检索结果-南通市图书馆

Genomic predictors for treatment of late stage prostate cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2016年第4期18卷 586-591页

作者： daniel h Shevrin Department of Medicine Division of Hematology/Oncology NorthShore University HealthSystem 2650 Ridge Avenue Evanston Illinois 60201 USA

In spite of the development of new treatments for late stage prostate cancer, significant challenges persist to match individuals with effective targeted therapies. Genomic classification using high-throughput sequencing technologies has the potential to achieve this goal and make precision medicine a reality in the management of men with castrate-resistant prostate cancer. This chapter reviews some of the most recent studies that have resulted in significant progress in determining the landscape of somatic genomic alterations in this cohort and, more importantly, have provided clinically actionable information that could guide treatment decisions. This chapter reviews the current understanding of common alterations such as alterations of the androgen receptor and PTEN pathway, as well as ETS gene fusions and the growing importance of PARP inhibition. It also reviews recent studies that characterize the evolution to neuroendocrine tumors, which is becoming an increasingly important clinical problem. Finally, this chapter reviews recent innovative studies that characterize the compelling evolutionary history of lethal prostate cancer evidenced by polyclonal seeding and interclonal cooperation between metastasis and the importance of tumor clone dynamics measured serially in response to treatment. The genomic landscape of late stage prostate cancer is becoming better defined, and the prospect for assigning clinically actionable data to inform rationale treatment for individuals with this disease is becoming a reality.

关键词： advanced prostate cancer genomic alterations lethal prostate cancer precision medicine targeted therapy whole-genomesequencing

Effects of longwall-induced stress and deformation on the stability and mechanical integrity of shale gas wells drilled through a longwall abutment pillar

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2017年第1期27卷 115-120页

作者： daniel W.h.Su National Institute for Occupational Safety and health Bruceton 15236PAUSA

This paper presents the results of a comprehensive study conducted by CONSOL Energy, Marcellus Shale Coalition, and Pennsylvania Coal Association to evaluate the effects of longwall-induced subsurface deformations on the mechanical integrity of shale gas wells drilled over a longwall abutment *** primary objective is to demonstrate that a properly constructed gas well in a standard longwall abutment pillar can maintain mechanical integrity during and after mining operations. A study site was selected over a southwestern Pennsylvania coal mine, which extracts 457-m-wide longwall faces under about 183 m of cover. Four test wells and four monitoring wells were drilled and installed over a 38-m by84-m centers abutment pillar. In addition to the test wells and monitoring wells, surface subsidence measurements and underground coal pillar pressure measurements were conducted as the 457-m-wide longwall panels on the south and north sides of the abutment pillar were mined by. To evaluate the resulting coal protection casing profile and lateral displacement, three separate 60-arm caliper surveys were conducted. This research represents a very important step and initiative to utilize the knowledge and science obtained from mining research to improve miner and public safety as well as the safety and health of the oil and gas industries.

关键词： Gas well Casing Abutment pillar Stability Safety and health Instrumentation Numerical simulation

simplifyEnrichment:A Bioconductor Package for Clustering and Visualizing Functional Enrichment Results

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2023年第1期21卷 190-202页

作者： Zuguang Gu daniel hübschmann Molecular Precision Oncology Program National Center for Tumor Diseases(NCT)HeidelbergD-69120 HeidelbergGermany heidelberg Institute of Stem Cell Technology and Experimental Medicine(hI-STEM) D-69120 HeidelbergGermany German Cancer Consortium(DKTK) D-69120 HeidelbergGermany Department of Pediatric Immunology Hematology and OncologyUniversity Hospital HeidelbergD-69120 HeidelbergGermany

Functional enrichment analysis or gene set enrichment analysis is a basic bioinformatics method that evaluates the biological importance of a list of genes of ***,it may produce a long list of significant terms with highly redundant information that is difficult to *** tools to simplify enrichment results by clustering them into groups either still produce redundancy between clusters or do not retain consistent term similarities within *** propose a new method named binary cut for clustering similarity matrices of functional *** comprehensive benchmarks on both simulated and real-world datasets,we demonstrated that binary cut could efficiently cluster functional terms into groups where terms showed consistent similarities within groups and were mutually exclusive between *** compared binary cut clustering on the similarity matrices obtained from different similarity measures and found that semantic similarity worked well with binary cut,while similarity matrices based on gene overlap showed less consistent *** implemented the binary cut algorithm in the R package simplifyEnrichment,which additionally provides functionalities for visualizing,summarizing,and comparing the *** simplifyEnrichment package and the documentation are available at https://***/packages/simplifyEnrichment/.

