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Dyslipidemias and Related Factors in Brazilian Adolescents from Rural and Urban Areas

Health 2014年第11期6卷 1191-1200页

作者： daniela alves silva Sylvia do Carmo Castro Franceschini Juliana Faria de Novaes Ricardo Henrique silva Santos Silvia Eloiza Priore Departamento de Fitotecnia Universidade Federal de Vi&ccedil osa Vi&ccedil osa Brazil Departamento de Nutriç ã o e Saúde Universidade Federal de Vi&ccedil osa Vi&ccedil osa Brazil

This study aimed to evaluate the prevalence of dyslipidemias and related factors, in Brazilian adolescents from rural and urban areas. This is a cross-sectional study with 182 adolescents aged 10 to 13 years, students, residing in the rural and urban area of Brazil;grouped according to age, gender and socioeconomic class. Sexual maturation, physical activity, blood pressure, nutritional status and body composition were evaluated. Total cholesterol, LDL, HDL and serum triglycerides were dosed. The food frequency questionnaire was applied, quantifying energy, carbohydrates, proteins, lipids, full fat and fibers. Bivariate and multiple analyses were carried out, by logistic regression. It was verified that 84.6% (n = 154) adolescents presented some lipid profile alteration. There was no difference in the lipid profile between adolescents for residence place. However, as for gender, it was noticed that girls presented higher levels of total cholesterol and HDL (p < 0.05). In addition, adolescents with excess weight and body fat showed lower HDL and higher triglycerides values compared with eutrophic and with those with appropriate body fat percentage (p < 0.05). In the multiple analyses, it was observed that gender and signs of sexual maturation were associated with total cholesterol;fiber intake remained associated with HDL and signs of sexual maturation with LDL (p < 0.05). For triglycerides the related factors were gender, nutritional status and protein intake (p < 0.05). The elevated prevalence of dyslipidemias found between adolescents from rural and urban areas reinforces the importance of monitoring these alterations and information as for the related risk factors, with programs for correction of changeable factors.

关键词： Dyslipidemias Adolescents Lifestyle Puberty

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Equity issues and the PeCUS index:an indirect analysis of community severance

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Geo-Spatial Information Science 2020年第4期23卷 293-304页

作者： daniela Vanessa Rodriguez Lara Antonio Nelson Rodrigues da silva Department of Transportation Engineering São Carlos School of EngineeringUniversity of São PauloSão PauloBrazil

Urban barriers are often a consequence of the unplanned expansion of transport infrastructures,housing growth nearby existing transport infrastructures,and the vehicular traffic *** process,also known as“community severance”,is a problem that affects the travel patterns of the population and causes negative impacts to adjacent communities,but it is not easy to *** an alternative to the costly technologies and restricted-access data sometimes used to analyze urban barriers,we propose an analytical approach that assesses community severance levels by classifying the quality of Pedestrian Crossings on Urban Streets(the PeCUS index).Additionally,the approach is used to identify possible inequities nearby the different classification groups regarding demographic *** used the chi-square(χ^(2))test of independence and the standardized Pearson residuals to indicate deficits and excesses of residents regarding the demographic characteristics studied surrounding the urban *** found the following evidences of associations:residents with low-income or those aged up to 19 tend to live close to the worst crossings,whereas residents with permanent mobility constraints or the elderly tend to live near the crossings with the best ***,the study shows that the assessment of community severance by the analysis of the PeCUS index is ***,it reveals that the distribution of residents surrounding the distinct classes of quality of crossings is equitable for vulnerable social groups,except for low-income or young residents.

