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Helicobacter pylori infection in patients with selective immunoglobulin E deficiency

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World Journal of Gastroenterology 2015年第1期21卷 240-245页

作者： Eli Magen Menachem Schlesinger Itzhak Ben-Zion daniel Vardy Leumit Health Services Ashdod 77456Israel Allergy and Clinical Immunology Unit Barzilai University Medical CenterAshkelon 78278Israel Ben-Gurion University of Negev Beer-Sheva 8410501Israel

AIM: To investigate the prevalence and clinical characteristics of Helicobacter pylori(***)-infected dyspeptic patients with selective immunoglobulin E deficiency(IgE d).METHODS: All individuals who underwent serum totalimmunoglobulin E(Ig E) measurement at the Leumit Healthcare Services(Israel) in 2012 were identified in an electronic database search(n = 18487).From these,selected case group subjects were ≥ 12 years of age and had serum total Ig E p was selected from a random sampling of the remaining subjects ≥ 12 years of age to obtain a case-control ratio of 1:20(n = 3160).Dyspeptic diseases,diagnosed no more than 5 years before serum total Ig E testing,were identified and retrieved from the electronic database using specific International Classification of Diseases diagnostic *** of C13-urea breath tests were used to identify subjects infected with *** variables between case and control subjects were analyzed using Fisher's exact tests,whereas continuous variables were analyzed using χ2 ***: Dyspepsia was present in 27.2%(43/158) of case subjects and 22.7%(718/3160) of *** these,significantly more case subjects(32/43,74.4%) than controls(223/718,31.1%) were positive for ***(p phagogastroduodenoscopy was performed in 19 case and 94 control subjects,revealing that gastritis was more prevalent in IgE d case subjects than in controls(57.9% vs 29.8%,p proportion of case subjects presented with peptic duodenal ulcers(63.2% vs 15.9%,p pathologic examination showed marked chronic inflammation,lymphoid follicle formation and prominent germinal centers,with polymorphonuclear cell infiltration of gastric glands,that was similar in case and control biopsy ***,Ig Ed case subjects that underwent esophagogastroduodenoscopy were more likely to exhibit treatment-refractory *** infections that require seco

关键词： Selective IgE deficiency Helicobacter pylori Dyspe

Gamma-aminobutyric acid(GABA) promotes recovery from spinal cord injury in lampreys: role of GABA receptors and perspective on the translation to mammals

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Neural Regeneration Research 2019年第10期14卷 1695-1696页

作者： daniel Romaus-Sanjurjo María Celina Rodicio Antón Barreiro-Iglesias Department of Functional Biology CIBUS Faculty of BiologyUniversidade de Santiago de Compostela

In mammals, spinal cord injury (SCI) is a devastating event that can lead to a permanent loss of motor, sensory and autonomic functions below the site of injury. In the last years, the role of different neurotransmitter systems on regeneration and recovery from SCI has been deciphered. For example, studies in lampreys have shown that neurotransmitters play a key role in modulating the survival and regeneration of brainstem descending neurons after SCI (Romaus-Sanjurjo et al., 2018;Sobrido-Camean et al., 2018).

关键词： In mammals devastating event regeneration

Assessment of widely used methods to derive depositional ages from detrital zircon populations

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Geoscience Frontiers 2019年第4期10卷 1421-1435页

作者： daniel S.Coutts William A.Matthews Stephen M.Hubbard Department of Geoscience University of Calgary