关键词： Functional enrichment Simplify enrichment Clustering R/Bioconductor Software Visualization

Disaster Risk Resilience:Conceptual Evolution,Key Issues,and Opportunities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2022年第3期13卷 330-341页

作者： Marie-hélène Graveline daniel Germain Institut des Sciences de l’Environnement(ISE) Universitédu QuébecàMontréalMontréalH3C 3P8Canada Department of Geography Universitédu QuébecàMontréalMontréalH3C 3P8Canada

Resilience has become a cornerstone for risk management and disaster ***,it has evolved extensively both etymologically and conceptually in time and across scientific *** concept has been(re)shaped by the evolution of research and practice *** the opposite of vulnerability for a long time,resilience was first defined as the ability to resist,bounce back,cope with,and recover quickly from the impacts of *** avoid the possible return to conditions of vulnerability and exposure to hazards,the notions of post-disaster development,transformation,and adaptation(build back better)and anticipation,innovation,and proactivity(bounce forward)were then ***,resilience is characterized by a multitude of components and several *** present a selection of 25 components used to define resilience,and an interesting linkage emerges between these components and the dimensions of risk management(prevention,preparedness,response,and recovery),offering a perspective to strengthen resilience through the development of *** its potential,resilience is subject to challenges regarding its operationalization,effectiveness,measurement,credibility,equity,and even its ***,it offers applicability and opportunities for local communities as well as an interdisciplinary look at global challenges.

关键词： Community Disaster risk Resilience Sustainable development

Salinity and cultivar effects on alfalfa forage yield and nutritive value in a Mediterranean climate

在线全文

学校读者我要写书评

暂无评论

Grassland Research 2023年第3期2卷 153-166页

作者： Aaron W.Anderson Umair Gull Sharon E.Benes Simarjeet Singh Robert B.hutmacher Edward Charles Brummer daniel.h.putnam Department of Agricultural Foodand Environmental SciencesUniversity of PerugiaPerugiaItaly Department of Agronomy Universityof AgricultureFaisalabadPakistan Department of Plant Science California State UniversityFresnoFresnoCaliforniaUSA Department of Plant Sciences University of CaliforniaDavisDavisCaliforniaUSA

Background:Soil and water salinity are increasing problems worldwide,causing significantly reduced crop ***(Medicago sativa L.)is often listed as salt-sensitive,but field testing of improved cultivars is *** systems and improved high-quality alfalfa varieties are needed to enable crop production under high salinity(hS)***:The objective of this study was to measure the yield and quality response of alfalfa to high saline conditions in the field and to document the relative saline tolerance of its *** irrigation water(electrical conductivity of water,or ECw 8.0–11.0 dS m−1)was applied to 33 nondormant alfalfa cultivars and were compared with low salinity(LS)treatments(ECw 0.5–1.2 dS m−1)over 4 years in a Mediterranean environment on a clay loam soil utilizing a split-plot *** were harvested seven to eight times per year,and the forage quality was measured on selected harvests utilizing near-infrared ***:The average yield loss due to hS treatment was 23.9%compared with LS treatment,but yields averaged 23.4 Mg ha−1 under hS over the 3 full years of *** level of production is considered to be economically viable in this *** in salinity tolerance between lines were identified in the field;individual cultivars lost 5%–35%of their LS yield when grown under hS *** quality was significantly improved under hS versus LS conditions,but improvements were negatively correlated with biomass yield(R2>0.81),similar to responses observed in drought-stressed ***:These yield results confirm greenhouse studies,indicating that alfalfa is highly salt tolerant once established in the field,with potential for further improvement with tolerant *** tolerance should be chosen based on total biomass yield as well as on the salinity tolerance index(hS yield relative to LS yield).Agronomic practices to mitigate salinity and sodicity are critical,along with

关键词： abiotic stress cultivar forage quality Medicago sativa nutritional value salinity tolerance soil health stress tolerance

Temporal scatterplots

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computational Visual Media 2020年第4期6卷 385-400页

作者： Or Patashnik Min Lu Amit h.Bermano daniel Cohen-Or Tel-Aviv University Tel-AvivIsrael Shenzhen University ShenzhenChina

Visualizing high-dimensional data on a 2D canvas is generally *** becomes significantly more difficult when multiple time-steps are to be presented,as the visual clutter quickly ***,the challenge to perceive the significant temporal evolution is even *** this paper,we present a method to plot temporal high-dimensional data in a static scatterplot;it uses the established PCA technique to project data from multiple *** key idea is to extend each individual displacement prior to applying PCA,so as to skew the projection process,and to set a projection plane that balances the directions of temporal change and spatial *** present numerous examples and various visual cues to highlight the data trajectories,and demonstrate the effectiveness of the method for visualizing temporal data.