关键词： Community severance transport barriers pedestrian crossings equity open data geographic information systems(GIS)

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Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5404-5416页

作者： Catarina Macedo-silva Vera Miranda-Gonçalves Nuno Tiago Tavares daniela Barros-silva Joana Lencart João Lobo Ângelo Oliveira Margareta PCorreia Lucia Altucci Carmen Jerónimo Cancer Biology&Epigenetics Group Research Center of IPO Porto(CI-IPOP)/CI-IPOP@RISE(Health Research Network)Portuguese Oncology Institute of Porto(IPO-Porto)/Porto Comprehensive Cancer Center Raquel Seruca(Porto.CCC)R.Dr.António Bernardino de Almeida4200-072PortoPortugal Department of Precision Medicine University of Campania“Luigi Vanvitelli”80138NaplesItaly Department of Pathology and Molecular Immunology ICBAS-School of Medicine&Biomedical SciencesUniversity of PortoR.Jorge de Viterbo Ferreira 2284050-313PortoPortugal Medical Physics Radiobiology and Radiation Protection Group-Research Center of IPO Porto(CI-IPOP)/CI-IPOP@RISE(Health Research Network)Portuguese Oncology Institute of Porto(IPO-Porto)/Porto Comprehensive Cancer Center Raquel Seruca(Porto.CCC)R.Dr.António Bernardino de Almeida4200-072PortoPortugal Department of Medical Physics Portuguese Oncology Institute of Porto4200-072PortoPortugal Department of Pathology Portuguese Oncology Institute of PortoPortoPortugal Department of Radiation Oncology Portuguese Oncology Institute of PortoPortoPortugal BIOGEM Molecular Biology and Genetics Research Institute83100AvellinoItaly IEOS Institute of Endocrinology and Oncology80100NaplesItaly

External beam radiotherapy(RT)is a leading first-line therapy for prostate cancer(PCa),and,in recent years,significant advances have been ***,RT resistance can arise and result in long-term recurrence or disease progression in the worst-case ***,making crucial the discovery of new targets for PCa ***,we generated a radioresistant PCa cell line,and found p53 to be highly expressed in radioresistant PCa cells,as well as in PCa patients with recurrent/disease progression submitted to *** dissection revealed that RT could promote p53 expression via epigenetic ***,a decrease of H3K27me3 occupancy at TP53 gene promoter,due to increased KDM6B activity,was observed in radioresistant PCa ***,p53 is essential for efficient DNA damage signaling response and cell recovery upon stress induction by prolonged fractionated ***,KDM6B inhibition by GSK-J4 significantly decreased p53 expression,consequently attenuating the radioresistant phenotype of PCa cells and hampering in vivo 3D tumor ***,this work contributes to improve the understanding of p53 as a mediator of signaling transduction in DNA damage repair,as well as the impact of epigenetic targeting for PCa radiosensitization.

关键词： TP53 damage cancer

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Tropical dendrochronology applied to invasive tree species in the Brazilian Atlantic Forest

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Journal of Forestry Research 2021年第1期32卷 91-101页

作者： Carolina Nogueira Xavier daniela Granato-Souza Ana Carolina M.C.Barbosa JoséReinaldo Moreira da silva Forest Sciences Department Federal University of Lavras(UFLA)C.P.3037Lavras 37200-000Brazil Department of Geosciences University of ArkansasFayettevilleAR 72701USA

The Atlantic Forest is one of the largest and most biodiverse rainforests of South America but anthropogenic activities are drastically changing these *** invasion of alien or exotic species is one of the greatest threats to *** are few studies of invasive species in tropical Brazilian *** research examines growth and ecological aspects of Syzygium cumini and Clitoria fairchildiana,two invasive tree species in the Pedra Branca State Park,an Atlantic Forest remnant in southeastern *** species were successfully dated,indicating an average age of 58 and 31 years,respectively.A positive relationship between growth and precipitation of the previous growing season suggests an ecological adaptive strategy,which could be facilitating their invasion into the *** growth diameter curves indicate slow and fast growth rates for *** and ***,*** release episodes detected in the tree rings indicate increased anthropogenic disturbances over the last 50 years.