The calculation of a maximum depositional age(MDA)from a detrital zircon sample can provide insight into a variety of geological ***,the impact of sample size and calculation method on the accuracy of a resulting MDA has not been *** use large populations of synthetic zircon dates(N≈25,000)to analyze the impact of varying sample size(n),measurement uncertainty,and the abundance of neardepositional-age zircons on the accuracy and uncertainty of 9 commonly used MDA calculation ***,a new method,the youngest statistical population is *** each method,500 samples of n synthetic dates were drawn from the parent population and MDAs were *** mean and standard deviation of each method ove r the 500 trials at each n-value(50-1000,in increments of 50)were compa red to the known depositional age of the synthetic population and used to compare the methods quantitatively in two simulation *** first simulation scenario varied the proportion of near-depositional-age grains in the synthetic *** second scenario varied the uncertainty of the dates used to calculate the *** sample size initially decreased the mean residual error and standard deviation calculated by each *** higher n-values(>~300 grains),calculated MDAs changed more slowly and the mean resid ual error increased or decreased depending on the method *** the p roportion of near-depositional-age grains and lowering measurement uncertainty decreased the number of measurements required for the calculated MDAs to stabilize and decreased the standard deviation in calculated MDAs of the 500 *** of the two simulation scenarios show that the most successful way to increase the accuracy of a calculated M DA is by acquiring a large number of low-uncertainty measurements(300300)approach is used if the calculation of accurate MDAs are key to research *** acquisition method s,such as high-to moderate-precision m

关键词： Detrital zircon Maximum depositional age Geochronology Basin chronology LA-ICp-MS

Effectiveness of peer-Led Intervention on KAp Related to Sexual Reproductive and Mental Health Issues among Adolescents in Low Resource Settings India: A Comparative Study among participants and Non-participants

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Health 2020年第9期12卷 1151-1168页

作者： Kavya p Sonali daniel Shumayla Shumayla Rajesh Sinha Sunil Mehra Mental Health Department Mamta-Health Institute for Mother and Child Delhi India Chronic Diseases and Adolescent Health Department Mamta-Health Institute for Mother and Child Delhi India Research Department Mamta-Health Institute for Mother and Child Delhi India Mamta-Health Institute for Mother and Child Delhi India

Background: India being the country with largest adolescent population in the world, needs a special focus on the health services as the status of an adolescent determines the health status in his/her adulthood. Some of the major issues faced by the adolescents include: mental health problems, early pregnancy and childbirth, (HIV/STI) and other infectious diseases, violence, injuries and malnutrition. The present study aims to understand the effectiveness of peer-led intervention on knowledge, attitude and practices related to sexual reproductive and mental health issues in adolescents among participants and non-participants. The study was carried out to improve the health-seeking behaviour of adolescents on sexual reproductive and mental health issues in low resource setting across four states in India. Methods: The study adopted a cross-sectional survey which was conducted on 400 adolescents from each of the four districts namely Bangalore, Khagaria-Bihar, Khed-pune and Sahinganj-Jharkhand. A comparative analysis was conducted between the participants and the non-participants of the intervention to understand the effectiveness of the intervention on the KAp related to sexual reproductive and mental health of adolescents. Results: The study shows that the participants from Karnataka and Maharashtra had better knowledge in emergency contraception, HIV awareness, use of contraceptives and consumption of IFA’s than the non-participants;both the participants and the non-participants showed a positive behaviour in help-seeking in case of psychological challenges. Conclusion: The peer-led approach was found to be an effective strategy for learning, sharing and monitoring adolescent sexual reproductive and mental health.

关键词： Adolescent Health Mental Health peer-Led Approach Sexual Reproductive Health

Evolution of heart transplant donor characteristics in the 21st century: A United States single center’s experience

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World Journal of Transplantation 2024年第3期14卷 22-29页

作者： Alexander M Spring Christiana Gjelaj Shivank Madan Snehal R patel Omar Saeed Sandhya Murthy Yogita Rochlani daniel B Sims Sasha Vukelic Stephen J Forest Jamil F Borgi daniel J Goldstein Ulrich p Jorde Montefiore-Einstein Center for Heart and Vascular Care Montefiore Medical CenterAlbert Einstein College of MedicineBronxNY 10467United States Division of Cardiothoracic Surgery Tulane UniversityNew OrleansLA 70112United States

Despite a record setting number of heart transplants performed annually,the national donor shortage continues to plague transplant teams across the United *** we describe the barriers to adaptation of numerous“non-traditional”orthotopic heart transplant donor characteristics including donors with hepatitis C virus,those meeting criteria for donation after cardiac death,donors with coronavirus disease 19 infection,donors with the human immunodeficiency virus,and grafts with left ventricular systolic *** center’s objective was to increase our transplant volume by expanding our donor pool from“traditional”donors to these“non-traditional”*** detail how medical advances such as certain laboratory studies,pharmacologic interventions,and organ care systems have allowed our center to expand the donor pool thereby increasing transplantation volume without adverse effects on outcomes.

