachers can hamper the motivation of their students by being controlling. The purpose of this study with 488 secondary school teachers from Austria was to examine the satisfaction of teachers＇ needs for autonomy, competence and relatedness and meaningful relations to perceived job-related pressure and self-efficacy, to gain an increased insight in autonomy supportive contexts. The results point out that there are various sources for pressure in the teaching profession and structural equation modeling revealing a reciprocal relation between the satisfaction of the need for autonomy and pressure in teaching, as well as between the satisfaction of the need for competence and self-efficacy. In addition perceived pressure had a negative impact on teachers＇ self-efficacy and self-efficacy in turn influenced the satisfaction of the need for autonomy. In summary, considering basic psychological needs satisfaction of teachers seems relevant to create autonomy supportive environments for pupils and teachers in schools.

关键词： Basic psychological needs pressure self-efficacy

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High in vitro survival rate of sheep in vitro produced blastocysts vitrified with a new method and device

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Journal of Animal Science and Biotechnology 2020年第1期11卷 71-80页

作者： Sergio Ledda Jen M.Kelly Stefano Nieddu daniela Bebbere Federica Ariu Luisa Bogliolo Dity Natan Amir Arav Department of Veterinary Medicine University of SassariSassariItaly South Australian Research and Development Institute Turretfield Research Centre129 Holland RoadRosedaleSA 5350Australia FertilSafe Ltd 11 Haharash st7403118 Ness ZionaIsrael.

Background:To advance the use of embryo vitrification in veterinary practice,we developed a system in which embryo vitrification,warming and dilution can be performed within a *** in vitro produced embryos(IVEP)were vitrified at either early(EBs:n=74)or fully expanded blastocyst stage(FEBs:n=195),using a new device named"***",composed by a 0.25-m L straw with a 50-μm pore polycarbonate grid at one *** at each stage(EBs and FEBs)were vitrified by either Two-step(TS)or Multi-step(MS;6 different concentrations of vitrification solutions)***-vitrified embryos(n=102)were maintained in in vitro culture as a *** consisted of placing the straws directly into 1.5 m L tubes containing a TCM-199 solution with three decreasing concentrations of *** re-expansion,embryo survival and hatching rate were evaluated at2,24 and 48 h post *** number of apoptotic cells was determined by TUNEL ***:Blastocyst re-expansion(2 h)after warming was higher(P<0.05)in FEBs group,vitrified with the MS and TS methods(77.90%and 71.25%,respectively)compared with the EBs group(MS:59.38%and TS:48.50%,respectively).Survival rates of vitrified FEBs after 24 h IVC were higher(P<0.001)in both methods(MS and TS)than vitrified EBs(MS:56.25%;TS:42.42%)and was higher(P<0.05)in the MS method(94.19%)compared with those in TS(83.75%).After 48 h of culture the hatching rate for FEBs vitrified in MS system(91.86%)was similar to control(91.89%),but higher than FEB TS(77.5%)and EBs vitrified in MS(37.5%)and TS(33.33%).Number of apoptotic cells were higher in EBs,irrespective of the system used,compared to *** number of apoptotic cells in FEBs vitrified with MS was comparable to the ***:A high survival rate of IVP embryos can be achieved by the new"***"device with hatching rates in vitro comparable with control fresh *** method has the potential for use in direct embryo transfer in field conditions.

关键词： Blastocysts High survival In-straw In vitro embryo produced Ovine

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