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Heart failure as an adverse effect of infliximab for Crohn's disease: A case report and review of the literature

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World Journal of Clinical Cases 2021年第33期9卷 10382-10391页

作者： Thais Gagno Grillo Luciana Rocha Almeida Rodrigo Fedatto Beraldo Mariana Barros Marcondes Diego Aparecido Rios Queiróz daniel Luiz da silva Rodrigo Quera Julio Pinheiro Baima Rogerio Saad-Hossne Ligia Yukie Sassaki Department of Internal Medicine São Paulo State University(Unesp)Medical SchoolBotucatu 18618687São PauloBrazil Department of Pathology São Paulo State University(Unesp)Medical SchoolBotucatu 18618687São PauloBrazil Inflammatory Bowel Disease Program Digestive Disease Center Clínica Universidad de los AndesSantiago 7550000Chile

BACKGROUND Anti-tumor necrosis factor agents were the first biologic therapy approved for the management of Crohn's disease(CD).Heart failure(HF)is a rare but potential adverse effect of these *** objective of this report is to describe a patient with CD who developed HF after the use of *** SUMMARY A 50-year-old woman with a history of hypertension and diabetes presented with abdominal pain,diarrhea,and weight *** and enterotomography showed ulcerations,areas of stenosis and dilation in the terminal ileum,and thickening of the intestinal *** patient underwent ileocolectomy and the surgical specimen confirmed the diagnosis of stenosing *** patient started infliximab and azathioprine treatment to prevent post-surgical *** 6 mo after initiating infliximab therapy,the patient complained of dyspnea,orthopnea,and paroxysmal nocturnal dyspnea that gradually *** revealed biventricular dysfunction,moderate cardiac insufficiency,an ejection fraction of 36%,and moderate pericardial effusion,consistent with *** cardiac disease was considered an infliximab adverse effect and the drug was *** patient received treatment with diuretics for HF and showed improvement of symptoms and cardiac ***,the patient is using anti-interleukin for CD and is *** This reported case supports the need to investigate risk factors for HF in inflammatory bowel disease patients and to consider the risk-benefit of introducing infliximab therapy in such patients presenting with HF risk factors.

关键词： Heart failure Infliximab Anti-tumor necrosis factor therapy Crohn's disease Inflammatory bowel disease Case report

Hematological reference values and animal welfare parameters of BALB/C-FMABC (Mus musculus) inoculated with Ehrlich tumor kept in the vivarium at ABC Medical School

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Animal Models and Experimental Medicine 2020年第1期3卷 32-39页

作者： Patrick Gabriel dos Santos Pessini Paula Regina Knox de Souza Camila dos Santos Chagas Emily Garcia Sampaio daniel Santos Neves Giuliana Petri Fernando Luiz Affonso Fonseca Emerson Barbosa da silva Clinical Analysis Laboratory of the ABC University Health Center Santo AndreBrazil Health Sciences Institute/Paulista University–UNIP Sao PauloBrazil

Background:Biochemical and hematological parameters are important tools for assessing the physiological profile of vital organs,and can be recorded to create reference values used for clinical diagnosis of *** research laboratories lack the means to establish their own set of reference parameters for use in their research,and while there are articles in the literature that discuss laboratory parameters for healthy BALB/c mice,few studies address the evaluation of these parameters in pathological situations,such as in mice inoculated with Ehrlich ***:BALB/c-FMABC mice previously inoculated with Ehrlich tumor were maintained under appropriate *** samples were taken for analysis of hematological parameters using automated and semi-automated equipment to create a set of the animal welfare parameters for ***:Results were obtained for all the hematological parameters for all groups *** showed:statistically significant differences between the initial and final tumor weight;comparable initial tumour volume and weight;an increase in leukocytes in the 7-day group with a characteristic predominance of lymphocytes and neutrophils;statistically significant changes in RDW in the 21-day group and in the welfare parameters in the 28-day ***:The study successfully defined and established reference values for hematological and welfare parameters for all groups analyzed.

关键词： ehrlich tumor carcinoma experimental animal model reference value welfare

Effects of a Neuropsychopedagogical Parenting Program on the Cognitive and Motor Development of Children with ADHD

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Journal of Behavioral and Brain Science 2022年第10期12卷 485-498页

作者： Luciana De Oliveira matos Cláudia Inês P. O. Abreu Deizeane Da Costa Abreu Fabrício Bruno Cardoso Vitor Da silva Loureiro Laboratory of Educational Innovations and Neuropsychopedagogical Studies (LIEENP) CENSUPEG S&atilde o Fidé lis Brazil