关键词： Orthotopic heart transplantation Hepatitis C virus COVID-19 Left ventricular systolic dysfunction Human immunodeficiency virus Donation after cardiac death

Bone-conditioned medium contributes to initiation and progression of osteogenesis by exhibiting synergistic TGF-β1/BMp-2 activity

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International Journal of Oral Science 2018年第4期10卷 203-211页

作者： Maria B.Asparuhova Jordi Caballé-Serrano daniel Buser Vivianne Chappuis Laboratory of Oral Cell Biology School of Dental MedicineUniversity of Bern Department of Oral Surgery and Stomatology School of Dental MedicineUniversity of Bern Department of Oral and Maxillofacial Surgery School of Dental MedicineUniversitat Internacional de Catalunya

Guided bone regeneration (GBR) often utilizes a combination of autologous bone grafts, deproteinized bovine bone mineral(DBBM), and collagen membranes. DBBM and collagen membranes pre-coated with bone-conditioned medium (BCM) extracted from locally harvested autologous bone chips have shown great regenerative potential in GBR. However, the underlying molecular mechanism remains largely unknown. Here, we investigated the composition of BCM and its activity on the osteogenic potential of mesenchymal stromal cells. We detected a fast and significant (p phogenetic protein-2 (BMp-2) release from 40 min onwards. BCMs harvested within short time periods (10, 20, or 40 min), corresponding to the time of a typical surgical procedure, significantly increased the proliferative activity and collagen matrix production of BCM-treated cells. Long-term (1, 3, or 6 days)-extracted BCMs promoted the later stages of osteoblast differentiation and maturation. Short-term-extracted BCMs, in which TGF-β1 but no BMp-2was detected, reduced the expression of the late differentiation marker osteocalcin. However, when both growth factors were present simultaneously in the BCM, no inhibitory effects on osteoblast differentiation were observed, suggesting a synergistic TGF-β1/BMp-2 activity. Consequently, in cells that were co-stimulated with recombinant TGF-β1 and BMp-2, we showed a significant stimulatory and dose-dependent effect of TGF-β1 on BMp-2-induced osteoblast differentiation due to prolonged BMp signaling and reduced expression of the BMp-2 antagonist noggin. Altogether, our data provide new insights into the molecular mechanisms underlying the favorable outcome from GBR procedures using BCM, derived from autologous bone grafts.

关键词： Bone-conditioned medium contributes to initiation and progression of osteogenesis by exhibiting synergistic TGF BMp-2 activity

Effect of matrix-nanoparticle interactions on recognition of aryldiazonium nanoparticle-imprinted matrices

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Nano Research 2019年第2期12卷 265-271页

作者： Netta Bruchiel-Spanier Linoy Dery Noam Tal Shahar Dery Elad Gross daniel Mandler Institute of Chemistry The Hebrew University of Jerusalem Jerusalem 9190401 Israel

The selective recognition of nanoparticles (Nps) can be achieved by nanoparticle-imprinted matrices (NAIMs),where Nps are imprinted in a matrix followed by their removal to form voids that can reuptake the original *** recognition depends on supramolecular interactions between the matrix and the shell of the Nps,as well as on the geometrical suitability of the imprinted voids to accommodate the ***,gold Nps stabilized with citrate (AuNps-cit) were preadsorbed onto a conductive surface followed by electrografting of p-aryldiazonium salts (ADS) with different functional *** thickness of the matrix was carefully controlled by altering the scan *** AuNps-cit were removed by electrochemical *** recognition of the NAIMs was determined by the reuptake of the original AuNps-cit by the imprinted *** found that the recognition efficiency is a function of the thickness of the NAIM layer and is sensitive to the chemical structure of the ***,a subtle change of the functional group of the p-aryldiazonium building block,which was varied from an ether to an ester,significantly affected the recognition of the Nps.