关键词： Atlantic Forest biome Invasive species Protected areas Tree rings

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Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus

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Animal Models and Experimental Medicine 2020年第4期3卷 304-315页

作者： Giorgio silva-Santana Juliet Cunha Bax Débora Cristina silva Fernandes daniela Tendler Leibel Bacellar Cleber Hooper Alexandre alves Souza Oliveira Dias Cristina Barbosa silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi Health Sciences Center Institute of Microbiology Paulo de GóesFederal University of Rio de JaneiroRio de JaneiroRJBrazil Laboratory of Diphtheria and Corynebacteria of Clinical Relevance Faculty of Medical SciencesUniversity of the State of Rio de JaneiroRio de JaneiroRJBrazil The Collaborating Centre for Reference and Research on Diphtheria/National Health Foundation/Ministry of Health Rio de JaneiroRJBrazil Laboratory of Clinical Research and Molecular Diagnostic Prof.Marcílio Dias do Nascimento Department of Clinical Practice and PathologyFluminense Federal UniversityNiteróiRJBrazil Laboratory Bacterial Vaccines Department of ImmunologyNational Institute for Quality Control in HealthOswaldo Cruz FoundationRio de JaneiroRJBrazil Institute of Science and Technology in Biomodels Oswaldo Cruz FoundationRio de JaneiroRJBrazil Institute of Biology Federal Fluminense UniversityNiteróiRJBrazil Biomedical Center College of Medical SciencesUniversity of the State of Rio de JaneiroRio de JaneiroRJBrazil

Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental *** lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific *** study seeks to establish reference values for hematological and biochemical parameters of four lineages of ***:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 *** were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical ***:Results are shown as means and standard deviation,grouped by lineage and *** the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual ***:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model.

关键词： B6D2F1 BALB/c biochemical C57BL/6 hematological Swiss

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Prevalence of congenital cytomegalovirus infection in preterm,small for gestational age and low birth weight newborns:characteristics and cytokines profile

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World Journal of Pediatrics 2022年第7期18卷 498-504页

作者： Janaina Fortes Lino Llian Martins Oliveira Diniz Debora Marques de Miranda daniela Valadao Freitas Rosa Nathalia Gualberto Souza e silva Eduardo de Souza Nicolau Larissa Goncalves Rezende Lais silva Carvalho Marianna Fischer de Paula Lopes Luisa Petri Correa Gabriela Mafra de Oliveira Flavia Miranda da silva alves Lorena Batista Pascoal Erika Lima Dolabella Teixeira da Costal Leni Marcia Anchieta Roberta Maia de Castro Romaneli Odete Valadares Maternity Hospital Belo HorizonteBrazil Pediatrics Department.Faculy of Medice of Federal University of Minas Gerais Belo Horizonte.Brazil Molecular Laboratory of the INCT-MM.Faculy of Medicine.Federal University of Minas Gerais-UFMG.Belo Horizonte Brazil Faculty of Medicine.Federal University of Minas Gerais-UFMG Belo Horizonte.Brazil Risoleta Tolentino.Neves University Hospital's Maternity Belo HorizonteBrazil Sofia Feldman Maternity Hospital Belo HorizonteBrazil Hospital das Clinicas Maternity-Federal University of Minas Gerais.Belo Horizonte Brazil Pediatrics Department of Federal University of Minas Gerais School Medicine.Minas Gerais.Av Professor Alfredo Balena 190.Belo Horizonte 30130-100Brazil

Cytomegalovirus is the most frequent agent of congenital viral infections,affecting approximately 0.2%-2.4%of live births in different countries[1-7].Universal screening for congenital cytomegalovirus infection in newborns is not a standard practice considering cost-benefit issues and viabil-ity of diagnostic ***,most newborns are asympto-matic and there is no effective treatment for this population[2-5].

关键词： weight birth characteristics

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Aquatic exercise program-modulated oxidative stress markers in patients with Parkinson's disease

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Neural Regeneration Research 2020年第11期15卷 2067-2072页

作者： Caroline Dani Isabel Teixeira Proenca Jessica Marinho Pamela Peccin Ivy Reichert Vital da silva Simone Nique Vera Striebel daniela Pochmann Viviane Rostirola Elsner Programa de Pos Graduacao em Biociencias e Reabilitacao do Centro Universitario Metodista-IPA Porto AlegreRSBrazil Curso de Fisioterapia do Centro Universitario Metodista-IPA Porto AlegreRSBrazil Programa de Pos Graduacao em Ciencias Biologicas:Fisiologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil Programa de Pos Graduacao em Farmacologia e Terapeutica Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil

