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Decreased Expression of TRPM3 and mAChRM3 in the Small Intestine in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

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International Journal of Clinical Medicine 2018年第5期9卷 467-480页

作者： Sonya Marshall-Gradisnik Marshall Fretel Natalie Eaton Helene Cabanas Cassandra Balinas Vinod Gopalan daniel petersen Rachel Passmore Kevin Tang Mazhar Haque Alfred Lam Donald Staines School of Medical Science Griffith University Brisbane Australia The National Centre for Neuroimmunology and Emerging Diseases Menzies Health Institute Queensland Griffith University Brisbane Australia Gold Coast University Hospital Parklands Australia Mater Hill Gastroenterology South Brisbane Australia

Introduction: Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is often associated with gastrointestinal disturbance and inflammatory markers;however, there have been no histological studies performed in the small intestine from CFS/ME patients. The aim of this investigation was to assess the expression of certain inflammatory markers and inflammatory receptors, namely transient receptor potential melastin 3 (TRPM3) ion channels and muscarinic acetylcholine M3 (mAChRM3) receptors, in small intestinal tissues in a case controlled study comprising a CFS/ME patient and a healthy non-fatigued control. Method: Immunohistochemistry was performed on a small intestinal biopsy from a CFS/ME patient (age = 50;female) with self-reported symptoms of gastrointestinal disturbance and a non-fatigued control (NFC), (age = 28;female). Semi-quantitative analysis of expression was undertaken for interferon-gamma (IFNy), interleukin-1 alpha (IL-1α), tumour necrosis factor-alpha (TNFα), TRPM3 ion channels and mAChRM3 acetylcholine receptors. Results: There was significantly decreased expression of TRPM3 in the CFS/ME patient (35% ±9%) and a significant decrease in mAChRM3 in the CFS/ME patient (54% ±9%). There was no difference in IL-1α between CFS/ME patient and NFC, however;there was an increase in IFNy (13% ±6%) in the CFS/ME patient compared to NFC. There was a difference observed in TNFα in CFS/ME compared to NFC. Conclusion: Differences were noted in the expression of specific TRP ion channels and cholinergic receptors in CFS/ME compared with NFC, with CFS/ME demonstrating decreased TRPM3 and mAChRM3. Further, IFNy was increased, and TNFα decreased, in the small intestine of the CFS/ME patient with reported gastrointestinal disturbance.

关键词： Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Irritable Bowel TRPM3 mAChRM3 Small Intestine Inflammation

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图和多图的生成树矩阵论方法

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国外科技新书评介 2015年第6期 6-6页

作者： daniel J. Gross 朱永贵不详中国传媒大学理学院

本书阐述的如何利用代数方法和分析方法计算多图生成树，包括多图生成树的最优化算法、多图生成树在网络可靠性理论中的应用、概率可靠性模型、矩阵理论和图论。多图最大生成树的最优化问题和子图连接的极小化是本书论述的重要内容。利... 详细信息

本书阐述的如何利用代数方法和分析方法计算多图生成树，包括多图生成树的最优化算法、多图生成树在网络可靠性理论中的应用、概率可靠性模型、矩阵理论和图论。多图最大生成树的最优化问题和子图连接的极小化是本书论述的重要内容。利用矩阵论方法计算生成树是本书给出的一个重要方法，如封面出现的petersen图就是矩阵论方法计算的2000个生成树之一。

关键词：最大生成树矩阵论 petersen图最优化算法可靠性理论可靠性模型最优化问题代数方法

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Molecular phylogeny, morphology, pigment chemistry and ecology in Hygrophoraceae (Agaricales)

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Fungal Diversity 2014年第1期64卷 1-99页

作者： D.Jean Lodge Mahajabeen Padamsee P.Brandon Matheny M.Catherine Aime Sharon A.Cantrell David Boertmann Alexander Kovalenko Alfredo Vizzini Bryn T.M.Dentinger Paul M.Kirk A.Martyn Ainsworth Jean-Marc Moncalvo Rytas Vilgalys Ellen Larsson Robert Lücking Gareth W.Griffith Matthew E.Smith Lorelei L.Norvell Dennis E.Desjardin Scott A.Redhead Clark L.Ovrebo Edgar B.Lickey Enrico Ercole Karen W.Hughes Régis Courtecuisse Anthony Young Manfred Binder Andrew M.Minnis daniel L.Lindner Beatriz Ortiz-Santana John Haight Thomas Læssøe Timothy J.Baroni József Geml Tsutomu Hattori Center for Forest Mycology Research Northern Research StationUSDA-Forest ServiceLuquilloPR 00773-1377USA Systematics Team Landcare Research231 Morrin RoadAuckland 1072New Zealand Ecology&Evolutionary Biology University of TennesseeKnoxvilleTN 37996-1610USA Department of Botany&Plant Pathology Purdue UniversityWest LafayetteIN 47907USA Science and Technology Universidad del TuraboGuraboPR 00778-3030USA Department of Bioscience Aarhus UniversityFrederiksborgvej 399DK-4000 RoskildeDenmark Komarov Botanical Institute of the Russian Academy of Sciences 2 Prof.Popov Str.St.Petersburg 197376Russia Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale P.A.Mattioli 2510125 TorinoItaly Mycology Royal Botanic GardensKewRichmondSurrey TW93DSUK Royal Ontario Museum 100 Queen’s ParkTorontoONCanada Biology Department Duke UniversityDurhamNC 27708-0338USA Biological&Environmental Sciences University of GothenburgGöteborgSweden Science&Eduaction Integrative Research&Collections(Botany)The Field Museum of Natural History1400 Lake Shore Dr.ChicagoIL 60605-2496USA University of Wales AberystwythCeredigion SY233DDUK Department of Plant Pathology University of FloridaGainesvilleFL 32611-0680USA Pacific Northwest Mycology Service 6720 NW Skyline BvdPortlandOR 97229-1309USA Department of Biology San Francisco State University1600 Holloway Ave.San FranciscoCA 94132USA National Mycological Herbarium(DAOM) Science and Technology BranchAgriculture&Agri-FoodsCanada960 Carling AvenueOttawaOntarioCanada ONT K1A 0C6 Department of Biology University of Central OklahomaEdmondOK 73034USA Department of Biology Bridgewater College402 E.College St.BridgewaterVA 22812USA Department of Botany Faculty of Pharmaceutical&Biological SciencesLilleFrance 100 Langton Road BlackbuttQld 4306Australia CBS Fungal Biodiversity Centre Evolutionary PhytopathologyInst.of the Royal Netherlands Academy of Arts&Sciences(KNAW)Uppsalalaan 83584 CT UtrechtThe Netherlands