This study aimed to evaluate the effects of a neuropsychopedagogical parenting program (NPP) on the cognitive and motor development of children with ADHD. 70 children with ADHD participated in the present study, of both sexes, aged between 06 and 08 years old (7.08 years old), who were divided into two groups: (A—35 children with ADHD who did not undergo the NPP;B—35 children with ADHD who underwent the NPP). The NPP had a duration of 25 sessions of 15 minutes each, at a frequency of 3 times a week. To evaluate the effects of the NPP, the children were submitted to the following protocols: 1) Swanson, Nolan and Pelham Questionaire (SNAP-IV);2) Assessment of Motor Competence through the Supine-to Stand (STS);3) Assessment of executive functioning through the HEAD-FOOT-KNEE- SHOULDER (HFKS) protocol;4) Assessment of Reading Comprehension. Both groups were evaluated before the NPP, after the NPP and four months after the end of the NPP. Our results show that GB children in the signs/ symptoms evaluated by SNAP-IV had a superior performance by ±11% (p < 0.01) in relation to GA children. Regarding motor competence, the children from GB had a superior performance by ±24% (p < 0.01) in relation to children from GA. When assessed for executive functioning when establishing an intergroup comparison, GB children performed ±23% better (p < 0.01) than GA children. Regarding reading ability, children from (GB) had a superior performance by ±9% (p < 0.05) compared to children from (GA), after undergoing the NPP.

关键词： Children ADHD Parental Program

Immature Embryo Rescue and in Vitro Development Evaluation of Intraspecific Hybrids from Brazilian Seedless Grapevine“Superior×Thompson”Clones

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American Journal of Plant Sciences 2014年第13期5卷 1956-1960页

作者： Eiryanne Fonseca de Menezes Eliene matos e silva Adriana Mayumi Yano-Melo Patricia Coelho de Souza Leao Natoniel Franklin de Melo State University of Feira de Santana—PPG on Plant Genetic Resources Feira de SantanaBrazil Federal University of Pernambuco—PPG in Biology of Fungi RecifeBrazil Federal University of Vale do Sao Francisco-CCA/CZOO PetrolinaBrazil Embrapa Semi-Arid Tropical Biotechnology LaboratoryPetrolinaBrazil

The fruit production for export is an economically significant activity in the Valley of S?o Francisco River, especially in the irrigated lands of Petrolina-PE/Juazeiro-BA, Brazil. The development of new genetic material most suitable to the tropical climate and the demands of the consumer market have led to the selection of new seedless grapes cultivars. In this case, the use of the embryo rescue technique has produced satisfactory results for obtaining such materials, especially in the semiarid region. This study aimed to evaluate the in vitro development of intraspecific hybrids of grapevine (Vitis vinifera L.), derived from the rescue of immature embryos resultant from the crossing of “Superior Seedless” and “Thompson Seedless” Brazilian clones. To establish and develop the cultivation, the culture media was supplemented with 30 g/L sucrose, 0.1 g/L myo-inositol, 0.002 g/L glycine, 0.1 mg/L indoleacetic acid (IAA), 6.5 g/L of agar, adjusted pH to 5.7. The experiment was evaluated after 90 days. The variables measured were: number of nodes, number of leaves, plant height (cm), number of roots and length (cm) of the root system and internodes. The period of 60 days of in vitro culture of ovules resulted in the highest values of embryos (about 50%), as well as better characterized developmental stages with higher germination (47.3%). The three types of hybrid grapes evaluated in micropropagation showed very similar values of the measured parameters, even having originated from embryos of different developmental stages.

关键词： Vitis vinifera Seedless Grapes in Vitro Embryo Cultivation

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Effects of the use of bioceramic wraps in patients with lower limb venous ulcers:A randomized double-blind placebo-controlled trial

作者： (美)丹尼尔·席尔瓦(daniel silva)

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Journal of Integrative Medicine 2020年第1期18卷 26-34页

作者： Gerli E.G.Herr Fábio Goulart da silva Francisco Jose Cidral-Filho Fabricia Petronilho Lucinéia Gainski danielski Mariana Pereira de Souza Goldim Afonso Shiguemi Inoue Salgado Franciane Bobinski daniel Fernandes Martins Eliane R.Winkelmann Integral Health Care Regional University of the Northwest of the State of Rio Grande do Sul(UNIJUí)and University of Cruz Alta(UNICRUZ)Ijuí98700-000RSBrazil Experimental Neuroscience Laboratory(LaNEx) University of Southern Santa CatarinaPalhoca 88137-270SCBrazil Laboratory of Neurobiology of Inflammatory and Metabolic Processes University of Southern Santa CatarinaTubarao 88704-900SCBrazil Integrative Physical Therapy Residency Philadelphia University CenterLondrina 86020-000PRBrazil Laboratory of Exercise Physiopathology Department of Life Sciences(DCVida)Regional University of the Northwest of the State of Rio Grande do Sul(UNIJUí)Ijuí98700-000RSBrazil