Parkinson's disease is a neurodegenerative *** stress,i.e.,the imbalance between the generation of reactive oxygen species and the antioxidant defense capacity of the body,plays an important role in the pathogenesis of this *** exercise can regulate oxidative *** purpose of this study was to analyze the short-and long-term effects of an aquatic exercise program on oxidative stress levels in patients with Parkinson's *** aquatic exercise program was carried out during 1 month with two sessions per week(1 hour/session).Blood samples were collected at four different time points:pre-intervention,immediately,48 hours,and 30 days after the first session of aquatic exercise *** results revealed that water-based programs modulated antioxidant enzyme activity,increased superoxide dismutase activity,reduced catalase activity,and increased the ratio of superoxide dismutase activity to catalase activity in patients with Parkinson's *** with pre-intervention and 48 hours after the first session of aquatic exercise program,superoxide dismutase activity was higher and catalase activity was lower immediately and 30 days after the first *** results demonstrated that aquatic exercise program could modulate oxidative stress,mainly by the effect of antioxidant enzyme *** results could better help understand the target of oxidative stress in Parkinson's *** study was approved by the Ethics Committee of Centro Universitário Metodista IPA(approval No.1.373.911)on August 9,2019 and registered with REBEC(registration number:RBR-6 NJ4 MK).

关键词： antioxidant enzyme antioxidants aquatic exercise exercise therapies neurodegenerative disease oxidative stress Parkinson's disease

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Chemical speciation of copper and manganese in solution of a copper-contaminated soil and young grapevine growth with amendment application

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Pedosphere 2023年第3期33卷 496-507页

作者： daniela Basso FACCO Edicarla TRENTIN Gerson Laerson DRESCHER Rodrigo Knevitz HAMMERSCHMITT Carlos Alberto CERETTA Leandro Souza DA silva Gustavo BRUNETTO Paulo Ademar Avelar FERREIRA Department of Soil Science Federal University of Santa MariaSanta Maria 97105-900(Brazil) University of Arkansas System Division of Agriculture Arkansas 72704(USA) Federal University of Santa Maria Campus Cachoeira do SulCachoeira do Sul 96506-310(Brazil)

Copper(Cu)-based fungicide application to control foliar diseases in grapevine(Vitis vinifera L.)can increase soil Cu *** soils have high natural Cu and manganese(Mn)concentrations,increasing the potential for toxicity to grapevine *** of amendment substances can reduce the concentrations of toxic chemical species of Cu and Mn in soil solution,especially for the soils grown with young *** evaluated the chemical speciation of Cu and Mn in soil solution and young grapevine growth using a contaminated soil with amendment *** seedlings of Paulsen 1103rootstock were grown for 12 months on an old vineyard(>30 years of cultivation)soil without(control)and with vermicompost or limestone *** dry matter,root morphological characteristics,and plant tissue Cu and Mn concentrations were *** cation and anion concentrations,dissolved organic carbon,p H,and chemical speciation of Cu and Mn in soil solution from different soil layers were *** application did not reduce Cu and Mn phytotoxicity,and grapevine plants died after winter *** soluble Mn concentration in soil(5.56 mg L-1in 0–45 cm soil layer)and Mn concentration in plant tissue at pruning(380.8 mg kg-1)might be the primary cause of plant *** application reduced Cu2+and Mn2+chemical species in soil solution,thereby increasing plant *** Cu2+and Mn2+species were negatively correlated(P<0.05)with grapevine shoot production at pruning(r=-0.92 and-0.97,respectively)and at the end of the trial(r=-0.73 and-0.51,respectively).Limestone application increased grapevine shoot and root dry matter production by 36%and 41%,respectively,while also presenting the highest root length and volume in the 5–10 cm soil *** application is a viable and profitable alternative for reducing soil Cu and Mn availability and their phytotoxic effects.