关键词： scatterplot temporal data visual clutter principle component analysis(PCA)

Effect of slab width on choice of appropriate casting speed in steel production

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2022年第1期29卷 71-79页

作者： daniel Christopher Merten Marc-Thorsten hütt Yilmaz Uygun Department of Mathematics and Logistics Jacobs University BremenBremen 28759Germany Department of Life Sciences and Chemistry Jacobs University BremenBremen 28759Germany

In steel continuous casting(CC),the choice of the appropriate speed at which the slab is cast can be influenced by many different factors and *** the slab thickness seems to have the biggest impact,other features like the slab width have been consistently *** fact,the slab width practically limits the casting speed via the mass flow constraint which governs the input and output balance at the ***,we present a case study that aims at analyzing steel production data from the perspective of casting speed *** studying the speed fluctuations of an industrial CC machine,we identify a strategic regime change toward a stricter consideration of the mass flow *** regime change manifests itself in a significant increase in the correlation between the actual casting speed and the maximal speed associated with the mass flow *** the surface,taking greater account of the input and output balance at the tundish has reduced the productivity of the continuous caster;however,one can argue that the lessened yield is compensated by a diminished risk of eventual slab *** the perspective of this trade-off,we establish a visualization technique that enables us to pinpoint the boundary beyond which one strategic regime becomes economically more advantageous than the other.

关键词： Continuous casting Casting speed Slab width Slab thickness Mass flow constraint Machine length constraint

Parkland trees on smallholder farms ameliorate soil physical-chemical properties in the semi-arid area of Tigray,Ethiopia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Arid Land 2024年第1期16卷 1-13页

作者： Selam LJALEM Emiru BIRhANE Kassa TEKA daniel h BERhE Department of Land Resources Management and Environmental Protection College of Dryland Agriculture and Natural ResourcesMekelle UniversityMekelle 231Ethiopia Institute of Climate and Society Mekelle UniversityMekelle 231Ethiopia Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life Sciences(NMBU)Ås 1432Norway Department of Natural Resources Management Adigrat UniversityAdigrat 50Ethiopia

Proposed agroforestry options should begin with the species that farmers are most familiar with,which would be the native multipurpose trees that have evolved under smallholder farms and socioeconomic *** African birch(Anogeissus leiocarpa(DC.)Guill.&Perr.)and pink jacaranda(Stereospermum kunthianum Cham.)trees are the dominant species in the agroforestry parkland system in the drylands of Tigray,*** farmers highly value these trees for their multifunctional uses including timber,firewood,charcoal,medicine,*** trees also could improve soil ***,the amount of soil physical and chemical properties enhanced by the two species must be determined to maintain the sustainable conservation of the species in the parklands and to scale up to similar agroecological ***,we selected twelve isolated trees,six from each species that had similar dendrometric characteristics and were growing in similar environmental *** divided the canopy cover of each tree into three radial distances:mid-canopy,canopy edge,and canopy gap(control).At each distance,we took soil samples from three different *** collected 216 soil samples(half disturbed and the other half undisturbed)from each canopy position and soil *** density(BD),soil moisture content(SMC),soil organic carbon(SOC),total nitrogen(TN),available phosphorus(AP),available potassium(AK),p h,electrical conductivity(EC),and cation exchange capacity(CEC)were *** revealed that soil physical and chemical properties significantly improved except for soil texture and EC under both species,CEC under ***,and soil p h under ***,all the studied soils were improved under both species canopy as compared with canopy ***,TN,AP,and AK under canopy of these trees were respectively 24.1%,11.1%,55.0%,and 9.3% higher than those soils under *** two parkland agroforestry species significantly enhanced soil fertility near the canopy of top

关键词： agroforestry bulk density carbon stock dispersed tree soil texture tree canopy

Potential of Sorghum as an Alternative to Corn Forage

在线全文

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2016年第7期7卷 1106-1121页

作者： Girma Getachew daniel h. putnam Christopher M. De Ben Edward J. De Peters Department of Plant Sciences University of California Davis CA USA Department of Animal Science University of California Davis CA USA

Climate change, which is currently characterized by increased atmospheric CO2, rising temperature, and altered pattern of precipitation, is affecting agricultural productivity. Rising temperatures and shifting precipitation patterns will alter the ability to meet crop water requirements, water availability, crop productivity, and costs of water access across the agricultural landscape. Searching for alternative crops with lower water requirements increased yield or organic matter per unit of water are important for agricultural sustainability. Sorghum is one of the world’s important crops;a crop that is adapted to a variety of agronomic and environmental conditions, particularly to areas with low rainfall or limited access of irrigation water. Forage Sorghum is able to produce comparable yield to corn suggesting that there is a potential for Sorghum to replace corn in areas where water supply is limited. But, there is a cost since corn silage, because of its high grain content, which is typically superior in digestible energy content to Sorghum forages. There is also a lack of information on the feeding value of Sorghum silages in high producing dairy cows as well as strategies that may be used for sorghum silage to replace a portion of the corn silage in dairy cattle diets.

关键词： Sorghum Climate Change Drought Tolerance Salinity