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Esophageal dilations in eosinophilic esophagitis: A single center experience

World Journal of Gastroenterology 2014年第28期20卷 9549-9555页

作者： Andrew Ukleja Jennifer Shiroky Amitesh Agarwal daniela allende Department of Gastroenterology Cleveland Clinic Florida the University of Texas Medical Branch at Galveston Cleveland Clinic

AIM: To diagnose the clinical and histologic features that may be associated with or predictive of the need for dilation and dilation related complications; examine the safety of dilation in patients with eosinophilic... 详细信息

关键词： Balloon dilation Dysphagia Esophagus disorder Esophageal stricture Esosinophilic esophagitis

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Pathologic tumor response to neoadjuvant therapy in borderline resectable pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 373-378页

作者： June S Peng Jane Wey Sricharan Chalikonda daniela S allende R Matthew Walsh Gareth Morris-Stiff Department of General Surgery Digestive Disease and Surgery InstituteCleveland Clinic Foundation9500 Euclid AvenueClevelandOHUSA Department of Pathology Pathology and Laboratory Medicine InstituteCleveland Clinic Foundation9500 Euclid AvenueClevelandOHUSA

Background:Previous studies have demonstrated the prognostic significance of pathologic tumor response in pancreatic adenocarcinoma following neoadjuvant therapy(NAT).The aim of this study was to determine the incidence of significant pathologic response to NAT in borderline resectable pancreatic cancer(BRPC),and association of NAT regimen and other clinico-pathologic characteristics with pathologic ***:Patients with BRPC who underwent NAT and pancreatic resection between January 2012 and June 2017 were *** response was assessed on a qualitative scale based on the College of American Pathologists grading *** and baseline characteristics,oncologic treatment,pathology,and survival outcomes were ***:Seventy-one patients were included for *** patients had complete pathologic responses(tumor regression score 0),12 patients had marked responses(score 1),42 had moderate responses(score 2),and 13 had minimal responses(score 3).Patients with complete or marked responses were more likely to have received neoadjuvant gemcitabine chemoradiation(62.5%,38.1%,and 23.1%of the complete/marked,moderate,and minimal response groups,respectively;P=0.04).Of the complete/marked,moderate,and minimal response groups,margins were negative in 75.0%,78.6%,and 46.2%(P=0.16);node negative disease was observed in 87.5%,54.8%,and 15.4%(P<0.01);and median overall survival was 50.0 months,31.7 months,and 23.2 months(P=0.563).Of the four patients with pathologic complete responses,three were disease-free at 66.1,41.7 and 31.4 months,and one was deceased with metastatic liver disease at 16.9 ***:A more pronounced pathologic tumor response to NAT in BRPC is correlated with node negative disease,but was not associated with a statistically significant survival benefit in this study.

关键词： Pancreatic cancer Borderline resectable Neoadjuvant therapy Pathologic response

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Risk factors for colorectal neoplasia in patients with underlying inflammatory bowel disease:a multicenter study

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Gastroenterology Report 2019年第1期7卷 67-73,I0002页

作者： Xian-Rui Wu Xiao-Bin Zheng Yan Huang Qian Cao Hong-Jie Zhang Ying-Lei Miao Kai-Fang Zou Min Chen Fa-Ming Zhang Qiao Mei David Gonzalo daniela allende Pin-Jin Hu Bo Shen Xiu-Li Liu Ping Lan Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongChina Department of Pathology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Gastroenterology Sir Run Run Shaw Hospital of Zhejiang University School of MedicineHangzhouChina Department of Gastroenterology Jiangsu Province HospitalNanjingChina Department of Gastroenterology The First Affiliated Hospital of Kunming Medical UniversityKunmingChina Department of Gastroenterology Wuhan Union HospitalWuhanChina Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhanChina Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical UniversityNanjingChina Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefeiChina Department of Pathology and Laboratory Medicine University of FloridaGainesvilleFLUSA Department of Anatomic Pathology The Cleveland Clinic FoundationClevelandOHUSA Department of Gastroenterology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Gastroenterology/Hepatology The Cleveland Clinic FoundationClevelandOHUSA

Background:This study sought to evaluate the risk factors for the development of colitis-associated neoplasia(CAN)in Chinese patients with inflammatory bowel disease(IBD).Methods:IBD patients who developed CAN between 1999 and 2016 were identified from eight medical *** addition to initial pathology evaluation,a CAN diagnosis was confirmed by two expert *** with CAN(n=29)were compared with non-CAN controls(n=87).Matching was performed for gender and IBD type with a ratio of three controls to one ***:Of the 29 patients with CAN,8(27.6%)had colorectal cancer(CRC),20(69.0%)had a final diagnosis of low-grade dysplasia and 1(3.4%)had high-grade *** analysis revealed that an older age at the time of IBD diagnosis and a longer IBD duration were independent risk factors for the development of CAN,with odds ratios of 1.09[95%confidence interval(CI):1.04–1.14,P<0.001]and 1.14(95%CI:1.03–1.27,P=0.013),*** between IBD patients with CRC and those with dysplasia indicated that the former were older at the time of IBD diagnosis(P=0.012)and had longer IBD durations(P=0.019).Conclusions:Older age at the time of IBD diagnosis and longer IBD duration were found to be associated with the development of CAN in IBD patients.

关键词： Colorectal neoplasia inflammatory bowel disease risk factor

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