关键词： bioavailability heavy metal limestone phytoxicity vermicompost vineyard Visual MINTEQ

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Therapeutic effectiveness of a single exercise session combined with WalkAide functional electrical stimulation in post-stroke patients:a crossover design study

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Neural Regeneration Research 2021年第5期16卷 805-812页

作者： Viviane Rostirola Elsner Lucieli Trevizol Isadora de Leon Marcos da silva ThaynáWeiss Milena Braga daniela Pochmann Amanda Stolzenberg Blembeel Caroline Dani Elenice Boggio Curso de Fisioterapia do Centro Universitário Metodista-IPA Porto AlegreRSBrasil Programa de Pós-Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA Porto AlegreRSBrasil Programa de Pós-Graduação em Ciências Biológicas:Fisiologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrasil

A growing body of evidence has suggested that the imbalance of epigenetic markers and oxidative stress appears to be involved in the pathophysiology and progression of ***,strategies that modulate these biomarkers might be considered targets for neuroprotection and novel therapeutic opportunities for these *** exercise has been reported to induce changes in these epigenetic markers and improve clinical outcomes in different ***,little is reported on this in post-stroke *** purpose of this study was to investigate the effect of a single exercise session with WalkAide functional electrical stimulation(FES)on cognitive performance,clinical functional parameters,oxidative stress and epigenetic modulation in post-stroke *** this crossover design study,12 post-stroke individuals aged 54–72 years of either sexes were included and subjected to a single session of exercise(45 minutes)without WalkAide functional electrical stimulation(EXE alone group),followed by another single session of exercise(45 minutes)with WalkAide functional electrical stimulation(EXE+FES group).The clinical functional outcome measures,cognitive performance and blood collections for biomarker measurements were assessed pre-and *** intervention,higher Berg Balance Scale scores were obtained in the EXE+FES group than in the EXE alone *** was no significant difference in the Timed Up and Go test results post-intervention between EXE alone and EXE+FES *** intervention,a better cognitive performance was found in both groups compared with before the *** intervention,the Timed Up and Go test scores were higher in the EXE+FES group than in the EXE alone *** addition,the intervention induced lower levels of lipid *** intervention,carbonyl level was lower,superoxide dismutase activity and superoxide dismutase/catalase activity ratio were higher in the EXE+FES group,compared with the

关键词： cognition epigenetic exercise functional electrical stimulation functional mobility oxidative stress stroke WalkAide

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Alkaline hydrolyzable nitrogen and properties that dictate its distribution in paddy soil profiles

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Pedosphere 2020年第3期30卷 326-335页

作者： Gerson Laerson DRESCHER Leandro Souza DA silva Qamar SARFARAZ Gustavo DAL MOLIN Laura Brondani MARZARI Augusto Ferreira LOPES Cesar CELLA daniela Basso FACCO Rodrigo Knevitz HAMMERSCHMITT Department of Soil Science Federal University of Santa MariaSanta Maria 97105-900Brazil Federal University of Santa Maria Campus Cachoeira do SulCachoeira do Sul 96506-310Brazil

Nitrogen(N) is a key nutrient for rice production, and its bioavailability in paddy soils is strongly coupled to soil organic matter(SOM) cycling. A better understanding of potentially available N forms in soil, such as alkaline hydrolyzable N(AH-N), and their depth distribution will support the development of best management practices to improve the N use efficiency of rice while minimizing adverse environmental effects. Fifteen rice(Oryza sativa L.) fields from Southern Brazil were selected, and stratified soil samples were taken to a depth of 60 cm before crop establishment. Selected soil physical and chemical properties were analyzed to evaluate their relationships with AH-N contents in the soil profile. The AH-N contents below 20 cm varied extensively(increased,reduced, or constant) compared with that above 20 cm. Although clay and clay + silt contents were highly correlated to AH-N for some soils, the major property dictating AH-N distribution by depth was total N(TN), as the correlation between TN and AH-N was mainly by direct effect. The proportion of TN recovered as AH-N across sites and depths presented high amplitude, and thus AH-N was not a constant N pool across depths, indicating that AH-N can be affected by soil management practices even when TN showed no major changes. The distinct distribution of AH-N across soil sampling sites and depths indicates that depths greater than 20 cm should be considered when calibrating the AH-N index for N fertilizer recommendations for flooded rice in Southern Brazil.

关键词： fertilizer recommendation nitrogen availability nutrient management practices organo-mineral interaction Oryza sativa L. soil analysis soil organic matter

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