Molecular phylogenies using 1–4 gene regions and information on ecology,morphology and pigment chemistry were used in a partial revision of the agaric family *** phylogenetically supported genera we recognize here in the Hygrophoraceae based on these and previous analyses are:Acantholichen,Ampulloclitocybe,Arrhenia,Cantharellula,Cantharocybe,Chromosera,Chrysomphalina,Cora,Corella,Cuphophyllus,Cyphellostereum,Dictyonema,Eonema,Gliophorus,Haasiella,Humidicutis,Hygroaster,Hygrocybe,Hygrophorus,Lichenomphalia,Neohygrocybe,Porpolomopsis and Pseudoarmillariella.A new genus that is sister to Chromosera is described as *** were made at the ranks of subfamily,tribe,genus,subgenus,section and *** present three new subfamilies,eight tribes(five new),eight subgenera(one new,one new combination and one ***.),26 sections(five new and three new combinations and two ***.)and 14 subsections(two new,two ***.).Species of Chromosera,Gliophorus,Humidicutis,and Neohygrocybe are often treated within the genus Hygrocybe;we therefore provide valid names in both classification *** used a minimalist approach in transferring genera and creating new names and ***,we retain in the Hygrophoraceae the basal cuphophylloid grade comprising the genera Cuphophyllus,Ampulloclitocybe andCantharocybe,despite weak phylogenetic *** include Aeruginospora and Semiomphalina in Hygrophoraceae based on morphology though molecular data are *** lower hygrophoroid clade is basal to Hygrophoraceae s.s.,comprising the genera Aphroditeola,Macrotyphula,Phyllotopsis,Pleurocybella,Sarcomyxa,Tricholomopsis and Typhula.

关键词： Hygrophoraceae Fungi Revisionary systematics Nomenclatural revision Phylogenetics Pigment chemistry Lamellar trama construction Hymenial morphology Ecology

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法罗群岛教育中心

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城市环境设计 2019年第2期118卷 84-99页

作者： H?gni Laksáfoss Alberte Danvig Alejandro Mata Gonzales Alessio Valmori Alexandre Carpentier Annette Birthe Jensen Armen Menendian Athena Morella Baptiste Blot Boris Peianov Camille Crepin Claudio Moretti Dag Pr?stegaard daniel Pihl David Zahle Edouard Boisse Elisha Nathoo Enea Michelesio Eskild Nordbud Ewelina Moszczynska Frederik Lyng Goda Luksaite Henrik Kania H?gni Laksáfoss Jakob Lange Jakob Teglg?rd Hansen Jan Besikov Jan Kudlicka Jan Magasanik Jeppe Ecklon Jesper Boye Andersen Ji-Young Yoon Johan Cool Kari-Ann petersen Kim Christensen Kristoffer Negendahl Long Zuo Martin Cajade Michael Sch?nemann Jensen Mikkel Marcker Stubgaard Niklas Rausch Norbert Nadudvari Oana Simionescu Richard Howis Sabine Kokina Simonas Petrakas Sofia Sofianou Takumi Iwasawam Tobias Hjortdal Tommy Bj?rnstrup Victor Bejenaru Xiao Xuan Lu Rasmus Hjortshoj 曲鸿

格拉西尔坐落于法罗群岛起伏的峡湾上,坐拥大海和青翠的海湾景观,首都托尔斯港的景色一览无余。格拉西尔旨在把法罗群岛体育学校、托尔斯港技术学院和法罗群岛商学院合并在一起,提高整体效率,惠及1 750名师生和员工。通过创新孵化器的形... 详细信息

格拉西尔坐落于法罗群岛起伏的峡湾上,坐拥大海和青翠的海湾景观,首都托尔斯港的景色一览无余。格拉西尔旨在把法罗群岛体育学校、托尔斯港技术学院和法罗群岛商学院合并在一起,提高整体效率,惠及1 750名师生和员工。通过创新孵化器的形式,不同于传统学校,格拉西尔既保留了三所学校的自主权,又为学校之间合作学习的蓬勃发展创造了理想条件。根据学生和教师的内部需求,

关键词：法罗群岛教师准备托尔斯港格拉西平面图卫生间教育中心

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