Background:Venous ulcer represents the most advanced stage of chronic venous *** is an important public health problem and has a significant impact on patients’quality of life due to chronic pain,inability to work,need for hospitalization and frequent outpatient ***:We investigated the treatment benefits of far-infrared ceramic(cFIR),in a 90-day study of lower limb venous ulcers and looked at ulcer healing scores,quality of life,serum bio-markers of oxidative stress and antioxidant defense ***,setting,participants and interventions:This is a randomized double-blind placebo-controlled study conducted in the Vascular Surgery Service of a hospital located in the northwest region of the State of Rio Grande do Sul,*** included patients with lower limb venous ulcers who were randomized to use either a bioceramics wrap or a placebo wrap for 90 *** outcome measures:The following evaluations were conducted at baseline and after 15,30,60 and90 days:ulcer healing score,quality of life,and serum markers of oxidative stress and antioxidant enzyme ***:Patients(n=24)with lower limb venous ulcers were randomized into two treatment *** decreased the ulcer size on day 30(P=0.042)and 90(P=0.034)and the total ulcer healing scale scores on day 30(P=0.049)and 90(P=0.02)of the treatment,when compared to ***,cFIR improved tissue type(epithelial tissue)on day 60(P=0.022)when compared to baseline ***:cFIR clinically improved ulcer healing in patients with lower limb venous *** registration:RBR-8c7xzn on ReBEC.

关键词： Far-infrared radiation Quality of life Oxidative stress Wound healing Randomized controlled trial Bioceramic wrap

The potential of Hoplias malabaricus(Characiformes:Erythrinidae),a Neotropical carnivore,for aquaculture

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Aquaculture and Fisheries 2019年第3期4卷 89-97页

作者： Marcos daniel Renó Faria Aderbal Cavalcante-Neto Ivan Bezerra Allaman Aline Dal’Olio Gomes Renata Guimarães Moreira Eric M.Hallerman Alexandre Wagner silva Hilsdorf Unit of Biotechnology University of Mogi das CruzesMogi das CruzesSP08780-970Brazil Department of Exact Sciences and Technology State University of Santa CruzIlhéusBA45662-900Brazil Department of Physiology Bioscience InstituteUniversity of São PauloSão PauloSP05508-020Brazil Department of Fish and Wildlife Conservation Virginia Polytechnic Institute and State UniversityBlacksburgVA 23061-0321USA

We describe key production-related traits of trahira(Hoplias malabaricus),an aquaculture candidate species,in a semi-intensive fish farming *** quantified growth from hatch through grow-out at two stocking densities and evaluated fillet protein,lipids and fatty-acid *** made 2430 observations of growth and morphometrics on 270 juvenile fish allocated to four fish ponds,two at 5 fish/m^(2)(90 animals)and two at 10 fish/m^(2)(180 animals)through 11 *** fish reached an average length of 27.5 cm(±0.38)and 27.0 cm(±0.24),and weight of 263.0 g(±10.54)and 246.7 g(±6.89),respectively,at the low and high *** was no significant difference in weight(P>0.05)between the densities for any of the parameters assessed,and hence the same growth curve applied to both densities(A=292.9;B=28.1;and K=0.65).Standard length,however,differed significantly(P<0.05)between densities,with K=0.35 at the low and K=0.29 at the high *** both stocking densities,total lipids increased throughout the trial,while protein content *** acid(C18:0)increased throughout the experimental period,while docosahexaenoic acid and the n3/n6 profile decreased,with no differences among stocking *** malabaricus may prove a viable aquaculture species in Neotropical regions,where development of native species may contribute to sustainable aquaculture production.

关键词： Farming Growth models Native species Trahira Fatty acids

A New Formulation to the Point Kinetics Equations Considering the Time Variation of the Neutron Currents

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World Journal of Nuclear Science and Technology 2015年第1期5卷 57-71页

作者： Anderson Lupo Nunes Aquilino Senra Martinez Fernando Carvalho da silva daniel Artur Pinheiro Palma Department of Nuclear Engineering COPPE/UFRJ Rio de Janeiro Brazil Brazilian Commission for Nuclear Energy Rio de Janeiro Brazil

The system of point kinetics equations describes the time behaviour of a nuclear reactor, assuming that, during the transient, the spatial form of the flux of neutrons varies very little. This system has been largely used in the analysis of transients, where the numerical solutions of the equations are limited by the stiffness problem that results from the different time scales of the instantaneous and delayed neutrons. Its derivation can be done directly from the neutron transport equation, from the neutron diffusion equation or through a heuristics procedure. All of them lead to the same functional form of the system of differential equations for point kinetics, but with different coefficients. However, the solution of the neutron transport equation is of little practical use as it requires the change of the existent core design systems, as used to calculate the design of the cores of nuclear reactors for different operating cycles. Several approximations can be made for the said derivation. One of them consists of disregarding the time derivative for neutron density in comparison with the remaining terms of the equation resulting from the P1 approximation of the transport equation. In this paper, we consider that the time derivative for neutron current density is not negligible in the P1 equation. Thus being, we obtained a new system of equations of point kinetics that we named as modified. The innovation of the method presented in the manuscript consists in adopting arising from the P1 equations, without neglecting the derivative of the current neutrons, to derive the modified point kinetics equations instead of adopting the Fick’s law which results in the classic point kinetics equations. The results of the comparison between the point kinetics equations, modified and classical, indicate that the time derivative for the neutron current density should not be disregarded in several of transient analysis situations.

关键词： Reactor Point-Kinetics Neutron Current Density Nuclear Power Density

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