关键词： diazonium salt nanoparticles imprinting electrochemistry focused ion beam

processing techniques of selected oilseed by-products of potential use in animal feed: Effects on proximate nutrient composition, amino acid profile and antinutrients

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Animal Nutrition 2018年第4期4卷 442-451页

作者： Collins p.Duodu daniel Adjei-Boateng Regina E.Edziyie Nelson W.Agbo Godfred Owusu-Boateng Bodil K.Larsen peter V.Skov Department of Fisheries and Watershed Management Faculty of Renewable Natural Resources Kwame Nkrumah University of Science and TechnologyPMB University Post Office Section for Aquaculture DTU Aqua Technical University of Denmark

The effects of processing by autoclaving(AC), soaking(SK), short-term fermentation(S-TF, 4 d) and longterm fermentation(L-TF, 14 d) on the nutritional composition, amino acid profile and some antinutrients were determined for cottonseed meal(CSM), groundnut meal(GNM) and groundnut husk(GH) in this study. After processing, crude protein content improved by 11% after L-TF, and crude lipid content 25%after SK for CSM; crude protein content improved by 27% after S-TF and L-TF, and crude lipid content 13%after SK for GNM. Soaking and fermentation were shown to significantly increase essential amino acid contents by 44%(SK, methionine) in CSM and 46% in GNM(L-TF, histidine). phosphorus content was reduced by 59% in CSM and 57% in GNM by L-TF. All processing techniques, with the exception of AC,reduced phytic acid and gossypol contents in CSM and GNM. It was concluded that SK and fermentation were simple, cost-effective, and efficient ways to improve the nutritional value of the selected oilseed byproducts.

关键词： Amino acid Autoclaving Fermentation proximate composition Soaking

Water-induced hydrogenation of graphene/metal interfaces at room temperature:Insights on water intercalation and identification of sites for water splitting

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Nano Research 2019年第12期12卷 3101-3108页

作者： Guangyu He Qi Wang Hak Ki Yu daniel Farias Yingchun Liu Antonio politano Department of Chemistry Zhejiang UniversityHangzhou 310027China Department of Materials Science and Engineering and Department of Energy Systems Research Ajou UniversitySuwon 16499Republic of Korea Departamento de Ftsica de la Materia Condensada Universidad Autonoma de MadridMadrid 28049Spain Instituto"Nicolas Cabrera"and Condensed Matter physics Center(IFIMAC) Universidad Autonoma de MadridMadrid 28049Spain Department of physical and Chemical Sciences University of L'AquilaVia Vetoio 10L'Aquila 1-67100Italy CNR-IMM Istituto per la Microelettronica e Microsistemi VIII strada 5Catania 1-95121Italy

Though it is well recognized that the space between graphene cover and the metal substrate canact as a two-dimensional(2D)nanoreactor,several issues are still unresolved,including the role of the metal substrate,the mechanisms ruling water intercalation and the identification ofsites at which water is ***,we solve these issues by means of density functional theory and high-resolution electron energyloss spectroscopy experiments carried out on graphene grown on(111)-oriented Cu ***,we observe decomposition of H2O atroom temperature with only H atoms forming bonds with graphene and with buried OH groups underneath the graphene *** model discloses physicochemical mechanisms ruling the migration and decomposition of water on graphene/*** discover thatthe edge of graphene can be easily saturated by H through decomposition of H2O,which allows H2O to migrate in the subsurface region from thedecoupled edge,where H2O decomposes at room *** atoms produced by the decomposition of H2O initially form a chemicalbond with graphene for the lower energy barrier compared with other *** findings are essential to exploit graphene/Cu interfaces incatalysis and in energy-related applications.

关键词： graphene/metal interfaces intercalation water splitting room temperature